{"id":"https://openalex.org/W2037261891","doi":"https://doi.org/10.1371/journal.pcbi.1002116","title":"In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans","display_name":"In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans","publication_year":2011,"publication_date":"2011-07-21","ids":{"openalex":"https://openalex.org/W2037261891","doi":"https://doi.org/10.1371/journal.pcbi.1002116","mag":"2037261891","pmid":"https://pubmed.ncbi.nlm.nih.gov/21814506"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002116","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002116","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002116&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002116&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073977487","display_name":"Christoph Kaleta","orcid":"https://orcid.org/0000-0001-8004-9514"},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Christoph Kaleta","raw_affiliation_strings":["Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Jena, Germany. christoph.kaleta@uni-jena.de","Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Jena, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Jena, Germany. christoph.kaleta@uni-jena.de","institution_ids":["https://openalex.org/I76198965"]},{"raw_affiliation_string":"Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053817856","display_name":"Lu\u00eds F. de Figueiredo","orcid":"https://orcid.org/0000-0003-0005-5629"},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lu\u00eds F. de Figueiredo","raw_affiliation_strings":["Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Jena, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041014738","display_name":"Sarah Werner","orcid":"https://orcid.org/0000-0002-6677-846X"},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sarah Werner","raw_affiliation_strings":["Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Jena, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113767813","display_name":"Reinhard Guthke","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Reinhard Guthke","raw_affiliation_strings":["Systems Biology/Bioinformatics Group, Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans Kn\u00f6ll Institute, Jena, Germany"],"affiliations":[{"raw_affiliation_string":"Systems Biology/Bioinformatics Group, Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans Kn\u00f6ll Institute, Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047183170","display_name":"Michael Ristow","orcid":"https://orcid.org/0000-0003-2109-2453"},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Ristow","raw_affiliation_strings":["Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam-Rehbr\u00fccke, Nuthetal, Germany","Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam-Rehbr\u00fccke, Nuthetal, Germany","institution_ids":["https://openalex.org/I4210162705"]},{"raw_affiliation_string":"Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101433039","display_name":"Stefan Schuster","orcid":null},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Schuster","raw_affiliation_strings":["Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Jena, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5073977487"],"corresponding_institution_ids":["https://openalex.org/I76198965"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.5346,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.89593114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"7","issue":"7","first_page":"e1002116","last_page":"e1002116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"Gluconeogenesis","score":0.9152741432189941},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6419520974159241},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.6260181069374084},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.5817509889602661},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5631567239761353},{"id":"https://openalex.org/keywords/carbohydrate","display_name":"Carbohydrate","score":0.48091599345207214},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.480608195066452},{"id":"https://openalex.org/keywords/carbohydrate-metabolism","display_name":"Carbohydrate metabolism","score":0.4323596954345703},{"id":"https://openalex.org/keywords/glycolysis","display_name":"Glycolysis","score":0.4222238063812256},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.4153740108013153},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.23882919549942017},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1077096164226532}],"concepts":[{"id":"https://openalex.org/C20904676","wikidata":"https://www.wikidata.org/wiki/Q191835","display_name":"Gluconeogenesis","level":3,"score":0.9152741432189941},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6419520974159241},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6260181069374084},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5817509889602661},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5631567239761353},{"id":"https://openalex.org/C2778977261","wikidata":"https://www.wikidata.org/wiki/Q11358","display_name":"Carbohydrate","level":2,"score":0.48091599345207214},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.480608195066452},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4323596954345703},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.4222238063812256},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4153740108013153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23882919549942017},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1077096164226532},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000105","descriptor_name":"Acetyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000105","descriptor_name":"Acetyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000105","descriptor_name":"Acetyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002116","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002116","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002116&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21814506","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21814506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.813.9959","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.813.9959","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ca/5e/pcbi.1002116.PMC3140964.