{"id":"https://openalex.org/W2036484650","doi":"https://doi.org/10.1371/journal.pcbi.1002290","title":"Dynamics of Mutant Cells in Hierarchical Organized Tissues","display_name":"Dynamics of Mutant Cells in Hierarchical Organized Tissues","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2036484650","doi":"https://doi.org/10.1371/journal.pcbi.1002290","mag":"2036484650","pmid":"https://pubmed.ncbi.nlm.nih.gov/22144884"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002290","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002290","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002290&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002290&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069836964","display_name":"Benjamin Werner","orcid":"https://orcid.org/0000-0002-6857-8699"},"institutions":[{"id":"https://openalex.org/I4210152351","display_name":"Max Planck Institute for Evolutionary Biology","ror":"https://ror.org/0534re684","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152351"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Benjamin Werner","raw_affiliation_strings":["Evolutionary Theory Group, Max-Planck-Institute for Evolutionary Biology, Pl\u00f6n, Germany. werner@evolbio.mpg.de","Evolutionary Theory Group; Max Planck Institute for Evolutionary Biology; Pl\u00f6n Germany"],"affiliations":[{"raw_affiliation_string":"Evolutionary Theory Group, Max-Planck-Institute for Evolutionary Biology, Pl\u00f6n, Germany. werner@evolbio.mpg.de","institution_ids":["https://openalex.org/I4210152351"]},{"raw_affiliation_string":"Evolutionary Theory Group; Max Planck Institute for Evolutionary Biology; Pl\u00f6n Germany","institution_ids":["https://openalex.org/I4210152351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007747233","display_name":"David Dingli","orcid":"https://orcid.org/0000-0001-7477-3004"},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"funder","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Dingli","raw_affiliation_strings":["Division of Hematology, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003581663","display_name":"Tom Lenaerts","orcid":"https://orcid.org/0000-0003-3645-1455"},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Tom Lenaerts","raw_affiliation_strings":["AI-LAB Computer Science Department, Vrije Universiteit Brussel, Brussels, Belgium","MLG, D\u00e9partement d'Informatique, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"],"affiliations":[{"raw_affiliation_string":"AI-LAB Computer Science Department, Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"MLG, D\u00e9partement d'Informatique, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073403497","display_name":"Jorge M. Pacheco","orcid":"https://orcid.org/0000-0002-2579-8499"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jorge M. Pacheco","raw_affiliation_strings":["ATP-group, CMAF, Lisboa, Portugal","Departmento de Matem\u00e1tica e Aplicac\u00f5es, Universidade do Minho, Braga, Portugal"],"affiliations":[{"raw_affiliation_string":"ATP-group, CMAF, Lisboa, Portugal","institution_ids":[]},{"raw_affiliation_string":"Departmento de Matem\u00e1tica e Aplicac\u00f5es, Universidade do Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041250586","display_name":"Arne Traulsen","orcid":"https://orcid.org/0000-0002-0669-5267"},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210152351","display_name":"Max Planck Institute for Evolutionary Biology","ror":"https://ror.org/0534re684","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152351"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Arne Traulsen","raw_affiliation_strings":["Evolutionary Theory Group, Max-Planck-Institute for Evolutionary Biology, Pl\u00f6n, Germany","Research Group Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society"],"affiliations":[{"raw_affiliation_string":"Evolutionary Theory Group, Max-Planck-Institute for Evolutionary Biology, Pl\u00f6n, Germany","institution_ids":["https://openalex.org/I4210152351"]},{"raw_affiliation_string":"Research Group Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society","institution_ids":["https://openalex.org/I4210152351","https://openalex.org/I149899117"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5041250586","https://openalex.org/A5069836964"],"corresponding_institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210152351"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2004,"currency":"EUR","value_usd":2161},"fwci":3.109,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.90056754,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"7","issue":"12","first_page":"e1002290","last_page":"e1002290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9846000075340271,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.8091197609901428},{"id":"https://openalex.org/keywords/compartment","display_name":"Compartment (ship)","score":0.7550110816955566},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.6414873003959656},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6201117634773254},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.5637898445129395},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5511684417724609},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.545474648475647},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.5282796025276184},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4790709912776947},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.47126245498657227},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4383960962295532},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3978157341480255},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3610527515411377},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.27837231755256653},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.16475006937980652},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.12379458546638489},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0906105637550354}],"concepts":[{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.8091197609901428},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.7550110816955566},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6414873003959656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6201117634773254},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5637898445129395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5511684417724609},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.545474648475647},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5282796025276184},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4790709912776947},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.47126245498657227},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4383960962295532},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3978157341480255},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3610527515411377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27837231755256653},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16475006937980652},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12379458546638489},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0906105637550354},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048708","descriptor_name":"Cell Growth Processes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":13,"locations":[{"id":"doi:10.1371/journal.pcbi.1002290","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002290","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002290&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22144884","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22144884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.666.4024","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.666.4024","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228763/pdf/pcbi.1002290.pdf","raw_type":"text"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/106222","is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/106222","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, 7 (12","raw_type":"info:ulb-repo/semantics/openurl/article"},{"id":"pmh:oai:doaj.org/article:9e6a84b9de8547e2915cbb058522089d","is_oa":true,"landing_page_url":"https://doaj.org/article/9e6a84b9de8547e2915cbb058522089d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 12, p e1002290 (2011)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:578932","is_oa":false,"landing_page_url":"http://edoc.mpg.de/578932","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, v.7 (2011)","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:2238901","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3228763","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/130915","is_oa":true,"landing_page_url":"https://figshare.com/articles/Dynamics_of_Mutant_Cells_in_Hierarchical_Organized_Tissues/130915","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.mpg.de:item_1504984","is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-000F-D379-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/63300","is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/63300","pdf_url":null,"source":{"id":"https://openalex.org/S4306401240","display_name":"Reposit\u00f3riUM (Universidade do Minho)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99682543","host_organization_name":"University of Minho","host_organization_lineage":["https://openalex.org/I99682543"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:oai:repositorium.uminho.pt:1822/63300","is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/63300","pdf_url":null,"source":{"id":"https://openalex.org/S4306400624","display_name":"Reposit\u00f3riUM (Universidade do Minho)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99682543","host_organization_name":"University of Minho","host_organization_lineage":["https://openalex.org/I99682543"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:249535","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:70887","is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/dynamics-of-mutant-cells-in-hierarchical-organized-tissues(040896c9-c302-4994-bc4c-4ae8fba341ab).