{"id":"https://openalex.org/W1967019376","doi":"https://doi.org/10.1371/journal.pcbi.1002313","title":"Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome","display_name":"Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome","publication_year":2011,"publication_date":"2011-12-15","ids":{"openalex":"https://openalex.org/W1967019376","doi":"https://doi.org/10.1371/journal.pcbi.1002313","mag":"1967019376","pmid":"https://pubmed.ncbi.nlm.nih.gov/22194679"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002313","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002313","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002313&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002313&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043366341","display_name":"Ismail Adeniran","orcid":"https://orcid.org/0000-0002-9775-3249"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ismail Adeniran","raw_affiliation_strings":["Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, UK","\u2002Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"\u2002Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111687921","display_name":"Mark J. McPate","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark J. McPate","raw_affiliation_strings":["Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, Bristol, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043507909","display_name":"Harry J. Witchel","orcid":"https://orcid.org/0000-0001-8404-3494"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harry J. Witchel","raw_affiliation_strings":["Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, Bristol, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037737415","display_name":"Jules C. Hancox","orcid":"https://orcid.org/0000-0002-2055-6482"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jules C. Hancox","raw_affiliation_strings":["Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, Bristol, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043271142","display_name":"Henggui Zhang","orcid":"https://orcid.org/0000-0002-0863-5807"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Henggui Zhang","raw_affiliation_strings":["Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037737415","https://openalex.org/A5043271142"],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.5537,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.89984845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"12","first_page":"e1002313","last_page":"e1002313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herg","display_name":"hERG","score":0.943693995475769},{"id":"https://openalex.org/keywords/short-qt-syndrome","display_name":"Short QT syndrome","score":0.8625036478042603},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.6401671767234802},{"id":"https://openalex.org/keywords/ventricle","display_name":"Ventricle","score":0.6394128799438477},{"id":"https://openalex.org/keywords/repolarization","display_name":"Repolarization","score":0.6326481699943542},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.5979050397872925},{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.593451201915741},{"id":"https://openalex.org/keywords/long-qt-syndrome","display_name":"Long QT syndrome","score":0.5510917901992798},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4379293918609619},{"id":"https://openalex.org/keywords/torsades-de-pointes","display_name":"Torsades de pointes","score":0.4222966432571411},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.36937063932418823},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32371091842651367},{"id":"https://openalex.org/keywords/potassium-channel","display_name":"Potassium channel","score":0.30628567934036255},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.2529340088367462}],"concepts":[{"id":"https://openalex.org/C2779362680","wikidata":"https://www.wikidata.org/wiki/Q905000","display_name":"hERG","level":3,"score":0.943693995475769},{"id":"https://openalex.org/C2779578097","wikidata":"https://www.wikidata.org/wiki/Q1484058","display_name":"Short QT syndrome","level":4,"score":0.8625036478042603},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6401671767234802},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.6394128799438477},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.6326481699943542},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5979050397872925},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.593451201915741},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.5510917901992798},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4379293918609619},{"id":"https://openalex.org/C2780486423","wikidata":"https://www.wikidata.org/wiki/Q1625433","display_name":"Torsades de pointes","level":3,"score":0.4222966432571411},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36937063932418823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32371091842651367},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.30628567934036255},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.2529340088367462},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":14,"locations":[{"id":"doi:10.1371/journal.pcbi.1002313","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002313","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002313&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22194679","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22194679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.835.1712","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.835.1712","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"http://research-information.bristol.ac.uk/files/7034979/journal.pcbi.1002313_1_.pdf","raw_type":"text"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire/482262ea-8e0e-493b-8cf1-1628e67ddba7","is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/482262ea-8e0e-493b-8cf1-1628e67ddba7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adeniran, I, McPate, MJW, Witchel, HJ, Hancox, JC & Zhang, H 2011, 'Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome', PLOS Computational Biology, vol. 12, no. 7, pp. e1002313. https://doi.org/10.1371/journal.pcbi.1002313","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.287.9665","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.287.9665","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c6/01/PLoS_Comput_Biol_2011_Dec_15_7(12)_e1002313.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002313","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002313","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:06ac06a0e37741b6b5cbcb200f346eeb","is_oa":true,"landing_page_url":"https://doaj.org/article/06ac06a0e37741b6b5cbcb200f346eeb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 12, p e1002313 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/130586","is_oa":true,"landing_page_url":"https://figshare.com/articles/Increased_Vulnerability_of_Human_Ventricle_to_Re_entrant_Excitation_in_hERG_linked_Variant_1_Short_QT_Syndrome/130586","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:figshare.com:article/23390534","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Increased_vulnerability_of_human_ventricle_to_re-entrant_excitation_in_hERG-linked_variant_1_short_QT_syndrome/23390534","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3240585","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3240585","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ea2bdb17-4156-4885-ae06-6c4f979333e2","is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/ea2bdb17-4156-4885-ae06-6c4f979333e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Adeniran, I, McPate, M J, Witchel, H J, Hancox, J C & Zhang, H 2011, 'Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome', PL o S Computational Biology, vol. 7, no. 12, e1002313. https://doi.org/10.1371/journal.pcbi.1002313","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:publications/ea2bdb17-4156-4885-ae06-6c4f979333e2","is_oa":false,"landing_page_url":"https://www.research.manchester.ac.uk/portal/en/publications/increased-vulnerability-of-human-ventricle-to-reentrant-excitation-in-herglinked-variant-1-short-qt-syndrome(ea2bdb17-4156-4885-ae06-6c4f979333e2).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:research-information.bris.ac.uk:publications/482262ea-8e0e-493b-8cf1-1628e67ddba7","is_oa":false,"landing_page_url":"https://hdl.handle.net/1983/482262ea-8e0e-493b-8cf1-1628e67ddba7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:sro.sussex.ac.uk:42065","is_oa":true,"landing_page_url":"http://sro.sussex.ac.uk/id/eprint/42065/1/journal.pcbi.1002313.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400129","display_name":"Sussex Research Online (University of Sussex)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I162608824","host_organization_name":"University of Sussex","host_organization_lineage":["https://openalex.org/I162608824"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002313","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002313","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002313&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3479487697","display_name":"BeatBox - HPC Environment for Biophysically and Anatomically Realistic Cardiac Simulations","funder_award_id":"EP/I029664/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5953223706","display_name":null,"funder_award_id":"PG/03/140/16236","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G6171266463","display_name":null,"funder_award_id":"EP/I030158/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6999771811","display_name":"BeatBox - HPC Environment for Biophysically and Anatomically Realistic Cardiac Simulations","funder_award_id":"EP/I029826/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G704554160","display_name":null,"funder_award_id":"EP/I029826/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7647634098","display_name":"BeatBox - HPC Environment for Biophysically and Anatomically Realistic Cardiac Simulations","funder_award_id":"EP/I030158/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G834161072","display_name":null,"funder_award_id":"EP/I029664/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8548008881","display_name":"\u57fa\u4e8e\u8ba1\u7b97\u5fc3\u810f\u6a21\u578b\u7684\u9057\u4f20\u6027\u77edQT\u7efc\u5408\u5f81\u53d1\u75c5\u673a\u5236\u7684\u7814\u7a76","funder_award_id":"61179009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1967019376.pdf","grobid_xml":"https://content.openalex.org/works/W1967019376.