{"id":"https://openalex.org/W1990160261","doi":"https://doi.org/10.1371/journal.pcbi.1002587","title":"Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia","display_name":"Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia","publication_year":2012,"publication_date":"2012-07-05","ids":{"openalex":"https://openalex.org/W1990160261","doi":"https://doi.org/10.1371/journal.pcbi.1002587","mag":"1990160261","pmid":"https://pubmed.ncbi.nlm.nih.gov/22792057"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002587","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002587","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002587&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002587&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056121087","display_name":"Peilin Jia","orcid":"https://orcid.org/0000-0003-4523-4153"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peilin Jia","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101537858","display_name":"Lily Wang","orcid":"https://orcid.org/0000-0002-6630-8767"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lily Wang","raw_affiliation_strings":["Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045026911","display_name":"Ayman H. Fanous","orcid":"https://orcid.org/0000-0002-5152-9989"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4210154891","display_name":"Washington DC VA Medical Center","ror":"https://ror.org/050fz5z96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210154891"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayman H. Fanous","raw_affiliation_strings":["Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America","Department of Psychiatry, Georgetown University School of Medicine, Washington, D.C., United States of America","Department of Psychiatry, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America","Washington VA Medical Center, Washington, D.C., United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Psychiatry, Georgetown University School of Medicine, Washington, D.C., United States of America","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"Department of Psychiatry, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Washington VA Medical Center, Washington, D.C., United States of America","institution_ids":["https://openalex.org/I4210154891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023507812","display_name":"Carlos N. Pato","orcid":"https://orcid.org/0000-0002-5858-266X"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos N. Pato","raw_affiliation_strings":["Department of Psychiatry, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004289607","display_name":"Todd L. Edwards","orcid":"https://orcid.org/0000-0003-4318-6119"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210105714","display_name":"Center for Human Genetics","ror":"https://ror.org/01gcrbc43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210105714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd L. Edwards","raw_affiliation_strings":["Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","Division of Epidemiolgy, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210105714"]},{"raw_affiliation_string":"Division of Epidemiolgy, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006688612","display_name":"Zhongming Zhao","orcid":"https://orcid.org/0000-0002-3477-0914"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhongming Zhao","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5006688612"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":8.053,"has_fulltext":true,"cited_by_count":109,"citation_normalized_percentile":{"value":0.98087644,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"8","issue":"7","first_page":"e1002587","last_page":"e1002587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9555000066757202,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.8652633428573608},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.6717681884765625},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5967085361480713},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"Schizophrenia (object-oriented programming)","score":0.5231679081916809},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.451604962348938},{"id":"https://openalex.org/keywords/candidate-gene","display_name":"Candidate gene","score":0.42827779054641724},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4278598427772522},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3803711533546448},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.37032634019851685},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3314134180545807}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.8652633428573608},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.6717681884765625},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5967085361480713},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5231679081916809},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.451604962348938},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.42827779054641724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4278598427772522},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3803711533546448},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37032634019851685},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3314134180545807},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1002587","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002587","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002587&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22792057","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22792057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:https://orca.cardiff.ac.uk:79796","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:scholarscompass.vcu.edu:psych_pubs-1046","is_oa":true,"landing_page_url":"https://scholarscompass.vcu.edu/psych_pubs/34","pdf_url":null,"source":{"id":"https://openalex.org/S4377196340","display_name":"VCU Scholars Compass (Virginia Commonwealth University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Psychiatry Publications","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002587","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002587","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:bcc2a5fa4b0146918ca082a4ba1e16d2","is_oa":true,"landing_page_url":"https://doaj.org/article/bcc2a5fa4b0146918ca082a4ba1e16d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 