{"id":"https://openalex.org/W2074200299","doi":"https://doi.org/10.1371/journal.pcbi.1003273","title":"Molecular Mechanical Differences between Isoforms of Contractile Actin in the Presence of Isoforms of Smooth Muscle Tropomyosin","display_name":"Molecular Mechanical Differences between Isoforms of Contractile Actin in the Presence of Isoforms of Smooth Muscle Tropomyosin","publication_year":2013,"publication_date":"2013-10-24","ids":{"openalex":"https://openalex.org/W2074200299","doi":"https://doi.org/10.1371/journal.pcbi.1003273","mag":"2074200299","pmid":"https://pubmed.ncbi.nlm.nih.gov/24204225"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003273","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003273","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003273&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003273&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052588728","display_name":"Lennart Hilbert","orcid":"https://orcid.org/0000-0003-4478-5607"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I4210142132","display_name":"Christie (Canada)","ror":"https://ror.org/03jp8j090","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210142132"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lennart Hilbert","raw_affiliation_strings":["Dept. Physiology, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada ; Centre for Applied Mathematics in Bioscience and Medicine, Montr\u00e9al, Qu\u00e9bec, Canada ; Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","Centre for Applied Mathematics in Bioscience and Medicine, Montr\u00e9al, Qu\u00e9bec, Canada","Dept. Physiology, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Physiology, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada ; Centre for Applied Mathematics in Bioscience and Medicine, Montr\u00e9al, Qu\u00e9bec, Canada ; Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":[]},{"raw_affiliation_string":"Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651","https://openalex.org/I4210142132"]},{"raw_affiliation_string":"Centre for Applied Mathematics in Bioscience and Medicine, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":[]},{"raw_affiliation_string":"Dept. Physiology, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066865211","display_name":"Genevieve Bates","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142132","display_name":"Christie (Canada)","ror":"https://ror.org/03jp8j090","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210142132"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Genevieve Bates","raw_affiliation_strings":["Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651","https://openalex.org/I4210142132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019877928","display_name":"Horia N. Roman","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142132","display_name":"Christie (Canada)","ror":"https://ror.org/03jp8j090","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210142132"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Horia N. Roman","raw_affiliation_strings":["Dept. Biomedical Engineering, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Biomedical Engineering, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651","https://openalex.org/I4210142132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030858668","display_name":"Jenna L. Blumenthal","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142132","display_name":"Christie (Canada)","ror":"https://ror.org/03jp8j090","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210142132"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jenna L. Blumenthal","raw_affiliation_strings":["Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651","https://openalex.org/I4210142132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051780442","display_name":"Nedjma B. Zitouni","orcid":null},"institutions":[{"id":"https://openalex.org/I4210142132","display_name":"Christie (Canada)","ror":"https://ror.org/03jp8j090","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210142132"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nedjma B. Zitouni","raw_affiliation_strings":["Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651","https://openalex.org/I4210142132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001077057","display_name":"Apolinary Sobieszek","orcid":"https://orcid.org/0000-0003-4915-9621"},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"funder","lineage":["https://openalex.org/I138211613"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Apolinary Sobieszek","raw_affiliation_strings":["Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria","institution_ids":["https://openalex.org/I138211613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026791955","display_name":"Michael C. Mackey","orcid":"https://orcid.org/0000-0002-8524-2396"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael C. Mackey","raw_affiliation_strings":["Centre for Applied Mathematics in Bioscience and Medicine, Montr\u00e9al, Qu\u00e9bec, Canada","Dept. Physics and Dept. Mathematics, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","Dept. Physiology, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Applied Mathematics in Bioscience and Medicine, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":[]},{"raw_affiliation_string":"Dept. Physics and Dept. Mathematics, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Dept. Physiology, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040186669","display_name":"Anne\u2010Marie Lauzon","orcid":"https://orcid.org/0000-0003-1199-7259"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I4210142132","display_name":"Christie (Canada)","ror":"https://ror.org/03jp8j090","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210142132"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Anne-Marie Lauzon","raw_affiliation_strings":["Dept. Biomedical Engineering, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","Dept. Medicine, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Biomedical Engineering, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Dept. Medicine, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Meakins-Christie