{"id":"https://openalex.org/W2085583614","doi":"https://doi.org/10.1371/journal.pcbi.1002907","title":"Structure-based Molecular Simulations Reveal the Enhancement of Biased Brownian Motions in Single-headed Kinesin","display_name":"Structure-based Molecular Simulations Reveal the Enhancement of Biased Brownian Motions in Single-headed Kinesin","publication_year":2013,"publication_date":"2013-02-14","ids":{"openalex":"https://openalex.org/W2085583614","doi":"https://doi.org/10.1371/journal.pcbi.1002907","mag":"2085583614","pmid":"https://pubmed.ncbi.nlm.nih.gov/23459019"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002907","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002907","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002907&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002907&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005844348","display_name":"Ryo Kanada","orcid":"https://orcid.org/0000-0003-1168-0606"},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Kanada","raw_affiliation_strings":["Department of Biophysics Graduate School of Science, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics Graduate School of Science, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076164483","display_name":"Takeshi Kuwata","orcid":null},"institutions":[{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Kuwata","raw_affiliation_strings":["Graduate School of Science and Technology, Kobe University, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Science and Technology, Kobe University, Kobe, Japan","institution_ids":["https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018496320","display_name":"Hiroo Kenzaki","orcid":null},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroo Kenzaki","raw_affiliation_strings":["Department of Biophysics Graduate School of Science, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics Graduate School of Science, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071626951","display_name":"Shoji Takada","orcid":"https://orcid.org/0000-0001-5385-7217"},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shoji Takada","raw_affiliation_strings":["CREST Japan Science and Technology Agency, Kawaguchi, Saitama, Japan","Department of Biophysics Graduate School of Science, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CREST Japan Science and Technology Agency, Kawaguchi, Saitama, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Department of Biophysics Graduate School of Science, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071626951"],"corresponding_institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210086780"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9837,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.73974631,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"9","issue":"2","first_page":"e1002907","last_page":"e1002907"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11879","display_name":"Protist diversity and phylogeny","score":0.9832000136375427,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinesin","display_name":"Kinesin","score":0.9193817377090454},{"id":"https://openalex.org/keywords/molecular-motor","display_name":"Molecular motor","score":0.7687028646469116},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.6759597063064575},{"id":"https://openalex.org/keywords/brownian-motion","display_name":"Brownian motion","score":0.6655409336090088},{"id":"https://openalex.org/keywords/brownian-dynamics","display_name":"Brownian dynamics","score":0.6494402885437012},{"id":"https://openalex.org/keywords/energy-landscape","display_name":"Energy landscape","score":0.6322171688079834},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.48840659856796265},{"id":"https://openalex.org/keywords/microtubule","display_name":"Microtubule","score":0.4640122652053833},{"id":"https://openalex.org/keywords/motor-protein","display_name":"Motor protein","score":0.46391335129737854},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.45280954241752625},{"id":"https://openalex.org/keywords/brownian-motor","display_name":"Brownian motor","score":0.43862056732177734},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2489071488380432},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.0961165726184845},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.09114429354667664},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.08606347441673279},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.07102733850479126},{"id":"https://openalex.org/keywords/ratchet","display_name":"Ratchet","score":0.05976632237434387}],"concepts":[{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.9193817377090454},{"id":"https://openalex.org/C160408235","wikidata":"https://www.wikidata.org/wiki/Q423905","display_name":"Molecular motor","level":2,"score":0.7687028646469116},{"id":"https://openalex.org/C141315368","wikidata":"https://www.wikidata.org/wiki/Q4654881","display_name":"ATP hydrolysis","level":4,"score":0.6759597063064575},{"id":"https://openalex.org/C112401455","wikidata":"https://www.wikidata.org/wiki/Q178036","display_name":"Brownian motion","level":2,"score":0.6655409336090088},{"id":"https://openalex.org/C130603088","wikidata":"https://www.wikidata.org/wiki/Q4976526","display_name":"Brownian dynamics","level":3,"score":0.6494402885437012},{"id":"https://openalex.org/C119621388","wikidata":"https://www.wikidata.org/wiki/Q5377166","display_name":"Energy landscape","level":2,"score":0.6322171688079834},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.48840659856796265},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.4640122652053833},{"id":"https://openalex.org/C93126451","wikidata":"https://www.wikidata.org/wiki/Q2383767","display_name":"Motor protein","level":3,"score":0.46391335129737854},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45280954241752625},{"id":"https://openalex.org/C25051078","wikidata":"https://www.wikidata.org/wiki/Q2126262","display_name":"Brownian