{"id":"https://openalex.org/W1973195879","doi":"https://doi.org/10.1371/journal.pcbi.1003218","title":"Thermal Adaptation of Conformational Dynamics in Ribonuclease H","display_name":"Thermal Adaptation of Conformational Dynamics in Ribonuclease H","publication_year":2013,"publication_date":"2013-10-03","ids":{"openalex":"https://openalex.org/W1973195879","doi":"https://doi.org/10.1371/journal.pcbi.1003218","mag":"1973195879","pmid":"https://pubmed.ncbi.nlm.nih.gov/24098095"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003218","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003218","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003218&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003218&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014635524","display_name":"Kate A. Stafford","orcid":"https://orcid.org/0000-0002-4144-4914"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate A. Stafford","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America","Department of Biochemistry and Molecular#N#                    Biophysics, Columbia University, New York, New York, United States of#N#                    America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular#N#                    Biophysics, Columbia University, New York, New York, United States of#N#                    America","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083330195","display_name":"Paul Robustelli","orcid":"https://orcid.org/0000-0002-9282-8993"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Robustelli","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America","Department of Biochemistry and Molecular#N#                    Biophysics, Columbia University, New York, New York, United States of#N#                    America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular#N#                    Biophysics, Columbia University, New York, New York, United States of#N#                    America","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055240763","display_name":"Arthur G. Palmer","orcid":"https://orcid.org/0000-0002-2770-0053"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arthur G. Palmer","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America","Department of Biochemistry and Molecular#N#                    Biophysics, Columbia University, New York, New York, United States of#N#                    America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular#N#                    Biophysics, Columbia University, New York, New York, United States of#N#                    America","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055240763"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.3599,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.88331328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"9","issue":"10","first_page":"e1003218","last_page":"e1003218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribonuclease","display_name":"Ribonuclease","score":0.7558310031890869},{"id":"https://openalex.org/keywords/rnase-p","display_name":"RNase P","score":0.660914421081543},{"id":"https://openalex.org/keywords/rnase-h","display_name":"RNase H","score":0.6389063596725464},{"id":"https://openalex.org/keywords/thermus-thermophilus","display_name":"Thermus thermophilus","score":0.6256447434425354},{"id":"https://openalex.org/keywords/protein-superfamily","display_name":"Protein superfamily","score":0.5330532789230347},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.5295218825340271},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.49127691984176636},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.487403929233551},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"Protein dynamics","score":0.48730480670928955},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.4629664421081543},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.45546019077301025},{"id":"https://openalex.org/keywords/globular-protein","display_name":"Globular protein","score":0.45020028948783875},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance-spectroscopy","display_name":"Nuclear magnetic resonance spectroscopy","score":0.44461116194725037},{"id":"https://openalex.org/keywords/ribonuclease-t1","display_name":"Ribonuclease T1","score":0.44337964057922363},{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.4285215735435486},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4196723401546478},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.40278249979019165},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36870110034942627},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.21151524782180786},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.19962412118911743},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.08139219880104065}],"concepts":[{"id":"https://openalex.org/C2778976237","wikidata":"https://www.wikidata.org/wiki/Q422523","display_name":"Ribonuclease","level":4,"score":0.7558310031890869},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.660914421081543},{"id":"https://openalex.org/C69766542","wikidata":"https://www.wikidata.org/wiki/Q3430179","display_name":"RNase