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002290","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002290","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002290&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1476661848","display_name":null,"funder_award_id":"Emmy-Noether","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4674357998","display_name":null,"funder_award_id":"FRS-FNRS","funder_id":"https://openalex.org/F4320321390","funder_display_name":"Fonds De La Recherche Scientifique - FNRS"}],"funders":[{"id":"https://openalex.org/F4320320875","display_name":"Deutscher Akademischer Austauschdienst","ror":"https://ror.org/039djdh30"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2036484650.pdf","grobid_xml":"https://content.openalex.org/works/W2036484650.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W126560450","https://openalex.org/W349368958","https://openalex.org/W1490477296","https://openalex.org/W1608329801","https://openalex.org/W1964562290","https://openalex.org/W1966909327","https://openalex.org/W1969399579","https://openalex.org/W1970511662","https://openalex.org/W1974559436","https://openalex.org/W1977905227","https://openalex.org/W1978675332","https://openalex.org/W1983199521","https://openalex.org/W1983217510","https://openalex.org/W2000362335","https://openalex.org/W2005327191","https://openalex.org/W2007570264","https://openalex.org/W2009331316","https://openalex.org/W2014600438","https://openalex.org/W2021546920","https://openalex.org/W2024561170","https://openalex.org/W2040649840","https://openalex.org/W2042038557","https://openalex.org/W2042321087","https://openalex.org/W2043619435","https://openalex.org/W2043946899","https://openalex.org/W2045496844","https://openalex.org/W2045662960","https://openalex.org/W2046429640","https://openalex.org/W2054345991","https://openalex.org/W2059729544","https://openalex.org/W2068409711","https://openalex.org/W2071558290","https://openalex.org/W2076372887","https://openalex.org/W2094698810","https://openalex.org/W2102787760","https://openalex.org/W2105670702","https://openalex.org/W2106154018","https://openalex.org/W2109336877","https://openalex.org/W2111712086","https://openalex.org/W2127807826","https://openalex.org/W2132691934","https://openalex.org/W2154856176","https://openalex.org/W2161092951","https://openalex.org/W4235776389","https://openalex.org/W4242285942"],"related_works":["https://openalex.org/W1963836821","https://openalex.org/W4372341890","https://openalex.org/W2015936510","https://openalex.org/W2158095771","https://openalex.org/W2553676377","https://openalex.org/W3048535921","https://openalex.org/W2033848999","https://openalex.org/W2907753834","https://openalex.org/W2913536934","https://openalex.org/W4225694350"],"abstract_inverted_index":{"Most":[0],"tissues":[1],"in":[2,60,167,193],"multicellular":[3],"organisms":[4],"are":[5,50,191],"maintained":[6],"by":[7,85,180],"continuous":[8],"cell":[9,24,32,34,75,144,148],"renewal":[10],"processes.":[11],"However,":[12],"high":[13],"turnover":[14],"of":[15,22,43,58,74,79,137,142,161,164,177,186,196,212,219,222],"many":[16],"cells":[17,49,59,166],"implies":[18],"a":[19,62,71,135,213],"large":[20],"number":[21],"error-prone":[23],"divisions.":[25],"Hierarchical":[26],"organized":[27],"tissue":[28],"structures":[29],"with":[30],"stem":[31,48,143,147],"driven":[33,149],"differentiation":[35],"provide":[36,134],"one":[37,174],"way":[38],"to":[39,108,120,155],"prevent":[40],"the":[41,55,80,100,127,138,162,182,194,210,217],"accumulation":[42],"mutations,":[44],"because":[45],"only":[46,209],"few":[47],"long":[51],"lived.":[52],"We":[53,92,172],"investigate":[54],"deterministic":[56],"dynamics":[57,78,163,185],"such":[61,168],"hierarchical":[63],"multi":[64],"compartment":[65,69,115,218],"model,":[66],"where":[67],"each":[68],"represents":[70],"certain":[72],"stage":[73],"differentiation.":[76],"The":[77,132],"interacting":[81],"system":[82],"is":[83,205,221],"described":[84],"ordinary":[86],"differential":[87],"equations":[88],"coupled":[89],"across":[90],"compartments.":[91],"present":[93],"analytical":[94],"solutions":[95,133],"for":[96,124],"these":[97],"equations,":[98],"calculate":[99],"corresponding":[101],"extinction":[102],"times":[103],"and":[104,145,151,158,184],"compare":[105],"our":[106],"results":[107],"individual":[109],"based":[110],"stochastic":[111],"simulations.":[112],"Our":[113],"general":[114,157],"structure":[116],"can":[117,152],"be":[118,153],"applied":[119],"different":[121],"tissues,":[122],"as":[123],"example":[125],"hematopoiesis,":[126],"epidermis,":[128],"or":[129],"colonic":[130],"crypts.":[131],"description":[136],"average":[139],"time":[140],"development":[141],"non":[146],"mutants":[150],"used":[154],"illustrate":[156,173],"specific":[159],"features":[160],"mutant":[165,188,214],"hierarchically":[169],"structured":[170],"populations.":[171],"possible":[175],"application":[176],"this":[178,203],"approach":[179],"discussing":[181],"origin":[183,220],"PIG-A":[187],"clones":[189],"that":[190,207],"found":[192],"bloodstream":[195],"virtually":[197],"every":[198],"healthy":[199],"adult":[200],"human.":[201],"From":[202],"it":[204],"apparent,":[206],"not":[208],"occurrence":[211],"but":[215],"also":[216],"importance.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5}],"updated_date":"2026-04-22T08:38:42.863108","created_date":"2025-10-10T00:00:00"}