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:3173673383e94a5a914ab49f70e179bb","is_oa":true,"landing_page_url":"https://doaj.org/article/3173673383e94a5a914ab49f70e179bb","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 7, p e1002116 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2156936","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3140964","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/134943","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_In_Silico_Evidence_for_Gluconeogenesis_from_Fatty_Acids_in_Humans/134943","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002116","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002116","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002116&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3284537356","display_name":null,"funder_award_id":"SFRH/B","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G352791218","display_name":null,"funder_award_id":"(BMBF)","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G5106512922","display_name":null,"funder_award_id":"Deutsche Forschungsgemeinschaft (DFG","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5818630289","display_name":null,"funder_award_id":"SFRH/BD/","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6024419964","display_name":null,"funder_award_id":"Deutsche Forschungsgemeinschaft (DFG)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6052429835","display_name":null,"funder_award_id":"(DFG)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G724804869","display_name":null,"funder_award_id":"SFRH/","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2037261891.pdf","grobid_xml":"https://content.openalex.org/works/W2037261891.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1510835874","https://openalex.org/W1541641692","https://openalex.org/W1551653316","https://openalex.org/W1758395617","https://openalex.org/W1894466633","https://openalex.org/W1967563625","https://openalex.org/W1969067437","https://openalex.org/W1970556744","https://openalex.org/W1971395059","https://openalex.org/W1986039855","https://openalex.org/W1989127656","https://openalex.org/W1990921780","https://openalex.org/W2001023062","https://openalex.org/W2001671331","https://openalex.org/W2005937283","https://openalex.org/W2006943154","https://openalex.org/W2010856194","https://openalex.org/W2013740448","https://openalex.org/W2018977971","https://openalex.org/W2035411783","https://openalex.org/W2037614307","https://openalex.org/W2042067428","https://openalex.org/W2053516242","https://openalex.org/W2059058805","https://openalex.org/W2064442639","https://openalex.org/W2071367634","https://openalex.org/W2071837299","https://openalex.org/W2073739585","https://openalex.org/W2074874277","https://openalex.org/W2079036093","https://openalex.org/W2079248431","https://openalex.org/W2079556238","https://openalex.org/W2092195115","https://openalex.org/W2103950919","https://openalex.org/W2104108767","https://openalex.org/W2106867120","https://openalex.org/W2108903857","https://openalex.org/W2112951169","https://openalex.org/W2114997947","https://openalex.org/W2127844534","https://openalex.org/W2131698027","https://openalex.org/W2140609274","https://openalex.org/W2143861551","https://openalex.org/W2154066017","https://openalex.org/W2154121276","https://openalex.org/W2154912659","https://openalex.org/W2159810756","https://openalex.org/W2162814004","https://openalex.org/W2163871517","https://openalex.org/W2248533784","https://openalex.org/W2287671349","https://openalex.org/W4235583278","https://openalex.org/W4250067018","https://openalex.org/W6630377760"],"related_works":["https://openalex.org/W2049558399","https://openalex.org/W3117581800","https://openalex.org/W156223726","https://openalex.org/W2121082646","https://openalex.org/W2167309544","https://openalex.org/W2336962986","https://openalex.org/W1911668424","https://openalex.org/W1875134308","https://openalex.org/W2035612098","https://openalex.org/W4388492048"],"abstract_inverted_index":{"The":[0],"question":[1,41],"whether":[2],"fatty":[3,76,157],"acids":[4,77,158],"can":[5,159],"be":[6],"converted":[7,90],"into":[8,91],"glucose":[9,95],"in":[10,17,28,31,80,105],"humans":[11],"has":[12,119],"a":[13,44,48],"long":[14],"standing":[15],"tradition":[16],"biochemistry,":[18],"and":[19,96,141,167],"the":[20,32,58,102,147,152,162,172],"expected":[21],"answer":[22],"is":[23,78],"\"No\".":[24],"Using":[25],"recent":[26],"advances":[27],"Systems":[29],"Biology":[30],"form":[33],"of":[34,47,60,87,94,99,125,132,138,143,154,164],"large-scale":[35],"metabolic":[36,51],"reconstructions,":[37],"we":[38,68,107],"reassessed":[39],"this":[40],"by":[42],"performing":[43],"global":[45],"investigation":[46],"genome-scale":[49],"human":[50],"network,":[52],"which":[53,73],"had":[54],"been":[55],"reconstructed":[56],"on":[57,72],"basis":[59],"experimental":[61],"results.":[62],"By":[63],"elementary":[64],"flux":[65],"pattern":[66],"analysis,":[67],"found":[69,108],"numerous":[70],"pathways":[71,104],"gluconeogenesis":[74,155],"from":[75,156],"feasible":[79],"humans.":[81],"On":[82],"these":[83],"pathways,":[84],"four":[85],"moles":[86,98],"acetyl-CoA":[88],"are":[89],"one":[92],"mole":[93],"two":[97],"CO\u2082.":[100],"Analyzing":[101],"detected":[103],"detail":[106],"that":[109],"their":[110,115],"energetic":[111,148],"requirements":[112],"potentially":[113],"limit":[114],"capacity.":[116],"This":[117],"study":[118],"many":[120],"other":[121],"biochemical":[122],"implications:":[123],"effect":[124],"starvation,":[126],"sports":[127],"physiology,":[128],"practically":[129],"carbohydrate-free":[130],"diets":[131,169],"inuit,":[133],"as":[134,136,171],"well":[135],"survival":[137],"hibernating":[139],"animals":[140],"embryos":[142],"egg-laying":[144],"animals.":[145],"Moreover,":[146],"loss":[149],"associated":[150],"to":[151],"usage":[153],"help":[160],"explain":[161],"efficiency":[163],"carbohydrate":[165],"reduced":[166],"ketogenic":[168],"such":[170],"Atkins":[173],"diet.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}