{"id":"https://openalex.org/W2069412330","doi":"https://doi.org/10.1371/journal.pcbi.1002568","title":"MC EMiNEM Maps the Interaction Landscape of the Mediator","display_name":"MC EMiNEM Maps the Interaction Landscape of the Mediator","publication_year":2012,"publication_date":"2012-06-21","ids":{"openalex":"https://openalex.org/W2069412330","doi":"https://doi.org/10.1371/journal.pcbi.1002568","mag":"2069412330","pmid":"https://pubmed.ncbi.nlm.nih.gov/22737066"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002568","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002568","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002568&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002568&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008575658","display_name":"Theresa Niederberger","orcid":null},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I189554337","display_name":"Center for Integrated Protein Science Munich","ror":"https://ror.org/032hzb643","country_code":"DE","type":"other","lineage":["https://openalex.org/I149899117","https://openalex.org/I189554337","https://openalex.org/I62916508","https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Theresa Niederberger","raw_affiliation_strings":["Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I189554337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002493901","display_name":"Stefanie Etzold","orcid":null},"institutions":[{"id":"https://openalex.org/I189554337","display_name":"Center for Integrated Protein Science Munich","ror":"https://ror.org/032hzb643","country_code":"DE","type":"other","lineage":["https://openalex.org/I149899117","https://openalex.org/I189554337","https://openalex.org/I62916508","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Etzold","raw_affiliation_strings":["Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I189554337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041268911","display_name":"Michael Lidschreiber","orcid":"https://orcid.org/0000-0002-6740-2755"},"institutions":[{"id":"https://openalex.org/I189554337","display_name":"Center for Integrated Protein Science Munich","ror":"https://ror.org/032hzb643","country_code":"DE","type":"other","lineage":["https://openalex.org/I149899117","https://openalex.org/I189554337","https://openalex.org/I62916508","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Lidschreiber","raw_affiliation_strings":["Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I189554337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103819042","display_name":"Kerstin C. Maier","orcid":null},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I189554337","display_name":"Center for Integrated Protein Science Munich","ror":"https://ror.org/032hzb643","country_code":"DE","type":"other","lineage":["https://openalex.org/I149899117","https://openalex.org/I189554337","https://openalex.org/I62916508","https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin C. Maier","raw_affiliation_strings":["Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I189554337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045144211","display_name":"Dietmar E. Martin","orcid":null},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I189554337","display_name":"Center for Integrated Protein Science Munich","ror":"https://ror.org/032hzb643","country_code":"DE","type":"other","lineage":["https://openalex.org/I149899117","https://openalex.org/I189554337","https://openalex.org/I62916508","https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dietmar E. Martin","raw_affiliation_strings":["Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I189554337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054001409","display_name":"Holger Fr\u00f6hlich","orcid":"https://orcid.org/0000-0002-5328-1243"},"institutions":[{"id":"https://openalex.org/I4210164149","display_name":"Bonn Aachen International Center for Information Technology","ror":"https://ror.org/054zhq066","country_code":"DE","type":"facility","lineage":["https://openalex.org/I135140700","https://openalex.org/I155417937","https://openalex.org/I4210164149","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Holger Fr\u00f6hlich","raw_affiliation_strings":["Bonn-Aachen International Center for IT (B-IT) Algorithmic Bioinformatics, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany"],"affiliations":[{"raw_affiliation_string":"Bonn-Aachen International Center for IT (B-IT) Algorithmic Bioinformatics, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I4210164149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008281609","display_name":"Patrick Cramer","orcid":"https://orcid.org/0000-0001-5454-7755"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I189554337","display_name":"Center for Integrated Protein Science Munich","ror":"https://ror.org/032hzb643","country_code":"DE","type":"other","lineage":["https://openalex.org/I149899117","https://openalex.org/I189554337","https://openalex.org/I62916508","https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick Cramer","raw_affiliation_strings":["Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I189554337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051074804","display_name":"Achim Tresch","orcid":"https://orcid.org/0000-0002-4146-6371"},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I189554337","display_name":"Center for Integrated Protein Science Munich","ror":"https://ror.org/032hzb643","country_code":"DE","type":"other","lineage":["https://openalex.org/I149899117","https://openalex.org/I189554337","https://openalex.org/I62916508","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4210141639","display_name":"Max Planck Institute for Plant Breeding