{"id":"https://openalex.org/W2056264942","doi":"https://doi.org/10.1371/journal.pcbi.1002170","title":"Identification of a Novel Class of Farnesylation Targets by Structure-Based Modeling of Binding Specificity","display_name":"Identification of a Novel Class of Farnesylation Targets by Structure-Based Modeling of Binding Specificity","publication_year":2011,"publication_date":"2011-10-06","ids":{"openalex":"https://openalex.org/W2056264942","doi":"https://doi.org/10.1371/journal.pcbi.1002170","mag":"2056264942","pmid":"https://pubmed.ncbi.nlm.nih.gov/21998565"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002170","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002170","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002170&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002170&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044428734","display_name":"Nir London","orcid":"https://orcid.org/0000-0003-2687-0699"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nir London","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem, Israel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060840579","display_name":"Corissa L. Lamphear","orcid":null},"institutions":[{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corissa L. Lamphear","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012376260","display_name":"James L. Hougland","orcid":"https://orcid.org/0000-0003-0444-1017"},"institutions":[{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L. Hougland","raw_affiliation_strings":["Department of Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062407037","display_name":"Carol A. Fierke","orcid":"https://orcid.org/0000-0002-1481-0579"},"institutions":[{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol A. Fierke","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America","Department of Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]},{"raw_affiliation_string":"Department of Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034150494","display_name":"Ora Schueler\u2010Furman","orcid":"https://orcid.org/0000-0002-1624-0362"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ora Schueler-Furman","raw_affiliation_strings":["Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, Institute for Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem, Israel","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5034150494"],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.001,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.8625386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"7","issue":"10","first_page":"e1002170","last_page":"e1002170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/farnesyltransferase","display_name":"Farnesyltransferase","score":0.9495692849159241},{"id":"https://openalex.org/keywords/prenylation","display_name":"Prenylation","score":0.9316753149032593},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.5295121669769287},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4542430639266968},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4460068941116333},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4213711619377136},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.4103362560272217},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.29799938201904297},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19284319877624512}],"concepts":[{"id":"https://openalex.org/C2778396349","wikidata":"https://www.wikidata.org/wiki/Q410994","display_name":"Farnesyltransferase","level":4,"score":0.9495692849159241},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.9316753149032593},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5295121669769287},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4542430639266968},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4460068941116333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4213711619377136},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.4103362560272217},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29799938201904297},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19284319877624512}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017368","descriptor_name":"Protein Prenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017368","descriptor_name":"Protein Prenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017368","descriptor_name":"Protein Prenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051231","descriptor_name":"Farnesyltranstransferase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002170","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002170","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002170&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21998565","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21998565","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.290.1181","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.290.1181","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/04/5c/PLoS_Comput_Biol_2011_Oct_6_7(10)_e1002170.