{"id":"https://openalex.org/W2082243235","doi":"https://doi.org/10.1371/journal.pcbi.1002214","title":"Chemical Basis of Metabolic Network Organization","display_name":"Chemical Basis of Metabolic Network Organization","publication_year":2011,"publication_date":"2011-10-13","ids":{"openalex":"https://openalex.org/W2082243235","doi":"https://doi.org/10.1371/journal.pcbi.1002214","mag":"2082243235","pmid":"https://pubmed.ncbi.nlm.nih.gov/22022254"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002214","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002214","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002214&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002214&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100659224","display_name":"Qiang Zhu","orcid":"https://orcid.org/0000-0003-0708-3016"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Zhu","raw_affiliation_strings":["National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China","Center for Bioinformatics, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Center for Bioinformatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054912558","display_name":"Tao Qin","orcid":"https://orcid.org/0000-0002-0128-8961"},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Qin","raw_affiliation_strings":["Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, China","institution_ids":["https://openalex.org/I119203015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042986217","display_name":"Yingying Jiang","orcid":"https://orcid.org/0000-0002-0788-8546"},"institutions":[{"id":"https://openalex.org/I119203015","display_name":"Shandong University of Technology","ror":"https://ror.org/02mr3ar13","country_code":"CN","type":"education","lineage":["https://openalex.org/I119203015"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying-Ying Jiang","raw_affiliation_strings":["Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, China","institution_ids":["https://openalex.org/I119203015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060868110","display_name":"Cong Ji","orcid":null},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Ji","raw_affiliation_strings":["Center for Bioinformatics, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081833384","display_name":"Kong De","orcid":"https://orcid.org/0000-0003-0744-116X"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"De-Xin Kong","raw_affiliation_strings":["Center for Bioinformatics, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013464460","display_name":"Bin\u2010Guang Ma","orcid":"https://orcid.org/0000-0002-9531-6643"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin-Guang Ma","raw_affiliation_strings":["Center for Bioinformatics, Huazhong Agricultural University, Wuhan, China","National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100412608","display_name":"Hongyu Zhang","orcid":"https://orcid.org/0000-0002-8078-4401"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hong-Yu Zhang","raw_affiliation_strings":["Center for Bioinformatics, Huazhong Agricultural University, Wuhan, China","National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"National Key Laboratory of Crop Genetic Improvement, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100412608"],"corresponding_institution_ids":["https://openalex.org/I204823248"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0642,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76088584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"10","first_page":"e1002214","last_page":"e1002214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.8442440629005432},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.8122698068618774},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.6360222101211548},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5410721302032471},{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.4748941957950592},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4328266978263855},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.38003450632095337},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3374800384044647},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.23225080966949463},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.08265811204910278}],"concepts":[{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.8442440629005432},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.8122698068618774},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.6360222101211548},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5410721302032471},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4748941957950592},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4328266978263855},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38003450632095337},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3374800384044647},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23225080966949463},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.08265811204910278},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002214","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002214","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002214&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22022254","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22022254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.289.9133","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.9133","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/bb/ec/PLoS_Comput_Biol_2011_Oct_13_7(10)_e1002214.