{"id":"https://openalex.org/W1991230688","doi":"https://doi.org/10.1371/journal.pcbi.1002476","title":"On Conduction in a Bacterial Sodium Channel","display_name":"On Conduction in a Bacterial Sodium Channel","publication_year":2012,"publication_date":"2012-04-05","ids":{"openalex":"https://openalex.org/W1991230688","doi":"https://doi.org/10.1371/journal.pcbi.1002476","mag":"1991230688","pmid":"https://pubmed.ncbi.nlm.nih.gov/22496637"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002476","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002476","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002476&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002476&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022820593","display_name":"Simone Furini","orcid":"https://orcid.org/0000-0002-1099-8279"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Simone Furini","raw_affiliation_strings":["Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom","Department of\u00a0Medical Surgery and Bioengineering, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of\u00a0Medical Surgery and Bioengineering, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074261138","display_name":"C\u00e1rmen Domene","orcid":"https://orcid.org/0000-0001-7115-4232"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Carmen Domene","raw_affiliation_strings":["Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074261138"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.2403,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.96484498,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"8","issue":"4","first_page":"e1002476","last_page":"e1002476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ion","display_name":"Ion","score":0.6902716159820557},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.5924423336982727},{"id":"https://openalex.org/keywords/potential-of-mean-force","display_name":"Potential of mean force","score":0.5651241540908813},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5481089949607849},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5399143695831299},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5249176621437073},{"id":"https://openalex.org/keywords/sodium","display_name":"Sodium","score":0.5016469955444336},{"id":"https://openalex.org/keywords/sodium-channel","display_name":"Sodium channel","score":0.47554466128349304},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.4615151584148407},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"Membrane potential","score":0.46045592427253723},{"id":"https://openalex.org/keywords/depolarization","display_name":"Depolarization","score":0.4249809980392456},{"id":"https://openalex.org/keywords/ion-transporter","display_name":"Ion transporter","score":0.41384053230285645},{"id":"https://openalex.org/keywords/light-gated-ion-channel","display_name":"Light-gated ion channel","score":0.4121939241886139},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.33579081296920776},{"id":"https://openalex.org/keywords/voltage-gated-ion-channel","display_name":"Voltage-gated ion channel","score":0.3246670961380005},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11074835062026978},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.1088871955871582},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.0793018639087677}],"concepts":[{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.6902716159820557},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.5924423336982727},{"id":"https://openalex.org/C175634916","wikidata":"https://www.wikidata.org/wiki/Q17075777","display_name":"Potential of mean force","level":3,"score":0.5651241540908813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5481089949607849},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5399143695831299},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5249176621437073},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.5016469955444336},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.47554466128349304},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.4615151584148407},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.46045592427253723},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.4249809980392456},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.41384053230285645},{"id":"https://openalex.org/C53465041","wikidata":"https://www.wikidata.org/wiki/Q6545938","display_name":"Light-gated ion channel","level":5,"score":0.4121939241886139},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.33579081296920776},{"id":"https://openalex.org/C37088560","wikidata":"https://www.wikidata.org/wiki/Q354550","display_name":"Voltage-gated ion channel","level":4,"score":0.3246670961380005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11074835062026978},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.1088871955871582},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0793018639087677},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pcbi.1002476","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002476","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002476&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22496637","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22496637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/aa8c03c0-15c0-49c7-80b0-f214711d09a7","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/aa8c03c0-15c0-49c7-80b0-f214711d09a7","pdf_url":"https://kclpure.kcl.ac.uk/ws/files/52746272/Furini_and_Domene_2012.PDF","source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Furini, S & Domene, C 2012, 'On Conduction in a Bacterial Sodium Channel', PL o S Computational Biology, vol. 8, no. 4, 