{"id":"https://openalex.org/W2003318443","doi":"https://doi.org/10.1371/journal.pcbi.1002132","title":"Conflicting Biomedical Assumptions for Mathematical Modeling: The Case of Cancer Metastasis","display_name":"Conflicting Biomedical Assumptions for Mathematical Modeling: The Case of Cancer Metastasis","publication_year":2011,"publication_date":"2011-10-06","ids":{"openalex":"https://openalex.org/W2003318443","doi":"https://doi.org/10.1371/journal.pcbi.1002132","mag":"2003318443","pmid":"https://pubmed.ncbi.nlm.nih.gov/21998558"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002132","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002132","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002132&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002132&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061024321","display_name":"Anna Divoli","orcid":"https://orcid.org/0000-0003-2324-3542"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Divoli","raw_affiliation_strings":["Department of Medicine, University of Chicago, Chicago, Illinois, United States of America","Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107413159","display_name":"Eneida A. Mendon\u00e7a","orcid":null},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eneida A. Mendon\u00e7a","raw_affiliation_strings":["Computation Institute, University of Chicago, Chicago, Illinois, United States of America","Department of Pediatrics, University of Chicago, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Computation Institute, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Pediatrics, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076633756","display_name":"James A. Evans","orcid":"https://orcid.org/0000-0001-9838-0707"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Evans","raw_affiliation_strings":["Computation Institute, University of Chicago, Chicago, Illinois, United States of America","Department of Sociology, University of Chicago, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Computation Institute, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Sociology, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004739989","display_name":"Andrey Rzhetsky","orcid":"https://orcid.org/0000-0001-6959-7405"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrey Rzhetsky","raw_affiliation_strings":["Computation Institute, University of Chicago, Chicago, Illinois, United States of America","Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America","Department of Medicine, University of Chicago, Chicago, Illinois, United States of America","Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Computation Institute, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Medicine, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004739989"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.1961,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.7684975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"7","issue":"10","first_page":"e1002132","last_page":"e1002132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9832000136375427,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9817000031471252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomedicine","display_name":"Biomedicine","score":0.646950900554657},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5900144577026367},{"id":"https://openalex.org/keywords/cancer-metastasis","display_name":"Cancer metastasis","score":0.5363622307777405},{"id":"https://openalex.org/keywords/viewpoints","display_name":"Viewpoints","score":0.4891079068183899},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.4673885107040405},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.451739102602005},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4479486644268036},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.4172573387622833},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4074747562408447},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3891989588737488},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.38587039709091187},{"id":"https://openalex.org/keywords/management-science","display_name":"Management science","score":0.3703659474849701},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.28218090534210205},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2627298831939697},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22003427147865295}],"concepts":[{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.646950900554657},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5900144577026367},{"id":"https://openalex.org/C2992691968","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Cancer metastasis","level":4,"score":0.5363622307777405},{"id":"https://openalex.org/C2776035091","wikidata":"https://www.wikidata.org/wiki/Q7928819","display_name":"Viewpoints","level":2,"score":0.4891079068183899},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4673885107040405},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.451739102602005},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4479486644268036},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.4172573387622833},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4074747562408447},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3891989588737488},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38587039709091187},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.3703659474849701},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28218090534210205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2627298831939697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22003427147865295},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005104","descriptor_name":"Expert Testimony","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005104","descriptor_name":"Expert Testimony","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005104","descriptor_name":"Expert Testimony","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002132","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002132","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002132&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21998558","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21998558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:uchicago.tind.io:10227","is_oa":true,"landing_page_url":"http://knowledge.uchicago.edu/record/10227","pdf_url":null,"source":{"id":"https://openalex.org/S4306402460","display_name":"Knowledge@UChicago (University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40347166","host_organization_name":"University