{"id":"https://openalex.org/W1603382630","doi":"https://doi.org/10.1371/journal.pcbi.1002270","title":"Multiscale Modeling of Red Blood Cell Mechanics and Blood Flow in Malaria","display_name":"Multiscale Modeling of Red Blood Cell Mechanics and Blood Flow in Malaria","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W1603382630","doi":"https://doi.org/10.1371/journal.pcbi.1002270","mag":"1603382630","pmid":"https://pubmed.ncbi.nlm.nih.gov/22144878"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002270","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002270","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002270&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"book-chapter","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002270&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090564844","display_name":"Dmitry A. Fedosov","orcid":"https://orcid.org/0000-0001-7469-9844"},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitry A. Fedosov","raw_affiliation_strings":["Division of Applied Mathematics, Brown University, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Mathematics, Brown University, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033544358","display_name":"Huan Lei","orcid":null},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huan Lei","raw_affiliation_strings":["Division of Applied Mathematics, Brown University, Providence, Rhode Island, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Mathematics, Brown University, Providence, Rhode Island, United States of America","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048901469","display_name":"Bruce Caswell","orcid":null},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Caswell","raw_affiliation_strings":["School of Engineering, Brown University, Providence, Rhode Island, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Engineering, Brown University, Providence, Rhode Island, United States of America","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101640166","display_name":"Subra Suresh","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subra Suresh","raw_affiliation_strings":["Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009658255","display_name":"George Em Karniadakis","orcid":"https://orcid.org/0000-0002-9713-7120"},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George E. Karniadakis","raw_affiliation_strings":["Division of Applied Mathematics, Brown University, Providence, Rhode Island, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Mathematics, Brown University, Providence, Rhode Island, United States of America","institution_ids":["https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5009658255"],"corresponding_institution_ids":["https://openalex.org/I27804330"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.25,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.62163968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"7","issue":"12","first_page":"e1002270","last_page":"e1002270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malaria","display_name":"Malaria","score":0.568015456199646},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.5327589511871338},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.4309201240539551},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.29502540826797485},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2440122365951538},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.13850238919258118},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.12092405557632446}],"concepts":[{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.568015456199646},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5327589511871338},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.4309201240539551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29502540826797485},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2440122365951538},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.13850238919258118},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12092405557632446}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004907","descriptor_name":"Erythrocyte Deformability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004907","descriptor_name":"Erythrocyte Deformability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004907","descriptor_name":"Erythrocyte Deformability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018056","descriptor_name":"Hemorheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018056","descriptor_name":"Hemorheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018056","descriptor_name":"Hemorheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055119","descriptor_name":"Elastic Modulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055119","descriptor_name":"Elastic Modulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055119","descriptor_name":"Elastic Modulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1371/journal.pcbi.1002270","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002270","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002270&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22144878","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22144878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:repository.cmu.edu:bme-1147","is_oa":true,"landing_page_url":"http://repository.cmu.edu/bme/139","pdf_url":null,"source":{"id":"https://openalex.org/S4306400668","display_name":"Research Showcase @ Carnegie Mellon University (Carnegie Mellon University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I74973139","host_organization_name":"Carnegie Mellon University","host_organization_lineage":["https://openalex.org/I74973139"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Biomedical Engineering","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.658.8196","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.658.8196","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nanomechanics.mit.edu//sites/default/files/documents/2011_PLoS.Comp.Bio_Malaria.