{"id":"https://openalex.org/W2026490303","doi":"https://doi.org/10.1371/journal.pcbi.1002677","title":"Versatility and Invariance in the Evolution of Homologous Heteromeric Interfaces","display_name":"Versatility and Invariance in the Evolution of Homologous Heteromeric Interfaces","publication_year":2012,"publication_date":"2012-08-30","ids":{"openalex":"https://openalex.org/W2026490303","doi":"https://doi.org/10.1371/journal.pcbi.1002677","mag":"2026490303","pmid":"https://pubmed.ncbi.nlm.nih.gov/22952442"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002677","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002677","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002677&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002677&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085624953","display_name":"Jessica Andr\u00e9ani","orcid":"https://orcid.org/0000-0003-4435-9093"},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jessica Andreani","raw_affiliation_strings":["CEA, iBiTecS, Service de Bioenergetique Biologie Structurale et Mecanismes (SB2SM), Laboratoire de Biologie Structurale et Radiobiologie (LBSR), Gif sur Yvette, France","CNRS, UMR 8221, Gif sur Yvette, France","Universit\u00e9 Paris Sud, UMR 8221, Orsay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA, iBiTecS, Service de Bioenergetique Biologie Structurale et Mecanismes (SB2SM), Laboratoire de Biologie Structurale et Radiobiologie (LBSR), Gif sur Yvette, France","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"CNRS, UMR 8221, Gif sur Yvette, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 Paris Sud, UMR 8221, Orsay, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076004653","display_name":"Guilhem Faure","orcid":"https://orcid.org/0000-0001-9537-2277"},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guilhem Faure","raw_affiliation_strings":["CEA, iBiTecS, Service de Bioenergetique Biologie Structurale et Mecanismes (SB2SM), Laboratoire de Biologie Structurale et Radiobiologie (LBSR), Gif sur Yvette, France","CNRS, UMR 8221, Gif sur Yvette, France","Universit\u00e9 Paris Sud, UMR 8221, Orsay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA, iBiTecS, Service de Bioenergetique Biologie Structurale et Mecanismes (SB2SM), Laboratoire de Biologie Structurale et Radiobiologie (LBSR), Gif sur Yvette, France","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"CNRS, UMR 8221, Gif sur Yvette, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 Paris Sud, UMR 8221, Orsay, France","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043668210","display_name":"Rapha\u00ebl Gu\u00e9rois","orcid":"https://orcid.org/0000-0001-5294-2858"},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Rapha\u00ebl Guerois","raw_affiliation_strings":["CEA, iBiTecS, Service de Bioenergetique Biologie Structurale et Mecanismes (SB2SM), Laboratoire de Biologie Structurale et Radiobiologie (LBSR), Gif sur Yvette, France","CNRS, UMR 8221, Gif sur Yvette, France","Universit\u00e9 Paris Sud, UMR 8221, Orsay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CEA, iBiTecS, Service de Bioenergetique Biologie Structurale et Mecanismes (SB2SM), Laboratoire de Biologie Structurale et Radiobiologie (LBSR), Gif sur Yvette, France","institution_ids":["https://openalex.org/I2738703131"]},{"raw_affiliation_string":"CNRS, UMR 8221, Gif sur Yvette, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 Paris Sud, UMR 8221, Orsay, France","institution_ids":["https://openalex.org/I102197404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043668210"],"corresponding_institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I2738703131"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.8414,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.84819445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"8","first_page":"e1002677","last_page":"e1002677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9800999760627747,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complementarity","display_name":"Complementarity (molecular biology)","score":0.7971267700195312},{"id":"https://openalex.org/keywords/interface","display_name":"Interface (matter)","score":0.6966617107391357},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4893307089805603},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.4145164489746094},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4137600362300873},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4083919823169708},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3990621864795685},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3409423530101776},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18327590823173523}],"concepts":[{"id":"https://openalex.org/C202269582","wikidata":"https://www.wikidata.org/wiki/Q2644277","display_name":"Complementarity (molecular biology)","level":2,"score":0.7971267700195312},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.6966617107391357},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4893307089805603},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4145164489746094},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4137600362300873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4083919823169708},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3990621864795685},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3409423530101776},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18327590823173523},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.0},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.0},{"id":"https://openalex.org/C129307140","wikidata":"https://www.wikidata.org/wiki/Q6795880","display_name":"Maximum bubble pressure method","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1002677","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002677","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002677&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22952442","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22952442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3431345","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3431345","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bcbe69d051bb483f8f20b2e9d3d16461","is_oa":true,"landing_page_url":"https://doaj.org/article/bcbe69d051bb483f8f20b2e9d3d16461","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 8, p e1002677 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/120606","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Versatility_and_Invariance_in_the_Evolution_of_Homologous_Heteromeric_Interfaces/120606","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002677","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002677","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002677&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.550000011920929,"id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G1848482737","display_name":"Paradigme d'inference bayesienne pour la Biologie structurale in silico","funder_award_id":"ANR-10-BINF-0003","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2026490303.pdf","grobid_xml":"https://content.openalex.org/works/W2026490303.