{"id":"https://openalex.org/W2008138566","doi":"https://doi.org/10.1371/journal.pcbi.1002624","title":"Inferring Dynamic Signatures of Microbes in Complex Host Ecosystems","display_name":"Inferring Dynamic Signatures of Microbes in Complex Host Ecosystems","publication_year":2012,"publication_date":"2012-08-02","ids":{"openalex":"https://openalex.org/W2008138566","doi":"https://doi.org/10.1371/journal.pcbi.1002624","mag":"2008138566","pmid":"https://pubmed.ncbi.nlm.nih.gov/22876171"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002624","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002624","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002624&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002624&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021626481","display_name":"Georg K. Gerber","orcid":"https://orcid.org/0000-0002-9149-5509"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georg K. Gerber","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041821939","display_name":"Andrew B. Onderdonk","orcid":"https://orcid.org/0000-0001-8998-8972"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew B. Onderdonk","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007342995","display_name":"Lynn Bry","orcid":"https://orcid.org/0000-0002-8792-8527"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lynn Bry","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007342995"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.284,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.8803246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"8","first_page":"e1002624","last_page":"e1002624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9625999927520752,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metagenomics","display_name":"Metagenomics","score":0.6503250002861023},{"id":"https://openalex.org/keywords/host","display_name":"Host (biology)","score":0.6390748620033264},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6007376909255981},{"id":"https://openalex.org/keywords/microbiome","display_name":"Microbiome","score":0.5546938180923462},{"id":"https://openalex.org/keywords/ecosystem","display_name":"Ecosystem","score":0.4984464645385742},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.48404568433761597},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.4687129855155945},{"id":"https://openalex.org/keywords/community-structure","display_name":"Community structure","score":0.4471493065357208},{"id":"https://openalex.org/keywords/human-microbiome","display_name":"Human microbiome","score":0.44160574674606323},{"id":"https://openalex.org/keywords/microbial-ecology","display_name":"Microbial ecology","score":0.4325050413608551},{"id":"https://openalex.org/keywords/approximate-bayesian-computation","display_name":"Approximate Bayesian computation","score":0.4259239733219147},{"id":"https://openalex.org/keywords/gut-flora","display_name":"Gut flora","score":0.41450393199920654},{"id":"https://openalex.org/keywords/microbial-population-biology","display_name":"Microbial population biology","score":0.4123408794403076},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4118727743625641},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2830508351325989},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.25570666790008545},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.22228673100471497},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18172478675842285},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12497949600219727},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11374413967132568}],"concepts":[{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.6503250002861023},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.6390748620033264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6007376909255981},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5546938180923462},{"id":"https://openalex.org/C110872660","wikidata":"https://www.wikidata.org/wiki/Q37813","display_name":"Ecosystem","level":2,"score":0.4984464645385742},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.48404568433761597},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.4687129855155945},{"id":"https://openalex.org/C133079900","wikidata":"https://www.wikidata.org/wiki/Q5155065","display_name":"Community structure","level":2,"score":0.4471493065357208},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.44160574674606323},{"id":"https://openalex.org/C69562835","wikidata":"https://www.wikidata.org/wiki/Q3054637","display_name":"Microbial ecology","level":3,"score":0.4325050413608551},{"id":"https://openalex.org/C2779377595","wikidata":"https://www.wikidata.org/wiki/Q21045424","display_name":"Approximate Bayesian computation","level":3,"score":0.4259239733219147},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.41450393199920654},{"id":"https://openalex.org/C81407943","wikidata":"https://www.wikidata.org/wiki/Q17149178","display_name":"Microbial