{"id":"https://openalex.org/W1971644094","doi":"https://doi.org/10.1371/journal.pcbi.1002271","title":"A Density-Dependent Switch Drives Stochastic Clustering and Polarization of Signaling Molecules","display_name":"A Density-Dependent Switch Drives Stochastic Clustering and Polarization of Signaling Molecules","publication_year":2011,"publication_date":"2011-11-10","ids":{"openalex":"https://openalex.org/W1971644094","doi":"https://doi.org/10.1371/journal.pcbi.1002271","mag":"1971644094","pmid":"https://pubmed.ncbi.nlm.nih.gov/22102805"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002271","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002271","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002271&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002271&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078178163","display_name":"Alexandra Jilkine","orcid":"https://orcid.org/0000-0001-5896-5962"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Jilkine","raw_affiliation_strings":["Molecular and Cellular Biology, University of Arizona, Tucson, United States of America","Green Center for Systems Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America"],"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology, University of Arizona, Tucson, United States of America","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Green Center for Systems Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068621385","display_name":"Sigurd Angenent","orcid":null},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sigurd B. Angenent","raw_affiliation_strings":["Mathematics Department, University of Wisconsin, Madison, Wisconsin, United States of America"],"affiliations":[{"raw_affiliation_string":"Mathematics Department, University of Wisconsin, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015397650","display_name":"Lani F. Wu","orcid":"https://orcid.org/0000-0002-0052-7537"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lani F. Wu","raw_affiliation_strings":["Green Center for Systems Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Green Center for Systems Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210155419"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072455858","display_name":"Steven J. Altschuler","orcid":"https://orcid.org/0000-0001-9142-0796"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"education","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven J. Altschuler","raw_affiliation_strings":["Green Center for Systems Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Green Center for Systems Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210155419"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015397650","https://openalex.org/A5068621385","https://openalex.org/A5072455858"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210155419","https://openalex.org/I867280407"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.4675,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.80519381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"7","issue":"11","first_page":"e1002271","last_page":"e1002271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7269657850265503},{"id":"https://openalex.org/keywords/positive-feedback","display_name":"Positive feedback","score":0.6616770029067993},{"id":"https://openalex.org/keywords/cell-signaling","display_name":"Cell signaling","score":0.5049934983253479},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.499251127243042},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.48480382561683655},{"id":"https://openalex.org/keywords/directionality","display_name":"Directionality","score":0.4596017003059387},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.4545353055000305},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4183228015899658},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.41236191987991333},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.40897414088249207},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38666099309921265},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.38086622953414917},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.3484939932823181},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3386625647544861},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.21641799807548523},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15538474917411804},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14135050773620605},{"id":"https://openalex.org/keywords/voltage","display_name":"Voltage","score":0.12086150050163269},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.10866084694862366}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7269657850265503},{"id":"https://openalex.org/C48207687","wikidata":"https://www.wikidata.org/wiki/Q918004","display_name":"Positive feedback","level":2,"score":0.6616770029067993},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.5049934983253479},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.499251127243042},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.48480382561683655},{"id":"https://openalex.org/C29648211","wikidata":"https://www.wikidata.org/wiki/Q1995607","display_name":"Directionality","level":2,"score":0.4596017003059387},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4545353055000305},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4183228015899658},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.41236191987991333},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40897414088249207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38666099309921265},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.38086622953414917},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.3484939932823181},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3386625647544861},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21641799807548523},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15538474917411804},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14135050773620605},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.12086150050163269},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10866084694862366},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1002271","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002271","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002271&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22102805","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22102805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:ark:/13030/qt3wj566hs","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1002271","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002271","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:0d1abec5de6f4f2eb9b387263a10def8","is_oa":true,"landing_page_url":"https://doaj.org/article/0d1abec5de6f4f2eb9b387263a10def8","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 