{"id":"https://openalex.org/W2007899513","doi":"https://doi.org/10.1371/journal.pcbi.1002396","title":"Equation-Free Analysis of Two-Component System Signalling Model Reveals the Emergence of Co-Existing Phenotypes in the Absence of Multistationarity","display_name":"Equation-Free Analysis of Two-Component System Signalling Model Reveals the Emergence of Co-Existing Phenotypes in the Absence of Multistationarity","publication_year":2012,"publication_date":"2012-06-28","ids":{"openalex":"https://openalex.org/W2007899513","doi":"https://doi.org/10.1371/journal.pcbi.1002396","mag":"2007899513","pmid":"https://pubmed.ncbi.nlm.nih.gov/22761552"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002396","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002396","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002396&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002396&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048599143","display_name":"Rebecca B. Hoyle","orcid":"https://orcid.org/0000-0002-1645-1071"},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rebecca B. Hoyle","raw_affiliation_strings":["Department of Mathematics, University of Surrey, Guildford, United Kingdom. r.hoyle@surrey.ac.uk","Department of Mathematics , University of Surrey , Guildford , United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Surrey, Guildford, United Kingdom. r.hoyle@surrey.ac.uk","institution_ids":["https://openalex.org/I28290843"]},{"raw_affiliation_string":"Department of Mathematics , University of Surrey , Guildford , United Kingdom","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046360782","display_name":"Daniele Avitabile","orcid":"https://orcid.org/0000-0003-3714-7973"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniele Avitabile","raw_affiliation_strings":["School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015589509","display_name":"Andrzej Kierzek","orcid":"https://orcid.org/0000-0002-2605-9057"},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrzej M. Kierzek","raw_affiliation_strings":["Division of Microbial Sciences, University of Surrey, Guildford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbial Sciences, University of Surrey, Guildford, United Kingdom","institution_ids":["https://openalex.org/I28290843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048599143"],"corresponding_institution_ids":["https://openalex.org/I28290843"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":0.8732,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.71064822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"6","first_page":"e1002396","last_page":"e1002396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.7792965769767761},{"id":"https://openalex.org/keywords/master-equation","display_name":"Master equation","score":0.6237914562225342},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5972491502761841},{"id":"https://openalex.org/keywords/stochastic-process","display_name":"Stochastic process","score":0.5860583782196045},{"id":"https://openalex.org/keywords/response-regulator","display_name":"Response regulator","score":0.583303689956665},{"id":"https://openalex.org/keywords/stochastic-modelling","display_name":"Stochastic modelling","score":0.5649771690368652},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.46224239468574524},{"id":"https://openalex.org/keywords/continuous-time-stochastic-process","display_name":"Continuous-time stochastic process","score":0.44655105471611023},{"id":"https://openalex.org/keywords/bifurcation","display_name":"Bifurcation","score":0.43747448921203613},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.43596014380455017},{"id":"https://openalex.org/keywords/steady-state","display_name":"Steady state (chemistry)","score":0.4221949577331543},{"id":"https://openalex.org/keywords/histidine-kinase","display_name":"Histidine kinase","score":0.41512784361839294},{"id":"https://openalex.org/keywords/range","display_name":"Range (aeronautics)","score":0.41374245285987854},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3605191707611084},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3089587688446045},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30633431673049927},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22534969449043274},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.20722708106040955},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.17833209037780762},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.14133140444755554},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12507364153862},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.12322193384170532}],"concepts":[{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.7792965769767761},{"id":"https://openalex.org/C128805008","wikidata":"https://www.wikidata.org/wiki/Q722878","display_name":"Master