{"id":"https://openalex.org/W2068289873","doi":"https://doi.org/10.1371/journal.pcbi.1002443","title":"Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines","display_name":"Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines","publication_year":2012,"publication_date":"2012-04-05","ids":{"openalex":"https://openalex.org/W2068289873","doi":"https://doi.org/10.1371/journal.pcbi.1002443","mag":"2068289873","pmid":"https://pubmed.ncbi.nlm.nih.gov/22496629"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002443","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002443","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002443&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002443&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083119247","display_name":"Antoine Baker","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoine Baker","raw_affiliation_strings":["Universit\u00e9 de Lyon, Lyon, France","Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","Laboratoire de Physique, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134"]},{"raw_affiliation_string":"Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physique, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046565506","display_name":"Benjamin Audit","orcid":"https://orcid.org/0000-0003-2683-9990"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benjamin Audit","raw_affiliation_strings":["Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","Laboratoire de Physique, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","Universit\u00e9 de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physique, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079584223","display_name":"Chun-Long Chen","orcid":"https://orcid.org/0000-0002-4795-0295"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Chun-Long Chen","raw_affiliation_strings":["Centre de G\u00e9n\u00e9tique Mol\u00e9culaire UPR 3404, CNRS, Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire UPR 3404, CNRS, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041088192","display_name":"Beno\u00eet Moindrot","orcid":"https://orcid.org/0000-0003-3915-7892"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benoit Moindrot","raw_affiliation_strings":["Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","Universit\u00e9 de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064428508","display_name":"Antoine Leleu","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoine Leleu","raw_affiliation_strings":["Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","Universit\u00e9 de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009491330","display_name":"Guillaume Guilbaud","orcid":"https://orcid.org/0000-0002-4345-6855"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210129409","display_name":"Institut de Biologie de l'\u00c9cole Normale Sup\u00e9rieure","ror":"https://ror.org/03mxktp47","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2746051580","https://openalex.org/I29607241","https://openalex.org/I4210096427","https://openalex.org/I4210129409"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Guilbaud","raw_affiliation_strings":["Institut de Biologie de l'Ecole Normale Sup\u00e9rieure, CNRS UMR8197, Inserm U1024, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie de l'Ecole Normale Sup\u00e9rieure, CNRS UMR8197, Inserm U1024, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210129409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076513102","display_name":"Aur\u00e9lien Rappailles","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210129409","display_name":"Institut de Biologie de l'\u00c9cole Normale Sup\u00e9rieure","ror":"https://ror.org/03mxktp47","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2746051580","https://openalex.org/I29607241","https://openalex.org/I4210096427","https://openalex.org/I4210129409"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aur\u00e9lien Rappailles","raw_affiliation_strings":["Institut de Biologie de l'Ecole Normale Sup\u00e9rieure, CNRS UMR8197, Inserm U1024, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie de l'Ecole Normale Sup\u00e9rieure, CNRS UMR8197, Inserm U1024, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210129409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107335581","display_name":"C\u00e9dric Vaillant","orcid":"https://orcid.org/0000-0003-2208-3831"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9dric Vaillant","raw_affiliation_strings":["Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","Laboratoire de Physique, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","Universit\u00e9 de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physique, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053305582","display_name":"Arach Goldar","orcid":"https://orcid.org/0000-0003-4139-247X"},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arach Goldar","raw_affiliation_strings":["Commissariat \u00e0 l'\u00e9nergie atomique, iBiTecS, Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Commissariat \u00e0 l'\u00e9nergie atomique, iBiTecS, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I2738703131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041988234","display_name":"Fabien Mong\u00e9lard","orcid":"https://orcid.org/0000-0002-5929-6120"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210100775","display_name":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule","ror":"https://ror.org/01bj4fd12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210100775"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabien Mongelard","raw_affiliation_strings":["Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","Laboratoire de Biologie Mol\u00e9culaire de la Cellule, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","Universit\u00e9 de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Biologie Mol\u00e9culaire de la Cellule, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I4210100775"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075024994","display_name":"Yves d\u2019Aubenton-Carafa","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves d'Aubenton-Carafa","raw_affiliation_strings":["Centre de G\u00e9n\u00e9tique Mol\u00e9culaire UPR 3404, CNRS, Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire UPR 3404, CNRS, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007655086","display_name":"Olivier Hyrien","orcid":"https://orcid.org/0000-0001-8879-675X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210129409","display_name":"Institut de Biologie de l'\u00c9cole Normale Sup\u00e9rieure","ror":"https://ror.org/03mxktp47","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2746051580","https://openalex.org/I29607241","https://openalex.org/I4210096427","https://openalex.org/I4210129409"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Hyrien","raw_affiliation_strings":["Institut de Biologie de l'Ecole Normale Sup\u00e9rieure, CNRS UMR8197, Inserm U1024, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie de l'Ecole Normale Sup\u00e9rieure, CNRS UMR8197, Inserm U1024, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210129409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076485251","display_name":"Claude Thermes","orcid":"https://orcid.org/0000-0002-0023-5294"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude Thermes","raw_affiliation_strings":["Centre de G\u00e9n\u00e9tique Mol\u00e9culaire UPR 3404, CNRS, Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire UPR 3404, CNRS, Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023201158","display_name":"A. Arn\u00e9odo","orcid":"https://orcid.org/0000-0002-3690-2108"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Alain Arneodo","raw_affiliation_strings":["Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","Laboratoire de Physique, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","Universit\u00e9 de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Joliot-Curie, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physique, CNRS, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5023201158"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":4.428,"has_fulltext":true,"cited_by_count":75,"citation_normalized_percentile":{"value":0.95639276,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"4","first_page":"e1002443","last_page":"e1002443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replication-timing","display_name":"Replication timing","score":0.8958937525749207},{"id":"https://openalex.org/keywords/pre-replication-complex","display_name":"Pre-replication complex","score":0.7327941060066223},{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.6701697111129761},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.645162045955658},{"id":"https://openalex.org/keywords/origin-of-replication","display_name":"Origin of replication","score":0.6358301043510437},{"id":"https://openalex.org/keywords/replication","display_name":"Replication (statistics)","score":0.6039418578147888},{"id":"https://openalex.org/keywords/origin-recognition-complex","display_name":"Origin recognition complex","score":0.5994166731834412},{"id":"https://openalex.org/keywords/licensing-factor","display_name":"Licensing factor","score":0.5872957706451416},{"id":"https://openalex.org/keywords/minichromosome-maintenance","display_name":"Minichromosome maintenance","score":0.5723773241043091},{"id":"https://openalex.org/keywords/control-of-chromosome-duplication","display_name":"Control of chromosome duplication","score":0.5407434105873108},{"id":"https://openalex.org/keywords/dna-replication-factor-cdt1","display_name":"DNA replication factor CDT1","score":0.5060283541679382},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.4871951937675476},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.46692606806755066},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4349074959754944},{"id":"https://openalex.org/keywords/germline","display_name":"Germline","score":0.4205440580844879},{"id":"https://openalex.org/keywords/eukaryotic-dna-replication","display_name":"Eukaryotic DNA replication","score":0.4047073423862457},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.33287501335144043},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20896726846694946}],"concepts":[{"id":"https://openalex.org/C2778512757","wikidata":"https://www.wikidata.org/wiki/Q7314076","display_name":"Replication timing","level":4,"score":0.8958937525749207},{"id":"https://openalex.org/C41141232","wikidata":"https://www.wikidata.org/wiki/Q3685229","display_name":"Pre-replication complex","level":5,"score":0.7327941060066223},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6701697111129761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.645162045955658},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.6358301043510437},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.6039418578147888},{"id":"https://openalex.org/C151158763","wikidata":"https://www.wikidata.org/wiki/Q1626856","display_name":"Origin recognition complex","level":5,"score":0.5994166731834412},{"id":"https://openalex.org/C54266558","wikidata":"https://www.wikidata.org/wiki/Q6543075","display_name":"Licensing factor","level":5,"score":0.5872957706451416},{"id":"https://openalex.org/C175248279","wikidata":"https://www.wikidata.org/wiki/Q3858415","display_name":"Minichromosome maintenance","level":5,"score":0.5723773241043091},{"id":"https://openalex.org/C104690221","wikidata":"https://www.wikidata.org/wiki/Q5165872","display_name":"Control of chromosome duplication","level":4,"score":0.5407434105873108},{"id":"https://openalex.org/C175193931","wikidata":"https://www.wikidata.org/wiki/Q18047065","display_name":"DNA replication factor CDT1","level":5,"score":0.5060283541679382},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4871951937675476},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46692606806755066},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4349074959754944},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.4205440580844879},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.4047073423862457},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33287501335144043},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20896726846694946},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018741","descriptor_name":"Replication Origin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018741","descriptor_name":"Replication Origin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018741","descriptor_name":"Replication