{"id":"https://openalex.org/W2039703489","doi":"https://doi.org/10.1371/journal.pcbi.1002864","title":"Effects of Ligand Binding on the Mechanical Properties of Ankyrin Repeat Protein Gankyrin","display_name":"Effects of Ligand Binding on the Mechanical Properties of Ankyrin Repeat Protein Gankyrin","publication_year":2013,"publication_date":"2013-01-17","ids":{"openalex":"https://openalex.org/W2039703489","doi":"https://doi.org/10.1371/journal.pcbi.1002864","mag":"2039703489","pmid":"https://pubmed.ncbi.nlm.nih.gov/23341763"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002864","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002864","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002864&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002864&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051903889","display_name":"Giovanni Settanni","orcid":"https://orcid.org/0000-0003-1338-937X"},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Giovanni Settanni","raw_affiliation_strings":["Physics Department, Johannes Gutenberg University, Mainz, Germany. settani@uni-mainz.de","Physics Department, Johannes Gutenberg University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physics Department, Johannes Gutenberg University, Mainz, Germany. settani@uni-mainz.de","institution_ids":["https://openalex.org/I197323543"]},{"raw_affiliation_string":"Physics Department, Johannes Gutenberg University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053947151","display_name":"David Serquera","orcid":null},"institutions":[{"id":"https://openalex.org/I4210089716","display_name":"MRC Cancer Unit","ror":"https://ror.org/015nth639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210087105","https://openalex.org/I4210089716","https://openalex.org/I4210106569","https://openalex.org/I90344618","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I4210106569","display_name":"Hutchison/MRC Research Centre","ror":"https://ror.org/01ajt3179","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I4210106569","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Serquera","raw_affiliation_strings":["MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I4210106569","https://openalex.org/I4210089716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070654488","display_name":"Piotr E. Marsza\u0142ek","orcid":"https://orcid.org/0000-0001-7948-8034"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Piotr E. Marszalek","raw_affiliation_strings":["Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering and Materials Science, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025815526","display_name":"Emanuele Paci","orcid":"https://orcid.org/0000-0002-4891-2768"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Emanuele Paci","raw_affiliation_strings":["School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom","Sch of Molecular and Cellular Biology, Univ of Leeds, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Sch of Molecular and Cellular Biology, Univ of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052850050","display_name":"Laura S. Itzhaki","orcid":"https://orcid.org/0000-0001-6504-2576"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Laura S. Itzhaki","raw_affiliation_strings":["University of Cambridge Department of Chemistry, Cambridge, United Kingdom","University of Cambridge, Department of Chemistry Cambridge United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge Department of Chemistry, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"University of Cambridge, Department of Chemistry Cambridge United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5025815526","https://openalex.org/A5051903889","https://openalex.org/A5052850050"],"corresponding_institution_ids":["https://openalex.org/I130828816","https://openalex.org/I197323543","https://openalex.org/I241749"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0473,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.76194397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"e1002864","last_page":"e1002864"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.987500011920929,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ankyrin-repeat","display_name":"Ankyrin repeat","score":0.9057215452194214},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.6589980721473694},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5474498867988586},{"id":"https://openalex.org/keywords/ankyrin","display_name":"Ankyrin","score":0.5281760096549988},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.4965720772743225},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.4578157961368561},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"Unfolded protein response","score":0.44873130321502686},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.41271114349365234},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3205169439315796},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3071247935295105},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.28185153007507324},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.15414878726005554}],"concepts":[{"id":"https://openalex.org/C113241181","wikidata":"https://www.wikidata.org/wiki/Q24784174","display_name":"Ankyrin repeat","level":3,"score":0.9057215452194214},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6589980721473694},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5474498867988586},{"id":"https://openalex.org/C182800266","wikidata":"https://www.wikidata.org/wiki/Q414971","display_name":"Ankyrin","level":3,"score":0.5281760096549988},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4965720772743225},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4578157961368561},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.44873130321502686},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.41271114349365234},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3205169439315796},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3071247935295105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28185153007507324},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15414878726005554},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1002864","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002864","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002864&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:23341763","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23341763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.798.9125","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.798.9125","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/dc/6e/pcbi.1002864.PMC3547791.