Laboratories, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I5023651","https://openalex.org/I4210142132"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5040186669"],"corresponding_institution_ids":["https://openalex.org/I4210142132","https://openalex.org/I5023651"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6169,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.74159298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"9","issue":"10","first_page":"e1003273","last_page":"e1003273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11246","display_name":"Sports injuries and prevention","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tropomyosin","display_name":"Tropomyosin","score":0.8832962512969971},{"id":"https://openalex.org/keywords/myosin","display_name":"Myosin","score":0.8523526787757874},{"id":"https://openalex.org/keywords/actin","display_name":"Actin","score":0.7122910022735596},{"id":"https://openalex.org/keywords/meromyosin","display_name":"Meromyosin","score":0.6578879356384277},{"id":"https://openalex.org/keywords/actin-remodeling","display_name":"Actin remodeling","score":0.5207145810127258},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48327070474624634},{"id":"https://openalex.org/keywords/gene-isoform","display_name":"Gene isoform","score":0.48324593901634216},{"id":"https://openalex.org/keywords/microfilament","display_name":"Microfilament","score":0.475576788187027},{"id":"https://openalex.org/keywords/myosin-light-chain-kinase","display_name":"Myosin light-chain kinase","score":0.472549170255661},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"Muscle contraction","score":0.466705322265625},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.45394471287727356},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4508880078792572},{"id":"https://openalex.org/keywords/myosin-head","display_name":"Myosin head","score":0.4348357915878296},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"Actin cytoskeleton","score":0.37454134225845337},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3579569458961487},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.30671197175979614},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"Cytoskeleton","score":0.25405940413475037},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.209102600812912},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.09500229358673096}],"concepts":[{"id":"https://openalex.org/C205875245","wikidata":"https://www.wikidata.org/wiki/Q418454","display_name":"Tropomyosin","level":3,"score":0.8832962512969971},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.8523526787757874},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.7122910022735596},{"id":"https://openalex.org/C18923293","wikidata":"https://www.wikidata.org/wiki/Q6819942","display_name":"Meromyosin","level":5,"score":0.6578879356384277},{"id":"https://openalex.org/C3620293","wikidata":"https://www.wikidata.org/wiki/Q14908027","display_name":"Actin remodeling","level":5,"score":0.5207145810127258},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48327070474624634},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.48324593901634216},{"id":"https://openalex.org/C189040839","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Microfilament","level":4,"score":0.475576788187027},{"id":"https://openalex.org/C8035138","wikidata":"https://www.wikidata.org/wiki/Q6017854","display_name":"Myosin light-chain kinase","level":3,"score":0.472549170255661},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.466705322265625},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45394471287727356},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4508880078792572},{"id":"https://openalex.org/C15954220","wikidata":"https://www.wikidata.org/wiki/Q24780076","display_name":"Myosin head","level":4,"score":0.4348357915878296},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.37454134225845337},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3579569458961487},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30671197175979614},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.25405940413475037},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.209102600812912},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.09500229358673096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014335","descriptor_name":"Tropomyosin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014335","descriptor_name":"Tropomyosin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014335","descriptor_name":"Tropomyosin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014335","descriptor_name":"Tropomyosin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014335","descriptor_name":"Tropomyosin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014335","descriptor_name":"Tropomyosin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014422","descriptor_name":"Turkeys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014422","descriptor_name":"Turkeys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014422","descriptor_name":"Turkeys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1003273","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003273","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003273&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24204225","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24204225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.794.5654","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.794.5654","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2e/66/pcbi.1003273.PMC3812040.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003273","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003273","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:494dcae7d24f47eea35101091263a3f4","is_oa":true,"landing_page_url":"https://doaj.org/article/494dcae7d24f47eea35101091263a3f4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 10, p e1003273 (2013)","raw_type":"article"},{"id":"pmh:oai:escholarship.mcgill.ca:fx719r04c","is_oa":true,"landing_page_url":"https://escholarship.mcgill.ca/concern/articles/fx719r04c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401568","display_name":"eScholarship@McGill (McGill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I5023651","host_organization_name":"McGill