{"id":"https://openalex.org/W2019819616","doi":"https://doi.org/10.1371/journal.pcbi.1002846","title":"Nucleoid-Associated Proteins Affect Mutation Dynamics in E. coli in a Growth Phase-Specific Manner","display_name":"Nucleoid-Associated Proteins Affect Mutation Dynamics in E. coli in a Growth Phase-Specific Manner","publication_year":2012,"publication_date":"2012-12-20","ids":{"openalex":"https://openalex.org/W2019819616","doi":"https://doi.org/10.1371/journal.pcbi.1002846","mag":"2019819616","pmid":"https://pubmed.ncbi.nlm.nih.gov/23284284"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002846","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002846","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002846&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002846&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005881819","display_name":"Tobias Warnecke","orcid":"https://orcid.org/0000-0002-4936-5428"},"institutions":[{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"funder","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I170486558","display_name":"Pompeu Fabra University","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Tobias Warnecke","raw_affiliation_strings":["Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), Barcelona, Spain. Tobias.Warnecke@crg.es","Universitat Pompeu Fabra (UPF), Barcelona, Spain","Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), Barcelona, Spain. Tobias.Warnecke@crg.es","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025364437","display_name":"Fran Supek","orcid":"https://orcid.org/0000-0002-7811-6711"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Pompeu Fabra University","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"funder","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fran Supek","raw_affiliation_strings":["Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), Barcelona, Spain","Universitat Pompeu Fabra (UPF), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071772605","display_name":"Ben Lehner","orcid":null},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"funder","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I170486558","display_name":"Pompeu Fabra University","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ben Lehner","raw_affiliation_strings":["EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain","Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain","Universitat Pompeu Fabra (UPF), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain","institution_ids":["https://openalex.org/I11932220","https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005881819"],"corresponding_institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210137962"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6718,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.68017948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"8","issue":"12","first_page":"e1002846","last_page":"e1002846"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleoid","display_name":"Nucleoid","score":0.9518005847930908},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7825193405151367},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.6715319752693176},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5304412841796875},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.5101704597473145},{"id":"https://openalex.org/keywords/dna-binding-protein","display_name":"DNA-binding protein","score":0.5035304427146912},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4930267035961151},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.46086016297340393},{"id":"https://openalex.org/keywords/sos-response","display_name":"SOS response","score":0.4439982771873474},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.4178355634212494},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.41427183151245117},{"id":"https://openalex.org/keywords/seqa-protein-domain","display_name":"SeqA protein domain","score":0.41384702920913696},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.36427146196365356},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1941971778869629},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.15590137243270874},{"id":"https://openalex.org/keywords/origin-of-replication","display_name":"Origin of replication","score":0.14789748191833496}],"concepts":[{"id":"https://openalex.org/C53642103","wikidata":"https://www.wikidata.org/wiki/Q459485","display_name":"Nucleoid","level":4,"score":0.9518005847930908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7825193405151367},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6715319752693176},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5304412841796875},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5101704597473145},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.5035304427146912},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4930267035961151},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.46086016297340393},{"id":"https://openalex.org/C2780852648","wikidata":"https://www.wikidata.org/wiki/Q143584","display_name":"SOS response","level":4,"score":0.4439982771873474},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4178355634212494},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.41427183151245117},{"id":"https://openalex.org/C55468747","wikidata":"https://www.wikidata.org/wiki/Q24725272","display_name":"SeqA protein domain","level":5,"score":0.41384702920913696},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36427146196365356},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1941971778869629},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.15590137243270874},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.14789748191833496}],"mesh":[{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1002846","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002846","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002846&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:23284284","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23284284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.775.3696","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.775.3696","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d7/79/pcbi.1002846.PMC3527292.