Research","ror":"https://ror.org/044g3zk14","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210141639"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Achim Tresch","raw_affiliation_strings":["Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany","Institute for Genetics, University of Cologne, Cologne, Germany","Max Planck Institute for Plant Breeding Research, Cologne, Germany"],"affiliations":[{"raw_affiliation_string":"Gene Center Munich and Center for integrated Protein Science CiPSM, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I189554337"]},{"raw_affiliation_string":"Institute for Genetics, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Max Planck Institute for Plant Breeding Research, Cologne, Germany","institution_ids":["https://openalex.org/I4210141639"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5051074804"],"corresponding_institution_ids":["https://openalex.org/I180923762","https://openalex.org/I189554337","https://openalex.org/I4210141639","https://openalex.org/I8204097"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.3134,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79277343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"6","first_page":"e1002568","last_page":"e1002568"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mediator","display_name":"Mediator","score":0.8404769897460938},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.601909875869751},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5355121493339539},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.5027203559875488},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4873290956020355},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.4781568944454193},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4473336935043335},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.44421181082725525},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.4164937138557434},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.31004995107650757},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.19243231415748596},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1455768644809723}],"concepts":[{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.8404769897460938},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.601909875869751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5355121493339539},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.5027203559875488},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4873290956020355},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4781568944454193},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4473336935043335},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.44421181082725525},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4164937138557434},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31004995107650757},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.19243231415748596},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1455768644809723},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056892","descriptor_name":"Mediator Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056892","descriptor_name":"Mediator Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056892","descriptor_name":"Mediator Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056892","descriptor_name":"Mediator Complex","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056892","descriptor_name":"Mediator Complex","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056892","descriptor_name":"Mediator Complex","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1002568","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002568","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002568&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22737066","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22737066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:dora:psi_11722","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002568","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002568","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:dd20bb50e6d840f99cb48e1863c7201b","is_oa":true,"landing_page_url":"https://doaj.org/article/dd20bb50e6d840f99cb48e1863c7201b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 6, p e1002568 (2012)","raw_type":"article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:15105","is_oa":false,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-15105-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology","raw_type":"doc-type:article"},{"id":"pmh:oai:figshare.com:article/123632","is_oa":true,"landing_page_url":"https://figshare.com/articles/MC_EMiNEM_Maps_the_Interaction_Landscape_of_the_Mediator/123632","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3380870","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3380870","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002568","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002568","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002568&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307844","display_name":"European Molecular Biology Organization","ror":"https://ror.org/04wfr2810"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322306","display_name":"Jung-Stiftung f\u00fcr Wissenschaft und Forschung","ror":"https://ror.org/01wc3vt02"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2069412330.pdf","grobid_xml":"https://content.openalex.org/works/W2069412330.