{"id":"https://openalex.org/W2024834494","doi":"https://doi.org/10.1371/journal.pcbi.1003101","title":"PUMA: A Unified Framework for Penalized Multiple Regression Analysis of GWAS Data","display_name":"PUMA: A Unified Framework for Penalized Multiple Regression Analysis of GWAS Data","publication_year":2013,"publication_date":"2013-06-27","ids":{"openalex":"https://openalex.org/W2024834494","doi":"https://doi.org/10.1371/journal.pcbi.1003101","mag":"2024834494","pmid":"https://pubmed.ncbi.nlm.nih.gov/23825936"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003101","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003101","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003101&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003101&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046862823","display_name":"Gabriel E. Hoffman","orcid":"https://orcid.org/0000-0002-0957-0224"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gabriel E. Hoffman","raw_affiliation_strings":["Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America. gh258@cornell.edu","Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America. gh258@cornell.edu","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042205466","display_name":"Benjamin A. Logsdon","orcid":"https://orcid.org/0000-0002-0572-2569"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin A. Logsdon","raw_affiliation_strings":["Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America","Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004096202","display_name":"Jason G. Mezey","orcid":"https://orcid.org/0000-0001-9250-6583"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason G. Mezey","raw_affiliation_strings":["Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America","Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004096202","https://openalex.org/A5046862823"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.4651,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.92693344,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"9","issue":"6","first_page":"e1003101","last_page":"e1003101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.7776511311531067},{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.5514703989028931},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.49647361040115356},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4855329990386963},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3238706588745117},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21352016925811768},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17564785480499268},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.10991999506950378}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7776511311531067},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.5514703989028931},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.49647361040115356},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4855329990386963},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3238706588745117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21352016925811768},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17564785480499268},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.10991999506950378},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1003101","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003101","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003101&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:23825936","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23825936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.788.3714","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.788.3714","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/30/66/pcbi.1003101.PMC3694815.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003101","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003101","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:df33d74e86dc45a2bc28814d4c499522","is_oa":true,"landing_page_url":"https://doaj.org/article/df33d74e86dc45a2bc28814d4c499522","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 6, p e1003101 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2696495","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3694815","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/733029","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_PUMA_A_Unified_Framework_for_Penalized_Multiple_Regression_Analysis_of_GWAS_Data_/733029","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003101","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003101","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003101&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3170341273","display_name":null,"funder_award_id":"HL084936","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5543682019","display_name":null,"funder_award_id":"P50 HL084936","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024834494.pdf","grobid_xml":"https://content.openalex.org/works/W2024834494.grobid-xml"},"referenced_works_count":128,"referenced_works":["https://openalex.org/W1483883706","https://openalex.org/W1523531473","https://openalex.org/W1603903339","https://openalex.org/W1618978521","https://openalex.org/W1767407970","https://openalex.org/W1959944918","https://openalex.org/W1965125844","https://openalex.org/W1965169081","https://openalex.org/W1966678470","https://openalex.org/W1970694857","https://openalex.org/W1973798273","https://openalex.org/W1977415187","https://openalex.org/W1978124765","https://openalex.org/W1980725116","https://openalex.org/W1980991473","https://openalex.org/W1986863496","https://openalex.org/W1989531990","https://openalex.org/W1996943976","https://openalex.org/W1997090182","https://openalex.org/W1998641738","https://openalex.org/W1998767819","https://openalex.org/W2005315219","https://openalex.org/W2007568722","https://openalex.org/W2008047653","https://openalex.org/W2013569035","https://openalex.org/W2014077667","https://openalex.org/W2015714093","https://openalex.org/W2016119924","https://openalex.org/W2016389876","https://openalex.org/W2017413905","https://openalex.org/W2020925091","https://openalex.org/W2024108088","https://openalex.org/W2024670158","https://openalex.org/W2024999855","https://openalex.org/W2031539362","https://openalex.org/W2032230252","https://openalex.org/W2033151532","https://openalex.org/W2035163714","https://openalex.org/W2039261408","https://openalex.org/W2041567916","https://openalex.org/W2046434400","https://openalex.org/W2051616