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W44838522","https://openalex.org/W59881567","https://openalex.org/W64123695","https://openalex.org/W1493802451","https://openalex.org/W1565060778","https://openalex.org/W1606576717","https://openalex.org/W1965633790","https://openalex.org/W1970863389","https://openalex.org/W1988498011","https://openalex.org/W1995281013","https://openalex.org/W1997071795","https://openalex.org/W2003251032","https://openalex.org/W2007825638","https://openalex.org/W2009517266","https://openalex.org/W2022583158","https://openalex.org/W2025470533","https://openalex.org/W2026247776","https://openalex.org/W2034287343","https://openalex.org/W2036041154","https://openalex.org/W2037832050","https://openalex.org/W2045548568","https://openalex.org/W2046995007","https://openalex.org/W2050841780","https://openalex.org/W2051248612","https://openalex.org/W2057663793","https://openalex.org/W2058240154","https://openalex.org/W2061451182","https://openalex.org/W2072672465","https://openalex.org/W2083749359","https://openalex.org/W2089431016","https://openalex.org/W2092718904","https://openalex.org/W2093186412","https://openalex.org/W2098878594","https://openalex.org/W2101929104","https://openalex.org/W2102295719","https://openalex.org/W2102313919","https://openalex.org/W2102516854","https://openalex.org/W2103111465","https://openalex.org/W2107658445","https://openalex.org/W2115765852","https://openalex.org/W2120263248","https://openalex.org/W2121217634","https://openalex.org/W2126036157","https://openalex.org/W2129393568","https://openalex.org/W2130321115","https://openalex.org/W2132249803","https://openalex.org/W2133315076","https://openalex.org/W2136755991","https://openalex.org/W2144148024","https://openalex.org/W2154806697","https://openalex.org/W2156609021","https://openalex.org/W2158824271","https://openalex.org/W2159561758","https://openalex.org/W2161424604","https://openalex.org/W2163071496","https://openalex.org/W2183380071","https://openalex.org/W2989128237","https://openalex.org/W3152342844","https://openalex.org/W4236987721","https://openalex.org/W6845249868"],"related_works":["https://openalex.org/W2012930217","https://openalex.org/W4250549632","https://openalex.org/W1971881653","https://openalex.org/W2180517827","https://openalex.org/W1997071795","https://openalex.org/W2388475879","https://openalex.org/W2338395168","https://openalex.org/W2004232572","https://openalex.org/W1970481980","https://openalex.org/W3045583965"],"abstract_inverted_index":{"The":[0],"short":[1],"QT":[2,13],"syndrome":[3],"(SQTS)":[4],"is":[5],"a":[6,96],"genetically":[7],"heterogeneous":[8],"condition":[9],"characterized":[10],"by":[11],"abbreviated":[12,107],"intervals":[14],"and":[15,21,82,85,88,94,116,134,181,209,219,227,250,262],"an":[16],"increased":[17,202],"susceptibility":[18],"to":[19,48,51,145,179,190,211,233],"arrhythmia":[20],"sudden":[22],"death.":[23],"This":[24,126],"simulation":[25],"study":[26],"identifies":[27],"arrhythmogenic":[28],"mechanisms":[29],"in":[30,55,128,160,183,193,201,243,268],"the":[31,40,62,104,118,136,161,167,175,223,234,245,256,263],"rapid-delayed":[32],"rectifier":[33],"K(+)":[34],"current":[35],"(I(Kr))-linked":[36],"SQT1":[37,244],"variant":[38],"of":[39,61,132,135,154,157,197,213,252,258,265],"SQTS.":[41],"Markov":[42],"chain":[43],"(MC)":[44],"models":[45,54,71,81],"were":[46,72],"found":[47,189],"be":[49,146,191],"superior":[50],"Hodgkin-Huxley":[52],"(HH)":[53],"reproducing":[56],"experimental":[57],"data":[58],"regarding":[59],"effects":[60,141],"N588K":[63,105,176,224],"mutation":[64,106,177,225,247],"on":[65,166],"KCNH2-encoded":[66],"hERG.":[67],"These":[68],"ionic":[69],"channel":[70],"then":[73],"incorporated":[74],"into":[75,83,95],"human":[76],"ventricular":[77,91,108,170,253],"action":[78],"potential":[79],"(AP)":[80],"1D":[84],"2D":[86,218],"idealised":[87],"realistic":[89],"transmural":[90,120,130,155],"tissue":[92,163,203,221],"simulations":[93],"3D":[97,220,269],"anatomical":[98],"model.":[99],"In":[100,217],"single":[101],"cell":[102,109],"models,":[103,222],"AP":[110],"duration":[111],"at":[112],"90%":[113],"repolarization":[114],"(APD(90))":[115],"decreased":[117,129],"maximal":[119],"voltage":[121],"heterogeneity":[122,131,156],"(\u03b4V)":[123],"during":[124],"APs.":[125],"resulted":[127],"APD(90)":[133],"effective":[137],"refractory":[138],"period":[139],"(ERP):":[140],"that":[142],"are":[143],"anticipated":[144],"anti-arrhythmic":[147],"rather":[148],"than":[149],"pro-arrhythmic.":[150],"However,":[151],"with":[152],"consideration":[153],"I(Kr)":[158],"density":[159],"intact":[162],"model":[164],"based":[165],"ten":[168],"Tusscher-Noble-Noble-Panfilov":[169],"model,":[171],"not":[172],"only":[173],"did":[174],"lead":[178],"QT-shortening":[180],"increases":[182],"T-wave":[184],"amplitude,":[185],"but":[186],"\u03b4V":[187],"was":[188],"augmented":[192],"some":[194],"local":[195],"regions":[196],"ventricle":[198],"tissue,":[199],"resulting":[200],"vulnerability":[204],"for":[205,239],"uni-directional":[206],"conduction":[207],"block":[208],"predisposing":[210],"formation":[212],"re-entrant":[214,229,259],"excitation":[215,230],"waves.":[216],"facilitated":[226],"maintained":[228],"waves":[231,261,267],"due":[232],"reduced":[235],"substrate":[236],"size":[237],"necessary":[238],"sustaining":[240],"re-entry.":[241],"Thus,":[242],"N588K-hERG":[246],"facilitates":[248],"initiation":[249],"maintenance":[251],"re-entry,":[254],"increasing":[255],"lifespan":[257],"spiral":[260],"stability":[264],"scroll":[266],"tissue.":[270]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}