{"id":"https://openalex.org/W2072241845","doi":"https://doi.org/10.1371/journal.pcbi.1002501","title":"Are Long-Range Structural Correlations Behind the Aggregration Phenomena of Polyglutamine Diseases?","display_name":"Are Long-Range Structural Correlations Behind the Aggregration Phenomena of Polyglutamine Diseases?","publication_year":2012,"publication_date":"2012-04-26","ids":{"openalex":"https://openalex.org/W2072241845","doi":"https://doi.org/10.1371/journal.pcbi.1002501","mag":"2072241845","pmid":"https://pubmed.ncbi.nlm.nih.gov/22577357"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002501","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002501","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1002501","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071912456","display_name":"Mahmoud Moradi","orcid":"https://orcid.org/0000-0002-0601-402X"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmoud Moradi","raw_affiliation_strings":["Center for High Performance Simulations (CHiPS) and Department of Physics, North Carolina State University, Raleigh, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for High Performance Simulations (CHiPS) and Department of Physics, North Carolina State University, Raleigh, North Carolina, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077363170","display_name":"Volodymyr Babin","orcid":null},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Volodymyr Babin","raw_affiliation_strings":["Center for High Performance Simulations (CHiPS) and Department of Physics, North Carolina State University, Raleigh, North Carolina, United States of America","University of Houston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for High Performance Simulations (CHiPS) and Department of Physics, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"University of Houston, United States of America","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067360381","display_name":"Christopher Roland","orcid":"https://orcid.org/0000-0003-4562-8136"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Roland","raw_affiliation_strings":["Center for High Performance Simulations (CHiPS) and Department of Physics, North Carolina State University, Raleigh, North Carolina, United States of America","University of Houston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for High Performance Simulations (CHiPS) and Department of Physics, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"University of Houston, United States of America","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001101043","display_name":"Celeste Sagui","orcid":"https://orcid.org/0000-0002-2750-5186"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Celeste Sagui","raw_affiliation_strings":["Center for High Performance Simulations (CHiPS) and Department of Physics, North Carolina State University, Raleigh, North Carolina, United States of America","Center for High Performance Simulations-CHiPS and Department of Physics, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for High Performance Simulations (CHiPS) and Department of Physics, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Center for High Performance Simulations-CHiPS and Department of Physics, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001101043"],"corresponding_institution_ids":["https://openalex.org/I137902535"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.65776564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"4","first_page":"e1002501","last_page":"e1002501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyproline-helix","display_name":"Polyproline helix","score":0.9412858486175537},{"id":"https://openalex.org/keywords/dihedral-angle","display_name":"Dihedral angle","score":0.9257996082305908},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.6289739608764648},{"id":"https://openalex.org/keywords/ramachandran-plot","display_name":"Ramachandran plot","score":0.5409607887268066},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.5108575224876404},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5004525184631348},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.49954652786254883},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4362741708755493},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35725367069244385},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2322169542312622},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.2145610749721527},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.1718445122241974},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1260991096496582},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.1025111973285675}],"concepts":[{"id":"https://openalex.org/C109300003","wikidata":"https://www.wikidata.org/wiki/Q4384651","display_name":"Polyproline helix","level":3,"score":0.9412858486175537},{"id":"https://openalex.org/C89025888","wikidata":"https://www.wikidata.org/wiki/Q911907","display_name":"Dihedral angle","level":4,"score":0.9257996082305908},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6289739608764648},{"id":"https://openalex.org/C14301744","wikidata":"https://www.wikidata.org/wiki/Q579211","display_name":"Ramachandran plot","level":3,"score":0.5409607887268066},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5108575224876404},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5004525184631348},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49954652786254883},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4362741708755493},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35725367069244385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2322169542312622},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.2145610749721527},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.1718445122241974},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1260991096496582},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.1025111973285675},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002501","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002501","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22577357","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22577357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:europepmc.org:2354795","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3343152","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1002.3738","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1002.3738","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC3343152%26blobtype%3Dpdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002501","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002501","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:ddae99cc45444c6db998055b38f77f2b","is_oa":true,"landing_page_url":"https://doaj.org/article/ddae99cc45444c6db998055b38f77f2b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 