{"id":"https://openalex.org/W2011667440","doi":"https://doi.org/10.1371/journal.pcbi.1002772","title":"Stochastic Modeling of Expression Kinetics Identifies Messenger Half-Lives and Reveals Sequential Waves of Co-ordinated Transcription and Decay","display_name":"Stochastic Modeling of Expression Kinetics Identifies Messenger Half-Lives and Reveals Sequential Waves of Co-ordinated Transcription and Decay","publication_year":2012,"publication_date":"2012-11-08","ids":{"openalex":"https://openalex.org/W2011667440","doi":"https://doi.org/10.1371/journal.pcbi.1002772","mag":"2011667440","pmid":"https://pubmed.ncbi.nlm.nih.gov/23144606"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002772","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002772","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002772&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002772&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007661526","display_name":"Filippo Cacace","orcid":"https://orcid.org/0000-0003-1060-744X"},"institutions":[{"id":"https://openalex.org/I155125353","display_name":"Universit\u00e0 Campus Bio-Medico","ror":"https://ror.org/04gqx4x78","country_code":"IT","type":"education","lineage":["https://openalex.org/I155125353"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Cacace","raw_affiliation_strings":["Universit\u00e0 Campus Biomedico, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e0 Campus Biomedico, Rome, Italy","institution_ids":["https://openalex.org/I155125353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043250067","display_name":"Paola Paci","orcid":"https://orcid.org/0000-0002-9393-2047"},"institutions":[{"id":"https://openalex.org/I155125353","display_name":"Universit\u00e0 Campus Bio-Medico","ror":"https://ror.org/04gqx4x78","country_code":"IT","type":"education","lineage":["https://openalex.org/I155125353"]},{"id":"https://openalex.org/I4210162062","display_name":"Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti","ror":"https://ror.org/054ye0e45","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210162062"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Paola Paci","raw_affiliation_strings":["CNR-Institute of Systems Analysis and Computer Science (IASI), BioMathLab, Rome, Italy","Universit\u00e0 Campus Biomedico, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-Institute of Systems Analysis and Computer Science (IASI), BioMathLab, Rome, Italy","institution_ids":["https://openalex.org/I4210162062"]},{"raw_affiliation_string":"Universit\u00e0 Campus Biomedico, Rome, Italy","institution_ids":["https://openalex.org/I155125353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034312302","display_name":"Valerio Cusimano","orcid":"https://orcid.org/0000-0002-1965-9054"},"institutions":[{"id":"https://openalex.org/I155125353","display_name":"Universit\u00e0 Campus Bio-Medico","ror":"https://ror.org/04gqx4x78","country_code":"IT","type":"education","lineage":["https://openalex.org/I155125353"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valerio Cusimano","raw_affiliation_strings":["Universit\u00e0 Campus Biomedico, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e0 Campus Biomedico, Rome, Italy","institution_ids":["https://openalex.org/I155125353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042421338","display_name":"Alfredo Germani","orcid":"https://orcid.org/0000-0003-4457-8800"},"institutions":[{"id":"https://openalex.org/I26415053","display_name":"University of L'Aquila","ror":"https://ror.org/01j9p1r26","country_code":"IT","type":"education","lineage":["https://openalex.org/I26415053"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfredo Germani","raw_affiliation_strings":["Dipartimento di Ingegneria e Scienze dell'Informazione e Matematica (DISIM), Universit\u00e0 de L'Aquila, L'Aquila, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Ingegneria e Scienze dell'Informazione e Matematica (DISIM), Universit\u00e0 de L'Aquila, L'Aquila, Italy","institution_ids":["https://openalex.org/I26415053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074179530","display_name":"Lorenzo Farina","orcid":"https://orcid.org/0000-0001-8314-6029"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Farina","raw_affiliation_strings":["Dipartimento di Informatica e Sistemistica, Sapienza Universit\u00e0 di Roma, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Informatica e Sistemistica, Sapienza Universit\u00e0 di Roma, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043250067"],"corresponding_institution_ids":["https://openalex.org/I155125353","https://openalex.org/I4210162062"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8591,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.7063235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"11","first_page":"e1002772","last_page":"e1002772"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.6595096588134766},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6233905553817749},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.606584906578064},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5990415215492249},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.535105288028717},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.5313045978546143},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.5261677503585815},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5078771710395813},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.45914316177368164},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4085747003555298},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.34848231077194214}],"concepts":[{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6595096588134766},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