{"id":"https://openalex.org/W2014392153","doi":"https://doi.org/10.1371/journal.pcbi.1002122","title":"A Mathematical Model for the Reciprocal Differentiation of T Helper 17 Cells and Induced Regulatory T Cells","display_name":"A Mathematical Model for the Reciprocal Differentiation of T Helper 17 Cells and Induced Regulatory T Cells","publication_year":2011,"publication_date":"2011-07-28","ids":{"openalex":"https://openalex.org/W2014392153","doi":"https://doi.org/10.1371/journal.pcbi.1002122","mag":"2014392153","pmid":"https://pubmed.ncbi.nlm.nih.gov/21829337"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002122","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002122","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002122&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002122&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072122666","display_name":"Tian Hong","orcid":"https://orcid.org/0000-0002-8212-7050"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian Hong","raw_affiliation_strings":["Genetics, Bioinformatics, and Computational Biology Program, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Genetics, Bioinformatics, and Computational Biology Program, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022028189","display_name":"Jianhua Xing","orcid":"https://orcid.org/0000-0002-3700-8765"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhua Xing","raw_affiliation_strings":["Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455242","display_name":"Liwu Li","orcid":"https://orcid.org/0000-0001-8870-5299"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liwu Li","raw_affiliation_strings":["Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028908910","display_name":"John J. Tyson","orcid":"https://orcid.org/0000-0001-7560-6013"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John J. Tyson","raw_affiliation_strings":["Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028908910"],"corresponding_institution_ids":["https://openalex.org/I859038795"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.3405,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.92579662,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"7","issue":"7","first_page":"e1002122","last_page":"e1002122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7068961262702942},{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.6377288699150085},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.6090312600135803},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5622527599334717},{"id":"https://openalex.org/keywords/effector","display_name":"Effector","score":0.5364620685577393},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5242871642112732},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"Retinoic acid","score":0.4230566918849945},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.32896676659584045},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.24440103769302368}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7068961262702942},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.6377288699150085},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6090312600135803},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5622527599334717},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5364620685577393},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5242871642112732},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.4230566918849945},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32896676659584045},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24440103769302368}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057132","descriptor_name":"Nuclear Receptor Subfamily 1, Group F, Member 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057132","descriptor_name":"Nuclear Receptor Subfamily 1, Group F, Member 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057132","descriptor_name":"Nuclear Receptor Subfamily 1, Group F, Member 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1002122","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002122","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002122&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21829337","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21829337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.349.6708","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.349.6708","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/5d/16/PLoS_Comput_Biol_2011_Jul_28_7(7)_e1002122.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002122","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002122","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:bbdadd1de16b4234bb1a342754193498","is_oa":true,"landing_page_url":"https://doaj.org/article/bbdadd1de16b4234bb1a342754193498","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 7, p e1002122 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2159187","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3145653","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/134724","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Mathematical_Model_for_the_Reciprocal_Differentiation_of_T_Helper_17_Cells_and_Induced_Regulatory_T_Cells/134724","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/73636","is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/73636","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002122","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002122","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002122&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2245685515","display_name":null,"funder_award_id":"DMS-0969417","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5783598936","display_name":"Model reduction in systems biology: the Mori-Zwanzig projection method","funder_award_id":"0969417","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014392153.pdf","grobid_xml":"https://content.openalex.org/works/W2014392153.