4, p e1002501 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/125831","is_oa":true,"landing_page_url":"https://figshare.com/articles/Are_Long_Range_Structural_Correlations_Behind_the_Aggregration_Phenomena_of_Polyglutamine_Diseases_/125831","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002501","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002501","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5043702098","display_name":"Transition Structures and the Evolution of Protein Folds","funder_award_id":"1021883","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5261498970","display_name":"FRG: Metalloproteins: Computational Challenges, Methods, and Tools","funder_award_id":"0804549","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310013","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1505352099","https://openalex.org/W1565709818","https://openalex.org/W1970434234","https://openalex.org/W1970456057","https://openalex.org/W1975769486","https://openalex.org/W1978672495","https://openalex.org/W1979706337","https://openalex.org/W1980176289","https://openalex.org/W1982138826","https://openalex.org/W1985730748","https://openalex.org/W1988760238","https://openalex.org/W1993117229","https://openalex.org/W1996565611","https://openalex.org/W2000250831","https://openalex.org/W2006298998","https://openalex.org/W2008708467","https://openalex.org/W2012850328","https://openalex.org/W2014355769","https://openalex.org/W2019574809","https://openalex.org/W2029667189","https://openalex.org/W2035471791","https://openalex.org/W2035720425","https://openalex.org/W2040809566","https://openalex.org/W2042716629","https://openalex.org/W2043354712","https://openalex.org/W2043899474","https://openalex.org/W2046132401","https://openalex.org/W2049902088","https://openalex.org/W2051642961","https://openalex.org/W2051858905","https://openalex.org/W2057673048","https://openalex.org/W2059266062","https://openalex.org/W2066024683","https://openalex.org/W2066734465","https://openalex.org/W2072287157","https://openalex.org/W2079250951","https://openalex.org/W2079726930","https://openalex.org/W2081176461","https://openalex.org/W2083731765","https://openalex.org/W2089998484","https://openalex.org/W2092743716","https://openalex.org/W2101816392","https://openalex.org/W2105103540","https://openalex.org/W2105747184","https://openalex.org/W2106318156","https://openalex.org/W2106490406","https://openalex.org/W2110113231","https://openalex.org/W2113998330","https://openalex.org/W2117178889","https://openalex.org/W2123544060","https://openalex.org/W2126103104","https://openalex.org/W2137220407","https://openalex.org/W2137373119","https://openalex.org/W2138023380","https://openalex.org/W2140797187","https://openalex.org/W2141920771","https://openalex.org/W2144288821","https://openalex.org/W2146575889","https://openalex.org/W2155333098","https://openalex.org/W2157208586","https://openalex.org/W2164270482","https://openalex.org/W2256578114","https://openalex.org/W2749203687","https://openalex.org/W2802808353","https://openalex.org/W3100855779","https://openalex.org/W3102805951","https://openalex.org/W4244370844","https://openalex.org/W6630355772","https://openalex.org/W6633901960","https://openalex.org/W6659674159","https://openalex.org/W6676064982"],"related_works":["https://openalex.org/W2000232506","https://openalex.org/W2164993354","https://openalex.org/W1600511639","https://openalex.org/W2022165499","https://openalex.org/W1974253064","https://openalex.org/W2914839778","https://openalex.org/W2584738069","https://openalex.org/W2119753067","https://openalex.org/W4295897800","https://openalex.org/W2112736312"],"abstract_inverted_index":{"We":[0,92,191],"have":[1],"characterized":[2],"the":[3,23,46,50,59,67,74,78,133,138,145,148,151,160,177,184,188,194,198,203],"conformational":[4],"ensembles":[5],"of":[6,10,25,49,58,77,82,99,137,150,179,187,197,205],"polyglutamine":[7,142,199],"Qn":[8],"peptides":[9,143],"various":[11,47],"lengths":[12],"n":[13],"(ranging":[14,126],"from":[15],"6":[16],"to":[17,44,173],"40),":[18],"both":[19,176],"with":[20,39,86,202],"and":[21,54,89,108,110,112,154,159,183],"without":[22],"presence":[24,204],"a":[26,40,95,123,170],"C-terminal":[27,171],"polyproline":[28],"hexapeptide.":[29],"For":[30,62,141],"this,":[31],"we":[32,118],"used":[33],"state-of-the-art":[34],"molecular":[35],"dynamics":[36],"simulations":[37],"combined":[38],"novel":[41],"statistical":[42],"analysis":[43],"characterize":[45],"properties":[48],"backbone":[51,134],"dihedral":[52,135,189],"angles":[53,136],"secondary":[55],"structural":[56],"motifs":[57,182],"glutamine":[60],"residues.":[61,140],"Q40":[63,117,174],"(i.e.,":[64],"just":[65],"above":[66],"pathological":[68,146],"length":[69],"\u224336":[70],"for":[71,103,116,127,212],"Huntington's":[72],"disease),":[73],"equilibrium":[75],"conformations":[76],"monomer":[79],"consist":[80],"primarily":[81],"disordered,":[83],"compact":[84],"structures":[85,101],"non-negligible":[87],"\u03b1-helical":[88],"turn":[90],"content.":[91],"also":[93],"observed":[94],"relatively":[96],"small":[97],"population":[98,149,178],"extended":[100,152],"suitable":[102],"forming":[104],"aggregates":[105],"including":[106],"\u03b2-":[107,111],"\u03b1-strands,":[109],"\u03b1-hairpins.":[113],"Most":[114],"importantly,":[115],"find":[119],"that":[120,193],"there":[121],"exists":[122],"long-range":[124,185,195],"correlation":[125,186,196],"at":[128],"least":[129],"20":[130],"residues)":[131],"among":[132],"Q":[139],"below":[144],"length,":[147],"strands":[153],"hairpins":[155],"is":[156],"considerably":[157],"smaller,":[158],"correlations":[161],"are":[162],"short-range":[163],"(at":[164],"most":[165],"5":[166],"residues":[167],"apart).":[168],"Adding":[169],"hexaproline":[172],"suppresses":[175],"these":[180,206],"rare":[181,207],"angles.":[190],"argue":[192],"homopeptide,":[200],"along":[201],"motifs,":[208],"could":[209],"be":[210],"responsible":[211],"its":[213],"aggregation":[214],"phenomena.":[215]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2025-10-10T00:00:00"}