6233905553817749},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.606584906578064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5990415215492249},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.535105288028717},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5313045978546143},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5261677503585815},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5078771710395813},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45914316177368164},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4085747003555298},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34848231077194214},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002772","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002772","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002772&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:23144606","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23144606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:iris.uniroma1.it:11573/503293","is_oa":true,"landing_page_url":"http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002772","pdf_url":"http://hdl.handle.net/11573/503293","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002772","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002772","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:906828ce762f4b64988fd3be19a0f70b","is_oa":false,"landing_page_url":"https://doaj.org/article/906828ce762f4b64988fd3be19a0f70b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 11, p e1002772 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2492632","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3493476","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/117337","is_oa":true,"landing_page_url":"https://figshare.com/articles/Stochastic_Modeling_of_Expression_Kinetics_Identifies_Messenger_Half_Lives_and_Reveals_Sequential_Waves_of_Co_ordinated_Transcription_and_Decay__/117337","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002772","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002772","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002772&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011667440.pdf","grobid_xml":"https://content.openalex.org/works/W2011667440.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1515773506","https://openalex.org/W1969289662","https://openalex.org/W1984688123","https://openalex.org/W2019478357","https://openalex.org/W2020783091","https://openalex.org/W2023160008","https://openalex.org/W2036799174","https://openalex.org/W2038963685","https://openalex.org/W2039357236","https://openalex.org/W2049047355","https://openalex.org/W2049402769","https://openalex.org/W2056701786","https://openalex.org/W2075656833","https://openalex.org/W2088860412","https://openalex.org/W2102406695","https://openalex.org/W2103014023","https://openalex.org/W2104820327","https://openalex.org/W2105598902","https://openalex.org/W2105934661","https://openalex.org/W2106014350","https://openalex.org/W2112047656","https://openalex.org/W2112345914","https://openalex.org/W2123902215","https://openalex.org/W2138348512","https://openalex.org/W2139956963","https://openalex.org/W2146308594","https://openalex.org/W2149480306","https://openalex.org/W2170233132","https://openalex.org/W2171356375","https://openalex.org/W2798813531","https://openalex.org/W4214816144"],"related_works":["https://openalex.org/W4315558101","https://openalex.org/W2399513595","https://openalex.org/W3200271510","https://openalex.org/W63366483","https://openalex.org/W1516770101","https://openalex.org/W4388386498","https://openalex.org/W1897466773","https://openalex.org/W2357011584","https://openalex.org/W4380882399","https://openalex.org/W2616002604"],"abstract_inverted_index":{"The":[0],"transcriptome":[1],"in":[2,112,120,148],"a":[3,9,43,52,136],"cell":[4,45],"is":[5,37],"finely":[6],"regulated":[7],"by":[8,76],"large":[10],"number":[11],"of":[12,35,42,87,105,117,123,143],"molecular":[13],"mechanisms":[14],"able":[15],"to":[16,47,59,95,150],"control":[17],"the":[18,83,100,115,140],"balance":[19],"between":[20,130],"mRNA":[21,63,79],"production":[22],"and":[23,32,102,127,132,145],"degradation.":[24],"Recent":[25],"experimental":[26],"findings":[27],"have":[28],"evidenced":[29],"that":[30],"fine":[31],"specific":[33],"regulation":[34],"degradation":[36,146],"needed":[38],"for":[39,139],"proper":[40,141],"orchestration":[41],"global":[44],"response":[46,149],"environmental":[48],"conditions.":[49],"We":[50,90],"developed":[51],"computational":[53],"technique":[54],"based":[55],"on":[56,99],"stochastic":[57],"modeling,":[58],"infer":[60],"condition-specific":[61],"individual":[62],"half-lives":[64],"directly":[65],"from":[66,71],"gene":[67],"expression":[68],"time-courses.":[69],"Predictions":[70],"our":[72,93,109],"method":[73],"were":[74],"validated":[75],"experimentally":[77],"measured":[78],"decay":[80,121],"rates":[81,122],"during":[82],"intraerythrocytic":[84],"developmental":[85],"cycle":[86,104],"Plasmodium":[88],"falciparum.":[89],"then":[91],"applied":[92],"methodology":[94],"publicly":[96],"available":[97],"data":[98],"reproductive":[101],"metabolic":[103],"budding":[106],"yeast.":[107],"Strikingly,":[108],"analysis":[110],"revealed,":[111],"all":[113],"cases,":[114],"presence":[116],"periodic":[118],"changes":[119],"sequentially":[124],"induced":[125],"genes":[126],"co-ordination":[128],"strategies":[129],"transcription":[131,144],"degradation,":[133],"thus":[134],"suggesting":[135],"general":[137],"principle":[138],"coordination":[142],"machinery":[147],"internal":[151],"and/or":[152],"external":[153],"stimuli.":[154]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
