{"id":"https://openalex.org/W23637590","doi":"https://doi.org/10.1371/journal.pcbi.1003045","title":"\u7b2c\u4e8c\u5c4a\u4e2d\u56fd\u56fd\u9645\u7d2b\u5916\u5149\uff0f\u7535\u5b50\u675f\u56fa\u5316\u6750\u6599\u3001\u8bbe\u5907\u53ca\u4ea7\u54c1\u5c55\u89c8\u4f1a","display_name":"\u7b2c\u4e8c\u5c4a\u4e2d\u56fd\u56fd\u9645\u7d2b\u5916\u5149\uff0f\u7535\u5b50\u675f\u56fa\u5316\u6750\u6599\u3001\u8bbe\u5907\u53ca\u4ea7\u54c1\u5c55\u89c8\u4f1a","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W23637590","doi":"https://doi.org/10.1371/journal.pcbi.1003045","mag":"23637590"},"language":"en","primary_location":{"id":"mag:23637590","is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/97588A/200603/21912267.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306543614","display_name":"\u4fe1\u606f\u8bb0\u5f55\u6750\u6599","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u4fe1\u606f\u8bb0\u5f55\u6750\u6599","raw_type":null},"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035759328","display_name":"\u674e\u971e","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\u674e\u971e","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035759328"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00286035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"3","first_page":"43","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32960009574890137}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32960009574890137}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:23637590","is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/97588A/200603/21912267.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306543614","display_name":"\u4fe1\u606f\u8bb0\u5f55\u6750\u6599","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u4fe1\u606f\u8bb0\u5f55\u6750\u6599","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Structural":[0],"flexibility":[1],"in":[2,29,155,183,217,234],"germline":[3,39,120,235],"gene-encoded":[4,40],"antibodies":[5,41,56,67,86,161,240,252],"allows":[6],"promiscuous":[7],"binding":[8,13,76,140,243],"to":[9,77,84,123,136,162,170],"diverse":[10,53,257],"antigens.":[11],"The":[12,94,115,149],"affinity":[14],"and":[15,112,224],"specificity":[16,209],"for":[17,44,50,102,232,256],"a":[18,70,78,124,146,164,167],"particular":[19],"epitope":[20,258],"typically":[21],"increase":[22],"as":[23],"antibody":[24,100,153,175,181],"genes":[25],"acquire":[26],"somatic":[27],"mutations":[28],"antigen-stimulated":[30],"B":[31],"cells.":[32],"In":[33,157],"this":[34],"work,":[35],"we":[36,213],"investigated":[37],"whether":[38],"are":[42,134,229],"optimal":[43],"polyspecificity":[45,233,255],"by":[46,55,58,69,128],"determining":[47],"the":[48,103,119,131,173,188,200,208,218,225,248],"basis":[49],"recognition":[51],"of":[52,64,141,172,196,207,210,239,242,251],"antigens":[54,91,144,245],"encoded":[57,68],"three":[59],"VH":[60,72,219],"gene":[61,121,220],"segments.":[62],"Panels":[63],"somatically":[65],"mutated":[66],"common":[71,147],"gene,":[73],"but":[74],"each":[75],"different":[79],"antigen,":[80,166],"were":[81],"computationally":[82],"redesigned":[83],"predict":[85],"that":[87,133,171,187,228,253],"could":[88],"engage":[89],"multiple":[90,244],"at":[92],"once.":[93],"Rosetta":[95,189],"multi-state":[96],"design":[97,130,191,238,250],"process":[98,150],"predicted":[99,116,135],"sequences":[101,117,122],"entire":[104],"heavy":[105],"chain":[106],"variable":[107],"region,":[108],"including":[109],"framework,":[110],"CDR1,":[111,222],"CDR2":[113],"mutations.":[114],"matched":[118],"remarkable":[125],"degree,":[126],"revealing":[127],"computational":[129,190],"residues":[132],"enable":[137],"polyspecificity,":[138],"i.e.,":[139],"many":[142],"unrelated":[143],"with":[145],"sequence.":[148],"thereby":[151],"reverses":[152],"maturation":[154,182],"silico.":[156,184],"contrast,":[158],"when":[159],"designing":[160],"bind":[163],"single":[165],"sequence":[168,176],"similar":[169],"mature":[174,211],"was":[177],"returned,":[178],"mimicking":[179],"natural":[180],"We":[185],"demonstrated":[186],"algorithm":[192],"captures":[193],"important":[194],"aspects":[195],"antibody/antigen":[197],"recognition.":[198],"While":[199],"hypervariable":[201],"region":[202],"CDR3":[203],"often":[204],"mediates":[205],"much":[206],"antibodies,":[212],"identified":[214],"key":[215],"positions":[216],"encoding":[221],"CDR2,":[223],"immunoglobulin":[226],"framework":[227],"critical":[230],"contributors":[231],"antibodies.":[236],"Computational":[237],"capable":[241],"may":[246],"allow":[247],"rational":[249],"retain":[254],"binding.":[259]},"counts_by_year":[],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2016-06-24T00:00:00"}
