{"id":"https://openalex.org/W2092686571","doi":"https://doi.org/10.1371/journal.pcbi.1003261","title":"Lipid Receptor S1P1 Activation Scheme Concluded from Microsecond All-Atom Molecular Dynamics Simulations","display_name":"Lipid Receptor S1P1 Activation Scheme Concluded from Microsecond All-Atom Molecular Dynamics Simulations","publication_year":2013,"publication_date":"2013-10-03","ids":{"openalex":"https://openalex.org/W2092686571","doi":"https://doi.org/10.1371/journal.pcbi.1003261","mag":"2092686571","pmid":"https://pubmed.ncbi.nlm.nih.gov/24098103"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003261","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003261","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003261&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003261&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022513985","display_name":"Shuguang Yuan","orcid":"https://orcid.org/0000-0001-9858-4742"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]},{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I4210120699","display_name":"International Institute of Molecular and Cell Biology","ror":"https://ror.org/01y3dkx74","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120699"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"funder","lineage":["https://openalex.org/I99542240"]}],"countries":["CH","PL"],"is_corresponding":true,"raw_author_name":"Shuguang Yuan","raw_affiliation_strings":["International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland ; Laboratory of Physical Chemistry of Polymers and Membranes, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, SB ISIC LCPPM, Lausanne, Switzerland ; Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland","International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland","Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland","Laboratory of Physical Chemistry of Polymers and Membranes, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, SB ISIC LCPPM, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland ; Laboratory of Physical Chemistry of Polymers and Membranes, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, SB ISIC LCPPM, Lausanne, Switzerland ; Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4210120699"]},{"raw_affiliation_string":"Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I16778253","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Laboratory of Physical Chemistry of Polymers and Membranes, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, SB ISIC LCPPM, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101182307","display_name":"Rongliang Wu","orcid":"https://orcid.org/0000-0002-5586-0628"},"institutions":[{"id":"https://openalex.org/I4210120699","display_name":"International Institute of Molecular and Cell Biology","ror":"https://ror.org/01y3dkx74","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120699"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Rongliang Wu","raw_affiliation_strings":["International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4210120699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077024945","display_name":"Dorota Latek","orcid":"https://orcid.org/0000-0002-0429-0637"},"institutions":[{"id":"https://openalex.org/I4210120699","display_name":"International Institute of Molecular and Cell Biology","ror":"https://ror.org/01y3dkx74","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210120699"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Dorota Latek","raw_affiliation_strings":["International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4210120699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065184964","display_name":"Bartosz Trzaskowski","orcid":"https://orcid.org/0000-0003-2385-1476"},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Bartosz Trzaskowski","raw_affiliation_strings":["Faculty of Chemistry, University of Warsaw, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, University of Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001609547","display_name":"S\u0142awomir Filipek","orcid":"https://orcid.org/0000-0003-3147-3858"},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Slawomir Filipek","raw_affiliation_strings":["Faculty of Chemistry, University of Warsaw, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, University of Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5001609547","https://openalex.org/A5022513985"],"corresponding_institution_ids":["https://openalex.org/I16778253","https://openalex.org/I4210120699","https://openalex.org/I4654613","https://openalex.org/I5124864","https://openalex.org/I99542240"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.0941,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.87127667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"10","first_page":"e1003261","last_page":"e1003261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.6369509696960449},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.6169033646583557},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.6028064489364624},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate-receptor","display_name":"Sphingosine-1-phosphate receptor","score":0.5467674732208252},{"id":"https://openalex.org/keywords/helix","display_name":"Helix (gastropod)","score":0.5377630591392517},{"id":"https://openalex.org/keywords/sphingosine","display_name":"Sphingosine","score":0.5163837671279907},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.4246925115585327},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4141959249973297},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3440038561820984},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3432103991508484},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.32103562355041504},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"Sphingosine-1-phosphate","score":0.28872793912887573}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6369509696960449},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6169033646583557},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6028064489364624},{"id":"https://openalex.org/C2776549689","wikidata":"https://www.wikidata.org/wiki/Q24782485","display_name":"Sphingosine-1-phosphate