1002476. https://doi.org/10.1371/journal.pcbi.1002476","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:usiena-air.unisi.it:11365/42889","is_oa":true,"landing_page_url":"http://hdl.handle.net/11365/42889","pdf_url":"http://hdl.handle.net/11365/42889","source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.270.40","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.270.40","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/4c/e0/PLoS_Comput_Biol_2012_Apr_5_8(4)_e1002476.tar.gz","raw_type":"text"},{"id":"pmh:oai:cris.unibo.it:11585/891966","is_oa":true,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002476","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:0e28717795504cc6a7ea0942fb074c2d","is_oa":true,"landing_page_url":"https://doaj.org/article/0e28717795504cc6a7ea0942fb074c2d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 4, p e1002476 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/126779","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/On_Conduction_in_a_Bacterial_Sodium_Channel/126779","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:dc107cfe-502f-48c5-8979-cd68ea622363","is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:dc107cfe-502f-48c5-8979-cd68ea622363","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PubMed (http://www.ncbi.nlm.nih.gov/pubmed/)","raw_type":"Journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3320569","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3320569","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002476","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002476","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002476&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.7200000286102295}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991230688.pdf","grobid_xml":"https://content.openalex.org/works/W1991230688.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1753746324","https://openalex.org/W1963480981","https://openalex.org/W1972758026","https://openalex.org/W1973589290","https://openalex.org/W1976499671","https://openalex.org/W1983132551","https://openalex.org/W1989195611","https://openalex.org/W1990323937","https://openalex.org/W1993177346","https://openalex.org/W1998227882","https://openalex.org/W2014633788","https://openalex.org/W2020866584","https://openalex.org/W2027408247","https://openalex.org/W2032734987","https://openalex.org/W2035687084","https://openalex.org/W2038758364","https://openalex.org/W2038827150","https://openalex.org/W2041845061","https://openalex.org/W2042733505","https://openalex.org/W2048094270","https://openalex.org/W2049275371","https://openalex.org/W2054469296","https://openalex.org/W2066070661","https://openalex.org/W2067081534","https://openalex.org/W2068739250","https://openalex.org/W2095134060","https://openalex.org/W2101204196","https://openalex.org/W2103945336","https://openalex.org/W2104415321","https://openalex.org/W2106207499","https://openalex.org/W2112154906","https://openalex.org/W2130890126","https://openalex.org/W2143070723","https://openalex.org/W2148183991","https://openalex.org/W2150981663","https://openalex.org/W2164829352","https://openalex.org/W2329394010","https://openalex.org/W2330085032"],"related_works":["https://openalex.org/W2101385736","https://openalex.org/W2375911737","https://openalex.org/W4223653241","https://openalex.org/W1487398837","https://openalex.org/W624714480","https://openalex.org/W2102575758","https://openalex.org/W4220975272","https://openalex.org/W2385454431","https://openalex.org/W2780571029","https://openalex.org/W2021163002"],"abstract_inverted_index":{"Voltage-gated":[0],"Na\u207a-channels":[1],"are":[2,6,160],"transmembrane":[3],"proteins":[4],"that":[5,112,115],"responsible":[7],"for":[8,33,86,155],"the":[9,14,34,40,43,91,95,139,142,152,168,172],"fast":[10],"depolarizing":[11],"phase":[12],"of":[13,24,37,42,47,63,94,100,116,141,171],"action":[15],"potential":[16],"in":[17,149,167],"nerve":[18],"and":[19,79,157,179],"muscular":[20],"cells.":[21],"Selective":[22],"permeability":[23],"Na\u207a":[25,58,64,87,156,177],"over":[26],"Ca\u00b2\u207a":[27],"or":[28],"K\u207a":[29,158,183],"ions":[30,143,159],"is":[31,108,114,165,185],"essential":[32],"biological":[35],"function":[36],"Na\u207a-channels.":[38,150],"After":[39],"emergence":[41],"first":[44],"high-resolution":[45],"structure":[46,99],"a":[48,82,101,117,162,175,181],"Na\u207a-channel,":[49],"an":[50],"anionic":[51],"coordination":[52],"site":[53,164],"was":[54],"proposed":[55],"to":[56,137,145],"confer":[57],"selectivity":[59,92],"through":[60,90],"partial":[61],"dehydration":[62],"via":[65],"its":[66],"direct":[67],"interaction":[68],"with":[69],"conserved":[70],"glutamate":[71],"side":[72],"chains.":[73],"By":[74],"combining":[75],"molecular":[76],"dynamics":[77],"simulations":[78],"free-energy":[80,133,153],"calculations,":[81],"low-energy":[83],"permeation":[84],"pathway":[85],"ion":[88],"translocation":[89],"filter":[93],"recently":[96],"determined":[97],"crystal":[98],"prokaryotic":[102],"sodium":[103],"channel":[104],"from":[105],"Arcobacter":[106],"butzleri":[107],"characterised.":[109],"The":[110],"picture":[111],"emerges":[113],"pore":[118],"preferentially":[119],"occupied":[120],"by":[121,130],"two":[122],"ions,":[123],"which":[124],"can":[125],"switch":[126],"between":[127],"different":[128],"configurations":[129],"crossing":[131],"low":[132],"barriers.":[134],"In":[135],"contrast":[136],"K\u207a-channels,":[138],"movements":[140],"appear":[144],"be":[146],"weakly":[147],"coupled":[148],"When":[151],"maps":[154],"compared,":[161],"selective":[163],"characterised":[166],"narrowest":[169],"region":[170],"filter,":[173],"where":[174],"hydrated":[176,182],"ion,":[178,184],"not":[180],"energetically":[186],"stable.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":8}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}