H","level":5,"score":0.6389063596725464},{"id":"https://openalex.org/C2780883830","wikidata":"https://www.wikidata.org/wiki/Q139470","display_name":"Thermus thermophilus","level":4,"score":0.6256447434425354},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.5330532789230347},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5295218825340271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49127691984176636},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.487403929233551},{"id":"https://openalex.org/C2775981520","wikidata":"https://www.wikidata.org/wiki/Q17156992","display_name":"Protein dynamics","level":3,"score":0.48730480670928955},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.4629664421081543},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.45546019077301025},{"id":"https://openalex.org/C105168689","wikidata":"https://www.wikidata.org/wiki/Q901969","display_name":"Globular protein","level":2,"score":0.45020028948783875},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.44461116194725037},{"id":"https://openalex.org/C2780856089","wikidata":"https://www.wikidata.org/wiki/Q4394321","display_name":"Ribonuclease T1","level":5,"score":0.44337964057922363},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.4285215735435486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4196723401546478},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40278249979019165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36870110034942627},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.21151524782180786},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.19962412118911743},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.08139219880104065},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016914","descriptor_name":"Ribonuclease H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1003218","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003218","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003218&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24098095","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24098095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:academiccommons.columbia.edu:10.7916/D82B8XGK","is_oa":false,"landing_page_url":"https://doi.org/10.7916/D82B8XGK","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Theses"},{"id":"pmh:oai:academiccommons.columbia.edu:10.7916/D8HH6KGF","is_oa":false,"landing_page_url":"https://doi.org/10.7916/D8HH6KGF","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:doaj.org/article:aa71bc5fb4884397a514b1fd02b813a1","is_oa":true,"landing_page_url":"https://doaj.org/article/aa71bc5fb4884397a514b1fd02b813a1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 10, p e1003218 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2783279","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3789780","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/813702","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Thermal_Adaptation_of_Conformational_Dynamics_in_Ribonuclease_H_/813702","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.7916/d82b8xgk","is_oa":true,"landing_page_url":"https://doi.org/10.7916/d82b8xgk","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.7916/d8hh6kgf","is_oa":true,"landing_page_url":"https://doi.org/10.7916/d8hh6kgf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402601","display_name":"Columbia Academic Commons (Columbia University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I78577930","host_organization_name":"Columbia University","host_organization_lineage":["https://openalex.org/I78577930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003218","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003218","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003218&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4032121503","display_name":null,"funder_award_id":"GM50291","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4485549514","display_name":null,"funder_award_id":"R01 GM050291","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7977620768","display_name":null,"funder_award_id":"GM50291","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8458739547","display_name":"NSF Postdoctoral Fellowship in Biology FY 2010","funder_award_id":"1002684","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973195879.pdf","grobid_xml":"https://content.openalex.org/works/W1973195879.