population biology","level":3,"score":0.4123408794403076},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4118727743625641},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2830508351325989},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.25570666790008545},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22228673100471497},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18172478675842285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12497949600219727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11374413967132568},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002624","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002624","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002624&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22876171","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22876171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:dash.harvard.edu:1/10465997","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10465997","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002624","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002624","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:951a9b9de25f4d3bae68ac603b60d8ba","is_oa":true,"landing_page_url":"https://doaj.org/article/951a9b9de25f4d3bae68ac603b60d8ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 8, p e1002624 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2419132","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3410865","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/121620","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Inferring_Dynamic_Signatures_of_Microbes_in_Complex_Host_Ecosystems/121620","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002624","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002624","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002624&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.75,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1950550369","display_name":null,"funder_award_id":"P30 DK034854","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2843050887","display_name":null,"funder_award_id":"R01 HD061916","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3644554757","display_name":null,"funder_award_id":"P30-DK034854","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G538855250","display_name":null,"funder_award_id":"HD061916","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5422332457","display_name":null,"funder_award_id":"P30-DK034854","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6325015508","display_name":null,"funder_award_id":"DK034854","funder_id":"https://openalex.org/F4320334528","funder_display_name":"Harvard Digestive Diseases Center, Harvard University"},{"id":"https://openalex.org/G7959390107","display_name":null,"funder_award_id":"R01-HD061916","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308347","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334528","display_name":"Harvard Digestive Diseases Center, Harvard University","ror":null},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008138566.pdf","grobid_xml":"https://content.openalex.org/works/W2008138566.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W346827628","https://openalex.org/W1492617550","https://openalex.org/W1545338101","https://openalex.org/W1552247668","https://openalex.org/W1644145788","https://openalex.org/W1725430864","https://openalex.org/W1910084854","https://openalex.org/W1967821667","https://openalex.org/W1969289662","https://openalex.org/W1972750202","https://openalex.org/W1982652137","https://openalex.org/W1995875735","https://openalex.org/W1996356495","https://openalex.org/W2013371150","https://openalex.org/W2014018052","https://openalex.org/W2014444740","https://openalex.org/W2015699002","https://openalex.org/W2017826290","https://openalex.org/W2017957151","https://openalex.org/W2022090300","https://openalex.org/W2032230795","https://openalex.org/W2033002674","https://openalex.org/W2036439754","https://openalex.org/W2038474505","https://openalex.org/W2038838030","https://openalex.org/W2041404167","https://openalex.org/W2041905826","https://openalex.org/W2042206860","https://openalex.org/W2043442946","https://openalex.org/W2045656233","https://openalex.org/W2050920580","https://openalex.org/W2051322058","https://openalex.org/W2053801811","https://openalex.org/W2065777365","https://openalex.org/W2073909558","https://openalex.org/W2076580309","https://openalex.org/W2082578477","https://openalex.org/W2087040738","https://openalex.org/W2090353374","https://openalex.org/W2091922579","https://openalex.org/W2094414211","https://openalex.org/W2103784576","https://openalex.org/W2106045204","https://openalex.org/W2108281900","https://