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1526151739","https://openalex.org/W1792865908","https://openalex.org/W1966381151","https://openalex.org/W1968555047","https://openalex.org/W1969327849","https://openalex.org/W1969761972","https://openalex.org/W1976261957","https://openalex.org/W1979249349","https://openalex.org/W1979762151","https://openalex.org/W1980800453","https://openalex.org/W1985153601","https://openalex.org/W1987546980","https://openalex.org/W1987749411","https://openalex.org/W1988644414","https://openalex.org/W1988739180","https://openalex.org/W1991917050","https://openalex.org/W1995245717","https://openalex.org/W1998063251","https://openalex.org/W1999390565","https://openalex.org/W2005870641","https://openalex.org/W2007746130","https://openalex.org/W2008897097","https://openalex.org/W2009533642","https://openalex.org/W2010485601","https://openalex.org/W2013988051","https://openalex.org/W2015649075","https://openalex.org/W2017680124","https://openalex.org/W2018820180","https://openalex.org/W2028615004","https://openalex.org/W2031772330","https://openalex.org/W2033573904","https://openalex.org/W2034573447","https://openalex.org/W2039063819","https://openalex.org/W2042591828","https://openalex.org/W2044322490","https://openalex.org/W2046407284","https://openalex.org/W2047696147","https://openalex.org/W2052599054","https://openalex.org/W2058017150","https://openalex.org/W2071461674","https://openalex.org/W2072228739","https://openalex.org/W2074719974","https://openalex.org/W2075770210","https://openalex.org/W2079818352","https://openalex.org/W2081897966","https://openalex.org/W2083978969","https://openalex.org/W2086240831","https://openalex.org/W2091710329","https://openalex.org/W2096915408","https://openalex.org/W2103210604","https://openalex.org/W2105607553","https://openalex.org/W2107457995","https://openalex.org/W2114597228","https://openalex.org/W2116099439","https://openalex.org/W2122376908","https://openalex.org/W2127086406","https://openalex.org/W2130479394","https://openalex.org/W2136525667","https://openalex.org/W2138905138","https://openalex.org/W2142972231","https://openalex.org/W2153181859","https://openalex.org/W2154937472","https://openalex.org/W2158100564","https://openalex.org/W2165054672","https://openalex.org/W2170997179","https://openalex.org/W4229880569","https://openalex.org/W4236678350","https://openalex.org/W4241657835","https://openalex.org/W4254259096","https://openalex.org/W4254371945","https://openalex.org/W4299061248"],"related_works":["https://openalex.org/W2521519254","https://openalex.org/W3139833644","https://openalex.org/W3123110765","https://openalex.org/W4383553409","https://openalex.org/W2212953222","https://openalex.org/W2104948296","https://openalex.org/W1735800226","https://openalex.org/W4285172739","https://openalex.org/W3123208392","https://openalex.org/W4372316851"],"abstract_inverted_index":{"Evolutionary":[0],"pressures":[1],"act":[2],"on":[3],"protein":[4],"complex":[5,93],"interfaces":[6,173,210],"so":[7],"that":[8,98,158],"they":[9],"preserve":[10],"their":[11],"complementarity.":[12],"Nonetheless,":[13],"the":[14,19,76,104,109,132,150],"elementary":[15],"interactions":[16,62],"which":[17,37,125],"compose":[18],"interface":[20,29,82,110,123],"are":[21],"highly":[22],"versatile":[23],"throughout":[24],"evolution.":[25],"Understanding":[26],"and":[27,54,66,73,138,206],"characterizing":[28],"plasticity":[30,88],"across":[31],"evolution":[32,133],"is":[33],"a":[34,47,64,101,159],"fundamental":[35],"issue":[36],"could":[38],"provide":[39],"new":[40],"insights":[41],"into":[42],"protein-protein":[43,61],"interaction":[44],"prediction.":[45],"Using":[46],"database":[48],"of":[49,52,69,78,81,103,108,134,161,172,202],"1,024":[50],"couples":[51],"close":[53],"remote":[55],"heteromeric":[56],"structural":[57,65],"interologs,":[58],"we":[59,119],"studied":[60],"from":[63,198],"evolutionary":[67,212],"point":[68],"view.":[70],"We":[71,156],"systematically":[72],"quantitatively":[74],"analyzed":[75],"conservation":[77,130],"different":[79],"types":[80],"contacts.":[83],"Our":[84],"study":[85],"highlights":[86],"astonishing":[87],"regarding":[89],"polar":[90],"contacts":[91,139,184],"at":[92],"interfaces.":[94],"It":[95],"also":[96],"reveals":[97],"up":[99],"to":[100,152,166,169,177,181],"quarter":[102],"residues":[105],"switch":[106],"out":[107],"when":[111,148],"comparing":[112],"two":[113,121,186],"homologous":[114],"complexes.":[115,155],"Despite":[116],"such":[117],"versatility,":[118],"identify":[120],"important":[122,192],"descriptors":[124],"correlate":[126],"with":[127],"an":[128],"increased":[129],"in":[131],"interfaces:":[135],"apolar":[136],"patches":[137],"surrounding":[140],"anchor":[141],"residues.":[142],"These":[143],"observations":[144],"hold":[145],"true":[146],"even":[147],"restricting":[149],"dataset":[151],"transiently":[153],"formed":[154],"show":[157],"combination":[160],"six":[162],"features":[163],"related":[164],"either":[165],"sequence":[167,200],"or":[168],"geometric":[170],"properties":[171],"can":[174],"be":[175],"used":[176],"rank":[178],"positions":[179],"likely":[180],"share":[182],"similar":[183],"between":[185],"interologs.":[187],"Altogether,":[188],"our":[189],"analysis":[190],"provides":[191],"tracks":[193],"for":[194,207],"extracting":[195],"meaningful":[196],"information":[197],"multiple":[199],"alignments":[201],"conserved":[203],"binding":[204],"partners":[205],"discriminating":[208],"near-native":[209],"using":[211],"information.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}