{"id":"https://openalex.org/W1999412829","doi":"https://doi.org/10.1371/journal.pcbi.1002597","title":"Suppressed Expression of T-Box Transcription Factors Is Involved in Senescence in Chronic Obstructive Pulmonary Disease","display_name":"Suppressed Expression of T-Box Transcription Factors Is Involved in Senescence in Chronic Obstructive Pulmonary Disease","publication_year":2012,"publication_date":"2012-07-19","ids":{"openalex":"https://openalex.org/W1999412829","doi":"https://doi.org/10.1371/journal.pcbi.1002597","mag":"1999412829","pmid":"https://pubmed.ncbi.nlm.nih.gov/22829758"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002597","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002597","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002597&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002597&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020172912","display_name":"George K. Acquaah-Mensah","orcid":"https://orcid.org/0000-0003-3984-8327"},"institutions":[{"id":"https://openalex.org/I165817395","display_name":"Massachusetts College of Pharmacy and Health Sciences","ror":"https://ror.org/02fvywg07","country_code":"US","type":"education","lineage":["https://openalex.org/I165817395"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George K. Acquaah-Mensah","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts, United States of America. george.acquaah-mensah@mcphs.edu","Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts, United States of America. george.acquaah-mensah@mcphs.edu","institution_ids":["https://openalex.org/I165817395"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts, United States of America","institution_ids":["https://openalex.org/I165817395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045229021","display_name":"Deepti Malhotra","orcid":"https://orcid.org/0000-0002-3879-3013"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepti Malhotra","raw_affiliation_strings":["Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America","Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048460544","display_name":"Madhulika Vulimiri","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhulika Vulimiri","raw_affiliation_strings":["Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America","University of North Carolina at Chapel Hill, Raleigh-Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Raleigh-Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020608405","display_name":"Jason McDermott","orcid":"https://orcid.org/0000-0003-2961-2572"},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason E. McDermott","raw_affiliation_strings":["Computational Biology and Bioinformatics Group Pacific Northwest National Laboratory, Richland, Washington, United States of America","Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology and Bioinformatics Group Pacific Northwest National Laboratory, Richland, Washington, United States of America","institution_ids":["https://openalex.org/I142606810"]},{"raw_affiliation_string":"Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, Washington, United States of America","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048650670","display_name":"Shyam Biswal","orcid":"https://orcid.org/0000-0003-0431-3939"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shyam Biswal","raw_affiliation_strings":["Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5020172912"],"corresponding_institution_ids":["https://openalex.org/I165817395"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.9671,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.86338843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"7","first_page":"e1002597","last_page":"e1002597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copd","display_name":"COPD","score":0.6374027132987976},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5351178646087646},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.4957166910171509},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.4903011620044708},{"id":"https://openalex.org/keywords/senescence","display_name":"Senescence","score":0.439205139875412},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.36372503638267517},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3517571985721588},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3483385443687439},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3357635736465454},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3276960551738739},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.31933051347732544},