equation","level":3,"score":0.6237914562225342},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5972491502761841},{"id":"https://openalex.org/C8272713","wikidata":"https://www.wikidata.org/wiki/Q176737","display_name":"Stochastic process","level":2,"score":0.5860583782196045},{"id":"https://openalex.org/C2781196521","wikidata":"https://www.wikidata.org/wiki/Q24965710","display_name":"Response regulator","level":4,"score":0.583303689956665},{"id":"https://openalex.org/C127491075","wikidata":"https://www.wikidata.org/wiki/Q7617825","display_name":"Stochastic modelling","level":2,"score":0.5649771690368652},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.46224239468574524},{"id":"https://openalex.org/C158535547","wikidata":"https://www.wikidata.org/wiki/Q5165437","display_name":"Continuous-time stochastic process","level":3,"score":0.44655105471611023},{"id":"https://openalex.org/C2781349735","wikidata":"https://www.wikidata.org/wiki/Q4904824","display_name":"Bifurcation","level":3,"score":0.43747448921203613},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.43596014380455017},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.4221949577331543},{"id":"https://openalex.org/C2778905257","wikidata":"https://www.wikidata.org/wiki/Q1620721","display_name":"Histidine kinase","level":4,"score":0.41512784361839294},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.41374245285987854},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3605191707611084},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3089587688446045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30633431673049927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22534969449043274},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.20722708106040955},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17833209037780762},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.14133140444755554},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12507364153862},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.12322193384170532},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C84114770","wikidata":"https://www.wikidata.org/wiki/Q46344","display_name":"Quantum","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002396","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002396","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002396&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22761552","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22761552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:alma.44SUR_INST:11139997190002346","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4210197018","display_name":"Open Research (University of Surrey)","issn_l":"2688-268X","issn":["2688-268X","2688-3988"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:eprints.soton.ac.uk:380225","is_oa":false,"landing_page_url":"http://doi.org/10.1371/journal.pcbi.1002396>).","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:epubs.surrey.ac.uk:718612","is_oa":false,"landing_page_url":"http://epubs.surrey.ac.uk/718612/1/HoyleAvitabileKierzek_postprint.pdf","pdf_url":"http://epubs.surrey.ac.uk/718612/1/HoyleAvitabileKierzek_postprint.pdf","source":{"id":"https://openalex.org/S4306400680","display_name":"Surrey Research Insight Open Access (The University of Surrey)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28290843","host_organization_name":"University of Surrey","host_organization_lineage":["https://openalex.org/I28290843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:2395235","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3386199","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:45a0b052f82f4ad88391d3cef329c41e","is_oa":true,"landing_page_url":"https://doaj.org/article/45a0b052f82f4ad88391d3cef329c41e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 6, p e1002396 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002396","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002396","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002396&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7300000190734863,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1293619147","display_name":"Integration of modelling with transcription and gene essentiality profiling to study interaction of MTB bacillus with macrophages and dendritic cells.","funder_award_id":"BB/I00453X/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2382994197","display_name":null,"funder_award_id":"BB/I00453X/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2666660476","display_name":null,"funder_award_id":"EP/H021779/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8235349907","display_name":"Evolution and Resilience of Industrial Ecosystems (ERIE)","funder_award_id":"EP/H021779/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320319993","display_name":"Leverhulme Trust","ror":"https://ror.org/012mzw131"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007899513.pdf","grobid_xml":"https://content.openalex.org/works/W2007899513.