{"id":"https://openalex.org/W2159443864","doi":"https://doi.org/10.1371/journal.pcbi.1002265","title":"Speed, Sensitivity, and Bistability in Auto-activating Signaling Circuits","display_name":"Speed, Sensitivity, and Bistability in Auto-activating Signaling Circuits","publication_year":2011,"publication_date":"2011-11-17","ids":{"openalex":"https://openalex.org/W2159443864","doi":"https://doi.org/10.1371/journal.pcbi.1002265","mag":"2159443864","pmid":"https://pubmed.ncbi.nlm.nih.gov/22125482"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002265","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002265","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002265&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002265&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031807185","display_name":"Rutger Hermsen","orcid":"https://orcid.org/0000-0003-4633-4877"},"institutions":[{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rutger Hermsen","raw_affiliation_strings":["Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California, USA. hermsen@ctbp.ucsd.edu","Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California, USA. hermsen@ctbp.ucsd.edu","institution_ids":["https://openalex.org/I4210145836"]},{"raw_affiliation_string":"Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I4210145836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014593609","display_name":"David W. Erickson","orcid":null},"institutions":[{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Erickson","raw_affiliation_strings":["Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I4210145836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052704218","display_name":"Terence Hwa","orcid":"https://orcid.org/0000-0003-1837-6842"},"institutions":[{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terence Hwa","raw_affiliation_strings":["Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I4210145836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5031807185"],"corresponding_institution_ids":["https://openalex.org/I4210145836"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.4633,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.81731305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"7","issue":"11","first_page":"e1002265","last_page":"e1002265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cooperativity","display_name":"Cooperativity","score":0.8232170939445496},{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.6743472814559937},{"id":"https://openalex.org/keywords/electronic-circuit","display_name":"Electronic circuit","score":0.6047126054763794},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5679391622543335},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.4769914746284485},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4314901530742645},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.4265534579753876},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.41707974672317505},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4131363034248352},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3621702790260315},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3570881485939026},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.35677748918533325},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3492591679096222},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.32436978816986084},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.32197320461273193},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.27850526571273804},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.232072114944458},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.1370098888874054},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12477880716323853}],"concepts":[{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.8232170939445496},{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.6743472814559937},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.6047126054763794},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5679391622543335},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4769914746284485},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4314901530742645},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.4265534579753876},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41707974672317505},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4131363034248352},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3621702790260315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3570881485939026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35677748918533325},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3492591679096222},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32436978816986084},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32197320461273193},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27850526571273804},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.232072114944458},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.1370098888874054},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12477880716323853},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002265","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002265","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002265&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22125482","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22125482","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.287.1427","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.287.1427","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/65/2a/PLoS_Comput_Biol_2011_Nov_17_7(11)_e1002265.