601","https://openalex.org/W2053061982","https://openalex.org/W2055510343","https://openalex.org/W2063978378","https://openalex.org/W2064628575","https://openalex.org/W2065742895","https://openalex.org/W2066874799","https://openalex.org/W2068646716","https://openalex.org/W2070082005","https://openalex.org/W2074682976","https://openalex.org/W2078242867","https://openalex.org/W2079927753","https://openalex.org/W2080235308","https://openalex.org/W2082213488","https://openalex.org/W2083944388","https://openalex.org/W2084974619","https://openalex.org/W2089225173","https://openalex.org/W2093435421","https://openalex.org/W2095741373","https://openalex.org/W2101605059","https://openalex.org/W2103551323","https://openalex.org/W2104111843","https://openalex.org/W2106398669","https://openalex.org/W2106779017","https://openalex.org/W2108306139","https://openalex.org/W2109353557","https://openalex.org/W2110846909","https://openalex.org/W2112409097","https://openalex.org/W2115718427","https://openalex.org/W2115783720","https://openalex.org/W2117393206","https://openalex.org/W2117446594","https://openalex.org/W2119412782","https://openalex.org/W2120160881","https://openalex.org/W2120358745","https://openalex.org/W2122189635","https://openalex.org/W2123027776","https://openalex.org/W2125332209","https://openalex.org/W2131060185","https://openalex.org/W2133303750","https://openalex.org/W2133578694","https://openalex.org/W2134755636","https://openalex.org/W2134783591","https://openalex.org/W2135046866","https://openalex.org/W2138019504","https://openalex.org/W2138069158","https://openalex.org/W2138284514","https://openalex.org/W2138345444","https://openalex.org/W2141642891","https://openalex.org/W2141885858","https://openalex.org/W2142635246","https://openalex.org/W2144011735","https://openalex.org/W2146374090","https://openalex.org/W2147272585","https://openalex.org/W2149414429","https://openalex.org/W2151660707","https://openalex.org/W2152905639","https://openalex.org/W2153699776","https://openalex.org/W2154560360","https://openalex.org/W2155496693","https://openalex.org/W2156097706","https://openalex.org/W2157752701","https://openalex.org/W2160068277","https://openalex.org/W2161633633","https://openalex.org/W2161998322","https://openalex.org/W2162897961","https://openalex.org/W2163924952","https://openalex.org/W2165872127","https://openalex.org/W2166472696","https://openalex.org/W2167700091","https://openalex.org/W2168175751","https://openalex.org/W2170129323","https://openalex.org/W2296319761","https://openalex.org/W2562162676","https://openalex.org/W2787894218","https://openalex.org/W3098306969","https://openalex.org/W3098713891","https://openalex.org/W3099090856","https://openalex.org/W3105702746","https://openalex.org/W4206653471","https://openalex.org/W4237471138","https://openalex.org/W4247055279","https://openalex.org/W4247571494","https://openalex.org/W4250589301","https://openalex.org/W4251079740","https://openalex.org/W4301861531","https://openalex.org/W4320301318"],"related_works":["https://openalex.org/W4205405116","https://openalex.org/W2594299395","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W1486217206","https://openalex.org/W1992310781"],"abstract_inverted_index":{"Penalized":[0],"Multiple":[1],"Regression":[2],"(PMR)":[3],"can":[4,180],"be":[5,88],"used":[6],"to":[7,24,87,148,172,240],"discover":[8,231],"novel":[9,232,247,265,279],"disease":[10],"associations":[11,27,83,225,248,266],"in":[12,28,187,252,260,269,274,285,288],"GWAS":[13,29,129,149,158,199],"datasets.":[14],"In":[15],"practice,":[16],"proposed":[17,67,127],"PMR":[18,178],"methods":[19,40,68,111,179],"have":[20],"not":[21,42,144],"been":[22,145],"able":[23],"identify":[25],"well-supported":[26],"that":[30,61,142,154,162,237],"are":[31,41,238],"undetectable":[32],"by":[33],"standard":[34,241],"association":[35,280],"tests":[36],"and":[37,51,78,109,168,207,229,257,271,277],"thus":[38],"these":[39,227],"widely":[43],"applied.":[44],"Here,":[45],"we":[46,160,197,230],"present":[47],"a":[48,94,140,282],"combined":[49,104],"algorithmic":[50],"heuristic":[52,106],"framework":[53,92,119,164],"for":[54,84,99,112,128,201,226,294],"PUMA":[55,118,297],"(Penalized":[56],"Unified":[57],"Multiple-locus":[58],"Association)":[59],"analysis":[60,130,222,298],"solves":[62],"the":[63,121,192,214],"problems":[64],"of":[65,80,114,195],"previously":[66,126,146],"including":[69,245],"computational":[70],"speed,":[71],"poor":[72],"performance":[73,167],"on":[74],"genome-scale":[75],"simulated":[76],"data,":[77,159],"identification":[79,113],"too":[81],"many":[82],"real":[85,157],"data":[86,200],"biologically":[89],"plausible.":[90],"The":[91,117],"includes":[93],"new":[95],"minorize-maximization":[96],"(MM)":[97],"algorithm":[98],"generalized":[100],"linear":[101],"models":[102],"(GLM)":[103],"with":[105],"model":[107],"selection":[108],"testing":[110,186],"robust":[115],"associations.":[116],"implements":[120],"penalized":[122],"maximum":[123],"likelihood":[124],"penalties":[125],"(i.e.":[131,150],"Lasso,":[132,134],"Adaptive":[133],"NEG,":[135],"MCP),":[136],"as":[137,139],"well":[138],"penalty":[141],"has":[143,165],"applied":[147],"LOG).":[151],"Using":[152],"simulations":[153],"closely":[155],"mirror":[156],"show":[161],"our":[163,296],"high":[166],"reliably":[169],"increases":[170],"power":[171],"detect":[173],"weak":[174],"associations,":[175],"while":[176],"existing":[177],"perform":[181],"worse":[182],"than":[183],"single":[184,242],"marker":[185,243],"overall":[188],"performance.":[189],"To":[190],"demonstrate":[191],"empirical":[193],"value":[194],"PUMA,":[196],"analyzed":[198],"type":[202,261],"1":[203,262],"diabetes,":[204],"Crohns's":[205],"disease,":[206],"rheumatoid":[208,289],"arthritis,":[209],"three":[210,264],"autoimmune":[211],"diseases":[212,228],"from":[213],"original":[215],"Wellcome":[216],"Trust":[217],"Case":[218],"Control":[219],"Consortium.":[220],"Our":[221],"replicates":[223],"known":[224],"etiologically":[233],"relevant":[234],"susceptibility":[235],"loci":[236],"invisible":[239],"tests,":[244],"six":[246],"implicating":[249,267,281],"genes":[250,268],"involved":[251,284],"pancreatic":[253],"function,":[254],"insulin":[255],"pathways":[256,273,287],"immune-cell":[258],"function":[259],"diabetes;":[263],"pro-":[270],"anti-inflammatory":[272],"Crohn's":[275],"disease;":[276],"one":[278],"gene":[283],"apoptosis":[286],"arthritis.":[290],"We":[291],"provide":[292],"software":[293],"applying":[295],"framework.":[299]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}