{"id":"https://openalex.org/W1975079024","doi":"https://doi.org/10.1371/journal.pcbi.1002465","title":"Optimization of Muscle Activity for Task-Level Goals Predicts Complex Changes in Limb Forces across Biomechanical Contexts","display_name":"Optimization of Muscle Activity for Task-Level Goals Predicts Complex Changes in Limb Forces across Biomechanical Contexts","publication_year":2012,"publication_date":"2012-04-12","ids":{"openalex":"https://openalex.org/W1975079024","doi":"https://doi.org/10.1371/journal.pcbi.1002465","mag":"1975079024","pmid":"https://pubmed.ncbi.nlm.nih.gov/22511857"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002465","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002465","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002465&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002465&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062566727","display_name":"J. Lucas McKay","orcid":"https://orcid.org/0000-0002-8361-8943"},"institutions":[{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]},{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Lucas McKay","raw_affiliation_strings":["The Wallace H. Coulter Department of Biomedical Engineering, Emory University and the Georgia Institute of Technology, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wallace H. Coulter Department of Biomedical Engineering, Emory University and the Georgia Institute of Technology, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I2802612298","https://openalex.org/I130701444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022013226","display_name":"Lena H. Ting","orcid":"https://orcid.org/0000-0001-6854-9444"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I2802612298","display_name":"The Wallace H. Coulter Department of Biomedical Engineering","ror":"https://ror.org/02j15s898","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444","https://openalex.org/I150468666","https://openalex.org/I2802612298"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lena H. Ting","raw_affiliation_strings":["The Wallace H. Coulter Department of Biomedical Engineering, Emory University and the Georgia Institute of Technology, Atlanta, Georgia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wallace H. Coulter Department of Biomedical Engineering, Emory University and the Georgia Institute of Technology, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I2802612298","https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022013226"],"corresponding_institution_ids":["https://openalex.org/I130701444","https://openalex.org/I2802612298"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.1841,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.91722181,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"4","first_page":"e1002465","last_page":"e1002465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10982","display_name":"Motor Control and Adaptation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10982","display_name":"Motor Control and Adaptation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11097","display_name":"Cerebral Palsy and Movement Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/redundancy","display_name":"Redundancy (engineering)","score":0.6033002138137817},{"id":"https://openalex.org/keywords/motor-control","display_name":"Motor control","score":0.5855536460876465},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.537628173828125},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5113077163696289},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.48047012090682983},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.34372198581695557},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.19314515590667725},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.19195926189422607},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14058518409729004},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1244160532951355},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09888258576393127}],"concepts":[{"id":"https://openalex.org/C152124472","wikidata":"https://www.wikidata.org/wiki/Q1204361","display_name":"Redundancy (engineering)","level":2,"score":0.6033002138137817},{"id":"https://openalex.org/C137813230","wikidata":"https://www.wikidata.org/wiki/Q2996165","display_name":"Motor control","level":2,"score":0.5855536460876465},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.537628173828125},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5113077163696289},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.48047012090682983},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.34372198581695557},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19314515590667725},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.19195926189422607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14058518409729004},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1244160532951355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09888258576393127},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004856","descriptor_name":"Postural Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004856","descriptor_name":"Postural Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004856","descriptor_name":"Postural Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009068","descriptor_name":"Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013647","descriptor_name":"Task