openalex.org/W2109957730","https://openalex.org/W2110065044","https://openalex.org/W2111900629","https://openalex.org/W2112957173","https://openalex.org/W2114104545","https://openalex.org/W2120391288","https://openalex.org/W2120636621","https://openalex.org/W2121968767","https://openalex.org/W2124351063","https://openalex.org/W2124424637","https://openalex.org/W2125826054","https://openalex.org/W2126218947","https://openalex.org/W2127634163","https://openalex.org/W2129917444","https://openalex.org/W2139884694","https://openalex.org/W2143831310","https://openalex.org/W2147279704","https://openalex.org/W2147618390","https://openalex.org/W2149348195","https://openalex.org/W2149573313","https://openalex.org/W2150473224","https://openalex.org/W2151646205","https://openalex.org/W2152239989","https://openalex.org/W2153248663","https://openalex.org/W2155637762","https://openalex.org/W2155988679","https://openalex.org/W2156145269","https://openalex.org/W2166569595","https://openalex.org/W2753666478","https://openalex.org/W4211188239","https://openalex.org/W4232383088","https://openalex.org/W4232513052","https://openalex.org/W4256520971"],"related_works":["https://openalex.org/W1603910045","https://openalex.org/W1222064643","https://openalex.org/W2466475499","https://openalex.org/W3037883442","https://openalex.org/W2377830324","https://openalex.org/W2086098522","https://openalex.org/W2148304448","https://openalex.org/W2017030127","https://openalex.org/W1577826155","https://openalex.org/W3084871860"],"abstract_inverted_index":{"The":[0],"human":[1,151,190,220,233],"gut":[2,221],"microbiota":[3,25,76,246],"comprise":[4],"a":[5,97,120,133,196,254],"complex":[6,264],"and":[7,15,77,177],"dynamic":[8,69,242,261],"ecosystem":[9],"that":[10,100,181,213],"profoundly":[11],"affects":[12],"host":[13,86,121],"development":[14],"physiology.":[16],"Standard":[17],"approaches":[18],"for":[19,198,258,273],"analyzing":[20],"time-series":[21],"data":[22,50],"of":[23,28,30,39,43,54,71,74,85,92,115,137,154,159,173,200,202,244,263],"the":[24,68,75,81,90,210,219,245,260],"involve":[26],"computation":[27],"measures":[29,38,165],"ecological":[31],"community":[32,62],"diversity":[33,164],"at":[34],"each":[35,153],"time-point,":[36],"or":[37],"dissimilarity":[40],"between":[41],"pairs":[42],"time-points.":[44],"Although":[45],"these":[46],"approaches,":[47],"which":[48,267],"treat":[49],"as":[51,122,124],"static":[52],"snapshots":[53],"microbial":[55,117,216,229,265],"communities,":[56],"can":[57],"identify":[58,112],"shifts":[59],"in":[60,215,218,247,276],"overall":[61],"structure,":[63],"they":[64],"fail":[65],"to":[66,80,111,132,185,235,240],"capture":[67],"properties":[70,243],"individual":[72,116],"members":[73],"their":[78],"contributions":[79],"underlying":[82],"time-varying":[83],"behavior":[84],"ecosystems.":[87],"To":[88],"address":[89],"limitations":[91],"current":[93],"methods,":[94],"we":[95,170,268],"present":[96],"computational":[98],"framework":[99,131,227,257],"uses":[101],"continuous-time":[102],"dynamical":[103],"models":[104],"coupled":[105],"with":[106,204],"Bayesian":[107],"dimensionality":[108],"adaptation":[109],"methods":[110],"time-dependent":[113],"signatures":[114,230],"taxa":[118,180],"within":[119],"well":[123],"across":[125,188],"multiple":[126,150,189],"hosts.":[127],"We":[128],"apply":[129],"our":[130,168,226,251],"publicly":[134],"available":[135],"dataset":[136],"16S":[138],"rRNA":[139],"gene":[140],"sequences":[141],"from":[142,149],"stool":[143],"samples":[144],"collected":[145],"over":[146],"ten":[147],"months":[148],"subjects,":[152],"whom":[155],"received":[156],"repeated":[157],"courses":[158],"oral":[160],"antibiotics.":[161],"Using":[162],"new":[163,248],"enabled":[166],"by":[167],"framework,":[169],"discover":[171],"groups":[172],"both":[174],"phylogenetically":[175],"close":[176],"distant":[178],"bacterial":[179],"exhibit":[182],"consensus":[183,193],"responses":[184,194],"antibiotic":[186,223],"exposure":[187],"subjects.":[191],"These":[192],"reveal":[195],"timeline":[197],"equilibration":[199],"sub-communities":[201],"micro-organisms":[203],"distinct":[205],"physiologies,":[206],"yielding":[207],"insights":[208],"into":[209],"successive":[211],"changes":[212],"occur":[214],"populations":[217],"after":[222],"treatments.":[224],"Additionally,":[225],"leverages":[228],"shared":[231],"among":[232],"subjects":[234],"automatically":[236],"design":[237],"optimal":[238],"experiments":[239],"interrogate":[241],"studies.":[249],"Overall,":[250],"approach":[252],"provides":[253],"powerful,":[255],"general-purpose":[256],"understanding":[259],"behaviors":[262],"ecosystems,":[266],"believe":[269],"will":[270],"prove":[271],"instrumental":[272],"future":[274],"studies":[275],"this":[277],"field.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":3}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
