{"id":"https://openalex.org/W1994709341","doi":"https://doi.org/10.1371/journal.pcbi.1003022","title":"Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure","display_name":"Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure","publication_year":2013,"publication_date":"2013-04-04","ids":{"openalex":"https://openalex.org/W1994709341","doi":"https://doi.org/10.1371/journal.pcbi.1003022","mag":"1994709341","pmid":"https://pubmed.ncbi.nlm.nih.gov/23592968"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003022","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003022","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003022&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003022&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109303276","display_name":"Xiaobo Wan","orcid":"https://orcid.org/0000-0001-5740-512X"},"institutions":[{"id":"https://openalex.org/I4210086405","display_name":"National Institute of Biological Sciences, Beijing","ror":"https://ror.org/00wksha49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210086405"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobo Wan","raw_affiliation_strings":["Graduate School in Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","National Institute of Biological Sciences, Beijing, Zhongguancun Life Science Park, Changping District, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School in Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"National Institute of Biological Sciences, Beijing, Zhongguancun Life Science Park, Changping District, Beijing, China","institution_ids":["https://openalex.org/I4210086405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016565377","display_name":"Yue Ma","orcid":"https://orcid.org/0000-0001-6880-4572"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Ma","raw_affiliation_strings":["Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048787474","display_name":"Christopher L. McClendon","orcid":"https://orcid.org/0000-0001-6411-4478"},"institutions":[{"id":"https://openalex.org/I6750721","display_name":"University of Montana","ror":"https://ror.org/0078xmk34","country_code":"US","type":"education","lineage":["https://openalex.org/I6750721"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. McClendon","raw_affiliation_strings":["Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America","institution_ids":["https://openalex.org/I6750721","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007083460","display_name":"Lily Huang","orcid":"https://orcid.org/0000-0002-5459-994X"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lily Jun-shen Huang","raw_affiliation_strings":["Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074665620","display_name":"Niu Huang","orcid":"https://orcid.org/0000-0002-6912-033X"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210086405","display_name":"National Institute of Biological Sciences, Beijing","ror":"https://ror.org/00wksha49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210086405"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Niu Huang","raw_affiliation_strings":["Graduate School in Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","National Institute of Biological Sciences, Beijing, Zhongguancun Life Science Park, Changping District, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School in Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"National Institute of Biological Sciences, Beijing, Zhongguancun Life Science Park, Changping District, Beijing, China","institution_ids":["https://openalex.org/I4210086405"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007083460","https://openalex.org/A5074665620"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210086405","https://openalex.org/I867280407"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.95,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.74952446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"9","issue":"4","first_page":"e1003022","last_page":"e1003022"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.967199981212616,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/janus-kinase-2","display_name":"Janus kinase 2","score":0.5791149735450745},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.5524800419807434},{"id":"https://openalex.org/keywords/janus-kinase","display_name":"Janus kinase","score":0.47654491662979126},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"Protein kinase A","score":0.4533140957355499},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4522862136363983},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"Mutagenesis","score":0.43973231315612793},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4372848868370056},{"id":"https://openalex.org/keywords/protein-kinase-domain","display_name":"Protein kinase domain","score":0.4350042939186096},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39212337136268616},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3814324140548706},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.2678941786289215},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.14960667490959167}],"concepts":[{"id":"https://openalex.org/C32465701","wikidata":"https://www.wikidata.org/wiki/Q14914514","display_name":"Janus kinase 2","level":3,"score":0.5791149735450745},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5524800419807434},{"id":"https://openalex.org/C112392421","wikidata":"https://www.wikidata.org/wiki/Q903451","display_name":"Janus kinase","level":3,"score":0.47654491662979126},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4533140957355499},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4522862136363983},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.43973231315612793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4372848868370056},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.4350042939186096},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39212337136268616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3814324140548706},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2678941786289215},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.14960667490959167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1003022","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003022","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003022&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:23592968","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23592968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.774.1213","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.774.1213","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ed/62/pcbi.1003022.PMC3616975.