{"id":"https://openalex.org/W2052056715","doi":"https://doi.org/10.1371/journal.pcbi.1002882","title":"Redirector: Designing Cell Factories by Reconstructing the Metabolic Objective","display_name":"Redirector: Designing Cell Factories by Reconstructing the Metabolic Objective","publication_year":2013,"publication_date":"2013-01-17","ids":{"openalex":"https://openalex.org/W2052056715","doi":"https://doi.org/10.1371/journal.pcbi.1002882","mag":"2052056715","pmid":"https://pubmed.ncbi.nlm.nih.gov/23341769"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002882","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002882","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002882&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002882&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005711954","display_name":"Graham N. Rockwell","orcid":"https://orcid.org/0000-0003-2738-326X"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210105714","display_name":"Center for Human Genetics","ror":"https://ror.org/01gcrbc43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Graham Rockwell","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. grockwell@genetics.med.harvard.edu","Program in Bioinformatics, Boston University, Boston, Massachusetts, United States of America","Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. grockwell@genetics.med.harvard.edu","institution_ids":["https://openalex.org/I4210105714"]},{"raw_affiliation_string":"Program in Bioinformatics, Boston University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081237427","display_name":"Nicholas J. Guido","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Guido","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America,","Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103076360","display_name":"George M. Church","orcid":"https://orcid.org/0000-0003-3535-2076"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George M. Church","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America,","Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.4766,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.89442781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"e1002882","last_page":"e1002882"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic engineering","score":0.8578134179115295},{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.6642149686813354},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.6353132724761963},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.6192001104354858},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6004009246826172},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.5988268852233887},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5905402898788452},{"id":"https://openalex.org/keywords/metabolic-flux-analysis","display_name":"Metabolic flux analysis","score":0.5818299055099487},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.5734435319900513},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5206822156906128},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.4672204256057739},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.4186103343963623},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.400994211435318},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.25723522901535034},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2343457043170929},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2342187762260437},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.20270124077796936},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1709110140800476},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.12746545672416687}],"concepts":[{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.8578134179115295},{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.6642149686813354},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.6353132724761963},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.6192001104354858},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6004009246826172},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5988268852233887},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5905402898788452},{"id":"https://openalex.org/C160941953","wikidata":"https://www.wikidata.org/wiki/Q6822342","display_name":"Metabolic flux analysis","level":3,"score":0.5818299055099487},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.5734435319900513},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5206822156906128},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4672204256057739},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.4186103343963623},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.400994211435318},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25723522901535034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2343457043170929},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2342187762260437},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20270124077796936},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1709110140800476},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.12746545672416687},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1002882","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002882","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002882&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:23341769","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23341769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:osti.gov:1904694","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1904694","pdf_url":"https://www.osti.gov/servlets/purl/1904694","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.774.7007","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.774.7007","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f4/9b/pcbi.1002882.PMC3547792.