{"id":"https://openalex.org/W2030296875","doi":"https://doi.org/10.1371/journal.pcbi.1002371","title":"Multi-Scale Modeling of HIV Infection in vitro and APOBEC3G-Based Anti-Retroviral Therapy","display_name":"Multi-Scale Modeling of HIV Infection in vitro and APOBEC3G-Based Anti-Retroviral Therapy","publication_year":2012,"publication_date":"2012-02-09","ids":{"openalex":"https://openalex.org/W2030296875","doi":"https://doi.org/10.1371/journal.pcbi.1002371","mag":"2030296875","pmid":"https://pubmed.ncbi.nlm.nih.gov/22346743"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002371","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002371","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002371&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002371&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054479636","display_name":"Iraj Hosseini","orcid":"https://orcid.org/0000-0001-6838-773X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iraj Hosseini","raw_affiliation_strings":["Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045576072","display_name":"Feilim Mac Gabhann","orcid":"https://orcid.org/0000-0003-3481-7740"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Feilim Mac Gabhann","raw_affiliation_strings":["Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045576072"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0434,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.73798812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"2","first_page":"e1002371","last_page":"e1002371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apobec3g","display_name":"APOBEC3G","score":0.9180905222892761},{"id":"https://openalex.org/keywords/cytidine-deaminase","display_name":"Cytidine deaminase","score":0.7802915573120117},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7007542252540588},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.6869853734970093},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6356399655342102},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5158504843711853},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.496023029088974},{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.44378378987312317},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.42769479751586914},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4110300838947296},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.34317728877067566},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3009148836135864},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25327545404434204},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.2501351237297058}],"concepts":[{"id":"https://openalex.org/C2781310106","wikidata":"https://www.wikidata.org/wiki/Q14916265","display_name":"APOBEC3G","level":4,"score":0.9180905222892761},{"id":"https://openalex.org/C2776985229","wikidata":"https://www.wikidata.org/wiki/Q18021211","display_name":"Cytidine deaminase","level":3,"score":0.7802915573120117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7007542252540588},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6869853734970093},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6356399655342102},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5158504843711853},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.496023029088974},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.44378378987312317},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42769479751586914},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4110300838947296},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.34317728877067566},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3009148836135864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25327545404434204},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2501351237297058},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071480","descriptor_name":"APOBEC-3G Deaminase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071480","descriptor_name":"APOBEC-3G Deaminase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071480","descriptor_name":"APOBEC-3G Deaminase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003564","descriptor_name":"Cytidine Deaminase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054320","descriptor_name":"vif Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054320","descriptor_name":"vif Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054320","descriptor_name":"vif Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002371","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002371","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002371&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22346743","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22346743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1002371","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002371","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:3e2aff00854248078ca0ef15f48bb12d","is_oa":true,"landing_page_url":"https://doaj.org/article/3e2aff00854248078ca0ef15f48bb12d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 2, p e1002371 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/128916","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Multi_Scale_Modeling_of_HIV_Infection_in_vitro_and_APOBEC3G_Based_Anti_Retroviral_Therapy/128916","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3276540","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3276540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002371","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002371","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002371&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7900000214576721}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2030296875.pdf","grobid_xml":"https://content.openalex.org/works/W2030296875.