7, p e1002587 (2012)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1395490","is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1395490/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS COMPUTATIONAL BIOLOGY , 8 (7) (2012)","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:2399933","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3390381","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/123064","is_oa":true,"landing_page_url":"https://figshare.com/articles/Network_Assisted_Investigation_of_Combined_Causal_Signals_from_Genome_Wide_Association_Studies_in_Schizophrenia/123064","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002587","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002587","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002587&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G771694649","display_name":null,"funder_award_id":"R01 LM011177","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G8008695583","display_name":null,"funder_award_id":"R01LM011177","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G8733929449","display_name":null,"funder_award_id":"R01LM011177","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320314070","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142"},{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320320359","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333423","display_name":"Stanley Center for Psychiatric Research, Broad Institute","ror":null},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1990160261.pdf","grobid_xml":"https://content.openalex.org/works/W1990160261.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1968744462","https://openalex.org/W1984286072","https://openalex.org/W2006700629","https://openalex.org/W2010768245","https://openalex.org/W2014596655","https://openalex.org/W2044666483","https://openalex.org/W2046831513","https://openalex.org/W2055292959","https://openalex.org/W2073544062","https://openalex.org/W2081038787","https://openalex.org/W2084974619","https://openalex.org/W2087467445","https://openalex.org/W2097099463","https://openalex.org/W2098597355","https://openalex.org/W2103017472","https://openalex.org/W2103606272","https://openalex.org/W2104261859","https://openalex.org/W2110065044","https://openalex.org/W2111064437","https://openalex.org/W2112811019","https://openalex.org/W2117446594","https://openalex.org/W2127205775","https://openalex.org/W2146653758","https://openalex.org/W2149098364","https://openalex.org/W2157752701","https://openalex.org/W2161633633","https://openalex.org/W2162960415","https://openalex.org/W2163480486","https://openalex.org/W2166963829","https://openalex.org/W2171437346"],"related_works":["https://openalex.org/W2900730647","https://openalex.org/W2373670798","https://openalex.org/W4283582241","https://openalex.org/W172227456","https://openalex.org/W3132065130","https://openalex.org/W2185171978","https://openalex.org/W2594299395","https://openalex.org/W2400017200","https://openalex.org/W2066467839","https://openalex.org/W2111842731"],"abstract_inverted_index":{"With":[0],"the":[1,72,119,133,202,207,220],"recent":[2],"success":[3],"of":[4,11,35,43,63,132,162,223],"genome-wide":[5],"association":[6,12,69,115],"studies":[7,218],"(GWAS),":[8],"a":[9,24,84,106,141,149,160],"wealth":[10],"data":[13,28,45],"has":[14,50],"been":[15,51],"accomplished":[16],"for":[17,27,92,96,237],"more":[18],"than":[19],"200":[20],"complex":[21,255],"diseases/traits,":[22],"proposing":[23],"strong":[25],"demand":[26],"integration":[29],"and":[30,46,76,103,126,173],"interpretation.":[31],"A":[32],"combinatory":[33],"analysis":[34,42,61,177],"multiple":[36,64,137,258],"GWAS":[37,44,65,101,138,245,259],"datasets,":[38],"or":[39],"an":[40,59,123],"integrative":[41,60],"other":[47,254],"high-throughput":[48],"data,":[49],"particularly":[52],"promising.":[53],"In":[54],"this":[55],"study,":[56],"we":[57,89,143],"proposed":[58],"framework":[62],"datasets":[66,260],"by":[67],"overlaying":[68],"signals":[70,243],"onto":[71],"protein-protein":[73],"interaction":[74],"network,":[75],"demonstrated":[77,230],"it":[78],"using":[79,136,219],"schizophrenia":[80,97,224],"datasets.":[81,139,246],"Building":[82],"on":[83,210],"dense":[85],"module":[86,111,120,146,157,195],"search":[87],"algorithm,":[88],"first":[90],"searched":[91],"significantly":[93,152],"enriched":[94],"subnetworks":[95],"in":[98,122,183,193,206,216,244],"each":[99],"single":[100],"dataset":[102],"then":[104],"implemented":[105],"discovery-evaluation":[107],"strategy":[108,234],"to":[109,226,252],"identify":[110],"genes":[112,121,147,158,165,180,196,240],"with":[113,148,154,241],"consistent":[114],"signals.":[116],"We":[117],"validated":[118],"independent":[124],"dataset,":[125],"also":[127],"examined":[128],"them":[129],"through":[130],"meta-analysis":[131,188],"related":[134,185],"SNPs":[135,192],"As":[140],"result,":[142],"identified":[144],"205":[145],"joint":[150],"effect":[151],"associated":[153],"schizophrenia;":[155],"these":[156,179],"included":[159],"number":[161],"well-studied":[163],"candidate":[164],"such":[166],"as":[167],"DISC1,":[168],"GNA12,":[169],"GNA13,":[170],"GNAI1,":[171],"GPR17,":[172],"GRIN2B.":[174],"Further":[175],"functional":[176],"suggested":[178],"are":[181,261],"involved":[182],"neuronal":[184],"processes.":[186],"Additionally,":[187],"found":[189],"that":[190],"18":[191],"9":[194],"had":[197],"P(meta)<1":[198],"\u00d7":[199],"10\u207b\u2074,":[200],"including":[201],"gene":[203],"HLA-DQA1":[204],"located":[205],"MHC":[208],"region":[209],"chromosome":[211],"6,":[212],"which":[213],"was":[214],"reported":[215],"previous":[217],"largest":[221],"cohort":[222],"patients":[225],"date.":[227],"These":[228],"results":[229],"our":[231],"bi-directional":[232],"network-based":[233],"is":[235],"efficient":[236],"identifying":[238],"disease-associated":[239],"modest":[242],"This":[247],"approach":[248],"can":[249],"be":[250],"applied":[251],"any":[253],"diseases/traits":[256],"where":[257],"available.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":5}],"updated_date":"2026-07-27T08:26:11.824852","created_date":"2025-10-10T00:00:00"}