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003022","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003022","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f1e01e537402430cbfda52ce21bb4408","is_oa":false,"landing_page_url":"https://doaj.org/article/f1e01e537402430cbfda52ce21bb4408","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 4, p e1003022 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2625590","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3616975","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/675448","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Ab_Initio_Modeling_and_Experimental_Assessment_of_Janus_Kinase_2_JAK2_Kinase_Pseudokinase_Complex_Structure/675448","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3616975","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3616975","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003022","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003022","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003022&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5030883464","display_name":null,"funder_award_id":"R01 HL089966","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6042519411","display_name":null,"funder_award_id":"OISE-1107560","funder_id":"https://openalex.org/F4320337370","funder_display_name":"Office of International Science and Engineering"},{"id":"https://openalex.org/G6233540304","display_name":"EAPSI:Modeling Allosteric Activation in a Metabolic Network","funder_award_id":"1107560","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7989167686","display_name":null,"funder_award_id":"R01HL089966","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337370","display_name":"Office of International Science and Engineering","ror":"https://ror.org/01k638r21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994709341.pdf","grobid_xml":"https://content.openalex.org/works/W1994709341.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1543124619","https://openalex.org/W1964432512","https://openalex.org/W1966969980","https://openalex.org/W1975588280","https://openalex.org/W1976499671","https://openalex.org/W1986191025","https://openalex.org/W1992945955","https://openalex.org/W1994105285","https://openalex.org/W1995353970","https://openalex.org/W1999390565","https://openalex.org/W2001094827","https://openalex.org/W2005578523","https://openalex.org/W2006795381","https://openalex.org/W2008429932","https://openalex.org/W2009263255","https://openalex.org/W2013726100","https://openalex.org/W2017715430","https://openalex.org/W2018336040","https://openalex.org/W2018983791","https://openalex.org/W2024469135","https://openalex.org/W2035266068","https://openalex.org/W2049902088","https://openalex.org/W2051165598","https://openalex.org/W2051381895","https://openalex.org/W2053448121","https://openalex.org/W2054753195","https://openalex.org/W2056777053","https://openalex.org/W2060428113","https://openalex.org/W2062891857","https://openalex.org/W2067174909","https://openalex.org/W2069663555","https://openalex.org/W2086177258","https://openalex.org/W2094162409","https://openalex.org/W2094186244","https://openalex.org/W2096577704","https://openalex.org/W2098066974","https://openalex.org/W2098624952","https://openalex.org/W2100561975","https://openalex.org/W2100794900","https://openalex.org/W2100798572","https://openalex.org/W2110869427","https://openalex.org/W2111387452","https://openalex.org/W2114520383","https://openalex.org/W2114713566","https://openalex.org/W2115167726","https://openalex.org/W2115295332","https://openalex.org/W2120408260","https://openalex.org/W2129153475","https://openalex.org/W2132437319","https://openalex.org/W2137015675","https://openalex.org/W2138165161","https://openalex.org/W2141032550","https://openalex.org/W2143052000","https://openalex.org/W2150063040","https://openalex.org/W2150192011","https://openalex.org/W2150444353","https://openalex.org/W2153228625","https://openalex.org/W2161835431","https://openalex.org/W2166317516","https://openalex.org/W2167482691","https://openalex.org/W2169224390","https://openalex.org/W2883755802","https://openalex.org/W3022020637","https://openalex.org/W4211210715","https://openalex.org/W4293003482","https://openalex.org/W6632540180"],"related_works":["https://openalex.org/W4234436715","https://openalex.org/W2010610742","https://openalex.org/W2472797272","https://openalex.org/W2029369517","https://openalex.org/W4234023686","https://openalex.org/W1988362962","https://openalex.org/W1983740210","https://openalex.org/W2141032550","https://openalex.org/W1978277432","https://openalex.org/W2141682274"],"abstract_inverted_index":{"The":[0],"Janus":[1],"Kinase":[2],"2":[3],"(JAK2)":[4],"plays":[5],"essential":[6],"roles":[7],"in":[8,21,101,127,135,144,181,184],"transmitting":[9],"signals":[10],"from":[11],"multiple":[12],"cytokine":[13],"receptors,":[14],"and":[15,24,64,105,117,147,187],"constitutive":[16],"activation":[17,97],"of":[18,50,54,99,109,179],"JAK2":[19,26,68,74,87,141,183],"results":[20],"hematopoietic":[22],"disorders":[23],"oncogenesis.":[25],"kinase":[27,61,110,142],"activity":[28,143],"is":[29,91],"negatively":[30],"regulated":[31],"by":[32],"its":[33],"pseudokinase":[34],"domain":[35,62],"(JH2),":[36],"where":[37,93],"the":[38,48,60,73,96,107,177],"gain-of-function":[39],"mutation":[40],"V617F":[41,66],"that":[42],"causes":[43],"myeloproliferative":[44],"neoplasms":[45],"resides.":[46],"In":[47],"absence":[49],"a":[51,79,167],"crystal":[52],"structure":[53,77],"full-length":[55],"JAK2,":[56],"how":[57,65],"JH2":[58,94,136,180],"inhibits":[59],"(JH1),":[63],"hyperactivates":[67],"remain":[69],"elusive.":[70],"We":[71],"modeled":[72],"JH1-JH2":[75,163],"complex":[76],"using":[78],"novel":[80],"informatics-guided":[81],"protein-protein":[82],"docking":[83],"strategy.":[84],"A":[85],"detailed":[86],"JH2-mediated":[88,157],"auto-inhibition":[89],"mechanism":[90],"proposed,":[92],"traps":[95],"loop":[98],"JH1":[100],"an":[102],"inactive":[103],"conformation":[104],"blocks":[106],"movement":[108],"\u03b1C":[111],"helix":[112],"through":[113],"critical":[114],"hydrophobic":[115],"contacts":[116],"extensive":[118],"electrostatic":[119],"interactions.":[120],"These":[121],"stabilizing":[122],"interactions":[123],"are":[124],"less":[125],"favorable":[126],"JAK2-V617F.":[128],"Notably,":[129],"several":[130],"predicted":[131],"binding":[132],"interfacial":[133],"residues":[134],"were":[137],"confirmed":[138],"to":[139,159,175],"hyperactivate":[140],"site-directed":[145],"mutagenesis":[146],"BaF3/EpoR":[148],"cell":[149],"transformation":[150],"studies.":[151],"Although":[152],"there":[153],"may":[154],"exist":[155],"other":[156],"mechanisms":[158],"control":[160],"JH1,":[161],"our":[162],"structural":[164],"model":[165],"represents":[166],"verifiable":[168],"working":[169],"hypothesis":[170],"for":[171],"further":[172],"experimental":[173],"studies":[174],"elucidate":[176],"role":[178],"regulating":[182],"both":[185],"normal":[186],"pathological":[188],"settings.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
