{"id":"https://openalex.org/W1997494129","doi":"https://doi.org/10.1371/journal.pcbi.1002330","title":"Joint Modelling of Confounding Factors and Prominent Genetic Regulators Provides Increased Accuracy in Genetical Genomics Studies","display_name":"Joint Modelling of Confounding Factors and Prominent Genetic Regulators Provides Increased Accuracy in Genetical Genomics Studies","publication_year":2012,"publication_date":"2012-01-05","ids":{"openalex":"https://openalex.org/W1997494129","doi":"https://doi.org/10.1371/journal.pcbi.1002330","mag":"1997494129","pmid":"https://pubmed.ncbi.nlm.nih.gov/22241974"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002330","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002330","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002330&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002330&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021028602","display_name":"Nicol\u00f2 Fusi","orcid":"https://orcid.org/0000-0002-4102-0169"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nicol\u00f3 Fusi","raw_affiliation_strings":["Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom. nicolo.fusi@sheffield.ac.uk","Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom. nicolo.fusi@sheffield.ac.uk","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091002491","display_name":"Oliver Stegle","orcid":"https://orcid.org/0000-0002-8818-7193"},"institutions":[{"id":"https://openalex.org/I4210135521","display_name":"Max Planck Institute for Intelligent Systems","ror":"https://ror.org/04fq9j139","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210135521"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Oliver Stegle","raw_affiliation_strings":["Machine Learning and Computational Biology Research Group, Max Planck Institute for Developmental Biology, T\u00fcbingen, Germany","Research Group Machine Learning and Computational Biology, Max Planck Institute for Intelligent Systems, Max Planck Society"],"affiliations":[{"raw_affiliation_string":"Machine Learning and Computational Biology Research Group, Max Planck Institute for Developmental Biology, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]},{"raw_affiliation_string":"Research Group Machine Learning and Computational Biology, Max Planck Institute for Intelligent Systems, Max Planck Society","institution_ids":["https://openalex.org/I4210135521","https://openalex.org/I149899117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023849469","display_name":"Neil D. Lawrence","orcid":"https://orcid.org/0000-0001-9258-1030"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Neil D. Lawrence","raw_affiliation_strings":["Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021028602","https://openalex.org/A5023849469","https://openalex.org/A5091002491"],"corresponding_institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210112458","https://openalex.org/I4210135521","https://openalex.org/I91136226"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":8.4896,"has_fulltext":true,"cited_by_count":120,"citation_normalized_percentile":{"value":0.98098025,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"e1002330","last_page":"e1002330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.843664824962616},{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.8414579033851624},{"id":"https://openalex.org/keywords/confounding","display_name":"Confounding","score":0.6957643032073975},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.6078518629074097},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5588318705558777},{"id":"https://openalex.org/keywords/covariate","display_name":"Covariate","score":0.49901366233825684},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.46897587180137634},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.4642859697341919},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.45976465940475464},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4588713049888611},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42979884147644043},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.4293835759162903},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.42604291439056396},{"id":"https://openalex.org/keywords/panama","display_name":"Panama","score":0.4208582937717438},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39940232038497925},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3597102761268616},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3559235632419586},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.32577943801879883},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2741173505783081},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1761302649974823},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16013413667678833},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.13169974088668823},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.12483048439025879},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.11123073101043701},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.10017004609107971}],"concepts":[{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.843664824962616},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.8414579033851624},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.6957643032073975},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.6078518629074097},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5588318705558777},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.49901366233825684},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.46897587180137634},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.4642859697341919},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.45976465940475464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4588713049888611},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42979884147644043},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4293835759162903},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.42604291439056396},{"id":"https://openalex.org/C2779234422","wikidata":"https://www.wikidata.org/wiki/Q3359556","display_name":"Panama","level":2,"score":0.4208582937717438},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39940232038497925},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3597102761268616},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3559235632419586},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.32577943801879883},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2741173505783081},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1761302649974823},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16013413667678833},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.13169974088668823},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.12483048439025879},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.11123073101043701},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.10017004609107971},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015986","descriptor_name":"Confounding