{"id":"https://openalex.org/W2062962548","doi":"https://doi.org/10.1371/journal.pcbi.1002288","title":"Deciphering the Arginine-Binding Preferences at the Substrate-Binding Groove of Ser/Thr Kinases by Computational Surface Mapping","display_name":"Deciphering the Arginine-Binding Preferences at the Substrate-Binding Groove of Ser/Thr Kinases by Computational Surface Mapping","publication_year":2011,"publication_date":"2011-11-17","ids":{"openalex":"https://openalex.org/W2062962548","doi":"https://doi.org/10.1371/journal.pcbi.1002288","mag":"2062962548","pmid":"https://pubmed.ncbi.nlm.nih.gov/22125489"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002288","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002288","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002288&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002288&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030238197","display_name":"Avraham Ben\u2010Shimon","orcid":null},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Avraham Ben-Shimon","raw_affiliation_strings":["Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment and The Fritz Haber Center for Molecular Dynamics, The Hebrew University, Israel"],"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment and The Fritz Haber Center for Molecular Dynamics, The Hebrew University, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034161188","display_name":"Masha Y. Niv","orcid":"https://orcid.org/0000-0001-8275-8795"},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Masha Y. Niv","raw_affiliation_strings":["Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment and The Fritz Haber Center for Molecular Dynamics, The Hebrew University, Israel"],"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment and The Fritz Haber Center for Molecular Dynamics, The Hebrew University, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034161188"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0672,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.75953719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"7","issue":"11","first_page":"e1002288","last_page":"e1002288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.7646666765213013},{"id":"https://openalex.org/keywords/arginine-kinase","display_name":"Arginine kinase","score":0.6851110458374023},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.6597496867179871},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.5467882752418518},{"id":"https://openalex.org/keywords/arginine","display_name":"Arginine","score":0.5028898119926453},{"id":"https://openalex.org/keywords/binding-selectivity","display_name":"Binding selectivity","score":0.4940243363380432},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.48454609513282776},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.4298437237739563},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4265667498111725},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.41220778226852417},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.37016093730926514}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7646666765213013},{"id":"https://openalex.org/C2776277561","wikidata":"https://www.wikidata.org/wiki/Q4789582","display_name":"Arginine kinase","level":4,"score":0.6851110458374023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6597496867179871},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5467882752418518},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.5028898119926453},{"id":"https://openalex.org/C96739231","wikidata":"https://www.wikidata.org/wiki/Q4914025","display_name":"Binding selectivity","level":2,"score":0.4940243363380432},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.48454609513282776},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4298437237739563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4265667498111725},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.41220778226852417},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37016093730926514},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002288","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002288","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002288&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22125489","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22125489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.287.5619","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.287.5619","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/73/e0/PLoS_Comput_Biol_2011_Nov_17_7(11)_e1002288.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:31f8eab4b2e546339a1413edb88c2bde","is_oa":true,"landing_page_url":"https://doaj.org/article/31f8eab4b2e546339a1413edb88c2bde","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 11, p e1002288 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2224261","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3219626","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/131255","is_oa":true,"landing_page_url":"https://figshare.com/articles/Deciphering_the_Arginine_Binding_Preferences_at_the_Substrate_Binding_Groove_of_Ser_Thr_Kinases_by_Computational_Surface_Mapping/131255","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002288","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002288","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002288&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2062962548.pdf","grobid_xml":"https://content.openalex.org/works/W2062962548.