{"id":"https://openalex.org/W2077314991","doi":"https://doi.org/10.1371/journal.pcbi.1002409","title":"Changes in Lysozyme Flexibility upon Mutation Are Frequent, Large and Long-Ranged","display_name":"Changes in Lysozyme Flexibility upon Mutation Are Frequent, Large and Long-Ranged","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W2077314991","doi":"https://doi.org/10.1371/journal.pcbi.1002409","mag":"2077314991","pmid":"https://pubmed.ncbi.nlm.nih.gov/22396637"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002409","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002409","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002409&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002409&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062942017","display_name":"Deeptak Verma","orcid":"https://orcid.org/0000-0003-0740-0624"},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deeptak Verma","raw_affiliation_strings":["Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073630563","display_name":"Donald J. Jacobs","orcid":"https://orcid.org/0000-0001-7711-1639"},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donald J. Jacobs","raw_affiliation_strings":["Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054458396","display_name":"Dennis R. Livesay","orcid":null},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dennis R. Livesay","raw_affiliation_strings":["Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America","institution_ids":["https://openalex.org/I102149020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054458396","https://openalex.org/A5073630563"],"corresponding_institution_ids":["https://openalex.org/I102149020"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.5528,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.89843196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"8","issue":"3","first_page":"e1002409","last_page":"e1002409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysozyme","display_name":"Lysozyme","score":0.8177979588508606},{"id":"https://openalex.org/keywords/cooperativity","display_name":"Cooperativity","score":0.727379560470581},{"id":"https://openalex.org/keywords/point-mutation","display_name":"Point mutation","score":0.5224329829216003},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.4854153096675873},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.43976709246635437},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4339437484741211},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4237421154975891},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3927730321884155},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38342708349227905},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.36970147490501404},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.35479211807250977},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19573813676834106},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1634526252746582},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.12749391794204712}],"concepts":[{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.8177979588508606},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.727379560470581},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.5224329829216003},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4854153096675873},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.43976709246635437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4339437484741211},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4237421154975891},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3927730321884155},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38342708349227905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36970147490501404},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.35479211807250977},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19573813676834106},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1634526252746582},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.12749391794204712}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002409","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002409","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002409&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22396637","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22396637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.790.9917","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.790.9917","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/46/e7/pcbi.1002409.PMC3291535.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9895023ac0704f068649fd7234cbd5e2","is_oa":true,"landing_page_url":"https://doaj.org/article/9895023ac0704f068649fd7234cbd5e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 3, p e1002409 (2012)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2304787","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3291535","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/128038","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Changes_in_Lysozyme_Flexibility_upon_Mutation_Are_Frequent_Large_and_Long_Ranged/128038","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002409","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002409","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002409&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3544974342","display_name":null,"funder_award_id":"R01 GM070382","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4830011505","display_name":null,"funder_award_id":"R01 GM070382","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320310016","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332431","display_name":"College of Engineering, Michigan State University","ror":"https://ror.org/05hs6h993"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2077314991.pdf","grobid_xml":"https://content.openalex.org/works/W2077314991.