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002882","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002882","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:dash.harvard.edu:1/37372854","is_oa":false,"landing_page_url":"https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372854","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8ccf9c618a2049d3898c432c6223ec0a","is_oa":true,"landing_page_url":"https://doaj.org/article/8ccf9c618a2049d3898c432c6223ec0a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 1, p e1002882 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/114399","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Redirector_Designing_Cell_Factories_by_Reconstructing_the_Metabolic_Objective/114399","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3547792","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3547792","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002882","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002882","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002882&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9","score":0.5099999904632568}],"awards":[{"id":"https://openalex.org/G1962169235","display_name":null,"funder_award_id":"DE-FG02-02ER63445","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G367941267","display_name":"MICROBIAL ECOLOGY, PROTEOGENO-MICS & COMPUTATIONAL OPTIMA","funder_award_id":"FG02-02ER63445","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3761283143","display_name":null,"funder_award_id":"DE-FG02-02ER63445","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G5237735415","display_name":null,"funder_award_id":"SA5283-11210","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7186324567","display_name":null,"funder_award_id":"DE-FG02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G801099662","display_name":null,"funder_award_id":"SA5283-11210","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8684078510","display_name":null,"funder_award_id":"DE-FG02","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2052056715.pdf","grobid_xml":"https://content.openalex.org/works/W2052056715.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W193111756","https://openalex.org/W1498020519","https://openalex.org/W1502529406","https://openalex.org/W1581582023","https://openalex.org/W1590222219","https://openalex.org/W1597762351","https://openalex.org/W1759632117","https://openalex.org/W1793938508","https://openalex.org/W1969983517","https://openalex.org/W1977675219","https://openalex.org/W1982836457","https://openalex.org/W1987607959","https://openalex.org/W1988250170","https://openalex.org/W1992167997","https://openalex.org/W1992306474","https://openalex.org/W1993899465","https://openalex.org/W2008875008","https://openalex.org/W2013357214","https://openalex.org/W2013685063","https://openalex.org/W2017731127","https://openalex.org/W2020241931","https://openalex.org/W2022750609","https://openalex.org/W2023403198","https://openalex.org/W2024172008","https://openalex.org/W2028343312","https://openalex.org/W2050461585","https://openalex.org/W2062819025","https://openalex.org/W2063921800","https://openalex.org/W2074893062","https://openalex.org/W2077997117","https://openalex.org/W2091124334","https://openalex.org/W2099395427","https://openalex.org/W2101809525","https://openalex.org/W2102164505","https://openalex.org/W2106176351","https://openalex.org/W2107409961","https://openalex.org/W2109880272","https://openalex.org/W2111167674","https://openalex.org/W2111421616","https://openalex.org/W2111905282","https://openalex.org/W2123097315","https://openalex.org/W2128746754","https://openalex.org/W2129899370","https://openalex.org/W2130364940","https://openalex.org/W2132124985","https://openalex.org/W2134759932","https://openalex.org/W2135422515","https://openalex.org/W2136670217","https://openalex.org/W2138885877","https://openalex.org/W2143814332","https://openalex.org/W2153238155","https://openalex.org/W2154797402","https://openalex.org/W2156974639","https://openalex.org/W2159022315","https://openalex.org/W2161227644","https://openalex.org/W2170427655","https://openalex.org/W2414710795","https://openalex.org/W4255087327"],"related_works":["https://openalex.org/W2046546139","https://openalex.org/W1992844569","https://openalex.org/W1999460937","https://openalex.org/W1918238777","https://openalex.org/W2113329733","https://openalex.org/W4285237197","https://openalex.org/W2133150343","https://openalex.org/W2341681417","https://openalex.org/W1984242440","https://openalex.org/W2613838074"],"abstract_inverted_index":{"Advances":[0],"in":[1,14,46,77,83,118,168],"computational":[2,24,196],"metabolic":[3,16,54,73,81,99,137],"optimization":[4,50,141],"are":[5],"required":[6],"to":[7,42,97,114,195,201],"realize":[8],"the":[9,21,78,84,93,98,105,115,133],"full":[10],"potential":[11],"of":[12,80,107,110,128,142,178],"new":[13,33],"vivo":[15,169],"engineering":[17,40,162],"technologies":[18],"by":[19,60,183],"bridging":[20],"gap":[22],"between":[23],"design":[25],"and":[26,123,126,159,174,191,198],"strain":[27],"development.":[28],"We":[29],"present":[30],"Redirector,":[31],"a":[32,67,108,147],"Flux":[34],"Balance":[35],"Analysis-based":[36],"framework":[37,87],"for":[38,140,207],"identifying":[39],"targets":[41,206],"optimize":[43],"metabolite":[44,109],"production":[45,106,145],"complex":[47],"pathways.":[48],"Previous":[49],"frameworks":[51],"have":[52],"modeled":[53],"alterations":[55,74],"as":[56,75,146,154,156,189],"directly":[57],"controlling":[58],"fluxes":[59,96],"setting":[61],"particular":[62],"flux":[63,103],"bounds.":[64],"Redirector":[65,150,186],"develops":[66],"more":[68],"biologically":[69],"relevant":[70,175],"approach,":[71],"modeling":[72],"changes":[76],"balance":[79],"objectives":[82],"system.":[85],"This":[86],"iteratively":[88],"selects":[89],"enzyme":[90,129,205],"targets,":[91,170],"adds":[92],"associated":[94],"reaction":[95],"objective,":[100],"thereby":[101],"incentivizing":[102],"towards":[104],"interest.":[111],"These":[112,164],"adjustments":[113],"objective":[116],"act":[117],"competition":[119],"with":[120,153],"cellular":[121],"growth":[122],"represent":[124],"up-regulation":[125],"down-regulation":[127],"mediated":[130],"reactions.":[131],"Using":[132],"iAF1260":[134],"E.":[135],"coli":[136],"network":[138],"model":[139],"fatty":[143,208],"acid":[144,209],"test":[148],"case,":[149],"generates":[151],"designs":[152,165],"many":[155,177],"39":[157],"simultaneous":[158],"111":[160],"unique":[161],"targets.":[163],"discover":[166],"proven":[167],"novel":[171],"supporting":[172],"pathways":[173],"interdependencies,":[176],"which":[179],"cannot":[180],"be":[181],"predicted":[182],"other":[184],"methods.":[185],"is":[187],"available":[188],"open":[190],"free":[192],"software,":[193],"scalable":[194],"resources,":[197],"powerful":[199],"enough":[200],"find":[202],"all":[203],"known":[204],"production.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4}],"updated_date":"2026-07-27T08:26:11.824852","created_date":"2025-10-10T00:00:00"}