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W93019692","https://openalex.org/W1042172125","https://openalex.org/W1490238718","https://openalex.org/W1493799579","https://openalex.org/W1504478980","https://openalex.org/W1786056430","https://openalex.org/W1850214287","https://openalex.org/W1875580551","https://openalex.org/W1965740949","https://openalex.org/W1970174659","https://openalex.org/W1970566610","https://openalex.org/W1970808596","https://openalex.org/W1977899779","https://openalex.org/W1979976148","https://openalex.org/W1983142511","https://openalex.org/W1992895976","https://openalex.org/W1992961208","https://openalex.org/W1999450178","https://openalex.org/W2006591686","https://openalex.org/W2006690368","https://openalex.org/W2015714994","https://openalex.org/W2020257412","https://openalex.org/W2022408916","https://openalex.org/W2023094266","https://openalex.org/W2024406870","https://openalex.org/W2030205108","https://openalex.org/W2030247471","https://openalex.org/W2030692331","https://openalex.org/W2034178448","https://openalex.org/W2035980266","https://openalex.org/W2043794217","https://openalex.org/W2045201777","https://openalex.org/W2050000500","https://openalex.org/W2051699208","https://openalex.org/W2052706007","https://openalex.org/W2053573771","https://openalex.org/W2056169996","https://openalex.org/W2056184329","https://openalex.org/W2056844350","https://openalex.org/W2056897249","https://openalex.org/W2059737633","https://openalex.org/W2059942519","https://openalex.org/W2064514012","https://openalex.org/W2067405360","https://openalex.org/W2073508409","https://openalex.org/W2073652162","https://openalex.org/W2074105113","https://openalex.org/W2074174599","https://openalex.org/W2074697882","https://openalex.org/W2075767774","https://openalex.org/W2077804275","https://openalex.org/W2079212402","https://openalex.org/W2080115585","https://openalex.org/W2080653934","https://openalex.org/W2084882261","https://openalex.org/W2089576405","https://openalex.org/W2090763498","https://openalex.org/W2093400327","https://openalex.org/W2096286606","https://openalex.org/W2096994057","https://openalex.org/W2097420030","https://openalex.org/W2100772783","https://openalex.org/W2102630250","https://openalex.org/W2108174107","https://openalex.org/W2116211618","https://openalex.org/W2117484859","https://openalex.org/W2119891507","https://openalex.org/W2123476709","https://openalex.org/W2129750277","https://openalex.org/W2130479394","https://openalex.org/W2135080928","https://openalex.org/W2138778824","https://openalex.org/W2142814231","https://openalex.org/W2144362290","https://openalex.org/W2144864517","https://openalex.org/W2145642736","https://openalex.org/W2147013899","https://openalex.org/W2148128684","https://openalex.org/W2153594105","https://openalex.org/W2165594346","https://openalex.org/W2165810843","https://openalex.org/W2165863663","https://openalex.org/W2169364535","https://openalex.org/W2170678561","https://openalex.org/W2171268876","https://openalex.org/W2416312308","https://openalex.org/W4295216797"],"related_works":["https://openalex.org/W2077866766","https://openalex.org/W2067022489","https://openalex.org/W2138033748","https://openalex.org/W1994645309","https://openalex.org/W2039629531","https://openalex.org/W2159571285","https://openalex.org/W2036545952","https://openalex.org/W2167798356","https://openalex.org/W1568427065","https://openalex.org/W2017650895"],"abstract_inverted_index":{"Protein":[0],"kinases":[1,32,78,169],"are":[2],"key":[3],"signaling":[4],"enzymes":[5],"that":[6,27,119,170,193,203],"catalyze":[7],"the":[8,21,24,29,37,75,105,174,188,204,215,256],"transfer":[9],"of":[10,31,77,96,140,228],"\u03b3-phosphate":[11],"from":[12,187,232,254],"an":[13],"ATP":[14],"molecule":[15],"to":[16,71,121],"a":[17,57,207,248],"phospho-accepting":[18],"residue":[19,242],"in":[20,94,138,157,173,251],"substrate.":[22],"Unraveling":[23],"molecular":[25],"features":[26],"govern":[28],"preference":[30,76,205],"for":[33,41,49,62,153,180,206],"particular":[34],"residues":[35,192],"flanking":[36],"phosphoacceptor":[38],"is":[39,210],"important":[40],"understanding":[42],"kinase":[43,158,195],"specificities":[44],"toward":[45,79,160,197],"their":[46,133],"substrates":[47,95],"and":[48,73,87,115,132,147,182,236,258],"designing":[50],"substrate-like":[51],"peptidic":[52],"inhibitors.":[53],"We":[54,82],"applied":[55],"ANCHORSmap,":[56],"new":[58],"fragment-based":[59],"computational":[60],"approach":[61],"mapping":[63],"amino":[64,144],"acid":[65,145],"side":[66],"chains":[67],"on":[68,84,167],"protein":[69],"surfaces,":[70],"predict":[72],"characterize":[74],"Arginine":[80,92],"binding.":[81],"focus":[83],"positions":[85,131,233],"P-2":[86,257],"P-5,":[88],"commonly":[89],"occupied":[90],"by":[91,112,125,214,224],"(Arg)":[93],"basophilic":[97],"Ser/Thr":[98],"kinases.":[99],"The":[100,128,240],"method":[101],"accurately":[102],"identified":[103],"all":[104],"P-2/P-5":[106],"Arg":[107,117,161,209,253],"binding":[108],"sites":[109],"previously":[110,154,221],"determined":[111],"X-ray":[113],"crystallography":[114],"produced":[116],"preferences":[118,159,179],"corresponded":[120],"those":[122],"experimentally":[123],"found":[124,202],"peptide":[126],"arrays.":[127],"predicted":[129],"Arg-binding":[130],"associated":[134],"pockets":[135],"were":[136,171],"analyzed":[137],"terms":[139],"shape,":[141],"physicochemical":[142],"properties,":[143],"composition,":[146],"in-silico":[148],"mutagenesis,":[149],"providing":[150],"structural":[151],"rationalization":[152],"unexplained":[155],"trends":[156],"moieties.":[162],"This":[163],"methodology":[164],"sheds":[165],"light":[166],"several":[168,225],"described":[172],"literature":[175],"as":[176,219,247],"having":[177],"non-trivial":[178],"Arg,":[181],"provides":[183],"some":[184],"surprising":[185],"departures":[186],"prevailing":[189],"views":[190],"regarding":[191],"determine":[194],"specificity":[196],"Arg.":[198],"In":[199],"particular,":[200],"we":[201],"P-5":[208,259],"not":[211],"necessarily":[212],"governed":[213],"170/230":[216],"acidic":[217,229,241],"pair,":[218],"was":[220],"assumed,":[222],"but":[223],"different":[226],"pairs":[227],"residues,":[230],"selected":[231],"133,":[234],"169,":[235],"230":[237,245],"(PKA":[238],"numbering).":[239],"at":[243],"position":[244],"serves":[246],"pivotal":[249],"element":[250],"recognizing":[252],"both":[255],"positions.":[260]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}