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002265","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002265","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9f435061163d4688876a2885c8dc6e3d","is_oa":true,"landing_page_url":"https://doaj.org/article/9f435061163d4688876a2885c8dc6e3d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 11, p e1002265 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2224254","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3219618","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/131248","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Speed_Sensitivity_and_Bistability_in_Auto_activating_Signaling_Circuits/131248","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002265","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002265","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002265&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3696996819","display_name":null,"funder_award_id":"PHY-0822283","funder_id":"https://openalex.org/F4320332603","funder_display_name":"University of California, San Diego"},{"id":"https://openalex.org/G3747673514","display_name":null,"funder_award_id":"PHY-0822283","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6200803884","display_name":null,"funder_award_id":"PHY-0822283","funder_id":"https://openalex.org/F4320332774","funder_display_name":"Center for Theoretical Biological Physics"},{"id":"https://openalex.org/G6776192592","display_name":"Center for Theoretical Biological Physics","funder_award_id":"0822283","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320332774","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/008zs3103"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2159443864.pdf","grobid_xml":"https://content.openalex.org/works/W2159443864.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1482637285","https://openalex.org/W1520325521","https://openalex.org/W1547922007","https://openalex.org/W1568314805","https://openalex.org/W1608194938","https://openalex.org/W1621540022","https://openalex.org/W1732832104","https://openalex.org/W1868993240","https://openalex.org/W1968163718","https://openalex.org/W1970070519","https://openalex.org/W1970202087","https://openalex.org/W1972227433","https://openalex.org/W1977063473","https://openalex.org/W1978319180","https://openalex.org/W1978469876","https://openalex.org/W1980944685","https://openalex.org/W1985161570","https://openalex.org/W1985654700","https://openalex.org/W2005486846","https://openalex.org/W2006064620","https://openalex.org/W2013244831","https://openalex.org/W2016546231","https://openalex.org/W2018383862","https://openalex.org/W2018435536","https://openalex.org/W2019460535","https://openalex.org/W2021076430","https://openalex.org/W2032570525","https://openalex.org/W2033514373","https://openalex.org/W2043487490","https://openalex.org/W2044771210","https://openalex.org/W2049281576","https://openalex.org/W2051453478","https://openalex.org/W2053460598","https://openalex.org/W2055945512","https://openalex.org/W2058473414","https://openalex.org/W2078097311","https://openalex.org/W2086634897","https://openalex.org/W2086937423","https://openalex.org/W2088922304","https://openalex.org/W2096436603","https://openalex.org/W2098708380","https://openalex.org/W2099531989","https://openalex.org/W2107238754","https://openalex.org/W2108559568","https://openalex.org/W2109295942","https://openalex.org/W2115368299","https://openalex.org/W2123880844","https://openalex.org/W2126464248","https://openalex.org/W2130036880","https://openalex.org/W2133620956","https://openalex.org/W2134027489","https://openalex.org/W2137288771","https://openalex.org/W2137464895","https://openalex.org/W2140347764","https://openalex.org/W2153832088","https://openalex.org/W2160170449","https://openalex.org/W2164806933","https://openalex.org/W2167953204","https://openalex.org/W2170543284","https://openalex.org/W3099658781"],"related_works":["https://openalex.org/W2037438428","https://openalex.org/W2057769265","https://openalex.org/W2024161258","https://openalex.org/W1911418903","https://openalex.org/W2338895903","https://openalex.org/W3044523069","https://openalex.org/W19581480","https://openalex.org/W2136248167","https://openalex.org/W2126646394","https://openalex.org/W1987445442"],"abstract_inverted_index":{"Cells":[0],"employ":[1],"a":[2,26,37,67,120,132,180,184],"myriad":[3],"of":[4,58,70,96,130,172],"signaling":[5,48,175,205],"circuits":[6,22,57],"to":[7,54,100,124,155,193],"detect":[8],"environmental":[9],"signals":[10],"and":[11,52,79,151,183,197],"drive":[12],"specific":[13],"gene":[14],"expression":[15],"responses.":[16],"A":[17],"common":[18],"motif":[19],"in":[20,50,160,174],"these":[21,208],"is":[23,152,191],"inducible":[24,188],"auto-activation:":[25],"transcription":[27,33],"factor":[28],"that":[29,89,135],"activates":[30],"its":[31],"own":[32],"upon":[34],"activation":[35],"by":[36,40,139],"ligand":[38],"or":[39],"post-transcriptional":[41],"modification.":[42],"Examples":[43,200],"range":[44],"from":[45,201],"the":[46,55,94,97,115,128,156,170],"two-component":[47,204],"systems":[49,206],"bacteria":[51],"plants":[53],"genetic":[56],"animal":[59],"viruses":[60],"such":[61,71],"as":[62],"HIV.":[63],"We":[64],"here":[65],"present":[66],"theoretical":[68],"study":[69],"circuits,":[72],"based":[73],"on":[74,169],"analytical":[75],"calculations,":[76],"numerical":[77],"computations,":[78],"simulation.":[80],"Our":[81],"results":[82],"reveal":[83],"several":[84],"surprising":[85],"characteristics.":[86],"They":[87],"show":[88],"auto-activation":[90,122,162,173,189],"can":[91,111],"drastically":[92],"enhance":[93],"sensitivity":[95,117,182],"circuit's":[98],"response":[99,110],"input":[101],"signals:":[102],"even":[103],"without":[104],"molecular":[105,149],"cooperativity,":[106],"an":[107,187],"ultra-sensitive":[108],"threshold":[109],"be":[112],"obtained.":[113],"However,":[114],"increased":[116],"comes":[118],"at":[119],"cost:":[121],"tends":[123],"severely":[125],"slow":[126],"down":[127],"speed":[129],"induction,":[131,186],"stochastic":[133],"effect":[134,145],"was":[136],"strongly":[137],"underestimated":[138],"earlier":[140],"deterministic":[141],"models.":[142],"This":[143],"slow-induction":[144],"again":[146],"requires":[147],"no":[148],"cooperativity":[150,196],"intimately":[153],"related":[154],"bimodality":[157],"recently":[158],"observed":[159],"non-cooperative":[161],"circuits.":[163],"These":[164],"phenomena":[165],"pose":[166],"strong":[167],"constraints":[168],"use":[171],"networks.":[176],"To":[177],"achieve":[178],"both":[179],"high":[181],"rapid":[185],"circuit":[190],"predicted":[192],"acquire":[194],"low":[195,198],"fold-induction.":[199],"Escherichia":[202],"coli's":[203],"support":[207],"predictions.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-05-02T08:42:23.175194","created_date":"2025-10-10T00:00:00"}