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c95fc0dd77804569910fd80da053b2a2","is_oa":true,"landing_page_url":"https://doaj.org/article/c95fc0dd77804569910fd80da053b2a2","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 12, p e1002270 (2011)","raw_type":"article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/69043","is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/69043","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS","raw_type":"http://purl.org/eprint/type/JournalArticle"},{"id":"pmh:oai:europepmc.org:2238905","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3228770","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/6096554","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Multiscale_modeling_of_red_blood_cell_mechanics_and_blood_flow_in_malaria_/6096554","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:juser.fz-juelich.de:18843","is_oa":false,"landing_page_url":"http://juser.fz-juelich.de/search?p=id:%22PreJuSER-18843%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401090","display_name":"JuSER (Forschungszentrum J\u00fclich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I171892758","host_organization_name":"Forschungszentrum J\u00fclich","host_organization_lineage":["https://openalex.org/I171892758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology 7, (2011). doi:10.1371/journal.pcbi.1002270","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1603382630","is_oa":false,"landing_page_url":"https://dspace.mit.edu/handle/1721.1/69043","pdf_url":null,"source":{"id":"https://openalex.org/S4306489179","display_name":"PLoS eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PLoS eBooks","raw_type":null},{"id":"doi:10.1184/r1/6096554","is_oa":true,"landing_page_url":"https://doi.org/10.1184/r1/6096554","pdf_url":null,"source":{"id":"https://openalex.org/S7407050927","display_name":"KiltHub Repository","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.1184/r1/6096554.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1184/r1/6096554.v1","pdf_url":null,"source":{"id":"https://openalex.org/S7407050927","display_name":"KiltHub Repository","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002270","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002270","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002270&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3192718787","display_name":"Multiscale Modeling of Flow over Functionalized Surfaces: Algorithms and Applications","funder_award_id":"0852948","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G362108760","display_name":null,"funder_award_id":"R01HL094270","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309369","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1603382630.pdf","grobid_xml":"https://content.openalex.org/works/W1603382630.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1969729759","https://openalex.org/W1972544143","https://openalex.org/W1975721615","https://openalex.org/W1981054060","https://openalex.org/W1989521108","https://openalex.org/W1991490664","https://openalex.org/W2004883880","https://openalex.org/W2006271210","https://openalex.org/W2015102116","https://openalex.org/W2016433880","https://openalex.org/W2032655419","https://openalex.org/W2035447238","https://openalex.org/W2036371652","https://openalex.org/W2039227742","https://openalex.org/W2046151550","https://openalex.org/W2052224066","https://openalex.org/W2053758185","https://openalex.org/W2060933310","https://openalex.org/W2065233752","https://openalex.org/W2070370882","https://openalex.org/W2075283957","https://openalex.org/W2085522866","https://openalex.org/W2087193602","https://openalex.org/W2087274883","https://openalex.org/W2093310284","https://openalex.org/W2096087854","https://openalex.org/W2098708326","https://openalex.org/W2099537317","https://openalex.org/W2104493858","https://openalex.org/W2114952318","https://openalex.org/W2119614267","https://openalex.org/W2121047360","https://openalex.org/W2123631818","https://openalex.org/W2125412432","https://openalex.org/W2139020009","https://openalex.org/W2148868397","https://openalex.org/W2152787205","https://openalex.org/W2163806629","https://openalex.org/W2264936970","https://openalex.org/W4253179564"],"related_works":["https://openalex.org/W2612979878","https://openalex.org/W2919781992","https://openalex.org/W3017240695","https://openalex.org/W2057115079","https://openalex.org/W2890848799","https://openalex.org/W2031972149","https://openalex.org/W981905780","https://openalex.org/W2133370274","https://openalex.org/W2745034193","https://openalex.org/W3017242140","https://openalex.org/W2345351991","https://openalex.org/W2979725136","https://openalex.org/W1997243219","https://openalex.org/W2546815243","https://openalex.org/W2116283468","https://openalex.org/W2550761645","https://openalex.org/W3048797220","https://openalex.org/W754256164","https://openalex.org/W12851126","https://openalex.org/W2624155835"],"abstract_inverted_index":{"Red":[0],"blood":[1,59,199],"cells":[2,46,190,218],"(RBCs)":[3],"infected":[4,35,67,181,209],"by":[5,159,165],"a":[6,17,54,72,100,108,201,220],"Plasmodium":[7],"parasite":[8,145],"in":[9,24,53,69,137,152,183,186,219],"malaria":[10,70,153],"may":[11],"lose":[12],"their":[13],"membrane":[14,19,167],"deformability":[15],"with":[16,26,89,107,156,188,211],"relative":[18],"stiffening":[20],"more":[21],"than":[22],"ten-fold":[23],"comparison":[25,187],"healthy":[27,43,189],"RBCs":[28,36,68,133,151,182,210],"leading":[29],"to":[30,39,41,48,98,118,213],"potential":[31],"capillary":[32],"occlusions.":[33],"Moreover,":[34],"are":[37,154],"able":[38],"adhere":[40],"other":[42],"and":[44,47,117,164,172,191],"parasitized":[45,132],"the":[49,62,78,86,92,104,120,178,214],"vascular":[50],"endothelium":[51],"resulting":[52],"substantial":[55],"disruption":[56],"of":[57,103,111,122,131,143,150,180,197,204,208,217],"normal":[58],"circulation.":[60],"In":[61],"present":[63,192],"work,":[64],"we":[65],"simulate":[66],"using":[71],"multiscale":[73],"RBC":[74,105],"model":[75,106],"based":[76],"on":[77],"dissipative":[79],"particle":[80],"dynamics":[81,179],"method,":[82],"coupling":[83],"scales":[84,90],"at":[85,91,169],"sub-cellular":[87],"level":[88],"vessel":[93],"size.":[94],"Our":[95],"objective":[96],"is":[97],"conduct":[99],"full":[101],"validation":[102],"diverse":[109],"set":[110],"experimental":[112],"data,":[113],"including":[114],"temperature":[115],"dependence,":[116],"identify":[119],"limitations":[121],"this":[123],"purely":[124],"mechanistic":[125],"model.":[126],"The":[127,147],"simulated":[128],"elastic":[129],"deformations":[130],"match":[134],"those":[135,157],"obtained":[136,158],"optical-tweezers":[138],"experiments":[139],"for":[140,200],"different":[141],"stages":[142],"intra-erythrocytic":[144],"development.":[146],"rheological":[148],"properties":[149],"compared":[155],"optical":[160],"magnetic":[161],"twisting":[162],"cytometry":[163],"monitoring":[166],"fluctuations":[168],"room,":[170],"physiological,":[171],"febrile":[173],"temperatures.":[174],"We":[175],"also":[176],"study":[177],"Poiseuille":[184],"flow":[185],"validated":[193],"bulk":[194],"viscosity":[195],"predictions":[196],"malaria-infected":[198],"wide":[202],"range":[203],"parasitemia":[205],"levels":[206],"(percentage":[207],"respect":[212],"total":[215],"number":[216],"unit":[221],"volume).":[222]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}