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.11678779125213623}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.6374027132987976},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5351178646087646},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4957166910171509},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4903011620044708},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.439205139875412},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36372503638267517},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3517571985721588},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3483385443687439},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3357635736465454},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3276960551738739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31933051347732544},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11678779125213623}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002597","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002597","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002597&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22829758","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22829758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.781.7720","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.781.7720","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/34/50/pcbi.1002597.PMC3400575.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6a72b1be3de14160b7cd6d7c391cdbd2","is_oa":true,"landing_page_url":"https://doaj.org/article/6a72b1be3de14160b7cd6d7c391cdbd2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 7, p e1002597 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2406401","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3400575","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/122506","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Suppressed_Expression_of_T_Box_Transcription_Factors_Is_Involved_in_Senescence_in_Chronic_Obstructive_Pulmonary_Disease/122506","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002597","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002597","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002597&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"awards":[{"id":"https://openalex.org/G1526097634","display_name":null,"funder_award_id":"P50HL084945","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1554152001","display_name":null,"funder_award_id":"P50 HL084945","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1724155629","display_name":null,"funder_award_id":"76RL01830","funder_id":"https://openalex.org/F4320337547","funder_display_name":"Laboratory Directed Research and Development"},{"id":"https://openalex.org/G2506945562","display_name":null,"funder_award_id":"76RL01830","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G294325831","display_name":null,"funder_award_id":"P50ES015903","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4499092682","display_name":null,"funder_award_id":"DE-AC06-76RL01830","funder_id":"https://openalex.org/F4320306250","funder_display_name":"Battelle"},{"id":"https://openalex.org/G5321382714","display_name":null,"funder_award_id":"76RL01830","funder_id":"https://openalex.org/F4320338354","funder_display_name":"Pacific Northwest National Laboratory"},{"id":"https://openalex.org/G7247582730","display_name":null,"funder_award_id":"DE-AC06-76RL01830","funder_id":"https://openalex.org/F4320338354","funder_display_name":"Pacific Northwest National Laboratory"},{"id":"https://openalex.org/G7288853145","display_name":null,"funder_award_id":"DE-AC06-76RL01830","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7328420964","display_name":null,"funder_award_id":"P50 ES015903","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306250","display_name":"Battelle","ror":"https://ror.org/01h5tnr73"},{"id":"https://openalex.org/F4320308625","display_name":"Flight Attendant Medical Research Institute","ror":"https://ror.org/00ybhm522"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337547","display_name":"Laboratory Directed Research and