{"id":"https://openalex.org/W1976493037","doi":"https://doi.org/10.1371/journal.pcbi.1002977","title":"Analysis of Physicochemical and Structural Properties Determining HIV-1 Coreceptor Usage","display_name":"Analysis of Physicochemical and Structural Properties Determining HIV-1 Coreceptor Usage","publication_year":2013,"publication_date":"2013-03-21","ids":{"openalex":"https://openalex.org/W1976493037","doi":"https://doi.org/10.1371/journal.pcbi.1002977","mag":"1976493037","pmid":"https://pubmed.ncbi.nlm.nih.gov/23555214"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002977","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002977","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002977&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002977&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078879923","display_name":"Katarzyna Bo\u017cek","orcid":"https://orcid.org/0000-0002-0917-6876"},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Katarzyna Bozek","raw_affiliation_strings":["Max Planck Institute for Computer Science, Saarbrucken, Germany. bozek@mpi-inf.mpg.de","Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Computer Science, Saarbrucken, Germany. bozek@mpi-inf.mpg.de","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023556977","display_name":"Thomas Lengauer","orcid":"https://orcid.org/0000-0003-3801-2640"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Lengauer","raw_affiliation_strings":["Max Planck Institute for Computer Science, Saarbrucken, Germany","Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Computer Science, Saarbrucken, Germany","institution_ids":["https://openalex.org/I4210109712"]},{"raw_affiliation_string":"Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031890624","display_name":"Saleta Sierra","orcid":"https://orcid.org/0000-0001-8527-2790"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Saleta Sierra","raw_affiliation_strings":["Institute of Virology, University of Cologne, Cologne, Germany","Institute of Virology, University of Cologne; Cologne Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Institute of Virology, University of Cologne; Cologne Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074420045","display_name":"Rolf Kaiser","orcid":"https://orcid.org/0000-0002-2640-2548"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Kaiser","raw_affiliation_strings":["Institute of Virology, University of Cologne, Cologne, Germany","Institute of Virology, University of Cologne; Cologne Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Institute of Virology, University of Cologne; Cologne Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056538121","display_name":"Francisco S. Domingues","orcid":"https://orcid.org/0000-0003-4567-4562"},"institutions":[{"id":"https://openalex.org/I1319360392","display_name":"Eurac Research","ror":"https://ror.org/01xt1w755","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I1319360392"]},{"id":"https://openalex.org/I4210118299","display_name":"Institute for Biomedicine","ror":"https://ror.org/02hsggv49","country_code":"IT","type":"facility","lineage":["https://openalex.org/I1319360392","https://openalex.org/I4210118299"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francisco S. Domingues","raw_affiliation_strings":["Center for Biomedicine, EURAC, Bolzano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomedicine, EURAC, Bolzano, Italy","institution_ids":["https://openalex.org/I4210118299","https://openalex.org/I1319360392"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5078879923"],"corresponding_institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210109712"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2015,"currency":"EUR","value_usd":2173},"fwci":2.1468,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.87611664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"3","first_page":"e1002977","last_page":"e1002977"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tropism","display_name":"Tropism","score":0.8923215866088867},{"id":"https://openalex.org/keywords/v3-loop","display_name":"V3 loop","score":0.8191333413124084},{"id":"https://openalex.org/keywords/maraviroc","display_name":"Maraviroc","score":0.8066654205322266},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6421456336975098},{"id":"https://openalex.org/keywords/tissue-tropism","display_name":"Tissue tropism","score":0.5666991472244263},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.553778886795044},{"id":"https://openalex.org/keywords/ccr5-receptor-antagonist","display_name":"CCR5 receptor antagonist","score":0.5367943048477173},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.44205567240715027},{"id":"https://openalex.org/keywords/loop","display_name":"Loop (graph theory)","score":0.42169392108917236},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4083862006664276},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.3736104369163513},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36009275913238525},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.2895094156265259},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.28255951404571533},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2159796953201294},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20809659361839294},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13789451122283936},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.08972093462944031}],"concepts":[{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.8923215866088867},{"id":"https://openalex.org/C2779921545","wikidata":"https://www.wikidata.org/wiki/Q12085358","display_name":"V3 loop","level":4,"score":0.8191333413124084},{"id":"https://openalex.org/C2778899366","wikidata":"https://www.wikidata.org/wiki/Q421369","display_name":"Maraviroc","level":3,"score":0.8066654205322266},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6421456336975098},{"id":"https://openalex.org/C33602714","wikidata":"https://www.wikidata.org/wiki/Q7809666","display_name":"Tissue tropism","level":4,"score":0.5666991472244263},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.553778886795044},{"id":"https://openalex.org/C37044404","wikidata":"https://www.wikidata.org/wiki/Q5009692","display_name":"CCR5 receptor antagonist","level":5,"score":0.5367943048477173},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.44205567240715027},{"id":"https://openalex.org/C184670325","wikidata":"https://www.wikidata.org/wiki/Q512604","display_name":"Loop (graph theory)","level":2,"score":0.42169392108917236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4083862006664276},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3736104369163513},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36009275913238525},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2895094156265259},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.28255951404571533},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2159796953201294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20809659361839294},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13789451122283936},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.08972093462944031},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018523","descriptor_name":"Tropism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018523","descriptor_name":"Tropism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018523","descriptor_name":"Tropism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1002977","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002977","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002977&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:23555214","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23555214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.786.1949","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.786.1949","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8e/47/pcbi.1002977.PMC3605109.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002977","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002977","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:alma.39UBZ_INST:11234997400001241","is_oa":false,"landing_page_url":"https://bia.unibz.it/esploro/outputs/journalArticle/Analysis-of-physicochemical-and-structural-properties/991005772528701241","pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"View","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e677e53692bc4e74b19aeff1ceabd273","is_oa":true,"landing_page_url":"https://doaj.org/article/e677e53692bc4e74b19aeff1ceabd273","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 3, p e1002977 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2606487","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3605109","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/656946","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Analysis_of_Physicochemical_and_Structural_Properties_Determining_HIV_1_Coreceptor_Usage__/656946","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.mpg.de:item_1857597","is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0015-7975-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002977","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002977","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002977&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1976493037.pdf","grobid_xml":"https://content.openalex.org/works/W1976493037.