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1538005302","https://openalex.org/W1886819223","https://openalex.org/W1939125543","https://openalex.org/W1966073503","https://openalex.org/W1977181138","https://openalex.org/W1981941131","https://openalex.org/W1982006380","https://openalex.org/W1984270581","https://openalex.org/W1987128447","https://openalex.org/W1987735044","https://openalex.org/W1992428669","https://openalex.org/W1993292726","https://openalex.org/W1997814909","https://openalex.org/W2004186675","https://openalex.org/W2012706589","https://openalex.org/W2014677321","https://openalex.org/W2016354087","https://openalex.org/W2027703497","https://openalex.org/W2028195000","https://openalex.org/W2029640857","https://openalex.org/W2029819700","https://openalex.org/W2029991507","https://openalex.org/W2035944097","https://openalex.org/W2036338631","https://openalex.org/W2037259928","https://openalex.org/W2043776488","https://openalex.org/W2046442721","https://openalex.org/W2052998574","https://openalex.org/W2062811432","https://openalex.org/W2070791475","https://openalex.org/W2072492970","https://openalex.org/W2080721009","https://openalex.org/W2081848717","https://openalex.org/W2092345398","https://openalex.org/W2097811455","https://openalex.org/W2110491264","https://openalex.org/W2114355189","https://openalex.org/W2116828514","https://openalex.org/W2116891319","https://openalex.org/W2117200840","https://openalex.org/W2120294390","https://openalex.org/W2128211931","https://openalex.org/W2140651397","https://openalex.org/W2142017607","https://openalex.org/W2142877732","https://openalex.org/W2152014155","https://openalex.org/W2154728251","https://openalex.org/W2155779547","https://openalex.org/W2160196028","https://openalex.org/W2160836190","https://openalex.org/W2161112755","https://openalex.org/W2165625463","https://openalex.org/W2166132142","https://openalex.org/W2167586970","https://openalex.org/W2168221215","https://openalex.org/W2172466148","https://openalex.org/W2772222670"],"related_works":["https://openalex.org/W4320492283","https://openalex.org/W1530034981","https://openalex.org/W4214695225","https://openalex.org/W3197607994","https://openalex.org/W2783284266","https://openalex.org/W4380992933","https://openalex.org/W1994697802","https://openalex.org/W1996256934","https://openalex.org/W2135691770","https://openalex.org/W2014889329"],"abstract_inverted_index":{"The":[0],"reciprocal":[1],"differentiation":[2,91,109,213,269],"of":[3,25,56,75,107,124,133,147,153,212,229,246],"T":[4,12,79,161],"helper":[5],"17":[6],"(T(H)17)":[7],"cells":[8,14,59,80,135,203],"and":[9,23,50,65,68,186,189,266],"induced":[10],"regulatory":[11],"(iT(reg))":[13],"plays":[15],"a":[16,34,73,104,131,210,219,237,243,250],"critical":[17],"role":[18],"in":[19,53,204,207],"both":[20,230],"the":[21,39,42,54,69,89,129,154,159,195,216,223],"pathogenesis":[22],"resolution":[24],"diverse":[26,86],"human":[27],"inflammatory":[28],"diseases.":[29],"Although":[30],"initial":[31],"studies":[32],"suggested":[33],"stable":[35,114],"commitment":[36],"to":[37,60,128,174,198,209,236],"either":[38],"T(H)17":[40,64],"or":[41],"iT(reg)":[43,66],"lineage,":[44],"recent":[45],"results":[46],"reveal":[47],"remarkable":[48],"plasticity":[49],"heterogeneity,":[51],"reflected":[52],"capacity":[55],"differentiated":[57],"effectors":[58],"be":[61,82,175,192],"reprogrammed":[62],"among":[63,275],"lineages":[67],"intriguing":[70],"phenomenon":[71],"that":[72,110,278],"group":[74,132],"na\u00efve":[76],"precursor":[77,134,252],"CD4(+)":[78],"can":[81,141],"programmed":[83],"into":[84,143],"phenotypically":[85,144],"populations":[87],"by":[88,118,180,194],"same":[90],"signal,":[92],"transforming":[93],"growth":[94],"factor":[95],"beta.":[96],"To":[97],"reconcile":[98,261],"these":[99,169],"observations,":[100],"we":[101],"have":[102,279],"built":[103],"mathematical":[105],"model":[106,217],"T(H)17/iT(reg)":[108],"exhibits":[111],"four":[112],"different":[113,276],"steady":[115],"states,":[116],"governed":[117],"pitchfork":[119],"bifurcations":[120],"with":[121,136,168,225],"certain":[122],"degrees":[123],"broken":[125],"symmetry.":[126],"According":[127],"model,":[130],"some":[137,256],"small":[138],"cell-to-cell":[139],"variability":[140],"differentiate":[142],"distinct":[145,151,201],"subsets":[146],"cells,":[148],"which":[149],"exhibit":[150],"levels":[152,228],"master":[155,231],"transcription-factor":[156],"regulators":[157],"for":[158,222],"two":[160],"cell":[162],"lineages.":[163],"A":[164],"dynamical":[165],"control":[166],"system":[167,197],"properties":[170],"is":[171],"flexible":[172],"enough":[173],"steered":[176],"down":[177],"alternative":[178],"pathways":[179],"polarizing":[181],"signals,":[182],"such":[183],"as":[184,271,273],"interleukin-6":[185],"retinoic":[187],"acid":[188],"it":[190],"may":[191],"used":[193],"immune":[196],"generate":[199],"functionally":[200],"effector":[202],"desired":[205],"fractions":[206],"response":[208],"range":[211],"signals.":[214],"Additionally,":[215],"suggests":[218],"quantitative":[220],"explanation":[221],"phenotype":[224,234],"high":[226],"expression":[227],"regulators.":[232],"This":[233],"corresponds":[235],"re-stabilized":[238],"co-expressing":[239],"state,":[240],"appearing":[241],"at":[242],"late":[244],"stage":[245],"differentiation,":[247],"rather":[248],"than":[249],"bipotent":[251],"state":[253],"observed":[254,283],"under":[255],"other":[257],"circumstances.":[258],"Our":[259],"simulations":[260],"most":[262],"published":[263],"experimental":[264],"observations":[265],"predict":[267],"novel":[268],"states":[270],"well":[272],"transitions":[274],"phenotypes":[277],"not":[280],"yet":[281],"been":[282],"experimentally.":[284]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