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W266858798","https://openalex.org/W1516989687","https://openalex.org/W1534152353","https://openalex.org/W1555985092","https://openalex.org/W1561651859","https://openalex.org/W1681177208","https://openalex.org/W1800345340","https://openalex.org/W1968366034","https://openalex.org/W1970850106","https://openalex.org/W1979378549","https://openalex.org/W1980100825","https://openalex.org/W1980397617","https://openalex.org/W1982904262","https://openalex.org/W1985767604","https://openalex.org/W1991917050","https://openalex.org/W1992717811","https://openalex.org/W1995730663","https://openalex.org/W2010591704","https://openalex.org/W2023414300","https://openalex.org/W2023882547","https://openalex.org/W2027743806","https://openalex.org/W2028968631","https://openalex.org/W2030495345","https://openalex.org/W2033916002","https://openalex.org/W2046218375","https://openalex.org/W2047682506","https://openalex.org/W2052216971","https://openalex.org/W2055497972","https://openalex.org/W2055939796","https://openalex.org/W2063147995","https://openalex.org/W2064187591","https://openalex.org/W2068475565","https://openalex.org/W2070780198","https://openalex.org/W2075460992","https://openalex.org/W2079541330","https://openalex.org/W2081504631","https://openalex.org/W2081893178","https://openalex.org/W2083526362","https://openalex.org/W2090577327","https://openalex.org/W2097107919","https://openalex.org/W2098473889","https://openalex.org/W2098787719","https://openalex.org/W2102388964","https://openalex.org/W2106937279","https://openalex.org/W2107644675","https://openalex.org/W2108196145","https://openalex.org/W2127362915","https://openalex.org/W2130060890","https://openalex.org/W2130881584","https://openalex.org/W2130947984","https://openalex.org/W2144029907","https://openalex.org/W2144288821","https://openalex.org/W2149395069","https://openalex.org/W2150662472","https://openalex.org/W2153066330","https://openalex.org/W2153076879","https://openalex.org/W2153228625","https://openalex.org/W2168240189","https://openalex.org/W4232483673"],"related_works":["https://openalex.org/W2033489687","https://openalex.org/W2150512577","https://openalex.org/W2116587672","https://openalex.org/W2081251716","https://openalex.org/W2887696034","https://openalex.org/W2158787422","https://openalex.org/W2133215398","https://openalex.org/W2019494020","https://openalex.org/W169205191","https://openalex.org/W2003479409"],"abstract_inverted_index":{"The":[0,20],"relationship":[1],"between":[2,74,126,172],"inherent":[3],"internal":[4],"conformational":[5,39,208],"processes":[6,179],"and":[7,82,103,118,128,135,175],"enzymatic":[8,104],"activity":[9],"or":[10],"thermodynamic":[11],"stability":[12],"of":[13,22,38,57,100,108,154,163,183,190,206],"proteins":[14,24,99],"has":[15,61],"proven":[16],"difficult":[17],"to":[18,68,187],"characterize.":[19],"study":[21],"homologous":[23,96],"with":[25],"differing":[26],"thermostabilities":[27,102],"offers":[28],"an":[29,47],"especially":[30],"useful":[31],"approach":[32],"for":[33,94,131,136,150],"understanding":[34],"the":[35,54,70,77,83,115,152,164,184,191,204],"functional":[36],"aspects":[37],"dynamics.":[40],"In":[41],"particular,":[42],"ribonuclease":[43],"HI":[44],"(RNase":[45],"H),":[46],"18":[48],"kD":[49],"globular":[50],"protein":[51,185],"that":[52,142,167],"hydrolyzes":[53],"RNA":[55],"strand":[56],"RNA:DNA":[58],"hybrid":[59],"substrates,":[60],"been":[62],"extensively":[63],"studied":[64],"by":[65],"NMR":[66,132],"spectroscopy":[67],"characterize":[69],"differences":[71],"in":[72,180],"dynamics":[73,90],"homologs":[75],"from":[76,106],"mesophilic":[78],"organism":[79,85],"E.":[80,116],"coli":[81,117],"thermophilic":[84],"T.":[86,119],"thermophilus.":[87],"Herein,":[88],"molecular":[89],"simulations":[91,144,165],"are":[92,201],"reported":[93],"five":[95],"RNase":[97],"H":[98],"varying":[101],"activities":[105],"organisms":[107],"markedly":[109],"different":[110,174],"preferred":[111],"growth":[112],"temperatures.":[113],"For":[114],"thermophilus":[120],"proteins,":[121],"strong":[122],"agreement":[123],"is":[124],"obtained":[125],"simulated":[127],"experimental":[129],"values":[130],"order":[133],"parameters":[134],"dynamically":[137],"averaged":[138],"chemical":[139],"shifts,":[140],"suggesting":[141],"these":[143,198,207],"can":[145],"be":[146],"a":[147,168,181],"productive":[148],"platform":[149],"predicting":[151],"effects":[153],"individual":[155],"amino":[156],"acid":[157],"residues":[158,196],"on":[159],"dynamic":[160,178],"behavior.":[161],"Analyses":[162],"reveal":[166],"single":[169],"residue":[170],"differentiates":[171],"two":[173,199],"otherwise":[176],"conserved":[177],"region":[182],"known":[186],"form":[188],"part":[189],"substrate-binding":[192],"interface.":[193],"Additional":[194],"key":[195],"within":[197],"categories":[200],"identified":[202],"through":[203],"temperature-dependence":[205],"processes.":[209]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