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002864","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002864","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:cris.unibo.it:11585/885193","is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/885193","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:b1d337f77ff94f668485a1b71edc5db1","is_oa":true,"landing_page_url":"https://doaj.org/article/b1d337f77ff94f668485a1b71edc5db1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 1, p e1002864 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/114379","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Effects_of_Ligand_Binding_on_the_Mechanical_Properties_of_Ankyrin_Repeat_Protein_Gankyrin__/114379","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3547791","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3547791","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002864","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002864","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002864&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1541927007","display_name":null,"funder_award_id":"R01-GM079563","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4468737262","display_name":null,"funder_award_id":"GM079563","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4588127297","display_name":null,"funder_award_id":"R01 GM079563","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6781191891","display_name":null,"funder_award_id":"G1002329","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2039703489.pdf","grobid_xml":"https://content.openalex.org/works/W2039703489.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1568358263","https://openalex.org/W1578810612","https://openalex.org/W1966686681","https://openalex.org/W1967708206","https://openalex.org/W1979824772","https://openalex.org/W1986916659","https://openalex.org/W1987553698","https://openalex.org/W1997828975","https://openalex.org/W1999602312","https://openalex.org/W2003131691","https://openalex.org/W2016027959","https://openalex.org/W2023167553","https://openalex.org/W2024766860","https://openalex.org/W2026532515","https://openalex.org/W2027059904","https://openalex.org/W2029667189","https://openalex.org/W2033619224","https://openalex.org/W2037720334","https://openalex.org/W2048492672","https://openalex.org/W2049535263","https://openalex.org/W2054373762","https://openalex.org/W2054927274","https://openalex.org/W2058912578","https://openalex.org/W2069698812","https://openalex.org/W2070333171","https://openalex.org/W2075484467","https://openalex.org/W2076235195","https://openalex.org/W2090757760","https://openalex.org/W2102375526","https://openalex.org/W2104715597","https://openalex.org/W2116130329","https://openalex.org/W2132262459","https://openalex.org/W2155839904","https://openalex.org/W2160939764","https://openalex.org/W2162166182","https://openalex.org/W2163891447","https://openalex.org/W2171138378","https://openalex.org/W3102045875"],"related_works":["https://openalex.org/W1995972219","https://openalex.org/W2059576907","https://openalex.org/W2092250360","https://openalex.org/W1516730417","https://openalex.org/W2010874410","https://openalex.org/W2144218767","https://openalex.org/W2039884257","https://openalex.org/W1985485809","https://openalex.org/W4206472390","https://openalex.org/W2518534345"],"abstract_inverted_index":{"Ankyrin":[0],"repeat":[1,11,119,159],"proteins":[2,160],"are":[3],"elastic":[4],"materials":[5],"that":[6,44,104],"unfold":[7,144],"and":[8,34,71,96,136,148,161],"refold":[9],"sequentially,":[10],"by":[12,201],"repeat,":[13],"under":[14],"force.":[15],"Herein":[16],"we":[17],"use":[18],"atomistic":[19],"molecular":[20],"dynamics":[21],"to":[22,54,61,80,140,143,157,188],"compare":[23],"the":[24,28,45,50,72,77,81,85,97,111,116,121,127,133,137,141,145,155,169,179],"mechanical":[25,55,73,113,166,180,202],"properties":[26],"of":[27,52,64,76,91,94,100,110,118,123,129,182],"7-ankyrin-repeat":[29],"oncoprotein":[30],"Gankyrin":[31,53,65],"in":[32,35,67,168],"isolation":[33],"complex":[36],"with":[37,69],"its":[38,149],"binding":[39,102,163,176,194],"partner":[40,197],"S6-C.":[41],"We":[42],"show":[43],"bound":[46],"S6-C":[47],"greatly":[48],"increases":[49],"resistance":[51],"stress.":[56,203],"The":[57,184],"effect":[58],"is":[59,103,199],"specific":[60],"those":[62],"repeats":[63,83],"directly":[66],"contact":[68],"S6-C,":[70],"'hot":[74],"spots'":[75],"interaction":[78],"map":[79],"same":[82],"as":[84],"thermodynamic":[86],"hot":[87],"spots.":[88],"A":[89],"consequence":[90],"stepwise":[92],"nature":[93,99,128],"unfolding":[95,124,152],"localized":[98],"ligand":[101,175],"it":[105],"impacts":[106],"on":[107],"all":[108],"aspects":[109],"protein's":[112],"behavior,":[114],"including":[115],"order":[117],"unfolding,":[120],"diversity":[122],"pathways":[125],"accessed,":[126],"partially":[130],"unfolded":[131],"intermediates,":[132],"forces":[134],"required":[135],"work":[138],"transferred":[139],"system":[142],"whole":[146],"protein":[147],"parts.":[150],"Stepwise":[151],"thus":[153],"provides":[154],"means":[156],"buffer":[158],"their":[162],"partners":[164],"from":[165],"stress":[167],"cell.":[170],"Our":[171],"results":[172],"illustrate":[173],"how":[174],"can":[177],"control":[178],"response":[181],"proteins.":[183],"data":[185],"also":[186],"point":[187],"a":[189],"cellular":[190],"mechano-switching":[191],"mechanism":[192],"whereby":[193],"between":[195],"two":[196],"macromolecules":[198],"regulated":[200]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}