Performance and Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013647","descriptor_name":"Task Performance and Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013647","descriptor_name":"Task Performance and Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002465","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002465","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002465&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22511857","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22511857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.270.878","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.270.878","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/61/e8/PLoS_Comput_Biol_2012_Apr_12_8(4)_e1002465.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002465","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002465","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:064049cab8b1406d8ae6d018a92991b9","is_oa":true,"landing_page_url":"https://doaj.org/article/064049cab8b1406d8ae6d018a92991b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 4, p e1002465 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2333645","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3325175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002465","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002465","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002465&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1975079024.pdf","grobid_xml":"https://content.openalex.org/works/W1975079024.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W13740476","https://openalex.org/W95059072","https://openalex.org/W1482575233","https://openalex.org/W1484809412","https://openalex.org/W1526626831","https://openalex.org/W1549114171","https://openalex.org/W1556863850","https://openalex.org/W1581909396","https://openalex.org/W1848976532","https://openalex.org/W1864094811","https://openalex.org/W1904024272","https://openalex.org/W1932999802","https://openalex.org/W1964847255","https://openalex.org/W1966066856","https://openalex.org/W1968106150","https://openalex.org/W1968784303","https://openalex.org/W1973012362","https://openalex.org/W1975712469","https://openalex.org/W1979733270","https://openalex.org/W1980440818","https://openalex.org/W1982666708","https://openalex.org/W1982865075","https://openalex.org/W1984719593","https://openalex.org/W1986168208","https://openalex.org/W1988698278","https://openalex.org/W1990810535","https://openalex.org/W2005609567","https://openalex.org/W2010617318","https://openalex.org/W2010757003","https://openalex.org/W2014841587","https://openalex.org/W2016452742","https://openalex.org/W2021300704","https://openalex.org/W2022499771","https://openalex.org/W2026044248","https://openalex.org/W2029776687","https://openalex.org/W2030275344","https://openalex.org/W2030849942","https://openalex.org/W2030886059","https://openalex.org/W2032704883","https://openalex.org/W2033299989","https://openalex.org/W2034134392","https://openalex.org/W2036407851","https://openalex.org/W2037080775","https://openalex.org/W2040620414","https://openalex.org/W2044890387","https://openalex.org/W2044951073","https://openalex.org/W2048528354","https://openalex.org/W2051055090","https://openalex.org/W2052067647","https://openalex.org/W2052210110","https://openalex.org/W2052928205","https://openalex.org/W2054857883","https://openalex.org/W2057658154","https://openalex.org/W2058945823","https://openalex.org/W2059929055","https://openalex.org/W2064169298","https://openalex.org/W2066957584","https://openalex.org/W2071307076","https://openalex.org/W2073046238","https://openalex.org/W2073610232","https://openalex.org/W2074376560","https://openalex.org/W2078652550","https://openalex.org/W2080487795","https://openalex.org/W2082356126","https://openalex.org/W2089745666","https://openalex.org/W2090373601","https://openalex.org/W2093231643","https://openalex.org/W2094697451","https://openalex.org/W2095858841","https://openalex.org/W2100949883","https://openalex.org/W2106518363","https://openalex.org/W2107325954","https://openalex.org/W2109174714","https://openalex.org/W2110107142","https://openalex.org/W2111960226","https://openalex.org/W2118082864","https://openalex.org/W2120168261","https://openalex.org/W2123236823","https://openalex.org/W2123516431","https://openalex.org/W2124577687","https://openalex.org/W2125783319","https://openalex.org/W2126522704","https://openalex.org/W2126561686","https://openalex.org/W2127733921","https://openalex.org/W2128118213","https://openalex.org/W2128748652","https://openalex.org/W2129945286","https://openalex.org