{"id":"https://openalex.org/W2005088757","doi":"https://doi.org/10.1371/journal.pcbi.1003122","title":"Interaction of Motility, Directional Sensing, and Polarity Modules Recreates the Behaviors of Chemotaxing Cells","display_name":"Interaction of Motility, Directional Sensing, and Polarity Modules Recreates the Behaviors of Chemotaxing Cells","publication_year":2013,"publication_date":"2013-07-04","ids":{"openalex":"https://openalex.org/W2005088757","doi":"https://doi.org/10.1371/journal.pcbi.1003122","mag":"2005088757","pmid":"https://pubmed.ncbi.nlm.nih.gov/23861660"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003122","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003122","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003122&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003122&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058852571","display_name":"Changji Shi","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changji Shi","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA","Department of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049458047","display_name":"Chuan\u2010Hsiang Huang","orcid":"https://orcid.org/0000-0001-9993-8004"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuan-Hsiang Huang","raw_affiliation_strings":["Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091366547","display_name":"Peter N. Devreotes","orcid":"https://orcid.org/0000-0002-3260-1455"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter N. Devreotes","raw_affiliation_strings":["Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004842912","display_name":"Pablo A. Iglesias","orcid":"https://orcid.org/0000-0002-0840-155X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210111875","display_name":"Max Planck Institute for the Physics of Complex Systems","ror":"https://ror.org/01bf9rw71","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210111875"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Pablo A. Iglesias","raw_affiliation_strings":["Biological Physics, Max Planck Institute for the Physics of Complex Systems, Dresden, Germany","Department of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Physics, Max Planck Institute for the Physics of Complex Systems, Dresden, Germany","institution_ids":["https://openalex.org/I4210111875"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004842912"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210111875"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":1963,"currency":"EUR","value_usd":2117},"fwci":5.9332,"has_fulltext":true,"cited_by_count":126,"citation_normalized_percentile":{"value":0.96935316,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"9","issue":"7","first_page":"e1003122","last_page":"e1003122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotaxis","display_name":"Chemotaxis","score":0.7528663277626038},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"Cell polarity","score":0.6815715432167053},{"id":"https://openalex.org/keywords/motility","display_name":"Motility","score":0.6750619411468506},{"id":"https://openalex.org/keywords/pattern-formation","display_name":"Pattern formation","score":0.6221652030944824},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"Cytoskeleton","score":0.5946880578994751},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5416089296340942},{"id":"https://openalex.org/keywords/polarization","display_name":"Polarization (electrochemistry)","score":0.49315184354782104},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.45660924911499023},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.44798994064331055},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3927575349807739},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3294970989227295},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.29842668771743774},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.29042890667915344},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.21107074618339539}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.7528663277626038},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.6815715432167053},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.6750619411468506},{"id":"https://openalex.org/C207016750","wikidata":"https://www.wikidata.org/wiki/Q1955627","display_name":"Pattern formation","level":2,"score":0.6221652030944824},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5946880578994751},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5416089296340942},{"id":"https://openalex.org/C205049153","wikidata":"https://www.wikidata.org/wiki/Q2698605","display_name":"Polarization (electrochemistry)","level":2,"score":0.49315184354782104},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.45660924911499023},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44798994064331055},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3927575349807739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3294970989227295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29842668771743774},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29042890667915344},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21107074618339539},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1003122","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003122","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003122&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:23861660","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23861660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:europepmc.org:2707574","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3701696","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003122","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003122","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9e877a84131a43c8a9f83b8b84e322b4","is_oa":false,"landing_page_url":"https://doaj.org/article/9e877a84131a43c8a9f83b8b84e322b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 7, p e1003122 (2013)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:680363","is_oa":false,"landing_page_url":"http://edoc.mpg.de/680363","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, v.9 (2013)","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/739861","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Interaction_of_Motility_Directional_Sensing_and_Polarity_Modules_Recreates_the_Behaviors_of_Chemotaxing_Cells_/739861","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.mpg.de:item_2219286","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0029-86A2-C","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003122","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003122","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003122&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.6499999761581421}],"awards":[{"id":"https://openalex.org/G140259921","display_name":"Computational