{"id":"https://openalex.org/W2116022040","doi":"https://doi.org/10.1371/journal.pcbi.1002187","title":"Heat Shock Partially Dissociates the Overlapping Modules of the Yeast Protein-Protein Interaction Network: A Systems Level Model of Adaptation","display_name":"Heat Shock Partially Dissociates the Overlapping Modules of the Yeast Protein-Protein Interaction Network: A Systems Level Model of Adaptation","publication_year":2011,"publication_date":"2011-10-13","ids":{"openalex":"https://openalex.org/W2116022040","doi":"https://doi.org/10.1371/journal.pcbi.1002187","mag":"2116022040","pmid":"https://pubmed.ncbi.nlm.nih.gov/22022244"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002187","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002187","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002187&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002187&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088566460","display_name":"\u00c1goston Mihalik","orcid":"https://orcid.org/0000-0002-4510-4933"},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"\u00c1goston Mihalik","raw_affiliation_strings":["Department of Medical Chemistry, Semmelweis University, Budapest, Hungary","Department of Medical Chemistry, Semmelweis University Budapest Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"Department of Medical Chemistry, Semmelweis University Budapest Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081215274","display_name":"P\u00e9ter Csermely","orcid":"https://orcid.org/0000-0001-9234-0659"},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Peter Csermely","raw_affiliation_strings":["Department of Medical Chemistry, Semmelweis University, Budapest, Hungary","Department of Medical Chemistry, Semmelweis University Budapest Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Chemistry, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"Department of Medical Chemistry, Semmelweis University Budapest Hungary","institution_ids":["https://openalex.org/I101202996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081215274"],"corresponding_institution_ids":["https://openalex.org/I101202996"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.0547,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.96374574,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"7","issue":"10","first_page":"e1002187","last_page":"e1002187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.6841119527816772},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.6726694107055664},{"id":"https://openalex.org/keywords/heat-shock-protein","display_name":"Heat shock protein","score":0.6377882957458496},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.48006924986839294},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4793599247932434},{"id":"https://openalex.org/keywords/heat-shock","display_name":"Heat shock","score":0.4526906907558441},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.4441230297088623},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4433622360229492},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.43777209520339966},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41642487049102783},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.40917032957077026},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39355459809303284},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3168279528617859},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11893019080162048},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.09575971961021423}],"concepts":[{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.6841119527816772},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6726694107055664},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.6377882957458496},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.48006924986839294},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4793599247932434},{"id":"https://openalex.org/C137984847","wikidata":"https://www.wikidata.org/wiki/Q1621258","display_name":"Heat shock","level":4,"score":0.4526906907558441},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.4441230297088623},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4433622360229492},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43777209520339966},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41642487049102783},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40917032957077026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39355459809303284},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3168279528617859},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11893019080162048},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09575971961021423}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018869","descriptor_name":"Heat-Shock Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018869","descriptor_name":"Heat-Shock Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018869","descriptor_name":"Heat-Shock Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002187","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002187","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002187&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22022244","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22022244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1105.2933","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1105.2933","pdf_url":"https://arxiv.org/pdf/1105.2933","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.289.9856","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.289.9856","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/28/84/PLoS_Comput_Biol_2011_Oct_13_7(10)_e1002187.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ce364966cdf14583bd4d242aef701ad1","is_oa":true,"landing_page_url":"https://doaj.org/article/ce364966cdf14583bd4d242aef701ad1","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 10, p e1002187 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2199891","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3192799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/132387","is_oa":true,"landing_page_url":"https://figshare.com/articles/Heat_Shock_Partially_Dissociates_the_Overlapping_Modules_of_the_Yeast_Protein_Protein_Interaction_Network_A_Systems_Level_Model_of_Adaptation/132387","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002187","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002187","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002187&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.7300000190734863}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321994","display_name":"Hungarian Scientific Research Fund","ror":"https://ror.org/00v349e63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2116022040.pdf","grobid_xml":"https://content.openalex.org/works/W2116022040.