/W2131049905","https://openalex.org/W2133859362","https://openalex.org/W2135561090","https://openalex.org/W2136378256","https://openalex.org/W2136704450","https://openalex.org/W2137243079","https://openalex.org/W2144741745","https://openalex.org/W2145860775","https://openalex.org/W2145890464","https://openalex.org/W2147804103","https://openalex.org/W2148820543","https://openalex.org/W2150572952","https://openalex.org/W2151522724","https://openalex.org/W2153593530","https://openalex.org/W2158404451","https://openalex.org/W2161288147","https://openalex.org/W2162056049","https://openalex.org/W2165346682","https://openalex.org/W2165873177","https://openalex.org/W2166226199","https://openalex.org/W2167633283","https://openalex.org/W2168741747","https://openalex.org/W2168851095","https://openalex.org/W2170661833","https://openalex.org/W2278676576","https://openalex.org/W2291467288","https://openalex.org/W2317215606","https://openalex.org/W2327408228","https://openalex.org/W2346569502","https://openalex.org/W2396332812","https://openalex.org/W2401335444","https://openalex.org/W2408525607","https://openalex.org/W2412879664","https://openalex.org/W2432567885","https://openalex.org/W2797181071","https://openalex.org/W4244562947","https://openalex.org/W4250749758","https://openalex.org/W4255563445"],"related_works":["https://openalex.org/W1495042958","https://openalex.org/W2494338568","https://openalex.org/W2122678784","https://openalex.org/W2282510344","https://openalex.org/W139987158","https://openalex.org/W2183994405","https://openalex.org/W4234013965","https://openalex.org/W2913443329","https://openalex.org/W1480486014","https://openalex.org/W2596347097"],"abstract_inverted_index":{"Optimality":[0],"principles":[1],"have":[2],"been":[3],"proposed":[4],"as":[5,226],"a":[6,106,154,160],"general":[7,24],"framework":[8,163],"for":[9,274],"understanding":[10],"motor":[11,29,54,111],"control":[12,44,80,214,223,240,259],"in":[13,27,64,92,153,270],"animals":[14],"and":[15,50,76,88,120,122,137,147,181],"humans":[16],"largely":[17],"based":[18],"on":[19],"their":[20],"ability":[21],"to":[22,37,45,102,126,168,211,233,244],"predict":[23,166],"features":[25],"movement":[26],"idealized":[28],"tasks.":[30],"However,":[31],"generalizing":[32],"these":[33],"concepts":[34],"past":[35],"proof-of-principle":[36],"understand":[38],"the":[39,110,212,234,253],"neuromechanical":[40],"transformation":[41],"from":[42],"task-level":[43,70,145,257],"detailed":[46,83],"execution-level":[47],"muscle":[48,86,198,227,246],"activity":[49,87],"forces":[51,75,91],"during":[52],"behaviorally-relevant":[53],"tasks":[55,265],"has":[56],"proved":[57],"difficult.":[58],"In":[59],"an":[60,93],"unrestrained":[61],"balance":[62],"task":[63,203],"cats,":[65],"we":[66,113,158],"demonstrate":[67],"that":[68,133,164,207,220,255],"achieving":[69],"constraints":[71],"center":[72],"of":[73,85,109,215],"mass":[74],"moments":[77],"while":[78],"minimizing":[79],"effort":[81,241],"predicts":[82],"patterns":[84],"ground":[89],"reaction":[90],"anatomically-realistic":[94],"musculoskeletal":[95],"model.":[96],"Whereas":[97],"optimization":[98,162],"is":[99],"typically":[100],"used":[101,269],"resolve":[103],"redundancy":[104,116],"at":[105],"single":[107,155],"level":[108],"hierarchy,":[112],"simultaneously":[114],"resolved":[115],"across":[117,129,177],"both":[118,178],"muscles":[119],"limbs":[121],"directly":[123],"compared":[124,243],"predictions":[125,152],"experimental":[127,170],"measures":[128],"multiple":[130],"perturbation":[131,179],"directions":[132,180],"elicit":[134],"different":[135,182],"intra-":[136],"interlimb":[138],"coordination":[139],"patterns.":[140],"Further,":[141],"although":[142],"some":[143],"candidate":[144],"variables":[146,204],"cost":[148],"functions":[149],"generated":[150],"indistinguishable":[151],"biomechanical":[156,183],"context,":[157],"identified":[159],"common":[161],"could":[165],"up":[167],"48":[169],"conditions":[171],"per":[172],"animal":[173],"(n":[174],"=":[175],"3)":[176],"contexts":[184],"created":[185],"by":[186,195],"altering":[187],"animals'":[188],"postural":[189],"configuration.":[190],"Predictions":[191],"were":[192],"further":[193],"improved":[194],"imposing":[196],"experimentally-derived":[197],"synergy":[199],"constraints,":[200],"suggesting":[201],"additional":[202],"or":[205],"costs":[206],"may":[208,266],"be":[209,268],"relevant":[210],"neural":[213,222,258],"balance.":[216,275],"These":[217],"results":[218,249],"suggested":[219],"reduced-dimension":[221],"mechanisms":[224,260],"such":[225],"synergies":[228],"can":[229],"achieve":[230],"similar":[231],"kinetics":[232],"optimal":[235],"solution,":[236],"but":[237],"with":[238,252,263],"increased":[239],"(\u22482\u00d7)":[242],"individual":[245],"control.":[247],"Our":[248],"are":[250],"consistent":[251],"idea":[254],"hierarchical,":[256],"previously":[261],"associated":[262],"voluntary":[264],"also":[267],"automatic":[271],"brainstem-mediated":[272],"pathways":[273]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