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:97d6d25ef4454004a05012b159a532b5","is_oa":true,"landing_page_url":"https://doaj.org/article/97d6d25ef4454004a05012b159a532b5","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 10, p e1002170 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2195566","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3188499","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/132602","is_oa":true,"landing_page_url":"https://figshare.com/articles/Identification_of_a_Novel_Class_of_Farnesylation_Targets_by_Structure_Based_Modeling_of_Binding_Specificity/132602","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002170","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002170","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002170&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4699999988079071,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G2364690958","display_name":null,"funder_award_id":"GM40602","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6979747846","display_name":null,"funder_award_id":"306/6","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G7127794324","display_name":null,"funder_award_id":"GM78894","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320323278","display_name":"Council for Higher Education","ror":"https://ror.org/036mqp197"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335375","display_name":"Planning and Budgeting Committee of the Council for Higher Education of Israel","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2056264942.pdf","grobid_xml":"https://content.openalex.org/works/W2056264942.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W145265700","https://openalex.org/W1482701468","https://openalex.org/W1527847472","https://openalex.org/W1530704185","https://openalex.org/W1548178570","https://openalex.org/W1583605194","https://openalex.org/W1963209155","https://openalex.org/W1970716791","https://openalex.org/W1971015478","https://openalex.org/W1971855004","https://openalex.org/W1979053057","https://openalex.org/W1979593913","https://openalex.org/W1981866993","https://openalex.org/W1987656526","https://openalex.org/W1990338952","https://openalex.org/W1990690495","https://openalex.org/W1991867962","https://openalex.org/W1991930569","https://openalex.org/W1992653365","https://openalex.org/W2001842251","https://openalex.org/W2019408526","https://openalex.org/W2020120027","https://openalex.org/W2021780570","https://openalex.org/W2022892730","https://openalex.org/W2023272942","https://openalex.org/W2031079064","https://openalex.org/W2035056536","https://openalex.org/W2039266469","https://openalex.org/W2040171181","https://openalex.org/W2044012842","https://openalex.org/W2051025707","https://openalex.org/W2051795211","https://openalex.org/W2057482592","https://openalex.org/W2058001460","https://openalex.org/W2061398096","https://openalex.org/W2070075606","https://openalex.org/W2084853207","https://openalex.org/W2088485431","https://openalex.org/W2090356463","https://openalex.org/W2091583410","https://openalex.org/W2094392347","https://openalex.org/W2094585531","https://openalex.org/W2102766810","https://openalex.org/W2103017472","https://openalex.org/W2107272456","https://openalex.org/W2116562970","https://openalex.org/W2116864669","https://openalex.org/W2116890528","https://openalex.org/W2128392882","https://openalex.org/W2129507901","https://openalex.org/W2130343520","https://openalex.org/W2134699117","https://openalex.org/W2135815512","https://openalex.org/W2146134187","https://openalex.org/W2152134842","https://openalex.org/W2158217645","https://openalex.org/W2160063693","https://openalex.org/W2162686344","https://openalex.org/W2167158605","https://openalex.org/W2167590728","https://openalex.org/W2176744910","https://openalex.org/W2441231988","https://openalex.org/W3145366215","https://openalex.org/W4211000692","https://openalex.org/W4240500453","https://openalex.org/W4285719527","https://openalex.org/W6718363994","https://openalex.org/W7043571410"],"related_works":["https://openalex.org/W2071070388","https://openalex.org/W3009150833","https://openalex.org/W1971015478","https://openalex.org/W1985238450","https://openalex.org/W2080671298","https://openalex.org/W2167991973","https://openalex.org/W2777381435","https://openalex.org/W1604895004","https://openalex.org/W2055429090","https://openalex.org/W2467522338"],"abstract_inverted_index":{"Farnesylation":[0],"is":[1,20,138],"an":[2,88],"important":[3],"post-translational":[4],"modification":[5],"catalyzed":[6],"by":[7],"farnesyltransferase":[8],"(FTase).":[9],"Until":[10],"recently":[11],"it":[12,127],"was":[13],"believed":[14],"that":[15,129],"a":[16,37,72,83,133,139],"C-terminal":[17,90],"CaaX":[18],"motif":[19],"required":[21],"for":[22,44,142],"farnesylation,":[23],"but":[24],"recent":[25],"experiments":[26,95],"have":[27],"revealed":[28],"larger":[29],"substrate":[30,85],"diversity.":[31],"In":[32,59,93],"this":[33],"study,":[34],"we":[35,69],"propose":[36],"general":[38],"structural":[39],"modeling":[40],"scheme":[41],"to":[42,61,112,135,154],"account":[43],"peptide":[45,134],"binding":[46],"specificity":[47],"and":[48,157,163],"recapitulate":[49],"the":[50,79,119,130,143,166],"experimentally":[51],"derived":[52],"selectivity":[53],"profile":[54],"of":[55,65,74,98,122,132,149,160],"FTase":[56,67,137],"in":[57,78,165],"vitro.":[58],"addition":[60],"highly":[62],"accurate":[63,156],"recovery":[64],"known":[66],"targets,":[68,106],"also":[70],"identify":[71],"range":[73,121],"novel":[75,104],"potential":[76],"targets":[77],"human":[80,105],"genome,":[81],"including":[82,102],"new":[84],"class":[86],"with":[87],"acidic":[89],"residue":[91],"(CxxD/E).":[92],"vitro":[94],"verified":[96],"farnesylation":[97,124,144],"26/29":[99],"tested":[100],"peptides,":[101],"both":[103],"as":[107,109],"well":[108],"peptides":[110],"predicted":[111],"tightly":[113],"bind":[114,136],"FTase.":[115],"This":[116],"study":[117],"extends":[118],"putative":[120],"biological":[123],"substrates.":[125],"Moreover,":[126],"suggests":[128],"ability":[131],"main":[140],"determinant":[141],"reaction.":[145],"Finally,":[146],"simple":[147],"adaptation":[148],"our":[150],"approach":[151],"can":[152],"contribute":[153],"more":[155],"complete":[158],"elucidation":[159],"peptide-mediated":[161],"interactions":[162],"modifications":[164],"cell.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}