University","host_organization_lineage":["https://openalex.org/I5023651"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003273","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:2808849","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3812040","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/831601","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Molecular_Mechanical_Differences_between_Isoforms_of_Contractile_Actin_in_the_Presence_of_Isoforms_of_Smooth_Muscle_Tropomyosin_/831601","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3812040","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3812040","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003273","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003273","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003273&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7450319438","display_name":null,"funder_award_id":"RO1-HL 103405-02","funder_id":"https://openalex.org/F4320310638","funder_display_name":"McGill University"}],"funders":[{"id":"https://openalex.org/F4320310638","display_name":"McGill University","ror":"https://ror.org/01pxwe438"},{"id":"https://openalex.org/F4320310682","display_name":"Faculty of Medicine, McGill University","ror":"https://ror.org/01pxwe438"},{"id":"https://openalex.org/F4320314000","display_name":"Compute Canada","ror":"https://ror.org/03ty8yr27"},{"id":"https://openalex.org/F4320314794","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19"},{"id":"https://openalex.org/F4320322572","display_name":"Studienstiftung des Deutschen Volkes","ror":"https://ror.org/05xwwfy96"},{"id":"https://openalex.org/F4320322675","display_name":"Mitacs","ror":"https://ror.org/00cjrc276"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2074200299.pdf","grobid_xml":"https://content.openalex.org/works/W2074200299.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W31313758","https://openalex.org/W199045229","https://openalex.org/W234646475","https://openalex.org/W952792670","https://openalex.org/W1545034454","https://openalex.org/W1557616259","https://openalex.org/W1558248215","https://openalex.org/W1596170938","https://openalex.org/W1683009307","https://openalex.org/W1957276195","https://openalex.org/W1970900771","https://openalex.org/W1975244725","https://openalex.org/W1976053070","https://openalex.org/W1981642548","https://openalex.org/W1983407178","https://openalex.org/W2001861759","https://openalex.org/W2002340060","https://openalex.org/W2002494763","https://openalex.org/W2002534145","https://openalex.org/W2007288168","https://openalex.org/W2008050998","https://openalex.org/W2026836008","https://openalex.org/W2031986520","https://openalex.org/W2036098262","https://openalex.org/W2036480849","https://openalex.org/W2053479137","https://openalex.org/W2053717929","https://openalex.org/W2057096287","https://openalex.org/W2058497997","https://openalex.org/W2076107024","https://openalex.org/W2076120192","https://openalex.org/W2086487198","https://openalex.org/W2090844617","https://openalex.org/W2090969926","https://openalex.org/W2094759154","https://openalex.org/W2117863128","https://openalex.org/W2122739844","https://openalex.org/W2128496574","https://openalex.org/W2144872573","https://openalex.org/W2145780151","https://openalex.org/W2154934072","https://openalex.org/W2156122211","https://openalex.org/W2163339377","https://openalex.org/W2224999195","https://openalex.org/W2231149392","https://openalex.org/W3023511788","https://openalex.org/W4247000966"],"related_works":["https://openalex.org/W2112739683","https://openalex.org/W1396645","https://openalex.org/W1194188777","https://openalex.org/W1995697648","https://openalex.org/W1992592186","https://openalex.org/W2002534145","https://openalex.org/W2811796540","https://openalex.org/W4319931830","https://openalex.org/W4310781519","https://openalex.org/W2010503455"],"abstract_inverted_index":{"The":[0],"proteins":[1],"involved":[2],"in":[3,37,57,141],"smooth":[4,63,297,302],"muscle's":[5],"molecular":[6],"contractile":[7],"mechanism":[8],"-":[9,25,178,189,204,236,256,268],"the":[10,43,140,220,227,241,244,269,287],"anti-parallel":[11],"motion":[12],"of":[13,46,144,294],"actin":[14,24,49,59,179,215,295],"and":[15,109,151,218,243,275,296],"myosin":[16,20,47,65,237,246],"filaments":[17],"driven":[18],"by":[19,62,131],"heads":[21],"interacting":[22],"with":[23,48,123],"are":[26,35,249],"found":[27],"as":[28,224],"different":[29,288],"isoforms.":[30],"While":[31],"their":[32,40],"expression":[33],"levels":[34],"altered":[36],"disease":[38],"states,":[39],"relevance":[41],"to":[42,161,193,225,239],"mechanical":[44,257,276],"interaction":[45,305],"is":[50,157,261,273,280],"not":[51,158],"sufficiently":[52],"understood.":[53],"Here,":[54],"we":[55],"analyzed":[56],"vitro":[58,142],"filament":[60],"propulsion":[61],"muscle":[64,298,303],"for":[66],"[Formula:":[67,73,83,93,99,110,145,148,152,173,184,199,231,251,263],"see":[68,71,74,76,79,81,84,86,89,91,94,97,100,102,105,107,111,113,116,118,146,149,153,155,170,174,176,185,187,200,202,232,234,252,254,264,266],"text]-actin":[69,95],"([Formula:":[70,78,88,96,104,115,169],"text]A),":[72,98],"text]-actin-tropomyosin-[Formula:":[75,85,101],"text]":[77,87,103,114,156,177,188,203,235,255,267],"text]A-Tm[Formula:":[80,90,106,117,154,175,186,201,233,253,265],"text]),":[82,92,108],"text]-actin-tropomoysin-[Formula:":[112],"text]).":[119],"Actin":[120],"sliding":[121,180,216],"analysis":[122,128],"our":[124,284],"specifically":[125],"developed":[126],"video":[127],"software":[129],"followed":[130],"statistical":[132],"assessment":[133],"(Bootstrapped":[134],"Principal":[135],"Component":[136],"Analysis)":[137],"indicated":[138],"that":[139,291],"motility":[143],"text]A,":[147,150],"distinguishable.":[159],"Compared":[160],"these":[162],"three":[163],"'baseline":[164],"conditions',":[165],"statistically":[166],"significant":[167],"differences":[168],"text])":[171],"were:":[172],"velocity":[181],"increased":[182],"1.12-fold,":[183],"motile":[190],"fraction":[191],"decreased":[192],"0.96-fold,":[194],"stop":[195],"time":[196,206],"elevated":[197,207],"1.6-fold,":[198],"run":[205],"1.7-fold.":[208],"We":[209],"constructed":[210],"a":[211],"mathematical":[212],"model,":[213],"simulated":[214],"data,":[217],"adjusted":[219],"kinetic":[221],"parameters":[222],"so":[223],"mimic":[226],"experimentally":[228],"observed":[229],"differences:":[230],"binding":[238],"actin,":[240],"main,":[242],"secondary":[245,270],"power":[247,271],"stroke":[248,272],"accelerated,":[250],"coupling":[258,277],"between":[259,278],"myosins":[260,279],"stronger,":[262],"decelerated":[274],"weaker.":[281],"In":[282],"summary,":[283],"results":[285],"explain":[286],"regulatory":[289],"effects":[290],"specific":[292],"combinations":[293],"tropomyosin":[299],"have":[300],"on":[301],"actin-myosin":[304],"kinetics.":[306]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