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1236321187","https://openalex.org/W1515698993","https://openalex.org/W1876024155","https://openalex.org/W1891781482","https://openalex.org/W1921865614","https://openalex.org/W1965106998","https://openalex.org/W1970655941","https://openalex.org/W1983923558","https://openalex.org/W1987363726","https://openalex.org/W1988263223","https://openalex.org/W1989921625","https://openalex.org/W1993009001","https://openalex.org/W1995089961","https://openalex.org/W1998203484","https://openalex.org/W2002574233","https://openalex.org/W2003516452","https://openalex.org/W2010371279","https://openalex.org/W2013947447","https://openalex.org/W2014879346","https://openalex.org/W2024839376","https://openalex.org/W2037102228","https://openalex.org/W2044539850","https://openalex.org/W2044775606","https://openalex.org/W2047940964","https://openalex.org/W2050721857","https://openalex.org/W2056043815","https://openalex.org/W2057264950","https://openalex.org/W2058485739","https://openalex.org/W2065304353","https://openalex.org/W2074986735","https://openalex.org/W2081050097","https://openalex.org/W2090317414","https://openalex.org/W2105801075","https://openalex.org/W2109281577","https://openalex.org/W2110620844","https://openalex.org/W2111554317","https://openalex.org/W2117219281","https://openalex.org/W2118279186","https://openalex.org/W2119782490","https://openalex.org/W2123318061","https://openalex.org/W2127048411","https://openalex.org/W2127754721","https://openalex.org/W2132488095","https://openalex.org/W2136074542","https://openalex.org/W2136760026","https://openalex.org/W2136850043","https://openalex.org/W2137683543","https://openalex.org/W2139553051","https://openalex.org/W2139665091","https://openalex.org/W2139939149","https://openalex.org/W2142029338","https://openalex.org/W2145290999","https://openalex.org/W2150566147","https://openalex.org/W2151041575","https://openalex.org/W2155037464","https://openalex.org/W2159675211","https://openalex.org/W2162032011","https://openalex.org/W2163480486","https://openalex.org/W2164635606","https://openalex.org/W2167785155","https://openalex.org/W2167867998","https://openalex.org/W2169528473","https://openalex.org/W2170427655","https://openalex.org/W2170778160","https://openalex.org/W2172039086","https://openalex.org/W2505553049","https://openalex.org/W2593186863","https://openalex.org/W2596018601","https://openalex.org/W2602816740","https://openalex.org/W2791411336","https://openalex.org/W2915108429","https://openalex.org/W2963200814","https://openalex.org/W3099481235","https://openalex.org/W3102641634","https://openalex.org/W4239029175","https://openalex.org/W4242095403","https://openalex.org/W4300030682","https://openalex.org/W6680634848","https://openalex.org/W6734910235"],"related_works":["https://openalex.org/W108401637","https://openalex.org/W2124445532","https://openalex.org/W2085889605","https://openalex.org/W3048595523","https://openalex.org/W2417176354","https://openalex.org/W2020103418","https://openalex.org/W2011687389","https://openalex.org/W2084664916","https://openalex.org/W2292895565","https://openalex.org/W2990536258"],"abstract_inverted_index":{"Network":[0],"analysis":[1,59],"became":[2,145],"a":[3,23,106,131,157,170,184,200,216,264,282,285],"powerful":[4],"tool":[5],"giving":[6],"new":[7],"insights":[8],"to":[9,169,189,204,290],"the":[10,17,49,58,61,64,76,79,82,86,111,123,127,141,175,179,195,220,224,272],"understanding":[11],"of":[12,19,28,60,63,78,81,88,98,115,126,140,147,160,174,191,206,219,223,237,267,275,284],"cellular":[13,29],"behavior.":[14],"Heat":[15],"shock,":[16],"archetype":[18],"stress":[20,46,68],"responses,":[21],"is":[22,33,101],"well-characterized":[24],"and":[25,45,113,249,262],"simple":[26],"model":[27,36,283],"dynamics.":[30],"S.":[31],"cerevisiae":[32],"an":[34],"appropriate":[35],"organism,":[37],"since":[38,178],"both":[39,110],"its":[40],"protein-protein":[41],"interaction":[42],"network":[43],"(interactome)":[44],"response":[47,144],"at":[48],"gene":[50],"expression":[51,90],"level":[52],"have":[53],"been":[54,71],"well":[55,153],"characterized.":[56],"However,":[57],"reorganization":[62],"yeast":[65,83,116,128,181,225],"interactome":[66,84,117,129,176,182,198],"during":[67],"has":[69],"not":[70],"investigated":[72],"yet.":[73],"We":[74],"calculated":[75],"changes":[77,87,167],"interaction-weights":[80],"from":[85],"mRNA":[89],"levels":[91],"upon":[92],"heat":[93,103,135,142,148,163,196,213],"shock.":[94,136,164],"The":[95,165],"major":[96],"finding":[97],"our":[99,278],"study":[100],"that":[102,190,205,212],"shock":[104,143,214],"induced":[105],"significant":[107],"decrease":[108,253],"in":[109,134,234,271],"overlaps":[112],"connections":[114],"modules.":[118],"In":[119],"agreement":[120],"with":[121],"this":[122],"weighted":[124],"diameter":[125],"had":[130,183,199],"4.9-fold":[132],"increase":[133],"Several":[137],"key":[138],"proteins":[139],"centers":[146],"shock-induced":[149],"local":[150],"communities,":[151],"as":[152,154,244],"bridges":[155],"providing":[156],"residual":[158],"connection":[159],"modules":[161],"after":[162],"observed":[166],"resemble":[168],"'stratus-cumulus'":[171],"type":[172],"transition":[173],"structure,":[177],"unstressed":[180],"globally":[185],"connected":[186],"organization,":[187,202],"similar":[188,203],"stratus":[192],"clouds,":[193],"whereas":[194],"shocked":[197],"multifocal":[201],"cumulus":[207],"clouds.":[208],"Our":[209],"results":[210],"showed":[211],"induces":[215],"partial":[217,265],"disintegration":[218,266],"global":[221,269],"organization":[222],"interactome.":[226],"This":[227],"change":[228],"may":[229,251,280],"be":[230],"rather":[231],"general":[232],"occurring":[233],"many":[235],"types":[236],"stresses.":[238],"Moreover,":[239],"other":[240],"complex":[241],"systems,":[242],"such":[243],"single":[245],"proteins,":[246],"social":[247],"networks":[248],"ecosystems":[250],"also":[252],"their":[254,268],"inter-modular":[255],"links,":[256],"thus":[257],"develop":[258],"more":[259],"compact":[260],"modules,":[261],"display":[263],"structure":[270],"initial":[273],"phase":[274],"crisis.":[276],"Thus,":[277],"work":[279],"provide":[281],"general,":[286],"system-level":[287],"adaptation":[288],"mechanism":[289],"environmental":[291],"changes.":[292]},"counts_by_year":[{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":11}],"updated_date":"2026-05-04T08:30:34.212998","created_date":"2025-10-10T00:00:00"}