{"id":"https://openalex.org/W2023072477","doi":"https://doi.org/10.1371/journal.pcbi.1003093","title":"Leveraging Prior Information to Detect Causal Variants via Multi-Variant Regression","display_name":"Leveraging Prior Information to Detect Causal Variants via Multi-Variant Regression","publication_year":2013,"publication_date":"2013-06-06","ids":{"openalex":"https://openalex.org/W2023072477","doi":"https://doi.org/10.1371/journal.pcbi.1003093","mag":"2023072477","pmid":"https://pubmed.ncbi.nlm.nih.gov/23762022"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003093","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003093","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003093&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003093&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109417188","display_name":"Nanye Long","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nanye Long","raw_affiliation_strings":["Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America. n.long@duke.edu","Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America. n.long@duke.edu","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102921887","display_name":"Samuel P. Dickson","orcid":"https://orcid.org/0000-0002-4622-1349"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel P. Dickson","raw_affiliation_strings":["Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America","Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001098235","display_name":"Jessica M. Maia","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica M. Maia","raw_affiliation_strings":["Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America","Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019042699","display_name":"Hee Shin Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hee Shin Kim","raw_affiliation_strings":["Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America","Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Center for Human Genome Variation, Duke University, School of Medicine, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057717552","display_name":"Qianqian Zhu","orcid":"https://orcid.org/0000-0003-2516-6675"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qianqian Zhu","raw_affiliation_strings":["Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026198048","display_name":"Andrew S. Allen","orcid":"https://orcid.org/0000-0002-7232-2143"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew S. Allen","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, United States of America","Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5109417188"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.8336,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.85713043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"9","issue":"6","first_page":"e1003093","last_page":"e1003093"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"Linkage disequilibrium","score":0.6103323698043823},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5579718351364136},{"id":"https://openalex.org/keywords/weighting","display_name":"Weighting","score":0.5425891876220703},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.5358572602272034},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.5033294558525085},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.49945545196533203},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.46692535281181335},{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.46328774094581604},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43343430757522583},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.4242037236690521},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3816331624984741},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.35309767723083496},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24602684378623962},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2397925853729248},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.23746263980865479},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.2253037691116333},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.19379767775535583},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16903114318847656},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.15930411219596863},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08742034435272217},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08446758985519409}],"concepts":[{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.6103323698043823},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5579718351364136},{"id":"https://openalex.org/C183115368","wikidata":"https://www.wikidata.org/wiki/Q856577","display_name":"Weighting","level":2,"score":0.5425891876220703},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.5358572602272034},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5033294558525085},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.49945545196533203},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.46692535281181335},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.46328774094581604},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43343430757522583},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4242037236690521},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3816331624984741},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35309767723083496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24602684378623962},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2397925853729248},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.23746263980865479},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.2253037691116333},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.19379767775535583},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16903114318847656},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.15930411219596863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08742034435272217},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08446758985519409},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003093","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003093","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003093&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:23762022","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23762022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1003093","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003093","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:6d26b9fd0549416e8e3aa0ce7b74d31e","is_oa":true,"landing_page_url":"https://doaj.org/article/6d26b9fd0549416e8e3aa0ce7b74d31e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 6, p e1003093 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2676221","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3675126","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/713731","is_oa":true,"landing_page_url":"https://figshare.com/articles/_Leveraging_Prior_Information_to_Detect_Causal_Variants_via_Multi_Variant_Regression_/713731","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003093","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003093","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003093&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6700000166893005,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2023072477.pdf","grobid_xml":"https://content.openalex.org/works/W2023072477.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1642457845","https://openalex.org/W1670573097","https://openalex.org/W1928998639","https://openalex.org/W1964998512","https://openalex.org/W1967296216","https://openalex.org/W1973595527","https://openalex.org/W1980991473","https://openalex.org/W1999149653","https://openalex.org/W2008738057","https://openalex.org/W2009729081","https://openalex.org/W2012949385","https://openalex.org/W2020040634","https://openalex.org/W2026373901","https://openalex.org/W2029387902","https://openalex.org/W2031956308","https://openalex.org/W2050029156","https://openalex.org/W2054185647","https://openalex.org/W2058148991","https://openalex.org/W2059867286","https://openalex.org/W2066874799","https://openalex.org/W2070984858","https://openalex.org/W2073309298","https://openalex.org/W2075183590","https://openalex.org/W2078663610","https://openalex.org/W2084959283","https://openalex.org/W2085967808","https://openalex.org/W2109235725","https://openalex.org/W2109372707","https://openalex.org/W2110745807","https://openalex.org/W2113251104","https://openalex.org/W2119398688","https://openalex.org/W2123751634","https://openalex.org/W2125860227","https://openalex.org/W2130076525","https://openalex.org/W2133268130","https://openalex.org/W2134783591","https://openalex.org/W2138790588","https://openalex.org/W2159998163","https://openalex.org/W2160906984","https://openalex.org/W2162224007","https://openalex.org/W2163953557","https://openalex.org/W2171060123","https://openalex.org/W2172260290","https://openalex.org/W2271902495"],"related_works":["https://openalex.org/W1971424770","https://openalex.org/W2111842731","https://openalex.org/W1523912222","https://openalex.org/W1480804049","https://openalex.org/W2066467839","https://openalex.org/W2594299395","https://openalex.org/W2771541573","https://openalex.org/W2765794416","https://openalex.org/W2170506381","https://openalex.org/W2039666944"],"abstract_inverted_index":{"Although":[0],"many":[1],"methods":[2,16],"are":[3,24],"available":[4],"to":[5,20],"test":[6,68],"sequence":[7,60,95],"variants":[8,23,89,108],"for":[9,69,105],"association":[10,72],"with":[11,73,90],"complex":[12],"diseases":[13],"and":[14,30,58,94],"traits,":[15],"that":[17,37,83],"specifically":[18],"seek":[19],"identify":[21],"causal":[22,107],"less":[25],"developed.":[26],"Here":[27],"we":[28,62],"develop":[29],"evaluate":[31],"a":[32,64,102],"Bayesian":[33],"hierarchical":[34],"regression":[35],"method":[36,76,100],"incorporates":[38],"prior":[39],"information":[40],"on":[41],"the":[42,74,98],"likelihood":[43],"of":[44,49,88],"variant":[45,50,67],"causality":[46],"through":[47],"weighting":[48,79],"effects.":[51],"By":[52],"simulation":[53],"studies":[54],"using":[55,77],"both":[56],"simulated":[57],"real":[59],"variants,":[61],"compared":[63],"standard":[65],"single":[66],"analyzing":[70],"variant-disease":[71],"proposed":[75,99],"different":[78],"schemes.":[80],"We":[81],"found":[82],"by":[84],"leveraging":[85],"linkage":[86],"disequilibrium":[87],"known":[91],"GWAS":[92],"signals":[93],"conservation":[96],"(phastCons),":[97],"provides":[101],"powerful":[103],"approach":[104],"detecting":[106],"while":[109],"controlling":[110],"false":[111],"positives.":[112]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