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W116703061","https://openalex.org/W1533335653","https://openalex.org/W1546952499","https://openalex.org/W1644724366","https://openalex.org/W1746680969","https://openalex.org/W1753000577","https://openalex.org/W1866577565","https://openalex.org/W1964895626","https://openalex.org/W1965652496","https://openalex.org/W1969761972","https://openalex.org/W1978308088","https://openalex.org/W1978627780","https://openalex.org/W1979141644","https://openalex.org/W1986602910","https://openalex.org/W1993018469","https://openalex.org/W2003829546","https://openalex.org/W2008109277","https://openalex.org/W2012248317","https://openalex.org/W2013785414","https://openalex.org/W2019136808","https://openalex.org/W2024093804","https://openalex.org/W2024645644","https://openalex.org/W2025074695","https://openalex.org/W2029099543","https://openalex.org/W2029235165","https://openalex.org/W2037145096","https://openalex.org/W2040965368","https://openalex.org/W2043719428","https://openalex.org/W2049311981","https://openalex.org/W2049633694","https://openalex.org/W2051612352","https://openalex.org/W2060814542","https://openalex.org/W2060987350","https://openalex.org/W2069252541","https://openalex.org/W2077941487","https://openalex.org/W2080567213","https://openalex.org/W2081098333","https://openalex.org/W2102221598","https://openalex.org/W2113235165","https://openalex.org/W2119541898","https://openalex.org/W2119740363","https://openalex.org/W2119778725","https://openalex.org/W2124876377","https://openalex.org/W2130941766","https://openalex.org/W2137300752","https://openalex.org/W2140850762","https://openalex.org/W2140948740","https://openalex.org/W2141304603","https://openalex.org/W2142437744","https://openalex.org/W2144791939","https://openalex.org/W2145819283","https://openalex.org/W2146206618","https://openalex.org/W2146264532","https://openalex.org/W2147356380","https://openalex.org/W2148780239","https://openalex.org/W2149920358","https://openalex.org/W2160697532","https://openalex.org/W2161064850","https://openalex.org/W2161409973","https://openalex.org/W2163485494","https://openalex.org/W2167190345","https://openalex.org/W2170778160","https://openalex.org/W2218660561","https://openalex.org/W2565214501","https://openalex.org/W2567948266","https://openalex.org/W2915108429","https://openalex.org/W3104952140","https://openalex.org/W3105621768","https://openalex.org/W4231704412","https://openalex.org/W4239029175","https://openalex.org/W4388323202","https://openalex.org/W4393372027","https://openalex.org/W6604774628","https://openalex.org/W6632813202","https://openalex.org/W6991076871"],"related_works":["https://openalex.org/W2096745402","https://openalex.org/W2050687559","https://openalex.org/W2043458004","https://openalex.org/W2032831587","https://openalex.org/W3018164423","https://openalex.org/W4366463262","https://openalex.org/W2071273015","https://openalex.org/W2765106736","https://openalex.org/W2078472628","https://openalex.org/W2063692203"],"abstract_inverted_index":{"The":[0,41],"Mediator":[1,47,126,142,154,210,233],"is":[2,10,53,81,168],"a":[3,23,61,88,159,184,204],"highly":[4],"conserved,":[5],"large":[6],"multiprotein":[7],"complex":[8],"that":[9,49,72,94],"involved":[11],"essentially":[12],"in":[13,129,218],"the":[14,37,65,96,141,148,153,175,179,195],"regulation":[15],"of":[16,44,67,90,98,124,133,152,162,181,197,232],"eukaryotic":[17],"mRNA":[18,77],"transcription.":[19,78],"It":[20,101],"acts":[21],"as":[22,183],"general":[24],"transcription":[25,236],"factor":[26],"by":[27],"integrating":[28],"regulatory":[29],"signals":[30,52],"from":[31],"gene-specific":[32],"activators":[33],"or":[34],"repressors":[35],"to":[36,115,119,147,202,212,227],"RNA":[38],"Polymerase":[39],"II.":[40],"internal":[42,164],"network":[43],"interactions":[45],"between":[46,70],"subunits":[48,211,234],"conveys":[50],"these":[51],"largely":[54],"unknown.":[55],"Here,":[56],"we":[57],"introduce":[58],"MC":[59,79,156,207],"EMiNEM,":[60],"novel":[62],"method":[63],"for":[64,113],"retrieval":[66],"functional":[68],"dependencies":[69],"proteins":[71],"have":[73],"pleiotropic":[74],"effects":[75],"on":[76,83],"EMiNEM":[80,157,208],"based":[82],"Nested":[84],"Effects":[85],"Models":[86],"(NEMs),":[87],"class":[89],"probabilistic":[91],"graphical":[92],"models":[93],"extends":[95],"idea":[97],"hierarchical":[99,160],"clustering.":[100],"combines":[102],"mode-hopping":[103],"Monte":[104],"Carlo":[105],"(MC)":[106],"sampling":[107],"with":[108,220],"an":[109,229],"Expectation-Maximization":[110],"(EM)":[111],"algorithm":[112],"NEMs":[114],"increase":[116],"sensitivity":[117],"compared":[118],"existing":[120],"methods.":[121],"A":[122],"meta-analysis":[123],"four":[125],"perturbation":[127],"studies":[128],"Saccharomyces":[130],"cerevisiae,":[131],"three":[132],"which":[134,167],"are":[135],"unpublished,":[136],"provides":[137],"new":[138],"insight":[139],"into":[140],"signaling":[143],"network.":[144],"In":[145],"addition":[146],"known":[149],"modular":[150],"organization":[151],"subunits,":[155],"reveals":[158],"ordering":[161],"its":[163],"information":[165],"flow,":[166],"putatively":[169],"transmitted":[170],"through":[171],"structural":[172,190],"changes":[173,191],"within":[174],"complex.":[176],"We":[177],"identify":[178],"N-terminus":[180],"Med7":[182,198],"peripheral":[185],"entity,":[186],"entailing":[187],"only":[188],"local":[189],"upon":[192],"perturbation,":[193],"while":[194],"C-terminus":[196],"and":[199,235],"Med19":[200],"appear":[201],"play":[203],"central":[205],"role.":[206],"associates":[209],"most":[213],"directly":[214],"affected":[215],"genes,":[216],"which,":[217],"conjunction":[219],"gene":[221],"set":[222],"enrichment":[223],"analysis,":[224],"allows":[225],"us":[226],"construct":[228],"interaction":[230],"map":[231],"factors.":[237]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}