{"id":"https://openalex.org/W1966406470","doi":"https://doi.org/10.1371/journal.pcbi.1002090","title":"An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins","display_name":"An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins","publication_year":2011,"publication_date":"2011-06-23","ids":{"openalex":"https://openalex.org/W1966406470","doi":"https://doi.org/10.1371/journal.pcbi.1002090","mag":"1966406470","pmid":"https://pubmed.ncbi.nlm.nih.gov/21731483"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002090","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002090","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002090&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002090&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039155418","display_name":"Greet De Baets","orcid":"https://orcid.org/0000-0001-8844-800X"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Greet De Baets","raw_affiliation_strings":["VIB Switch Laboratory, VIB, Brussels, Belgium","Vrije Universiteit Brussel, Brussels, Belgium"],"affiliations":[{"raw_affiliation_string":"VIB Switch Laboratory, VIB, Brussels, Belgium","institution_ids":["https://openalex.org/I4210153928"]},{"raw_affiliation_string":"Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068993139","display_name":"Joke Reumers","orcid":"https://orcid.org/0000-0001-5434-6515"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Joke Reumers","raw_affiliation_strings":["VIB Switch Laboratory, VIB, Brussels, Belgium","Vrije Universiteit Brussel, Brussels, Belgium"],"affiliations":[{"raw_affiliation_string":"VIB Switch Laboratory, VIB, Brussels, Belgium","institution_ids":["https://openalex.org/I4210153928"]},{"raw_affiliation_string":"Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085029107","display_name":"Javier Delgado","orcid":"https://orcid.org/0000-0003-1302-5445"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Javier Delgado Blanco","raw_affiliation_strings":["VIB Switch Laboratory, VIB, Brussels, Belgium","Vrije Universiteit Brussel, Brussels, Belgium"],"affiliations":[{"raw_affiliation_string":"VIB Switch Laboratory, VIB, Brussels, Belgium","institution_ids":["https://openalex.org/I4210153928"]},{"raw_affiliation_string":"Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074140420","display_name":"Joaqu\u0131\u0301n Dopazo","orcid":"https://orcid.org/0000-0003-3318-120X"},"institutions":[{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]},{"id":"https://openalex.org/I4210161579","display_name":"Instituto de Investigaci\u00f3n de Enfermedades Raras","ror":"https://ror.org/05mwdqq98","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210161579","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joaquin Dopazo","raw_affiliation_strings":["CIBER de Enfermedades Raras (CIBERER), Valencia, Spain","Department of Bioinformatics and Genomics, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF), Valencia, