{"id":"https://openalex.org/W2042941423","doi":"https://doi.org/10.1371/journal.pcbi.1002421","title":"Cytoskeletal Signaling: Is Memory Encoded in Microtubule Lattices by CaMKII Phosphorylation?","display_name":"Cytoskeletal Signaling: Is Memory Encoded in Microtubule Lattices by CaMKII Phosphorylation?","publication_year":2012,"publication_date":"2012-03-08","ids":{"openalex":"https://openalex.org/W2042941423","doi":"https://doi.org/10.1371/journal.pcbi.1002421","mag":"2042941423","pmid":"https://pubmed.ncbi.nlm.nih.gov/22412364"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002421","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002421","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002421&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002421&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015576193","display_name":"Travis J. A. Craddock","orcid":"https://orcid.org/0000-0001-7244-6317"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Travis J. A. Craddock","raw_affiliation_strings":["Department of Physics, University of Alberta, Edmonton, Canada. travisc@ualberta.ca","Department of Physics, University of Alberta, Edmonton, CANADA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, University of Alberta, Edmonton, Canada. travisc@ualberta.ca","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Department of Physics, University of Alberta, Edmonton, CANADA","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082024795","display_name":"Jack A. Tuszy\u0144ski","orcid":"https://orcid.org/0000-0001-9976-0429"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jack A. Tuszynski","raw_affiliation_strings":["Department of Experimental Oncology, Cross Cancer Institute, Edmonton, Canada","Department of Physics, University of Alberta, Edmonton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology, Cross Cancer Institute, Edmonton, Canada","institution_ids":[]},{"raw_affiliation_string":"Department of Physics, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051102175","display_name":"Stuart R. Hameroff","orcid":"https://orcid.org/0000-0003-1988-5526"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart Hameroff","raw_affiliation_strings":["Departments of Anesthesiology and Psychology, Center for Consciousness Studies, University of Arizona, Tucson, Arizona, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Psychology, Center for Consciousness Studies, University of Arizona, Tucson, Arizona, United States of America","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015576193"],"corresponding_institution_ids":["https://openalex.org/I154425047"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":8.0144,"has_fulltext":true,"cited_by_count":161,"citation_normalized_percentile":{"value":0.98420142,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"8","issue":"3","first_page":"e1002421","last_page":"e1002421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtubule","display_name":"Microtubule","score":0.7906651496887207},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"Cytoskeleton","score":0.7796967029571533},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.7341703176498413},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.7068368196487427},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4441588222980499},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41976386308670044},{"id":"https://openalex.org/keywords/signaling-proteins","display_name":"Signaling proteins","score":0.41214147210121155},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.35496678948402405},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15211156010627747},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.10202327370643616}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.7906651496887207},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.7796967029571533},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7341703176498413},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7068368196487427},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4441588222980499},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41976386308670044},{"id":"https://openalex.org/C2994130171","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Signaling proteins","level":3,"score":0.41214147210121155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35496678948402405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15211156010627747},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10202327370643616}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002421","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002421","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002421&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22412364","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22412364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:nsuworks.nova.edu:cps_facarticles-1247","is_oa":false,"landing_page_url":"https://nsuworks.nova.edu/cps_facarticles/851","pdf_url":null,"source":{"id":"https://openalex.org/S4377196410","display_name":"NSUWorks (Nova Southeastern University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I203088144","host_organization_name":"Nova Southeastern University","host_organization_lineage":["https://openalex.org/I203088144"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Articles","raw_type":"article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.271.7237","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.271.7237","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/19/83/PLoS_Comput_Biol_2012_Mar_8_8(3)_e1002421.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f844c05f5346481dbd8e7cd485444064","is_oa":true,"landing_page_url":"https://doaj.org/article/f844c05f5346481dbd8e7cd485444064","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 3, p e1002421 (2012)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3297561","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3297561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002421","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002421","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002421&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315044","display_name":"Ministry of Advanced Education, Government of Alberta","ror":"https://ror.org/05gyngk54"},{"id":"https://openalex.org/F4320319862","display_name":"Alberta Cancer Foundation","ror":"https://ror.org/01k1b2g25"},{"id":"https://openalex.org/F4320323221","display_name":"Allard Foundation","ror":"https://ror.org/02ng6yf94"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2042941423.pdf","grobid_xml":"https://content.openalex.org/works/W2042941423.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W562259709","https://openalex.org/W570519621","https://openalex.org/W585835727","https://openalex.org/W951033839","https://openalex.org/W1520365513","https://openalex.org/W1540428291","https://openalex.org/W1553905802","https://openalex.org/W1566370426","https://openalex.org/W1573751470","https://openalex.org/W1585007738","https://openalex.org/W1589379007","https://openalex.org/W1594493864","https://openalex.org/W1607739146","https://openalex.org/W1622048111","https://openalex.org/W1642243794","https://openalex.org/W1661843733","https://openalex.org/W1832281723","https://openalex.org/W1961384091","https://openalex.org/W1966041739","https://openalex.org/W1970792572","https://openalex.org/W1977083838","https://openalex.org/W1977083964","https://openalex.org/W1979169606","https://openalex.org/W1980661496","https://openalex.org/W1981662243","https://openalex.org/W1983311824","https://openalex.org/W1986597140","https://openalex.org/W1991909451","https://openalex.org/W1994345832","https://openalex.org/W2007309241","https://openalex.org/W2007393704","https://openalex.org/W2008936540","https://openalex.org/W2011760920","https://openalex.org/W2013485362","https://openalex.org/W2017135737","https://openalex.org/W2020270282","https://openalex.org/W2022873534","https://openalex.org/W2023047993","https://openalex.org/W2023129668","https://openalex.org/W2025510893","https://openalex.org/W2029582401","https://openalex.org/W2029667189","https://openalex.org/W2030005835","https://openalex.org/W2030179515","https://openalex.org/W2033844584","https://openalex.org/W2033942553","https://openalex.org/W2036145275","https://openalex.org/W2036242918","https://openalex.org/W2037066635","https://openalex.org/W2039650569","https://openalex.org/W2044770804","https://openalex.org/W2047399603","https://openalex.org/W2050066016","https://openalex.org/W2051394287","https://openalex.org/W2058101090","https://openalex.org/W2058997498","https://openalex.org/W2059584584","https://openalex.org/W2065283382","https://openalex.org/W2070148022","https://openalex.org/W2078963112","https://openalex.org/W2082067280","https://openalex.org/W2086524338","https://openalex.org/W2089514327","https://openalex.org/W2092424552","https://openalex.org/W2093910183","https://openalex.org/W2097729800","https://openalex.org/W2106873519","https://openalex.org/W2115990221","https://openalex.org/W2116170706","https://openalex.org/W2120816696","https://openalex.org/W2143221073","https://openalex.org/W2146451057","https://openalex.org/W2147974692","https://openalex.org/W2148457087","https://openalex.org/W2148791497","https://openalex.org/W2149856303","https://openalex.org/W2150981663","https://openalex.org/W2152447281","https://openalex.org/W2152997175","https://openalex.org/W2157508442","https://openalex.org/W2160699371","https://openalex.org/W2163886718","https://openalex.org/W2164333417","https://openalex.org/W2165305160","https://openalex.org/W2165565773","https://openalex.org/W2166555967","https://openalex.org/W2180958084","https://openalex.org/W2363557629","https://openalex.org/W2469069652","https://openalex.org/W2802282696","https://openalex.org/W2994602346","https://openalex.org/W3170406251","https://openalex.org/W4210955860","https://openalex.org/W4234836034","https://openalex.org/W4235309223","https://openalex.org/W6632325497","https://openalex.org/W6680786667","https://openalex.org/W7023726515"],"related_works":["https://openalex.org/W2068787210","https://openalex.org/W2137159400","https://openalex.org/W2106363574","https://openalex.org/W4234097411","https://openalex.org/W2463130200","https://openalex.org/W2969388149","https://openalex.org/W4243789837","https://openalex.org/W2357239809","https://openalex.org/W93379968","https://openalex.org/W2024720864"],"abstract_inverted_index":{"Memory":[0],"is":[1,25],"attributed":[2],"to":[3,192],"strengthened":[4],"synaptic":[5,12,23,97,179],"connections":[6],"among":[7],"particular":[8],"brain":[9],"neurons,":[10],"yet":[11],"membrane":[13],"components":[14],"are":[15],"transient,":[16],"whereas":[17],"memories":[18],"can":[19,76,94],"endure.":[20],"This":[21,163],"suggests":[22,164],"information":[24,99,180,213,225],"encoded":[26],"and":[27,44,140,148,187,201,205,224,229],"'hard-wired'":[28],"elsewhere,":[29],"e.g.":[30,177],"at":[31],"molecular":[32,45,113,137],"levels":[33],"within":[34,227],"the":[35,55,133,151],"post-synaptic":[36,49],"neuron.":[37],"In":[38],"long-term":[39],"potentiation":[40],"(LTP),":[41],"a":[42,62,123,127,218],"cellular":[43],"model":[46],"for":[47,110,221],"memory,":[48],"calcium":[50],"ion":[51],"(Ca\u00b2\u207a)":[52],"flux":[53],"activates":[54],"hexagonal":[56,67,130,161,172],"Ca\u00b2\u207a-calmodulin":[57],"dependent":[58],"kinase":[59,71,74,154,169],"II":[60],"(CaMKII),":[61],"dodacameric":[63],"holoenzyme":[64],"containing":[65],"2":[66],"sets":[68,165],"of":[69,90,105,129,132,150,159,166,184],"6":[70],"domains.":[72],"Each":[73],"domain":[75],"either":[77],"phosphorylate":[78,171],"substrate":[79],"proteins,":[80],"or":[81],"not":[82],"(i.e.":[83],"encoding":[84,202],"one":[85],"bit).":[86],"Thus":[87],"each":[88],"set":[89],"extended":[91,152],"CaMKII":[92,111,153,168],"kinases":[93],"potentially":[95],"encode":[96],"Ca\u00b2\u207a":[98],"via":[100],"phosphorylation":[101],"as":[102,181],"ordered":[103,182],"arrays":[104,183],"binary":[106],"'bits'.":[107],"Candidate":[108],"sites":[109],"phosphorylation-encoded":[112],"memory":[114,223],"include":[115],"microtubules":[116],"(MTs),":[117],"cylindrical":[118],"organelles":[119],"whose":[120],"surfaces":[121],"represent":[122],"regular":[124],"lattice":[125,174],"with":[126,190],"pattern":[128],"polymers":[131],"protein":[134],"tubulin.":[135],"Using":[136],"mechanics":[138],"modeling":[139],"electrostatic":[141],"profiling,":[142],"we":[143],"find":[144],"that":[145],"spatial":[146],"dimensions":[147],"geometry":[149],"domains":[155,170],"precisely":[156],"match":[157],"those":[158],"MT":[160,173],"lattices.":[162],"six":[167,185],"neighborhoods":[175],"collectively,":[176],"conveying":[178],"\"bits\",":[186],"thus":[188],"\"bytes\",":[189],"64":[191],"5,281":[193],"possible":[194],"bit":[195],"states":[196],"per":[197],"CaMKII-MT":[198],"byte.":[199],"Signaling":[200],"in":[203],"MTs":[204],"other":[206,230],"cytoskeletal":[207],"structures":[208],"offer":[209],"rapid,":[210],"robust":[211],"solid-state":[212],"processing":[214,226],"which":[215],"may":[216],"reflect":[217],"general":[219],"code":[220],"MT-based":[222],"neurons":[228],"eukaryotic":[231],"cells.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":11}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}