Factors, Epidemiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015986","descriptor_name":"Confounding Factors, Epidemiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015986","descriptor_name":"Confounding Factors, Epidemiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1371/journal.pcbi.1002330","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002330","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002330&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22241974","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22241974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:eprints.whiterose.ac.uk:108794","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002330","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002330","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4b6151bc571d47f289677404c95410ea","is_oa":true,"landing_page_url":"https://doaj.org/article/4b6151bc571d47f289677404c95410ea","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 8, Iss 1, p e1002330 (2012)","raw_type":"article"},{"id":"pmh:oai:escidoc.org:escidoc:1787783","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0013-B860-E","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:2263472","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3252274","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/129932","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Joint_Modelling_of_Confounding_Factors_and_Prominent_Genetic_Regulators_Provides_Increased_Accuracy_in_Genetical_Genomics_Studies/129932","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.mpg.de:item_1703353","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-000E-EA89-C","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_1746917","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-000E-FDD4-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/300877","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/300877","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.47952","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.47952","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002330","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002330","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002330&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320291","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27"},{"id":"https://openalex.org/F4320320342","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044"},{"id":"https://openalex.org/F4320320882","display_name":"Volkswagen Foundation","ror":"https://ror.org/03bsmfz84"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997494129.pdf","grobid_xml":"https://content.openalex.org/works/W1997494129.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1585006589","https://openalex.org/W1967874493","https://openalex.org/W1972698844","https://openalex.org/W1973455222","https://openalex.org/W1986911601","https://openalex.org/W1990987722","https://openalex.org/W2027455260","https://openalex.org/W2038225430","https://openalex.org/W2041467022","https://openalex.org/W2048612325","https://openalex.org/W2053818267","https://openalex.org/W2059742736","https://openalex.org/W2079927753","https://openalex.org/W2088486634","https://openalex.org/W2094248448","https://openalex.org/W2102751249","https://openalex.org/W2107665951","https://openalex.org/W2112087830","https://openalex.org/W2116944195","https://openalex.org/W2117007075","https://openalex.org/W2127684760","https://openalex.org/W2134036574","https://openalex.org/W2137499573","https://openalex.org/W2157752701","https://openalex.org/W2166469005","https://openalex.org/W2169986196"],"related_works":["https://openalex.org/W2322917389","https://openalex.org/W2885711405","https://openalex.org/W2325250610","https://openalex.org/W4212875151","https://openalex.org/W1973455222","https://openalex.org/W3120350366","https://openalex.org/W2071852132","https://openalex.org/W4384126845","https://openalex.org/W2095234911","https://openalex.org/W2100045083"],"abstract_inverted_index":{"Expression":[0],"quantitative":[1],"trait":[2],"loci":[3],"(eQTL)":[4],"studies":[5,27],"are":[6,28,169],"an":[7,85],"integral":[8],"tool":[9],"to":[10,79,90,129],"investigate":[11],"the":[12,23,51,99],"genetic":[13,63,103,116],"component":[14],"of":[15,25,72,101,162,184],"gene":[16],"expression":[17,52],"variation.":[18,121],"A":[19,181],"major":[20],"challenge":[21],"in":[22,50,147],"analysis":[24],"such":[26,32],"hidden":[29,95],"confounding":[30,82,120],"factors,":[31],"as":[33],"unobserved":[34],"covariates":[35],"or":[36,60],"unknown":[37],"subtle":[38],"environmental":[39],"perturbations.":[40],"These":[41],"factors":[42,83,96],"can":[43,111,174],"induce":[44],"a":[45,75,106,159],"pronounced":[46],"artifactual":[47],"correlation":[48],"structure":[49],"profiles,":[53],"which":[54],"may":[55],"create":[56],"spurious":[57],"false":[58],"associations":[59],"mask":[61],"real":[62],"association":[64,117],"signals.":[65],"Here,":[66],"we":[67],"report":[68],"PANAMA":[69,93,138,185],"(Probabilistic":[70],"ANAlysis":[71],"genoMic":[73],"dAta),":[74],"novel":[76],"probabilistic":[77],"model":[78,110,125],"account":[80],"for":[81],"within":[84],"eQTL":[86],"analysis.":[87],"In":[88],"contrast":[89],"previous":[91],"methods,":[92,144],"learns":[94],"jointly":[97],"with":[98],"effect":[100],"prominent":[102],"regulators.":[104,152],"As":[105],"result,":[107],"this":[108],"new":[109],"more":[112,150,171],"accurately":[113],"distinguish":[114],"true":[115],"signals":[118],"from":[119],"We":[122],"applied":[123],"our":[124,154],"and":[126,135,145,173],"compared":[127],"it":[128],"existing":[130],"methods":[131],"on":[132],"different":[133],"datasets":[134],"biological":[136],"systems.":[137],"consistently":[139],"performs":[140],"better":[141,176],"than":[142],"alternative":[143],"finds":[146],"particular":[148],"substantially":[149],"trans":[151],"Importantly,":[153],"approach":[155],"not":[156],"only":[157],"identifies":[158],"greater":[160],"number":[161],"associations,":[163],"but":[164],"also":[165],"yields":[166],"hits":[167],"that":[168],"biologically":[170],"plausible":[172],"be":[175],"reproduced":[177],"between":[178],"independent":[179],"studies.":[180],"software":[182],"implementation":[183],"is":[186],"freely":[187],"available":[188],"online":[189],"at":[190],"http://ml.sheffield.ac.uk/qtl/.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