11, p e1002271 (2011)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt3wj566hs","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3wj566hs","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 7, iss 11","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2220538","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3213192","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/131516","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Density_Dependent_Switch_Drives_Stochastic_Clustering_and_Polarization_of_Signaling_Molecules/131516","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002271","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002271","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002271&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5540667113","display_name":null,"funder_award_id":"I-1619","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G7667978582","display_name":null,"funder_award_id":"I-1644","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320306590","display_name":"Rita Allen Foundation","ror":"https://ror.org/0515k5w36"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1971644094.pdf","grobid_xml":"https://content.openalex.org/works/W1971644094.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1586486602","https://openalex.org/W1635552303","https://openalex.org/W1876456565","https://openalex.org/W1964816418","https://openalex.org/W1965650717","https://openalex.org/W1967940959","https://openalex.org/W1971938644","https://openalex.org/W1974934611","https://openalex.org/W1974974415","https://openalex.org/W1976337404","https://openalex.org/W1976852702","https://openalex.org/W1976988610","https://openalex.org/W1977056005","https://openalex.org/W1980661496","https://openalex.org/W1980926711","https://openalex.org/W1981903873","https://openalex.org/W1985482228","https://openalex.org/W1997698024","https://openalex.org/W2009994916","https://openalex.org/W2015188565","https://openalex.org/W2015586742","https://openalex.org/W2027733508","https://openalex.org/W2031497507","https://openalex.org/W2034063805","https://openalex.org/W2039166035","https://openalex.org/W2043938190","https://openalex.org/W2045243735","https://openalex.org/W2054799935","https://openalex.org/W2057405727","https://openalex.org/W2059488680","https://openalex.org/W2060006253","https://openalex.org/W2061943709","https://openalex.org/W2068780958","https://openalex.org/W2070126991","https://openalex.org/W2070752850","https://openalex.org/W2072159031","https://openalex.org/W2076367743","https://openalex.org/W2077396903","https://openalex.org/W2078097311","https://openalex.org/W2078227548","https://openalex.org/W2078423846","https://openalex.org/W2081113319","https://openalex.org/W2084043967","https://openalex.org/W2085056826","https://openalex.org/W2089840306","https://openalex.org/W2096018880","https://openalex.org/W2099856732","https://openalex.org/W2102787760","https://openalex.org/W2106362845","https://openalex.org/W2112730617","https://openalex.org/W2114870653","https://openalex.org/W2119806797","https://openalex.org/W2123880844","https://openalex.org/W2125808663","https://openalex.org/W2153683741","https://openalex.org/W2162689493","https://openalex.org/W2165803049","https://openalex.org/W2171520735","https://openalex.org/W3008437073","https://openalex.org/W3023958910","https://openalex.org/W3100481103","https://openalex.org/W3100805608","https://openalex.org/W3203680921","https://openalex.org/W4237699394","https://openalex.org/W4242285942","https://openalex.org/W4246488417","https://openalex.org/W4247428450","https://openalex.org/W4250555403","https://openalex.org/W4298084067","https://openalex.org/W4300059230","https://openalex.org/W6639355426","https://openalex.org/W6785044993","https://openalex.org/W6802020090"],"related_works":["https://openalex.org/W2789936093","https://openalex.org/W1603824164","https://openalex.org/W2897954926","https://openalex.org/W1998677285","https://openalex.org/W4230360037","https://openalex.org/W2771707358","https://openalex.org/W4250776960","https://openalex.org/W2106469366","https://openalex.org/W2899244556","https://openalex.org/W2051497876"],"abstract_inverted_index":{"Positive":[0],"feedback":[1,47,80,186,201],"plays":[2],"a":[3,77,93,135,145,180,184,209],"key":[4],"role":[5],"in":[6,17,28,114,128,159],"the":[7,18,29,63,83,115,152,168,174],"ability":[8,198],"of":[9,22,31,65,96,122,134,141,147,156,176,199],"signaling":[10,97,177],"molecules":[11,142,178],"to":[12,151,164,188,203,219],"form":[13],"highly":[14,105],"localized":[15,106],"clusters":[16,66,107],"membrane":[19],"or":[20,41,154],"cytosol":[21],"cells.":[23],"Such":[24],"clustering":[25,99,207],"can":[26],"occur":[27],"absence":[30],"localizing":[32],"mechanisms":[33],"such":[34],"as":[35,167],"pre-existing":[36],"spatial":[37,222],"cues,":[38],"diffusional":[39],"barriers,":[40],"molecular":[42,123],"cross-linking.":[43],"What":[44],"prevents":[45],"positive":[46,79,185,200],"from":[48],"amplifying":[49,90],"inevitable":[50],"biological":[51,217],"noise":[52],"when":[53,67],"an":[54,68],"un-clustered":[55,194],"\"off\"":[56],"state":[57,70],"is":[58,71,143,208],"desired?":[59,72],"And,":[60],"what":[61],"limits":[62],"spread":[64],"\"on\"":[69],"Here,":[73],"we":[74],"show":[75],"that":[76,119,212],"minimal":[78],"circuit":[81,187],"provides":[82,179],"general":[84,210],"principle":[85],"for":[86,138,183],"both":[87,202],"suppressing":[88],"and":[89,193,205],"noise:":[91],"below":[92],"critical":[94],"density":[95,175],"molecules,":[98],"switches":[100],"off;":[101],"above":[102],"this":[103],"threshold,":[104],"are":[108],"recurrently":[109],"generated.":[110],"Clustering":[111],"occurs":[112],"only":[113],"stochastic":[116],"regime,":[117],"suggesting":[118],"finite":[120,139,160],"sizes":[121],"populations":[124],"cannot":[125],"be":[126],"ignored":[127],"signal":[129],"transduction":[130],"networks.":[131],"The":[132,196],"emergence":[133],"dominant":[136],"cluster":[137],"numbers":[140],"partly":[144],"phenomenon":[146],"random":[148],"sampling,":[149],"analogous":[150],"fixation":[153],"loss":[155],"neutral":[157],"mutations":[158],"populations.":[161],"We":[162],"refer":[163],"our":[165],"model":[166],"\"neutral":[169],"drift":[170],"polarity":[171],"model.\"":[172],"Regulating":[173],"simple":[181],"mechanism":[182,211],"robustly":[189],"switch":[190],"between":[191],"clustered":[192],"states.":[195],"intrinsic":[197],"create":[204,220],"suppress":[206],"could":[213],"operate":[214],"within":[215],"diverse":[216],"networks":[218],"dynamic":[221],"organization.":[223]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
