{"id":"https://openalex.org/W2002633382","doi":"https://doi.org/10.1371/journal.pcbi.1002273","title":"Reversible and Noisy Progression towards a Commitment Point Enables Adaptable and Reliable Cellular Decision-Making","display_name":"Reversible and Noisy Progression towards a Commitment Point Enables Adaptable and Reliable Cellular Decision-Making","publication_year":2011,"publication_date":"2011-11-10","ids":{"openalex":"https://openalex.org/W2002633382","doi":"https://doi.org/10.1371/journal.pcbi.1002273","mag":"2002633382","pmid":"https://pubmed.ncbi.nlm.nih.gov/22102806"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002273","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002273","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002273&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002273&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102848527","display_name":"Anna Kuchina","orcid":"https://orcid.org/0000-0002-7267-101X"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Kuchina","raw_affiliation_strings":["Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, United States of America","Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, United States of America","institution_ids":[]},{"raw_affiliation_string":"Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047556842","display_name":"Lorena Espinar","orcid":"https://orcid.org/0000-0003-3881-3886"},"institutions":[{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lorena Espinar","raw_affiliation_strings":["Departament de F\u00edsica i Enginyeria Nuclear, Universitat Polit\u00e8cnica de Catalunya, Terrassa, Spain"],"affiliations":[{"raw_affiliation_string":"Departament de F\u00edsica i Enginyeria Nuclear, Universitat Polit\u00e8cnica de Catalunya, Terrassa, Spain","institution_ids":["https://openalex.org/I9617848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054261070","display_name":"Jordi Garc\u00eda\u2010Ojalvo","orcid":"https://orcid.org/0000-0002-3716-7520"},"institutions":[{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Garcia-Ojalvo","raw_affiliation_strings":["Departament de F\u00edsica i Enginyeria Nuclear, Universitat Polit\u00e8cnica de Catalunya, Terrassa, Spain"],"affiliations":[{"raw_affiliation_string":"Departament de F\u00edsica i Enginyeria Nuclear, Universitat Polit\u00e8cnica de Catalunya, Terrassa, Spain","institution_ids":["https://openalex.org/I9617848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043906650","display_name":"G\u00fcrol M. S\u00fcel","orcid":"https://orcid.org/0000-0003-0819-7867"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G\u00fcrol M. S\u00fcel","raw_affiliation_strings":["Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210155419"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043906650"],"corresponding_institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I867280407"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.4014,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.88724759,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"11","first_page":"e1002273","last_page":"e1002273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adaptability","display_name":"Adaptability","score":0.6534761786460876},{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.5207816958427429},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"Cell fate determination","score":0.5070090293884277},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5039348006248474},{"id":"https://openalex.org/keywords/reliability","display_name":"Reliability (semiconductor)","score":0.4885019063949585},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4879979193210602},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.45128968358039856},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4349074959754944},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.4123896360397339},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.41058802604675293},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4049256145954132},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.35072752833366394},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21132367849349976},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.19329100847244263},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.17061540484428406}],"concepts":[{"id":"https://openalex.org/C177606310","wikidata":"https://www.wikidata.org/wiki/Q5674297","display_name":"Adaptability","level":2,"score":0.6534761786460876},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5207816958427429},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.5070090293884277},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5039348006248474},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.4885019063949585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4879979193210602},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45128968358039856},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4349074959754944},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.4123896360397339},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41058802604675293},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4049256145954132},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35072752833366394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21132367849349976},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19329100847244263},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.17061540484428406},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013171","descriptor_name":"Spores, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013171","descriptor_name":"Spores, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013171","descriptor_name":"Spores, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002273","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002273","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002273&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22102806","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22102806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:recercat.cat:2072/315456","is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/23710","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.6761","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.6761","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/3f/01/pcbi.1002273.PMC3213189.