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:27d82e5ee9e04d8ea8b73d39e90cea5a","is_oa":true,"landing_page_url":"https://doaj.org/article/27d82e5ee9e04d8ea8b73d39e90cea5a","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 10, p e1002214 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2199903","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3192814","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/132429","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Chemical_Basis_of_Metabolic_Network_Organization/132429","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002214","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002214","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002214&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Responsible consumption and production","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/12"}],"awards":[{"id":"https://openalex.org/G1454242410","display_name":null,"funder_award_id":"30870520","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1561270887","display_name":null,"funder_award_id":"2011PY142","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G2000777301","display_name":null,"funder_award_id":"2010CB126100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2311519157","display_name":null,"funder_award_id":"21173092","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G2505794705","display_name":null,"funder_award_id":"2012CB721000","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2552281287","display_name":null,"funder_award_id":"21173092","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3215399152","display_name":null,"funder_award_id":"2011PY142","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4790600325","display_name":null,"funder_award_id":"2012CB721000","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5407567829","display_name":null,"funder_award_id":"2012CB721000","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G7257798165","display_name":null,"funder_award_id":"2010CB126100","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8676853664","display_name":null,"funder_award_id":"2011PY142","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8698139497","display_name":null,"funder_award_id":"21173092","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8750547793","display_name":null,"funder_award_id":"2010CB126100","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2082243235.pdf","grobid_xml":"https://content.openalex.org/works/W2082243235.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1524662923","https://openalex.org/W1757313384","https://openalex.org/W1964357740","https://openalex.org/W2004235182","https://openalex.org/W2008620264","https://openalex.org/W2046594601","https://openalex.org/W2047632644","https://openalex.org/W2070517137","https://openalex.org/W2085993965","https://openalex.org/W2103795997","https://openalex.org/W2108859156","https://openalex.org/W2113221321","https://openalex.org/W2115137666","https://openalex.org/W2116332911","https://openalex.org/W2118572979","https://openalex.org/W2143610637","https://openalex.org/W2144656637","https://openalex.org/W2144885342","https://openalex.org/W2148192047","https://openalex.org/W2151144604","https://openalex.org/W2157194285","https://openalex.org/W2159675211","https://openalex.org/W2161450094","https://openalex.org/W2163480486","https://openalex.org/W2201639514","https://openalex.org/W2220239985","https://openalex.org/W2950798877","https://openalex.org/W3103786587"],"related_works":["https://openalex.org/W2378339845","https://openalex.org/W1726300337","https://openalex.org/W1969404643","https://openalex.org/W1969539025","https://openalex.org/W2977457557","https://openalex.org/W2063475537","https://openalex.org/W2341681417","https://openalex.org/W4206444712","https://openalex.org/W1961707331","https://openalex.org/W2112933939"],"abstract_inverted_index":{"Although":[0],"the":[1,5,19,34,63,166],"metabolic":[2,15,54,64,78,129,149,171,180],"networks":[3,79,130],"of":[4,8,11,80,83,111,118,122,144,155],"three":[6],"domains":[7],"life":[9],"consist":[10],"different":[12],"constituents":[13],"and":[14,53,85,90,102,108,183],"pathways,":[16],"they":[17],"exhibit":[18],"same":[20],"scale-free":[21],"organization.":[22],"This":[23,126,157],"phenomenon":[24],"has":[25,176],"been":[26],"hypothetically":[27],"explained":[28],"by":[29,148],"preferential":[30,167],"attachment":[31,168],"principle":[32,169],"that":[33,41,62,98,128],"new-recruited":[35],"metabolites":[36,48,114],"attach":[37],"preferentially":[38],"to":[39,134,151,165],"those":[40],"are":[42,49,56,121,131],"already":[43],"well":[44],"connected.":[45],"However,":[46],"since":[47],"usually":[50],"small":[51],"molecules":[52],"processes":[55],"basically":[57],"chemical":[58,70,109,163],"reactions,":[59],"we":[60],"speculate":[61],"network":[65,106,172,181],"organization":[66],"may":[67],"have":[68],"a":[69,135,153,162],"basis.":[71],"In":[72],"this":[73],"paper,":[74],"chemoinformatic":[75],"analyses":[76],"on":[77],"Kyoto":[81],"Encyclopedia":[82],"Genes":[84],"Genomes":[86],"(KEGG),":[87],"Escherichia":[88],"coli":[89],"Saccharomyces":[91],"cerevisiae":[92],"were":[93],"performed.":[94],"It":[95],"was":[96,139],"found":[97],"there":[99],"exist":[100],"qualitative":[101],"quantitative":[103],"correlations":[104],"between":[105],"topology":[107],"properties":[110],"metabolites.":[112],"The":[113],"with":[115],"larger":[116],"degrees":[117],"connectivity":[119],"(hubs)":[120],"relatively":[123],"stronger":[124],"polarity.":[125],"suggests":[127],"chemically":[132],"organized":[133],"certain":[136],"extent,":[137],"which":[138],"further":[140],"elucidated":[141],"in":[142],"terms":[143],"high":[145],"concentrations":[146],"required":[147],"hubs":[150],"drive":[152],"variety":[154],"reactions.":[156],"finding":[158],"not":[159],"only":[160],"provides":[161],"explanation":[164],"for":[170,179],"expansion,":[173],"but":[174],"also":[175],"important":[177],"implications":[178],"design":[182],"metabolite":[184],"concentration":[185],"prediction.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-05-03T08:25:01.440150","created_date":"2025-10-10T00:00:00"}