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1593308984","https://openalex.org/W1645304047","https://openalex.org/W1968316870","https://openalex.org/W1977063473","https://openalex.org/W1978017495","https://openalex.org/W1978329448","https://openalex.org/W1978546416","https://openalex.org/W1988507461","https://openalex.org/W2000951555","https://openalex.org/W2001074883","https://openalex.org/W2008186432","https://openalex.org/W2018258573","https://openalex.org/W2019353564","https://openalex.org/W2023083241","https://openalex.org/W2042225931","https://openalex.org/W2066253471","https://openalex.org/W2068978083","https://openalex.org/W2069488810","https://openalex.org/W2070460788","https://openalex.org/W2077737358","https://openalex.org/W2082507312","https://openalex.org/W2091198609","https://openalex.org/W2091248557","https://openalex.org/W2092620403","https://openalex.org/W2111167674","https://openalex.org/W2116738290","https://openalex.org/W2123660300","https://openalex.org/W2123716202","https://openalex.org/W2123880844","https://openalex.org/W2131766020","https://openalex.org/W2143842076","https://openalex.org/W2148323109","https://openalex.org/W2148717806","https://openalex.org/W2149886218","https://openalex.org/W2155418451","https://openalex.org/W2161251399","https://openalex.org/W2167953204","https://openalex.org/W2171228793","https://openalex.org/W3098041616","https://openalex.org/W3099658781","https://openalex.org/W3102562631","https://openalex.org/W4232212213"],"related_works":["https://openalex.org/W2141612196","https://openalex.org/W1535625299","https://openalex.org/W2278025825","https://openalex.org/W2110343075","https://openalex.org/W2093358630","https://openalex.org/W2166247218","https://openalex.org/W2085792075","https://openalex.org/W2367285648","https://openalex.org/W2010394763","https://openalex.org/W4247683679"],"abstract_inverted_index":{"Phenotypic":[0],"differences":[1],"of":[2,18,29,41,62,70,83,98,106,124,157,168,171,178,189,222,232,247,269,274],"genetically":[3],"identical":[4],"cells":[5],"under":[6],"the":[7,15,27,57,68,96,113,121,137,158,166,187,202,220,245,267,272],"same":[8,212],"environmental":[9],"conditions":[10],"have":[11,23],"been":[12,24],"attributed":[13],"to":[14,51,67,127,186,200,251],"inherent":[16],"stochasticity":[17,217,270],"biochemical":[19,254],"processes.":[20],"Various":[21],"mechanisms":[22],"suggested,":[25],"including":[26],"existence":[28],"alternative":[30,92],"steady":[31],"states":[32,164],"in":[33,87,95,219,271],"regulatory":[34],"networks":[35],"that":[36,91,117,161,175,198,216,260],"are":[37,147],"reached":[38],"by":[39,131],"means":[40],"stochastic":[42,80,133,141,159,172,209],"fluctuations,":[43],"long":[44],"transient":[45],"excursions":[46],"from":[47,112],"a":[48,63,71,78,103,144,195,228,252],"stable":[49],"state":[50],"an":[52,169,190,223],"unstable":[53],"excited":[54],"state,":[55],"and":[56,60,89,115,143,154,194,258],"switching":[58,142],"on":[59,239],"off":[61],"reaction":[64,108,255],"network":[65,256],"according":[66],"availability":[69],"constituent":[72],"chemical":[73],"species.":[74],"Here":[75],"we":[76,243],"analyse":[77],"detailed":[79,253],"kinetic":[81],"model":[82,160],"two-component":[84],"system":[85],"signalling":[86],"bacteria,":[88],"show":[90,215,259],"phenotypes":[93],"emerge":[94],"absence":[97],"these":[99],"features.":[100],"We":[101],"perform":[102],"bifurcation":[104],"analysis":[105],"deterministic":[107,240],"rate":[109],"equations":[110],"derived":[111],"model,":[114,257],"find":[116],"they":[118],"cannot":[119],"reproduce":[120],"whole":[122],"range":[123,231],"qualitative":[125],"responses":[126],"external":[128,233],"signals":[129,234],"demonstrated":[130],"direct":[132],"simulations.":[134],"In":[135],"particular,":[136],"mixed":[138,203],"mode,":[139,204],"where":[140],"graded":[145,196],"response":[146,180,197,226],"seen":[148],"simultaneously,":[149],"is":[150],"absent.":[151],"However,":[152],"probabilistic":[153],"equation-free":[155,249],"analyses":[156],"calculate":[162],"stationary":[163],"for":[165],"mean":[167],"ensemble":[170],"trajectories":[173],"reveal":[174],"slow":[176],"transcription":[177],"either":[179],"regulator":[181],"or":[182],"histidine":[183],"kinase":[184],"leads":[185],"coexistence":[188],"approximate":[191],"basal":[192],"solution":[193],"combine":[199],"produce":[201],"thus":[205],"establishing":[206],"its":[207],"essential":[208],"nature.":[210],"The":[211],"techniques":[213],"also":[214],"results":[218],"observation":[221],"all-or-none":[224],"bistable":[225],"over":[227],"much":[229],"wider":[230],"than":[235],"would":[236],"be":[237],"expected":[238],"grounds.":[241],"Thus":[242],"demonstrate":[244],"application":[246],"numerical":[248],"methods":[250],"it":[261],"can":[262],"provide":[263],"new":[264],"insight":[265],"into":[266],"role":[268],"emergence":[273],"phenotypic":[275],"diversity.":[276]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}