{"id":"https://openalex.org/W22022247","doi":"https://doi.org/10.1371/journal.pcbi.1002192","title":"Calculation of fast reactor shielding.","display_name":"Calculation of fast reactor shielding.","publication_year":1973,"publication_date":"1973-04-30","ids":{"openalex":"https://openalex.org/W22022247","doi":"https://doi.org/10.1371/journal.pcbi.1002192","mag":"22022247"},"language":"en","primary_location":{"id":"mag:22022247","is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/4534757-calculation-fast-reactor-shielding","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039426815","display_name":"J. Burian","orcid":"https://orcid.org/0000-0003-4989-1417"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. Burian","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4989-1417","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052119723","display_name":"B. Stoces","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Stoces","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039426815"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0079966,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"10","first_page":"e1002192","last_page":"e1002192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13465","display_name":"Graphite, nuclear technology, radiation studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13465","display_name":"Graphite, nuclear technology, radiation studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10597","display_name":"Nuclear reactor physics and engineering","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2202","display_name":"Aerospace Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13923","display_name":"Nuclear and radioactivity studies","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/2213","display_name":"Safety, Risk, Reliability and Quality"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electromagnetic-shielding","display_name":"Electromagnetic shielding","score":0.5372113585472107},{"id":"https://openalex.org/keywords/nuclear-engineering","display_name":"Nuclear engineering","score":0.4776564836502075},{"id":"https://openalex.org/keywords/environmental-science","display_name":"Environmental science","score":0.3736557364463806},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36152634024620056},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.20228633284568787},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.1195513904094696}],"concepts":[{"id":"https://openalex.org/C2265751","wikidata":"https://www.wikidata.org/wiki/Q332007","display_name":"Electromagnetic shielding","level":2,"score":0.5372113585472107},{"id":"https://openalex.org/C116915560","wikidata":"https://www.wikidata.org/wiki/Q83504","display_name":"Nuclear engineering","level":1,"score":0.4776564836502075},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.3736557364463806},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36152634024620056},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.20228633284568787},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.1195513904094696}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:22022247","is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/4534757-calculation-fast-reactor-shielding","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.4399999976158142,"id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W106875160","https://openalex.org/W3184857282","https://openalex.org/W150443293","https://openalex.org/W1673424","https://openalex.org/W3185975649","https://openalex.org/W3186673871","https://openalex.org/W224398206","https://openalex.org/W187336813","https://openalex.org/W26215678","https://openalex.org/W2239046409","https://openalex.org/W868731784","https://openalex.org/W1599500910","https://openalex.org/W79231249","https://openalex.org/W2290445050","https://openalex.org/W83533082","https://openalex.org/W1879317","https://openalex.org/W2276542359","https://openalex.org/W350051007","https://openalex.org/W48353666","https://openalex.org/W216717559"],"abstract_inverted_index":{"Numerous":[0],"signaling":[1],"proteins":[2],"use":[3,247],"multivalent":[4,26,49],"binding":[5,23,27,32,116,151],"to":[6,40,92,129,138,152,198,250,261,287],"increase":[7],"the":[8,16,21,31,48,67,85,90,93,102,130,153,173,208,212,227,235,240,252,263,276,289,292,298],"specificity":[9],"and":[10,44,115,168,246,284],"affinity":[11],"of":[12,47,51,87,104,112,133,141,150,157,178,189,211,230,242,265,291],"their":[13],"interactions":[14,50],"within":[15],"cell.":[17],"Enhancement":[18],"arises":[19],"because":[20],"effective":[22],"constant":[24],"for":[25,34,106,239],"is":[28,196,221,275],"larger":[29],"than":[30,226],"constants":[33,238],"each":[35],"individual":[36],"interaction.":[37],"We":[38,205,272],"seek":[39],"gain":[41],"both":[42],"qualitative":[43],"quantitative":[45],"understanding":[46],"an":[52,121,185],"adaptor":[53],"protein,":[54],"growth":[55],"factor":[56,70],"receptor":[57],"bound":[58,197],"protein-2":[59],"(Grb2),":[60],"containing":[61,74],"two":[62,154],"SH3":[63,131,155,187,194,218],"domains":[64,132,156],"interacting":[65],"with":[66],"nucleotide":[68],"exchange":[69,103],"son-of-sevenless":[71],"1":[72],"(Sos1)":[73],"multiple":[75],"polyproline":[76,123,143,180,201],"motifs":[77,144,214],"separated":[78],"by":[79,100],"flexible":[80],"unstructured":[81],"regions.":[82],"Grb2":[83,190,217,243],"mediates":[84],"recruitment":[86],"Sos1":[88,126,146,183,213,245],"from":[89],"cytosol":[91],"plasma":[94],"membrane":[95],"where":[96],"it":[97],"activates":[98],"Ras":[99],"inducing":[101],"GDP":[105],"GTP.":[107],"First,":[108],"using":[109,160],"a":[110,139,161,179,199,216],"combination":[111],"evolutionary":[113],"information":[114],"energy":[117],"calculations,":[118],"we":[119,171,233,258],"predict":[120,262],"additional":[122],"motif":[124,181,202],"in":[125,145,175,297],"that":[127,147,207,215,267,280,294],"binds":[128],"Grb2.":[134,158],"This":[135],"gives":[136],"rise":[137],"total":[140],"five":[142],"are":[148,259,295],"capable":[149],"Then,":[159],"hybrid":[162],"method":[163],"combining":[164],"molecular":[165],"dynamics":[166],"simulations":[167],"polymer":[169],"models,":[170],"estimate":[172],"enhancement":[174],"local":[176,209],"concentration":[177,210,229],"on":[182,203,244],"near":[184],"unbound":[186],"domain":[188,195,219],"when":[191],"its":[192],"other":[193],"different":[200],"Sos1.":[204,231],"show":[206],"experiences":[220],"approximately":[222],"1000":[223],"times":[224],"greater":[225],"cellular":[228,299],"Finally,":[232],"calculate":[234,251],"intramolecular":[236],"equilibrium":[237,256],"crosslinking":[241],"thermodynamic":[248,285],"modeling":[249],"stoichiometry.":[253],"With":[254],"these":[255],"constants,":[257],"able":[260],"distribution":[264],"complexes":[266,293],"form":[268],"at":[269],"physiological":[270],"concentrations.":[271],"believe":[273],"this":[274],"first":[277],"systematic":[278],"analysis":[279],"combines":[281],"sequence,":[282],"structure,":[283],"analyses":[286],"determine":[288],"stoichiometry":[290],"dominant":[296],"environment.":[300]},"counts_by_year":[],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2016-06-24T00:00:00"}