receptor","level":5,"score":0.5467674732208252},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5377630591392517},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.5163837671279907},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4246925115585327},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4141959249973297},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3440038561820984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3432103991508484},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32103562355041504},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.28872793912887573},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049349","descriptor_name":"Receptors, Lysosphingolipid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049349","descriptor_name":"Receptors, Lysosphingolipid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049349","descriptor_name":"Receptors, Lysosphingolipid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049349","descriptor_name":"Receptors, Lysosphingolipid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049349","descriptor_name":"Receptors, Lysosphingolipid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049349","descriptor_name":"Receptors, Lysosphingolipid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049349","descriptor_name":"Receptors, Lysosphingolipid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049349","descriptor_name":"Receptors, Lysosphingolipid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049349","descriptor_name":"Receptors, Lysosphingolipid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1003261","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003261","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003261&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24098103","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24098103","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.794.7024","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.794.7024","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b3/76/pcbi.1003261.PMC3789783.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:cbad0f3702544a84924e7a2641c576b6","is_oa":true,"landing_page_url":"https://doaj.org/article/cbad0f3702544a84924e7a2641c576b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 10, p e1003261 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2783282","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3789783","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/813576","is_oa":true,"landing_page_url":"https://figshare.com/articles/Lipid_Receptor_S1P_1_Activation_Scheme_Concluded_from_Microsecond_All_Atom_Molecular_Dynamics_Simulations/813576","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:infoscience.epfl.ch:199202","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/199202","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003261","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003261","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003261&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.7900000214576721}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2092686571.pdf"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1833104430","https://openalex.org/W1965469554","https://openalex.org/W1973892716","https://openalex.org/W1975032814","https://openalex.org/W1976161355","https://openalex.org/W1980831456","https://openalex.org/W1983579356","https://openalex.org/W1985588649","https://openalex.org/W1988839950","https://openalex.org/W1990724722","https://openalex.org/W1991558659","https://openalex.org/W1992203600","https://openalex.org/W2003120338","https://openalex.org/W2006985918","https://openalex.org/W2007804411","https://openalex.org/W2007878869","https://openalex.org/W2009423060","https://openalex.org/W2014118668","https://openalex.org/W2017835622","https://openalex.org/W2020954343","https://openalex.org/W2021832765","https://openalex.org/W2025205036","https://openalex.org/W2025273956","https://openalex.org/W2035266068","https://openalex.org/W2039399096","https://openalex.org/W2041485278","https://openalex.org/W2041791898","https://openalex.org/W2048866816","https://openalex.org/W2049863334","https://openalex.org/W2052091241","https://openalex.org/W2052702367","https://openalex.org/W2052801177","https://openalex.org/W2053740939","https://openalex.org/W2061457959","https://openalex.org/W2066414494","https://openalex.org/W2071288349","https://openalex.org/W2078845055","https://openalex.org/W2085488090","https://openalex.org/W2090977730","https://openalex.org/W2100561975","https://openalex.org/W2102513649","https://openalex.org/W2109254532","https://openalex.org/W2112816777","https://openalex.org/W2113786559","https://openalex.org/W2117003397","https://openalex.org/W2127553917","https://openalex.org/W2127739127","https://openalex.org/W2129241376","https://openalex.org/W2132579946","https://openalex.org/W2151535044","https://openalex.org/W2168966210","https://openalex.org/W2883755802","https://openalex.org/W2953211276","https://openalex.org/W4230277786"],"related_works":["https://openalex.org/W2312748819","https://openalex.org/W2128629299","https://openalex.org/W2001063978","https://openalex.org/W2118746823","https://openalex.org/W1985511873","https://openalex.org/W2069857733","https://openalex.org/W1998813251","https://openalex.org/W2382839978","https://openalex.org/W1979917621","https://openalex.org/W2023276420"],"abstract_inverted_index":{"Sphingosine":[0],"1-phosphate":[1,12,44],"(S1P)":[2],"is":[3,81,224],"a":[4,17,107,168,225],"lysophospholipid":[5],"mediator":[6],"which":[7,80,127,173],"activates":[8],"G":[9],"protein-coupled":[10],"sphingosine":[11,43],"receptors":[13],"and":[14,21,30,98,149,202,239],"thus":[15],"evokes":[16],"variety":[18],"of":[19,41,54,66,74,95,102,106,113,121,133,136,143,194,198,211,219,233,241],"cell":[20],"tissue":[22],"responses":[23],"including":[24],"lymphocyte":[25],"trafficking,":[26],"endothelial":[27],"development,":[28],"integrity,":[29],"maturation.":[31],"We":[32,60,185],"performed":[33],"five":[34],"all-atom":[35],"700":[36],"ns":[37],"molecular":[38],"dynamics":[39],"simulations":[40],"the":[42,63,72,84,92,96,119,125,130,137,144,152,162,176,182,188,191,195,199,216,220,234,242],"receptor":[45,56,97,126,235,243],"1":[46],"(S1P\u2081)":[47],"based":[48],"on":[49],"recently":[50],"released":[51],"crystal":[52],"structure":[53],"that":[55,62],"with":[57,167],"an":[58],"antagonist.":[59],"found":[61],"initial":[64],"movements":[65,112,120],"amino":[67],"acid":[68],"residues":[69,89,115],"occurred":[70],"in":[71,78,91,129,215,230],"area":[73],"highly":[75],"conserved":[76],"W269\u2076\u00b7\u2074\u2078":[77],"TM6":[79],"close":[82],"to":[83,100,118,161,179,209],"ligand":[85],"binding":[86],"location.":[87],"Those":[88],"located":[90],"central":[93,217],"part":[94,135,165,218,232],"adjacent":[99],"kinks":[101],"TM":[103],"helices":[104,147],"comprise":[105],"transmission":[108,200],"switch.":[109],"Side":[110],"chains":[111],"those":[114],"were":[116,146],"coupled":[117],"water":[122,212,237],"molecules":[123,213],"inside":[124],"helped":[128],"gradual":[131],"opening":[132,240],"intracellular":[134,164,183,231],"receptor.":[138,221],"The":[139],"most":[140],"stable":[141],"parts":[142],"protein":[145],"TM1":[148],"TM2,":[150],"while":[151],"largest":[153],"movement":[154],"was":[155],"observed":[156],"for":[157,187,227],"TM7,":[158],"possibly":[159],"due":[160],"short":[163],"starting":[166],"helix":[169,178],"kink":[170],"at":[171,181],"P\u2077\u00b7\u2075\u2070,":[172],"might":[174],"be":[175],"first":[177,189],"move":[180],"side.":[184],"show":[186],"time":[190],"detailed":[192],"view":[193],"concerted":[196],"action":[197],"switch":[201,207],"Trp":[203],"(W\u2076\u00b7\u2074\u2078)":[204],"rotamer":[205],"toggle":[206],"leading":[208],"redirection":[210],"flow":[214],"That":[222],"event":[223],"prerequisite":[226],"subsequent":[228],"changes":[229],"involving":[236],"influx":[238],"structure.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}