Development","ror":"https://ror.org/01e41cf67"},{"id":"https://openalex.org/F4320338354","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1999412829.pdf","grobid_xml":"https://content.openalex.org/works/W1999412829.grobid-xml"},"referenced_works_count":160,"referenced_works":["https://openalex.org/W48473742","https://openalex.org/W142376632","https://openalex.org/W1481919380","https://openalex.org/W1505543021","https://openalex.org/W1548932088","https://openalex.org/W1565642631","https://openalex.org/W1588911128","https://openalex.org/W1635484243","https://openalex.org/W1774886260","https://openalex.org/W1778321542","https://openalex.org/W1815468667","https://openalex.org/W1965713984","https://openalex.org/W1966168239","https://openalex.org/W1968417129","https://openalex.org/W1970199869","https://openalex.org/W1970778161","https://openalex.org/W1975060004","https://openalex.org/W1976544913","https://openalex.org/W1982245104","https://openalex.org/W1983751803","https://openalex.org/W1984512240","https://openalex.org/W1985002063","https://openalex.org/W1985425785","https://openalex.org/W1986688807","https://openalex.org/W1986805358","https://openalex.org/W1986820083","https://openalex.org/W1987782593","https://openalex.org/W1989215255","https://openalex.org/W1989966522","https://openalex.org/W1990482858","https://openalex.org/W1990644947","https://openalex.org/W1991364991","https://openalex.org/W1991494214","https://openalex.org/W1992469882","https://openalex.org/W1995031758","https://openalex.org/W1995467463","https://openalex.org/W1995875735","https://openalex.org/W1996463845","https://openalex.org/W1996533042","https://openalex.org/W1997023365","https://openalex.org/W1998767677","https://openalex.org/W2000426971","https://openalex.org/W2007460671","https://openalex.org/W2009886380","https://openalex.org/W2012382065","https://openalex.org/W2014184505","https://openalex.org/W2015523200","https://openalex.org/W2020140586","https://openalex.org/W2023892684","https://openalex.org/W2024625151","https://openalex.org/W2026571063","https://openalex.org/W2030563465","https://openalex.org/W2030587074","https://openalex.org/W2031674791","https://openalex.org/W2032448449","https://openalex.org/W2032703463","https://openalex.org/W2034030391","https://openalex.org/W2036372337","https://openalex.org/W2041905826","https://openalex.org/W2042450062","https://openalex.org/W2042653712","https://openalex.org/W2044525257","https://openalex.org/W2045131140","https://openalex.org/W2049633694","https://openalex.org/W2054931962","https://openalex.org/W2055708395","https://openalex.org/W2060369930","https://openalex.org/W2060950603","https://openalex.org/W2061656219","https://openalex.org/W2067200597","https://openalex.org/W2069293753","https://openalex.org/W2069988949","https://openalex.org/W2072579699","https://openalex.org/W2073952925","https://openalex.org/W2078149659","https://openalex.org/W2079651105","https://openalex.org/W2080046652","https://openalex.org/W2081633257","https://openalex.org/W2081755434","https://openalex.org/W2088889277","https://openalex.org/W2094127052","https://openalex.org/W2096401155","https://openalex.org/W2096581062","https://openalex.org/W2097819739","https://openalex.org/W2098782173","https://openalex.org/W2099111195","https://openalex.org/W2099364141","https://openalex.org/W2099622909","https://openalex.org/W2100074859","https://openalex.org/W2101099235","https://openalex.org/W2103017472","https://openalex.org/W2104116409","https://openalex.org/W2104902995","https://openalex.org/W2105978567","https://openalex.org/W2110065044","https://openalex.org/W2112421342","https://openalex.org/W2113002082","https://openalex.org/W2116141140","https://openalex.org/W2118749829","https://openalex.org/W2119767177","https://openalex.org/W2123162730","https://openalex.org/W2124478777","https://openalex.org/W2125828034","https://openalex.org/W2127597194","https://openalex.org/W2127748163","https://openalex.org/W2127951128","https://openalex.org/W2129265801","https://openalex.org/W2130646768","https://openalex.org/W2133863770","https://openalex.org/W2135441474","https://openalex.org/W2136044979","https://openalex.org/W2136630225","https://openalex.org/W2137035181","https://openalex.org/W2137592705","https://openalex.org/W2137674326","https://openalex.org/W2138336750","https://openalex.org/W2139224746","https://openalex.org/W2139712402","https://openalex.org/W2141759991","https://openalex.org/W2141885858","https://openalex.org/W2142575284","https://openalex.org/W2143747809","https://openalex.org/W2144792853","https://openalex.org/W2148250334","https://openalex.org/W2148670691","https://openalex.org/W2148768745","https://openalex.org/W2149458200","https://openalex.org/W2150573491","https://openalex.org/W2150930396","https://openalex.org/W2150978030","https://openalex.org/W2151326548","https://openalex.org/W2153856498","https://openalex.org/W2156131212","https://openalex.org/W2156749394","https://openalex.org/W2158021558","https://openalex.org/W2158