Origin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002443","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002443","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002443&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22496629","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22496629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3320577","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3320577","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:HAL:inserm-00706043v1","is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00706043","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ploscompbiol.org/","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:7d11a983c8a84058b54c32765c749815","is_oa":true,"landing_page_url":"https://doaj.org/article/7d11a983c8a84058b54c32765c749815","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 4, p e1002443 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/126719","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Replication_Fork_Polarity_Gradients_Revealed_by_Megabase_Sized_U_Shaped_Replication_Timing_Domains_in_Human_Cell_Lines/126719","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002443","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002443","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002443&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G4502106676","display_name":null,"funder_award_id":"10 BLAN 1615 01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320309749","display_name":"Association pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2068289873.pdf","grobid_xml":"https://content.openalex.org/works/W2068289873.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W32149096","https://openalex.org/W1851269111","https://openalex.org/W1970722699","https://openalex.org/W1973646952","https://openalex.org/W1981437154","https://openalex.org/W1983461014","https://openalex.org/W1993557546","https://openalex.org/W1995496004","https://openalex.org/W2000830981","https://openalex.org/W2005290796","https://openalex.org/W2009065172","https://openalex.org/W2013559800","https://openalex.org/W2018760184","https://openalex.org/W2024515529","https://openalex.org/W2029746887","https://openalex.org/W2030665161","https://openalex.org/W2033421234","https://openalex.org/W2042439225","https://openalex.org/W2046299964","https://openalex.org/W2054748846","https://openalex.org/W2055571464","https://openalex.org/W2056298514","https://openalex.org/W2058306877","https://openalex.org/W2060278966","https://openalex.org/W2064371940","https://openalex.org/W2075432652","https://openalex.org/W2075863343","https://openalex.org/W2078526277","https://openalex.org/W2083886963","https://openalex.org/W2084082653","https://openalex.org/W2087627409","https://openalex.org/W2090037139","https://openalex.org/W2092390808","https://openalex.org/W2094077182","https://openalex.org/W2095560405","https://openalex.org/W2101412414","https://openalex.org/W2102056802","https://openalex.org/W2102304447","https://openalex.org/W2106130068","https://openalex.org/W2109176256","https://openalex.org/W2112582433","https://openalex.org/W2114536076","https://openalex.org/W2114970231","https://openalex.org/W2118515267","https://openalex.org/W2118683755","https://openalex.org/W2123219153","https://openalex.org/W2125079242","https://openalex.org/W2125397535","https://openalex.org/W2136247993","https://openalex.org/W2136724873","https://openalex.org/W2143922456","https://openalex.org/W2144141448","https://openalex.org/W2150437854","https://openalex.org/W2150733855","https://openalex.org/W2152294273","https://openalex.org/W2153087859","https://openalex.org/W2156361395","https://openalex.org/W2157251845","https://openalex.org/W2162362951","https://openalex.org/W2168783124","https://openalex.org/W2466817136","https://openalex.org/W4299407461","https://openalex.org/W7058562822"],"related_works":["https://openalex.org/W2144021776","https://openalex.org/W2038164592","https://openalex.org/W1966435085","https://openalex.org/W2087013595","https://openalex.org/W2474140576","https://openalex.org/W3134744679","https://openalex.org/W2417440641","https://openalex.org/W4226082309","https://openalex.org/W3099246975","https://openalex.org/W4315874454"],"abstract_inverted_index":{"In":[0],"higher":[1],"eukaryotes,":[2],"replication":[3,37,48,65,94,117,148,159,169],"program":[4,170],"specification":[5],"in":[6,30,108,120,171],"different":[7,58],"cell":[8,20,59],"types":[9],"remains":[10],"to":[11,138],"be":[12],"fully":[13],"understood.":[14],"We":[15,143],"show":[16],"for":[17,147],"seven":[18],"human":[19,173],"lines":[21,60],"that":[22,32,76,99,102,135],"about":[23],"half":[24],"of":[25,57,92,113,116,126,155,167],"the":[26,74,77,86,90,93,100,111,156,165,168,172],"genome":[27,157],"is":[28,53,81],"divided":[29],"domains":[31,66],"display":[33],"a":[34,68,106],"characteristic":[35],"U-shaped":[36],"timing":[38,95],"profile":[39],"with":[40,63],"early":[41],"initiation":[42],"zones":[43],"at":[44,49],"borders":[45],"and":[46,61,89,122,130],"late":[47],"centers.":[50],"Significant":[51],"overlap":[52],"observed":[54],"between":[55],"U-domains":[56,109,136],"also":[62],"germline":[64,123],"exhibiting":[67],"N-shaped":[69],"nucleotide":[70],"compositional":[71,87],"skew.":[72],"From":[73],"demonstration":[75],"average":[78],"fork":[79,118],"polarity":[80,119],"directly":[82],"reflected":[83],"by":[84],"both":[85],"skew":[88],"derivative":[91,104],"profile,":[96],"we":[97],"argue":[98],"fact":[101],"this":[103],"displays":[105],"N-shape":[107],"sustains":[110],"existence":[112],"large-scale":[114],"gradients":[115],"somatic":[121],"cells.":[124],"Analysis":[125],"chromatin":[127,131,140],"interaction":[128],"(Hi-C)":[129],"marker":[132],"data":[133],"reveals":[134],"correspond":[137],"high-order":[139],"structural":[141],"units.":[142],"discuss":[144],"possible":[145],"models":[146],"origin":[149],"activation":[150],"within":[151],"U/N-domains.":[152],"The":[153],"compartmentalization":[154],"into":[158],"U/N-domains":[160],"provides":[161],"new":[162],"insights":[163],"on":[164],"organization":[166],"genome.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":10}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