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W105326446","https://openalex.org/W613635340","https://openalex.org/W1522687244","https://openalex.org/W1531756347","https://openalex.org/W1557952727","https://openalex.org/W1572649493","https://openalex.org/W1585397042","https://openalex.org/W1640130878","https://openalex.org/W1744129015","https://openalex.org/W1753464271","https://openalex.org/W1796915314","https://openalex.org/W1966343819","https://openalex.org/W1973398091","https://openalex.org/W1978920270","https://openalex.org/W1980462967","https://openalex.org/W1986198261","https://openalex.org/W1991069890","https://openalex.org/W1992738293","https://openalex.org/W1993897877","https://openalex.org/W1994531792","https://openalex.org/W1995117749","https://openalex.org/W1995753924","https://openalex.org/W1996233798","https://openalex.org/W2001375348","https://openalex.org/W2004640739","https://openalex.org/W2005094593","https://openalex.org/W2005813015","https://openalex.org/W2009378735","https://openalex.org/W2011630381","https://openalex.org/W2012564250","https://openalex.org/W2014067586","https://openalex.org/W2014914975","https://openalex.org/W2017585121","https://openalex.org/W2020862462","https://openalex.org/W2022098233","https://openalex.org/W2023035407","https://openalex.org/W2024302505","https://openalex.org/W2029930485","https://openalex.org/W2030205508","https://openalex.org/W2030844138","https://openalex.org/W2032235371","https://openalex.org/W2032567002","https://openalex.org/W2033464993","https://openalex.org/W2040502797","https://openalex.org/W2049780088","https://openalex.org/W2054310224","https://openalex.org/W2059300778","https://openalex.org/W2061536824","https://openalex.org/W2064059889","https://openalex.org/W2065608903","https://openalex.org/W2071271697","https://openalex.org/W2076559238","https://openalex.org/W2076575760","https://openalex.org/W2078614030","https://openalex.org/W2080527819","https://openalex.org/W2082291203","https://openalex.org/W2083283696","https://openalex.org/W2084938297","https://openalex.org/W2089797553","https://openalex.org/W2094624624","https://openalex.org/W2096197897","https://openalex.org/W2098183178","https://openalex.org/W2104808073","https://openalex.org/W2105451542","https://openalex.org/W2105893126","https://openalex.org/W2107551331","https://openalex.org/W2108623691","https://openalex.org/W2110013539","https://openalex.org/W2111949375","https://openalex.org/W2114328298","https://openalex.org/W2122579172","https://openalex.org/W2124681852","https://openalex.org/W2127713363","https://openalex.org/W2131531822","https://openalex.org/W2139033519","https://openalex.org/W2139455598","https://openalex.org/W2142678763","https://openalex.org/W2143148297","https://openalex.org/W2146827846","https://openalex.org/W2149138273","https://openalex.org/W2149643442","https://openalex.org/W2152480547","https://openalex.org/W2153977602","https://openalex.org/W2157876432","https://openalex.org/W2160935824","https://openalex.org/W2166434950","https://openalex.org/W2166711458","https://openalex.org/W2167917127","https://openalex.org/W2168736565","https://openalex.org/W2177381833","https://openalex.org/W3124539787","https://openalex.org/W4232273699"],"related_works":["https://openalex.org/W1515041121","https://openalex.org/W4301759136","https://openalex.org/W2055187903","https://openalex.org/W2126801736","https://openalex.org/W2033631070","https://openalex.org/W2023255625","https://openalex.org/W4291398905","https://openalex.org/W2041401655","https://openalex.org/W2808735207","https://openalex.org/W2068742284"],"abstract_inverted_index":{"The":[0,65,230,249],"human":[1],"APOBEC3G":[2],"is":[3,206,260],"an":[4,183],"innate":[5],"restriction":[6],"factor":[7],"that,":[8],"in":[9,24,140,166,265],"the":[10,92,96,111,127,137,163,171,217,234,243,254],"absence":[11],"of":[12,21,39,52,79,88,102,107,139,150,155,177,188,193,236,256],"Vif,":[13],"restricts":[14],"HIV-1":[15],"replication":[16],"by":[17,60,122,135,258],"inducing":[18],"excessive":[19],"deamination":[20],"cytidine":[22],"residues":[23],"nascent":[25],"reverse":[26,30],"transcripts":[27],"and":[28,32,56,77,81,84,86,99,153,190,239],"inhibiting":[29],"transcription":[31],"integration.":[33],"To":[34],"shed":[35],"light":[36],"on":[37,42,246],"impact":[38],"A3G-Vif":[40],"interactions":[41],"HIV":[43,247,266],"replication,":[44],"we":[45,221],"developed":[46],"a":[47,105,201,262],"multi-scale":[48],"computational":[49],"system":[50],"consisting":[51],"intracellular":[53],"(single-cell),":[54],"cellular":[55],"extracellular":[57],"(multicellular)":[58],"events":[59,70],"using":[61],"ordinary":[62],"differential":[63],"equations.":[64],"single-cell":[66],"model":[67,94,112,134,172,228,250],"describes":[68,95],"molecular-level":[69],"within":[71,104],"individual":[72],"cells":[73],"(such":[74],"as":[75],"production":[76],"degradation":[78,255],"host":[80],"viral":[82,97,156],"proteins,":[83],"assembly":[85],"release":[87,241],"new":[89],"virions),":[90],"whereas":[91],"multicellular":[93],"dynamics":[98],"multiple":[100],"cycles":[101],"infection":[103],"population":[106],"cells.":[108],"We":[109,130,168],"estimated":[110],"parameters":[113],"either":[114],"directly":[115],"from":[116],"previously":[117],"published":[118],"experimental":[119,164],"data":[120],"or":[121],"running":[123],"simulations":[124],"to":[125,161,173,185,196,208,225],"find":[126],"optimum":[128],"values.":[129],"validated":[131],"our":[132,197],"integrated":[133],"reproducing":[136],"results":[138,165,231],"vitro":[141],"T":[142],"cell":[143],"culture":[144],"experiments.":[145],"Crucially,":[146],"both":[147],"downstream":[148],"effects":[149],"A3G":[151,199,257],"(hypermutation":[152],"reduction":[154],"burst":[157],"size)":[158],"were":[159],"necessary":[160],"replicate":[162],"silico.":[167],"also":[169,251],"used":[170],"study":[174],"anti-HIV":[175],"capability":[176],"several":[178],"possible":[179],"therapeutic":[180],"strategies":[181],"including:":[182],"antibody":[184],"Vif;":[186],"upregulation":[187],"A3G;":[189],"mutated":[191,202],"forms":[192],"A3G.":[194],"According":[195],"simulations,":[198],"with":[200],"Vif":[203,259],"binding":[204],"site":[205],"predicted":[207,252],"be":[209],"significantly":[210],"more":[211],"effective":[212],"than":[213],"other":[214],"molecules":[215],"at":[216],"same":[218],"dose.":[219],"Ultimately,":[220],"performed":[222],"sensitivity":[223],"analysis":[224],"identify":[226],"important":[227],"parameters.":[229],"showed":[232],"that":[233,253],"timing":[235],"particle":[237],"formation":[238],"virus":[240],"had":[242],"highest":[244],"impacts":[245],"replication.":[248],"not":[261],"crucial":[263],"step":[264],"pathogenesis.":[267]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-07-08T08:33:18.762332","created_date":"2025-10-10T00:00:00"}