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W33974125","https://openalex.org/W101727076","https://openalex.org/W255996521","https://openalex.org/W1503362797","https://openalex.org/W1563310348","https://openalex.org/W1900729316","https://openalex.org/W1967195968","https://openalex.org/W1971777539","https://openalex.org/W1971896762","https://openalex.org/W1986574361","https://openalex.org/W1987971958","https://openalex.org/W1992473537","https://openalex.org/W1999048558","https://openalex.org/W1999526713","https://openalex.org/W2012356776","https://openalex.org/W2014731953","https://openalex.org/W2017519756","https://openalex.org/W2017592356","https://openalex.org/W2021106586","https://openalex.org/W2024011553","https://openalex.org/W2024368431","https://openalex.org/W2027738518","https://openalex.org/W2045949915","https://openalex.org/W2047337597","https://openalex.org/W2053088580","https://openalex.org/W2054331494","https://openalex.org/W2059106941","https://openalex.org/W2085825095","https://openalex.org/W2087347434","https://openalex.org/W2099308199","https://openalex.org/W2104275641","https://openalex.org/W2105307973","https://openalex.org/W2106882534","https://openalex.org/W2114903401","https://openalex.org/W2117798874","https://openalex.org/W2119862467","https://openalex.org/W2130479394","https://openalex.org/W2135046866","https://openalex.org/W2143426320","https://openalex.org/W2145126338","https://openalex.org/W2147169218","https://openalex.org/W2149026172","https://openalex.org/W2169054534","https://openalex.org/W2395808804","https://openalex.org/W2911964244","https://openalex.org/W4285719527","https://openalex.org/W6601348139"],"related_works":["https://openalex.org/W1888155289","https://openalex.org/W2103138322","https://openalex.org/W2790559265","https://openalex.org/W2128056683","https://openalex.org/W2067925490","https://openalex.org/W2125205795","https://openalex.org/W1980369921","https://openalex.org/W2090030489","https://openalex.org/W1974470921","https://openalex.org/W4207081274"],"abstract_inverted_index":{"The":[0,68,187,209,252],"relationship":[1],"of":[2,12,18,43,47,58,74,79,81,92,128,139,157,169,189,192,196,201,216,240],"HIV":[3,75],"tropism":[4,36,76,197],"with":[5,112],"disease":[6],"progression":[7],"and":[8,41,65,77,119,149,205,220,228],"the":[9,16,39,44,48,59,82,93,105,126,129,136,140,167,193,199,217,221,237,241,249],"recent":[10],"development":[11],"CCR5-blocking":[13],"drugs":[14],"underscore":[15],"importance":[17,200],"monitoring":[19],"virus":[20,35,49],"coreceptor":[21,89,250],"usage.":[22,90],"As":[23],"an":[24],"alternative":[25],"to":[26,172,179],"costly":[27],"phenotypic":[28],"assays,":[29],"computational":[30],"methods":[31],"aim":[32],"at":[33,125],"predicting":[34],"based":[37,107],"on":[38,109,143,213],"sequence":[40,111,147],"structure":[42],"V3":[45,60,83,110],"loop":[46,61,84,194,203,218,242],"gp120":[50],"protein.":[51],"Here":[52],"we":[53,165],"present":[54],"a":[55,100,151,245],"numerical":[56],"descriptor":[57,69,95],"encoding":[62],"its":[63],"physicochemical":[64,207],"structural":[66,190],"properties.":[67,208],"allows":[70],"for":[71,88,96,248],"structure-based":[72],"prediction":[73,97,106],"identification":[78],"properties":[80],"that":[85],"are":[86,211,224,232],"crucial":[87],"Use":[91],"proposed":[94],"results":[98],"in":[99,117,123,155,233,236],"statistically":[101,152],"significant":[102,153],"improvement":[103,116,154],"over":[104,161],"solely":[108],"3":[113,158],"percentage":[114,121,159],"points":[115,122,160],"AUC":[118,156],"7":[120],"sensitivity":[124],"specificity":[127],"11/25":[130],"rule":[131],"(95%).":[132],"We":[133],"additionally":[134],"assessed":[135],"predictive":[137],"power":[138],"new":[141],"method":[142,171,253],"clinically":[144],"derived":[145],"'bulk'":[146],"data":[148],"obtained":[150],"sequence-based":[162],"prediction.":[163],"Furthermore,":[164],"demonstrated":[166],"capacity":[168],"our":[170],"predict":[173],"therapy":[174],"outcome":[175],"by":[176],"applying":[177],"it":[178],"53":[180],"samples":[181],"from":[182],"patients":[183],"undergoing":[184],"Maraviroc":[185],"therapy.":[186],"analysis":[188],"features":[191,223],"informative":[195],"indicates":[198],"two":[202],"regions":[204,210,231],"their":[206],"located":[212],"opposite":[214],"strands":[215],"stem":[219],"respective":[222],"predominantly":[225],"charge-,":[226],"hydrophobicity-":[227],"structure-related.":[229],"These":[230],"close":[234],"proximity":[235],"bound":[238],"conformation":[239],"potentially":[243],"forming":[244],"site":[246],"determinant":[247],"binding.":[251],"is":[254],"available":[255],"via":[256],"server":[257],"under":[258],"http://structure.bioinf.mpi-inf.mpg.de/.":[259]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