motor","level":4,"score":0.43862056732177734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2489071488380432},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0961165726184845},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.09114429354667664},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.08606347441673279},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.07102733850479126},{"id":"https://openalex.org/C2777694918","wikidata":"https://www.wikidata.org/wiki/Q11171014","display_name":"Ratchet","level":3,"score":0.05976632237434387},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002907","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002907","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002907&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:23459019","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23459019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:2504e30b3a2f45f689cfb74ce2e78e5b","is_oa":false,"landing_page_url":"https://doaj.org/article/2504e30b3a2f45f689cfb74ce2e78e5b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 2, p e1002907 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2586463","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3572960","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/156991","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Structure_based_Molecular_Simulations_Reveal_the_Enhancement_of_Biased_Brownian_Motions_in_Single_headed_Kinesin__/156991","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3572960","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3572960","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002907","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002907","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002907&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2085583614.pdf","grobid_xml":"https://content.openalex.org/works/W2085583614.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1523096427","https://openalex.org/W1607931568","https://openalex.org/W1882922344","https://openalex.org/W1963863239","https://openalex.org/W1966790730","https://openalex.org/W1967609633","https://openalex.org/W1969231606","https://openalex.org/W1972362449","https://openalex.org/W1974160934","https://openalex.org/W1983728565","https://openalex.org/W1986922416","https://openalex.org/W1988852106","https://openalex.org/W1989829257","https://openalex.org/W1993085892","https://openalex.org/W1993140172","https://openalex.org/W1998367993","https://openalex.org/W1999353363","https://openalex.org/W2005321323","https://openalex.org/W2010713749","https://openalex.org/W2011904538","https://openalex.org/W2030275382","https://openalex.org/W2035150925","https://openalex.org/W2035333393","https://openalex.org/W2037069908","https://openalex.org/W2054752913","https://openalex.org/W2057733928","https://openalex.org/W2059425402","https://openalex.org/W2061092318","https://openalex.org/W2061272721","https://openalex.org/W2061803377","https://openalex.org/W2062714245","https://openalex.org/W2065864578","https://openalex.org/W2071777531","https://openalex.org/W2089286435","https://openalex.org/W2090047847","https://openalex.org/W2094397610","https://openalex.org/W2094795801","https://openalex.org/W2095051959","https://openalex.org/W2106906854","https://openalex.org/W2152516404","https://openalex.org/W2153492153","https://openalex.org/W2159875359","https://openalex.org/W2167387669","https://openalex.org/W2168166944","https://openalex.org/W2171755502","https://openalex.org/W2178631187","https://openalex.org/W2883755802","https://openalex.org/W3022909842"],"related_works":["https://openalex.org/W2950045261","https://openalex.org/W2172014355","https://openalex.org/W1830011917","https://openalex.org/W2800495128","https://openalex.org/W2058178091","https://openalex.org/W1971756681","https://openalex.org/W1468280468","https://openalex.org/W2329913011","https://openalex.org/W2584271813","https://openalex.org/W1520109592"],"abstract_inverted_index":{"Kinesin":[0],"is":[1],"a":[2,34,45,48,54,72,98,115,124,148,206,218],"family":[3],"of":[4,40,90,100,103,173,181,196,202,209,217],"molecular":[5,101],"motors":[6],"that":[7,145],"move":[8,29],"unidirectionally":[9,30],"along":[10,58],"microtubules":[11],"(MT)":[12],"using":[13],"ATP":[14,110,164],"hydrolysis":[15,111,165],"free":[16],"energy.":[17],"In":[18],"the":[19,21,41,76,81,86,93,104,154,171,174,182,188,197,200,210,215],"family,":[20],"conventional":[22,77],"two-headed":[23],"kinesin":[24,78],"was":[25,185,192],"experimentally":[26],"characterized":[27],"to":[28,79,127,153],"through":[31],"\"walking\"":[32],"in":[33,63,123,129,194,223],"hand-over-hand":[35],"fashion":[36],"by":[37,62],"coordinated":[38],"motions":[39],"two":[42],"heads.":[43],"Interestingly":[44],"single-headed":[46],"kinesin,":[47],"truncated":[49,105],"KIF1A,":[50,134],"still":[51],"can":[52,156],"generate":[53,157],"biased":[55,140,159],"Brownian":[56,160],"movement":[57],"MT,":[59],"as":[60],"observed":[61],"vitro":[64],"single":[65],"molecule":[66],"experiments.":[67,130],"Thus,":[68],"KIF1A":[69,106,146,175,183,224],"must":[70],"use":[71],"different":[73],"mechanism":[74,116],"from":[75,176],"achieve":[80],"unidirectional":[82],"motions.":[83],"Based":[84],"on":[85],"energy":[87],"landscape":[88],"view":[89],"proteins,":[91],"for":[92],"first":[94],"time,":[95],"we":[96,135,143],"conducted":[97],"set":[99],"simulations":[102],"movements":[107,122,161],"over":[108],"an":[109,163],"cycle":[112],"and":[113,118],"found":[114,144],"exhibiting":[117],"enhancing":[119],"stochastic":[120],"forward-biased":[121],"similar":[125],"way":[126],"those":[128],"First,":[131],"simulating":[132],"stand-alone":[133],"did":[136],"not":[137],"find":[138],"any":[139],"movements,":[141],"while":[142],"with":[147],"large":[149,189],"friction":[150],"cargo-analog":[151,169],"attached":[152],"C-terminus":[155],"clearly":[158],"upon":[162],"cycle.":[166],"The":[167,212],"linked":[168],"enhanced":[170],"detachment":[172],"MT.":[177],"Once":[178],"detached,":[179],"diffusion":[180],"head":[184,198],"restricted":[186],"around":[187],"cargo":[190,213],"which":[191],"located":[193],"front":[195],"at":[199],"time":[201],"detachment,":[203],"thus":[204],"generating":[205],"forward":[207],"bias":[208],"diffusion.":[211],"plays":[214],"role":[216],"diffusional":[219],"anchor,":[220],"or":[221],"cane,":[222],"\"walking.\"":[225]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}