of Chicago","host_organization_lineage":["https://openalex.org/I40347166"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://knowledge.uchicago.edu/record/10227","raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002132","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002132","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:ae62ebaaa8044032be870328fd7a95da","is_oa":true,"landing_page_url":"https://doaj.org/article/ae62ebaaa8044032be870328fd7a95da","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 10, p e1002132 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2195560","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3188482","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/132715","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Conflicting_Biomedical_Assumptions_for_Mathematical_Modeling_The_Case_of_Cancer_Metastasis/132715","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002132","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002132","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002132&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2547184436","display_name":null,"funder_award_id":"R01LM010132","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3611247453","display_name":null,"funder_award_id":"R01GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7823177495","display_name":null,"funder_award_id":"010132","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320311496","display_name":"Ludwig Institute for Cancer Research","ror":"https://ror.org/05qdwtz81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003318443.pdf","grobid_xml":"https://content.openalex.org/works/W2003318443.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W583714170","https://openalex.org/W638341567","https://openalex.org/W1487597009","https://openalex.org/W1541009479","https://openalex.org/W1967304777","https://openalex.org/W1985727076","https://openalex.org/W2004016276","https://openalex.org/W2004077802","https://openalex.org/W2013821356","https://openalex.org/W2022872496","https://openalex.org/W2034269086","https://openalex.org/W2050283732","https://openalex.org/W2050434578","https://openalex.org/W2082510242","https://openalex.org/W2114202040","https://openalex.org/W2133469585","https://openalex.org/W2143254816","https://openalex.org/W2144981148","https://openalex.org/W2155513791","https://openalex.org/W2158719122","https://openalex.org/W2170310928","https://openalex.org/W2243629635","https://openalex.org/W2314720973","https://openalex.org/W2332423244","https://openalex.org/W2334220360","https://openalex.org/W2753533763","https://openalex.org/W3011865677","https://openalex.org/W3021664385","https://openalex.org/W3143255087","https://openalex.org/W4237327899","https://openalex.org/W4245558686","https://openalex.org/W4300182378","https://openalex.org/W6622243269","https://openalex.org/W6629208196","https://openalex.org/W6653967188","https://openalex.org/W6662873913","https://openalex.org/W7072335933"],"related_works":["https://openalex.org/W2408369942","https://openalex.org/W2764246122","https://openalex.org/W2509747167","https://openalex.org/W2460541251","https://openalex.org/W2800988295","https://openalex.org/W2314032833","https://openalex.org/W2394613142","https://openalex.org/W2111584953","https://openalex.org/W1559869854","https://openalex.org/W2404855022"],"abstract_inverted_index":{"Computational":[0],"models":[1],"in":[2,37,58,78,101,186,197],"biomedicine":[3,198],"rely":[4],"on":[5,94,121,258],"biological":[6,64],"and":[7,44,52,80,86,127,184,218,241,281,286,291],"clinical":[8,79],"assumptions.":[9,141],"The":[10,245],"selection":[11],"of":[12,30,47,68,83,97,149,169,177,212,224,231,261,268],"these":[13,48,150],"assumptions":[14,49,280],"contributes":[15],"substantially":[16],"to":[17,137,202,214],"modeling":[18],"success":[19],"or":[20,123,147,155],"failure.":[21],"Assumptions":[22],"used":[23],"by":[24],"experts":[25,77,91,118,134,151,204],"at":[26,237],"the":[27,66,95,113,143,161,187,221,235,243,259,269],"cutting":[28],"edge":[29],"research,":[31],"however,":[32],"are":[33,135,195],"rarely":[34],"explicitly":[35],"described":[36],"scientific":[38],"publications.":[39],"One":[40],"can":[41,255],"directly":[42],"collect":[43],"assess":[45],"some":[46],"through":[50,271],"interviews":[51],"surveys.":[53],"Here":[54],"we":[55,276],"investigate":[56],"diversity":[57,176],"expert":[59,105,216],"views":[60,194],"about":[61,139,158],"a":[62,156,170,208,248],"complex":[63],"phenomenon,":[65],"process":[67,260],"cancer":[69,84,239],"metastasis.":[70,262],"We":[71,111,189,206],"harvested":[72,284],"individual":[73,98],"viewpoints":[74],"from":[75],"28":[76],"molecular":[81],"aspects":[82],"metastasis":[85,108,213],"summarized":[87],"them":[88],"computationally.":[89],"While":[90],"predominantly":[92],"agreed":[93],"definition":[96],"steps":[99],"involved":[100],"metastasis,":[102],"no":[103],"two":[104,117,131,146],"scenarios":[106],"for":[107,182,289],"were":[109],"identical.":[110],"computed":[112],"probability":[114,144,162],"that":[115,129,145,163,191,278],"any":[116,130],"would":[119,264],"disagree":[120,138,166],"k":[122],"fewer":[124],"metastatic":[125,159,225],"stages":[126,230],"found":[128],"randomly":[132],"selected":[133],"likely":[136],"several":[140],"Considering":[142],"more":[148],"review":[152],"an":[153],"article":[154],"proposal":[157],"cascades,":[160],"they":[164],"will":[165],"with":[167],"elements":[168],"proposed":[171],"model":[172,211,228,246,270,279],"approaches":[173],"1.":[174],"This":[175,227,263],"conceptions":[178],"has":[179],"clear":[180],"consequences":[181],"advance":[183],"deadlock":[185],"field.":[188],"suggest":[190],"strong,":[192],"incompatible":[193],"common":[196],"but":[199],"largely":[200],"invisible":[201],"biomedical":[203],"themselves.":[205],"built":[207],"formal":[209,249],"Markov":[210],"encapsulate":[215],"convergence":[217],"divergence":[219],"regarding":[220],"entire":[222],"sequence":[223],"stages.":[226],"revealed":[229],"greatest":[232],"disagreement,":[233],"including":[234],"points":[236],"which":[238,253],"enters":[240],"leaves":[242],"bloodstream.":[244],"provides":[247],"probabilistic":[250,273],"hypothesis":[251],"against":[252],"researchers":[254],"evaluate":[256],"data":[257],"enable":[265],"subsequent":[266],"improvement":[267],"Bayesian":[272],"update.":[274],"Practically,":[275],"propose":[277],"hunches":[282],"be":[283],"systematically":[285],"made":[287],"available":[288],"modelers":[290],"scientists.":[292]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