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:2b93f33f0e2541fd8409f0b067182562","is_oa":true,"landing_page_url":"https://doaj.org/article/2b93f33f0e2541fd8409f0b067182562","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 11, p e1002273 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2220537","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3213189","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/131499","is_oa":true,"landing_page_url":"https://figshare.com/articles/Reversible_and_Noisy_Progression_towards_a_Commitment_Point_Enables_Adaptable_and_Reliable_Cellular_Decision_Making/131499","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002273","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002273","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002273&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions","score":0.49000000953674316}],"awards":[{"id":"https://openalex.org/G4359693134","display_name":null,"funder_award_id":"NIGMS","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306183","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19"},{"id":"https://openalex.org/F4320322121","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002633382.pdf","grobid_xml":"https://content.openalex.org/works/W2002633382.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1497138669","https://openalex.org/W1551633858","https://openalex.org/W1555165987","https://openalex.org/W1870056855","https://openalex.org/W1942644614","https://openalex.org/W1967668980","https://openalex.org/W1975635548","https://openalex.org/W1976681765","https://openalex.org/W1981598092","https://openalex.org/W1981925964","https://openalex.org/W1988704611","https://openalex.org/W1998083657","https://openalex.org/W1998735328","https://openalex.org/W2003702678","https://openalex.org/W2004449943","https://openalex.org/W2008855387","https://openalex.org/W2020657021","https://openalex.org/W2021606207","https://openalex.org/W2023543015","https://openalex.org/W2030065348","https://openalex.org/W2030911977","https://openalex.org/W2031822229","https://openalex.org/W2032570525","https://openalex.org/W2043487490","https://openalex.org/W2046391028","https://openalex.org/W2047064510","https://openalex.org/W2052205534","https://openalex.org/W2052360631","https://openalex.org/W2060735645","https://openalex.org/W2067697244","https://openalex.org/W2068151033","https://openalex.org/W2068371312","https://openalex.org/W2068978083","https://openalex.org/W2073087696","https://openalex.org/W2074782921","https://openalex.org/W2077791698","https://openalex.org/W2083421142","https://openalex.org/W2092740268","https://openalex.org/W2094644908","https://openalex.org/W2096015757","https://openalex.org/W2097659572","https://openalex.org/W2099595405","https://openalex.org/W2099604042","https://openalex.org/W2102407350","https://openalex.org/W2103508212","https://openalex.org/W2105057212","https://openalex.org/W2121633536","https://openalex.org/W2123475271","https://openalex.org/W2127013070","https://openalex.org/W2131672676","https://openalex.org/W2137908831","https://openalex.org/W2146695490","https://openalex.org/W2148323109","https://openalex.org/W2149750189","https://openalex.org/W2152954381","https://openalex.org/W2160845585","https://openalex.org/W2161251399","https://openalex.org/W2162899221","https://openalex.org/W2166360670","https://openalex.org/W2168403192","https://openalex.org/W4242009368"],"related_works":["https://openalex.org/W2357124094","https://openalex.org/W2387399993","https://openalex.org/W2389739210","https://openalex.org/W2348924972","https://openalex.org/W2365736347","https://openalex.org/W4293061103","https://openalex.org/W2047454415","https://openalex.org/W2070040999","https://openalex.org/W2387293848","https://openalex.org/W3121791438"],"abstract_inverted_index":{"Cells":[0],"must":[1],"make":[2],"reliable":[3,160,188],"decisions":[4],"under":[5,134],"fluctuating":[6,215],"extracellular":[7,136],"conditions,":[8],"but":[9],"also":[10],"be":[11],"flexible":[12],"enough":[13],"to":[14,16,59,104,129,146,149,211],"adapt":[15],"such":[17],"changes.":[18],"How":[19],"cells":[20,49,145],"reconcile":[21],"these":[22,97],"seemingly":[23],"contradictory":[24],"requirements":[25],"through":[26,67],"the":[27,51,57,107,118,123,127,155],"dynamics":[28],"of":[29,50,85,109,120,162,176,194],"cellular":[30,112],"decision-making":[31,189,203],"is":[32,167],"poorly":[33],"understood.":[34],"To":[35],"study":[36],"this":[37],"issue":[38],"we":[39,79,99,116],"quantitatively":[40],"measured":[41],"gene":[42,86],"expression":[43,87],"and":[44,69,82,88,131,181,187],"protein":[45,90],"localization":[46,91],"in":[47,126,172,196],"single":[48],"model":[52],"organism":[53],"Bacillus":[54],"subtilis":[55],"during":[56,93],"progression":[58,128,143],"spore":[60],"formation.":[61],"We":[62],"found":[63],"that":[64,141,166,202],"sporulation":[65],"proceeded":[66],"noisy":[68],"reversible":[70,142],"steps":[71],"towards":[72],"an":[73],"irreversible,":[74],"all-or-none":[75],"commitment":[76,157],"point.":[77],"Specifically,":[78],"observed":[80],"cell-autonomous":[81],"spontaneous":[83],"bursts":[84],"transient":[89],"events":[92],"sporulation.":[94],"Based":[95],"on":[96,122],"measurements":[98],"developed":[100],"mathematical":[101],"population":[102],"models":[103],"investigate":[105],"how":[106],"degree":[108],"reversibility":[110,121],"affects":[111],"decision-making.":[113],"In":[114,153],"particular,":[115],"evaluated":[117],"effect":[119],"1)":[124],"reliability":[125],"sporulation,":[130],"2)":[132],"adaptability":[133],"changing":[135],"stress":[137],"conditions.":[138,198,217],"Results":[139],"show":[140],"allows":[144],"remain":[147],"responsive":[148],"long-term":[150],"environmental":[151,197,216],"fluctuations.":[152],"contrast,":[154],"irreversible":[156],"point":[158],"supports":[159],"execution":[161],"cell":[163],"fate":[164],"choice":[165],"robust":[168],"against":[169],"short-term":[170],"reductions":[171],"stress.":[173],"This":[174],"combination":[175],"opposite":[177],"dynamic":[178],"behaviors":[179],"(reversible":[180],"irreversible)":[182],"thus":[183],"maximizes":[184],"both":[185],"adaptable":[186],"over":[190],"a":[191,207],"broad":[192],"range":[193],"changes":[195],"These":[199],"results":[200],"suggest":[201],"systems":[204],"might":[205],"employ":[206],"general":[208],"hybrid":[209],"strategy":[210],"cope":[212],"with":[213],"unpredictably":[214]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-04-11T08:14:18.477133","created_date":"2025-10-10T00:00:00"}