Models of Cell Division","funder_award_id":"5r01gm086704-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2492663123","display_name":null,"funder_award_id":"GM86704","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3342284955","display_name":null,"funder_award_id":"R37 GM028007","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5665962485","display_name":"Signaling Networks in Chemotaxis and Cytokinesis","funder_award_id":"5r37gm028007-35","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5987347435","display_name":null,"funder_award_id":"R01 GM028007","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G617783802","display_name":null,"funder_award_id":"GM28007","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G638208998","display_name":null,"funder_award_id":"GM 34933","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6515128291","display_name":"Temporal and Spatial Signaling in Chemotaxis","funder_award_id":"2r01gm034933-29","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6739482112","display_name":null,"funder_award_id":"R01 GM086704","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7643904066","display_name":null,"funder_award_id":"R01 GM034933","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005088757.pdf","grobid_xml":"https://content.openalex.org/works/W2005088757.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W562664541","https://openalex.org/W1490390655","https://openalex.org/W1964145620","https://openalex.org/W1965062923","https://openalex.org/W1965259349","https://openalex.org/W1965456488","https://openalex.org/W1965650717","https://openalex.org/W1969129477","https://openalex.org/W1971057250","https://openalex.org/W1972669224","https://openalex.org/W1978678623","https://openalex.org/W1978764703","https://openalex.org/W1979018319","https://openalex.org/W1985482228","https://openalex.org/W1994370397","https://openalex.org/W1999628770","https://openalex.org/W2004084950","https://openalex.org/W2007250557","https://openalex.org/W2015273863","https://openalex.org/W2015603830","https://openalex.org/W2015664235","https://openalex.org/W2017266862","https://openalex.org/W2021460799","https://openalex.org/W2024813407","https://openalex.org/W2027052704","https://openalex.org/W2028878400","https://openalex.org/W2029507167","https://openalex.org/W2031497507","https://openalex.org/W2034490742","https://openalex.org/W2036265613","https://openalex.org/W2037866119","https://openalex.org/W2038867093","https://openalex.org/W2046088625","https://openalex.org/W2047433701","https://openalex.org/W2051277229","https://openalex.org/W2051413099","https://openalex.org/W2061472058","https://openalex.org/W2063993190","https://openalex.org/W2068780958","https://openalex.org/W2078423846","https://openalex.org/W2082279421","https://openalex.org/W2083192142","https://openalex.org/W2086312582","https://openalex.org/W2086405845","https://openalex.org/W2087538969","https://openalex.org/W2089607882","https://openalex.org/W2093013362","https://openalex.org/W2098136731","https://openalex.org/W2101679999","https://openalex.org/W2102337085","https://openalex.org/W2102723402","https://openalex.org/W2105110686","https://openalex.org/W2108779387","https://openalex.org/W2119276853","https://openalex.org/W2120170134","https://openalex.org/W2125164122","https://openalex.org/W2125852686","https://openalex.org/W2130439154","https://openalex.org/W2133069751","https://openalex.org/W2133493253","https://openalex.org/W2134557279","https://openalex.org/W2139288598","https://openalex.org/W2139677881","https://openalex.org/W2142080413","https://openalex.org/W2143684023","https://openalex.org/W2145258422","https://openalex.org/W2147610677","https://openalex.org/W2148857656","https://openalex.org/W2153969860","https://openalex.org/W2157737080","https://openalex.org/W2157886337","https://openalex.org/W2160422029","https://openalex.org/W2162058407","https://openalex.org/W2164318727","https://openalex.org/W2164495477","https://openalex.org/W2166343829","https://openalex.org/W2168399397","https://openalex.org/W2169304395","https://openalex.org/W2170384419","https://openalex.org/W2170740693","https://openalex.org/W2171520735","https://openalex.org/W2188659719"],"related_works":["https://openalex.org/W1596865785","https://openalex.org/W2085357479","https://openalex.org/W2763451661","https://openalex.org/W175199992","https://openalex.org/W3080737261","https://openalex.org/W3109768450","https://openalex.org/W2774655603","https://openalex.org/W2397751340","https://openalex.org/W2396441806","https://openalex.org/W1821905048"],"abstract_inverted_index":{"Chemotaxis":[0],"involves":[1],"the":[2,38,50,61,76,81,117,129,133,158,165],"coordinated":[3],"action":[4],"of":[5,37,40,56,75,101,160,174],"separable":[6],"but":[7],"interrelated":[8],"processes:":[9],"motility,":[10],"gradient":[11],"sensing,":[12],"and":[13,31,60,104,153],"polarization.":[14],"We":[15],"have":[16],"hypothesized":[17],"that":[18,25,92,115,171],"these":[19,28],"are":[20,52,67],"mediated":[21,107],"by":[22,108,156],"separate":[23],"modules":[24,51],"account":[26],"for":[27,94,142],"processes":[29],"individually":[30],"that,":[32],"when":[33],"combined,":[34],"recreate":[35],"most":[36],"behaviors":[39,170],"chemotactic":[41],"cells.":[42],"Here,":[43],"we":[44,167],"describe":[45],"a":[46,72,109],"mathematical":[47],"model":[48,74,166],"where":[49],"implemented":[53,79],"in":[54,64,69,80,119,144,164],"terms":[55],"reaction-diffusion":[57],"equations.":[58],"Migration":[59],"accompanying":[62],"changes":[63],"cellular":[65,169],"morphology":[66],"demonstrated":[68],"simulations":[70],"using":[71],"mechanical":[73],"cell":[77,177],"cortex":[78],"level":[82],"set":[83],"framework.":[84],"The":[85,97],"central":[86],"module":[87,114,126],"is":[88,106,122],"an":[89],"excitable":[90,130],"network":[91,131],"accounts":[93],"random":[95],"migration.":[96],"response":[98],"to":[99,128,138,146],"combinations":[100],"uniform":[102],"stimuli":[103],"gradients":[105],"local":[110],"excitation,":[111],"global":[112],"inhibition":[113],"biases":[116],"direction":[118],"which":[120],"excitability":[121],"directed.":[123],"A":[124],"polarization":[125],"linked":[127],"through":[132],"cytoskeleton":[134],"allows":[135],"unstimulated":[136],"cells":[137,143],"move":[139],"persistently":[140],"and,":[141],"gradients,":[145],"gradually":[147],"acquire":[148],"distinct":[149],"sensitivity":[150],"between":[151],"front":[152],"back.":[154],"Finally,":[155],"varying":[157],"strengths":[159],"various":[161],"feedback":[162],"loops":[163],"obtain":[168],"mirror":[172],"those":[173],"genetically":[175],"altered":[176],"lines.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":4}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}