912859","https://openalex.org/W2159675211","https://openalex.org/W2161568934","https://openalex.org/W2161823547","https://openalex.org/W2163030477","https://openalex.org/W2163267243","https://openalex.org/W2163296115","https://openalex.org/W2166215442","https://openalex.org/W2169888652","https://openalex.org/W2170989872","https://openalex.org/W2240470164","https://openalex.org/W2266909492","https://openalex.org/W2316483644","https://openalex.org/W2320665398","https://openalex.org/W2332237006","https://openalex.org/W2469063809","https://openalex.org/W2478708596","https://openalex.org/W3099289621","https://openalex.org/W3215332570","https://openalex.org/W4210400672","https://openalex.org/W4211263216","https://openalex.org/W4285719527","https://openalex.org/W6648982606","https://openalex.org/W6656941554","https://openalex.org/W6674851815"],"related_works":["https://openalex.org/W3146691973","https://openalex.org/W3142286882","https://openalex.org/W4245372082","https://openalex.org/W3215586121","https://openalex.org/W2979314934","https://openalex.org/W2146527561","https://openalex.org/W2770084104","https://openalex.org/W2059272320","https://openalex.org/W4386476622","https://openalex.org/W4387875454"],"abstract_inverted_index":{"Chronic":[0],"obstructive":[1],"pulmonary":[2],"disease":[3],"(COPD)":[4],"is":[5,277],"a":[6,81,103,178],"major":[7],"global":[8],"health":[9],"problem.":[10],"The":[11,226,269],"etiology":[12,45,149,189],"of":[13,26,59,66,83,87,94,119,133,150,190,194,207,228,246],"COPD":[14,32,44,124,191,218,282],"has":[15],"been":[16],"associated":[17],"with":[18,108,217,267],"apoptosis,":[19],"oxidative":[20],"stress,":[21],"and":[22,71,127,163,169,209,239,255,274],"inflammation.":[23],"However,":[24],"understanding":[25],"the":[27,48,64,109,117,120,136,148,188,205,212,229,244,260],"molecular":[28,50,140],"interactions":[29,129],"that":[30,204],"modulate":[31],"pathogenesis":[33],"remains":[34],"only":[35],"partly":[36],"resolved.":[37],"We":[38,52,73],"conducted":[39],"an":[40,122,220],"exploratory":[41],"study":[42,105,202],"on":[43],"to":[46,144,197],"identify":[47],"key":[49],"participants.":[51],"used":[53],"information-theoretic":[54],"algorithms":[55],"including":[56],"Context":[57],"Likelihood":[58],"Relatedness":[60],"(CLR),":[61],"Algorithm":[62],"for":[63],"Reconstruction":[65],"Accurate":[67],"Cellular":[68],"Networks":[69],"(ARACNE),":[70],"Inferelator.":[72],"captured":[74],"direct":[75,179],"functional":[76],"associations":[77],"among":[78],"genes,":[79],"given":[80],"compendium":[82],"gene":[84],"expression":[85,206,227,245],"profiles":[86],"human":[88],"lung":[89,213,262],"epithelial":[90],"cells.":[91],"A":[92],"set":[93],"genes":[95,134,168,208],"differentially":[96],"expressed":[97],"in":[98,102,116,135,147,177,187,199,211,259,281],"COPD,":[99],"as":[100,184,252],"reported":[101],"previous":[104],"were":[106,142],"superposed":[107],"resulting":[110],"transcriptional":[111,180],"regulatory":[112,181],"networks.":[113],"After":[114],"factoring":[115],"properties":[118],"networks,":[121,138],"established":[123],"susceptibility":[125],"locus":[126],"domain-domain":[128],"involving":[130],"protein":[131],"products":[132],"generated":[137],"several":[139],"candidates":[141],"predicted":[143],"be":[145],"involved":[146],"COPD.":[151,268],"These":[152],"include":[153],"COL4A3,":[154],"CFLAR,":[155],"GULP1,":[156],"PDCD1,":[157],"CASP10,":[158],"PAX3,":[159],"BOK,":[160],"HSPD1,":[161],"PITX2,":[162],"PML.":[164],"Furthermore,":[165],"T-box":[166],"(TBX)":[167],"cyclin-dependent":[170],"kinase":[171],"inhibitor":[172],"2A":[173],"(CDKN2A),":[174],"which":[175],"are":[176],"relationship,":[182],"emerged":[183],"preeminent":[185],"participants":[186],"by":[192],"means":[193],"senescence.":[195,225],"Contrary":[196],"observations":[198],"neoplasms,":[200],"our":[201],"reveals":[203],"proteins":[210],"samples":[214,264],"from":[215,265],"patients":[216,266],"indicate":[219],"increased":[221],"tendency":[222],"towards":[223,279],"cellular":[224,248],"anti-senescence":[230,275],"mediators":[231],"TBX":[232],"transcription":[233],"factors,":[234],"chromatin":[235],"modifiers":[236],"histone":[237],"deacetylases,":[238],"sirtuins":[240],"was":[241,257],"suppressed;":[242],"while":[243],"TBX-regulated":[247],"senescence":[249,273,280],"markers":[250],"such":[251],"CDKN2A,":[253],"CDKN1A,":[254],"CAV1":[256],"elevated":[258],"peripheral":[261],"tissue":[263],"critical":[270],"balance":[271],"between":[272],"factors":[276],"disrupted":[278],"lungs.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