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W163999250","https://openalex.org/W409604127","https://openalex.org/W1964118138","https://openalex.org/W1966770601","https://openalex.org/W1967250058","https://openalex.org/W1968064498","https://openalex.org/W1968696021","https://openalex.org/W1970553877","https://openalex.org/W1973563455","https://openalex.org/W1974059729","https://openalex.org/W1979038840","https://openalex.org/W1979123965","https://openalex.org/W1981747417","https://openalex.org/W1986272199","https://openalex.org/W1986931250","https://openalex.org/W2001466699","https://openalex.org/W2002095965","https://openalex.org/W2008437627","https://openalex.org/W2012369940","https://openalex.org/W2012455318","https://openalex.org/W2014899829","https://openalex.org/W2015049308","https://openalex.org/W2019004327","https://openalex.org/W2019683054","https://openalex.org/W2021759674","https://openalex.org/W2021844857","https://openalex.org/W2027052763","https://openalex.org/W2028364860","https://openalex.org/W2032105354","https://openalex.org/W2035610379","https://openalex.org/W2040660309","https://openalex.org/W2041492687","https://openalex.org/W2046002103","https://openalex.org/W2047842317","https://openalex.org/W2051134680","https://openalex.org/W2052485605","https://openalex.org/W2054130762","https://openalex.org/W2057400263","https://openalex.org/W2063304732","https://openalex.org/W2064726001","https://openalex.org/W2065796798","https://openalex.org/W2066433988","https://openalex.org/W2070379981","https://openalex.org/W2075379119","https://openalex.org/W2075999310","https://openalex.org/W2082161182","https://openalex.org/W2092591319","https://openalex.org/W2093460307","https://openalex.org/W2093497067","https://openalex.org/W2093547815","https://openalex.org/W2095420958","https://openalex.org/W2099112321","https://openalex.org/W2100284567","https://openalex.org/W2101062247","https://openalex.org/W2101481219","https://openalex.org/W2103578846","https://openalex.org/W2107036878","https://openalex.org/W2108596293","https://openalex.org/W2117458899","https://openalex.org/W2121403868","https://openalex.org/W2127369588","https://openalex.org/W2128846604","https://openalex.org/W2132959008","https://openalex.org/W2136166518","https://openalex.org/W2137496915","https://openalex.org/W2141179031","https://openalex.org/W2142134255","https://openalex.org/W2142320009","https://openalex.org/W2145317354","https://openalex.org/W2145760403","https://openalex.org/W2146043630","https://openalex.org/W2149202960","https://openalex.org/W2149638071","https://openalex.org/W2152382876","https://openalex.org/W2154030500","https://openalex.org/W2159010139","https://openalex.org/W2161488169","https://openalex.org/W2162880348","https://openalex.org/W2168397649","https://openalex.org/W2170090899","https://openalex.org/W2171841882","https://openalex.org/W2401397121","https://openalex.org/W3000525006","https://openalex.org/W4246223295","https://openalex.org/W6606593943","https://openalex.org/W6614319057","https://openalex.org/W6681461337"],"related_works":["https://openalex.org/W1996644775","https://openalex.org/W1992456676","https://openalex.org/W2027886330","https://openalex.org/W2472574657","https://openalex.org/W1990964909","https://openalex.org/W101124211","https://openalex.org/W2104473363","https://openalex.org/W2096591960","https://openalex.org/W2077314991","https://openalex.org/W2559755116"],"abstract_inverted_index":{"We":[0],"investigate":[1],"changes":[2,40,132],"in":[3,31,41,90,101,104,120,144,211],"human":[4,158,194],"c-type":[5],"lysozyme":[6,77,149],"flexibility":[7,32,78,92,121,168,191],"upon":[8],"mutation":[9,113],"via":[10],"a":[11,17,71,99,115,118],"Distance":[12],"Constraint":[13],"Model,":[14],"which":[15,152,173],"gives":[16],"statistical":[18],"mechanical":[19,49],"treatment":[20],"of":[21,52,95,106,130],"network":[22],"rigidity.":[23],"Specifically,":[24,85],"two":[25],"dynamical":[26],"metrics":[27],"are":[28,58,138],"tracked.":[29],"Changes":[30],"index":[33],"quantify":[34,45],"differences":[35,46],"within":[36,47,133,170,192],"backbone":[37,91],"flexibility,":[38],"whereas":[39],"the":[42,54,96,126,131,145,171,183,193,202],"cooperativity":[43,102],"correlation":[44],"pairwise":[48],"couplings.":[50],"Regardless":[51],"metric,":[53],"same":[55],"general":[56],"conclusions":[57],"drawn.":[59],"That":[60],"is,":[61],"small":[62],"structural":[63],"perturbations":[64],"introduced":[65],"by":[66],"single":[67,134],"point":[68,135,162],"mutations":[69,163,210],"have":[70],"frequent":[72],"and":[73,98,128,195],"pronounced":[74],"affect":[75],"on":[76],"that":[79,180],"can":[80],"extend":[81],"over":[82],"long":[83],"distances.":[84],"an":[86],"appreciable":[87],"change":[88,100,119],"occurs":[89,103],"for":[93,186],"48%":[94],"residues,":[97],"42%":[105],"residue":[107],"pairs.":[108],"The":[109],"average":[110],"distance":[111],"from":[112],"to":[114,166],"site":[116,185],"with":[117,157,176],"is":[122,174,182,198],"17-20":[123],"\u00c5.":[124],"Interestingly,":[125],"frequency":[127],"scale":[129],"mutant":[136],"structures":[137],"generally":[139],"larger":[140],"than":[141],"those":[142],"observed":[143],"hen":[146],"egg":[147],"white":[148],"(HEWL)":[150],"ortholog,":[151],"shares":[153],"61%":[154],"sequence":[155,204],"identity":[156],"lysozyme.":[159],"For":[160],"example,":[161],"often":[164],"lead":[165],"substantial":[167],"increases":[169],"\u03b2-subdomain,":[172],"consistent":[175],"experimental":[177],"results":[178,207],"indicating":[179],"it":[181],"nucleation":[184],"amyloid":[187],"formation.":[188],"However,":[189],"\u03b2-subdomain":[190],"HEWL":[196,212],"orthologs":[197],"more":[199],"similar":[200],"despite":[201],"lowered":[203],"identity.":[205],"These":[206],"suggest":[208],"compensating":[209],"reestablish":[213],"desired":[214],"properties.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-28T08:01:55.173337","created_date":"2025-10-10T00:00:00"}