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:96d22b5189354d91ae73270456fca0d5","is_oa":true,"landing_page_url":"https://doaj.org/article/96d22b5189354d91ae73270456fca0d5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 12, p e1002846 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2534514","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3527292","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/115622","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Nucleoid_Associated_Proteins_Affect_Mutation_Dynamics_in_E_coli_in_a_Growth_Phase_Specific_Manner__/115622","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:06b16d4d-e48a-4162-b178-2ec341e43882","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OpenAlex","raw_type":"http://purl.org/coar/resource_type/c_dcae04bc"},{"id":"pmh:oai:pubmedcentral.nih.gov:3527292","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3527292","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002846","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002846","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002846&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.4300000071525574}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019819616.pdf","grobid_xml":"https://content.openalex.org/works/W2019819616.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1555259393","https://openalex.org/W1721587352","https://openalex.org/W1963677684","https://openalex.org/W1965218097","https://openalex.org/W1967229113","https://openalex.org/W1978953588","https://openalex.org/W1989456683","https://openalex.org/W1993222662","https://openalex.org/W2006824446","https://openalex.org/W2008244038","https://openalex.org/W2008655300","https://openalex.org/W2009096224","https://openalex.org/W2011114339","https://openalex.org/W2011836722","https://openalex.org/W2016160555","https://openalex.org/W2018177077","https://openalex.org/W2019385975","https://openalex.org/W2027299912","https://openalex.org/W2027854680","https://openalex.org/W2030578934","https://openalex.org/W2037429521","https://openalex.org/W2038445174","https://openalex.org/W2041257508","https://openalex.org/W2042840751","https://openalex.org/W2049848181","https://openalex.org/W2055167460","https://openalex.org/W2057586248","https://openalex.org/W2063239546","https://openalex.org/W2076316122","https://openalex.org/W2081331677","https://openalex.org/W2086376495","https://openalex.org/W2088011045","https://openalex.org/W2096873549","https://openalex.org/W2099191396","https://openalex.org/W2102699299","https://openalex.org/W2110335151","https://openalex.org/W2113843263","https://openalex.org/W2115176701","https://openalex.org/W2126702940","https://openalex.org/W2127558534","https://openalex.org/W2128738149","https://openalex.org/W2128996981","https://openalex.org/W2130432929","https://openalex.org/W2133990480","https://openalex.org/W2142402047","https://openalex.org/W2144657442","https://openalex.org/W2147847666","https://openalex.org/W2150609775","https://openalex.org/W2151442351","https://openalex.org/W2151589270","https://openalex.org/W2152296969","https://openalex.org/W2162906511","https://openalex.org/W2168333121","https://openalex.org/W2168493758","https://openalex.org/W2168696662","https://openalex.org/W2911964244"],"related_works":["https://openalex.org/W2329100574","https://openalex.org/W2070905289","https://openalex.org/W2911540414","https://openalex.org/W2087360968","https://openalex.org/W1938688528","https://openalex.org/W2168002962","https://openalex.org/W2136355431","https://openalex.org/W2900536401","https://openalex.org/W2139004845","https://openalex.org/W2087903802"],"abstract_inverted_index":{"The":[0],"binding":[1,52,128],"of":[2,19,53,69,124],"proteins":[3,21,146],"can":[4,116],"shield":[5],"DNA":[6,100,137],"from":[7],"mutagenic":[8],"processes":[9],"but":[10,153],"also":[11],"interfere":[12],"with":[13,75,135],"efficient":[14],"repair.":[15],"How":[16],"the":[17,51,82,88,93,143],"presence":[18],"DNA-binding":[20],"shapes":[22],"intra-genomic":[23],"differences":[24],"in":[25,31,45,48,81,156,161],"mutability":[26,80,103],"and,":[27],"ultimately,":[28],"sequence":[29,43,84,159],"variation":[30,160],"natural":[32],"populations,":[33],"however,":[34],"remains":[35],"poorly":[36],"understood.":[37],"In":[38],"this":[39,109],"study,":[40],"we":[41],"examine":[42],"evolution":[44],"Escherichia":[46],"coli":[47],"relation":[49],"to":[50,105],"four":[54,144],"abundant":[55],"nucleoid-associated":[56,145],"proteins:":[57],"Fis,":[58],"H-NS,":[59],"IhfA,":[60],"and":[61,78,115,131],"IhfB.":[62],"We":[63,140],"find":[64],"that,":[65],"for":[66],"a":[67,151],"subset":[68],"mutations,":[70],"protein":[71,89],"occupancy":[72],"is":[73,90,113],"associated":[74],"both":[76],"increased":[77],"decreased":[79],"underlying":[83],"depending":[85],"on":[86],"when":[87],"bound":[91],"during":[92,122],"bacterial":[94],"growth":[95,126],"cycle.":[96],"On":[97],"average,":[98],"protein-bound":[99],"exhibits":[101],"reduced":[102],"compared":[104],"protein-free":[106],"DNA.":[107],"However,":[108],"net":[110],"protective":[111],"effect":[112],"weak":[114],"be":[117],"abolished":[118],"or":[119],"even":[120],"reversed":[121],"stages":[123],"colony":[125],"where":[127],"coincides":[129],"-":[130,136],"hence":[132],"likely":[133],"interferes":[134],"repair":[138],"activity.":[139],"suggest":[141],"that":[142],"analyzed":[147],"here":[148],"have":[149],"played":[150],"minor":[152],"significant":[154],"role":[155],"patterning":[157],"extant":[158],"E.":[162],"coli.":[163]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}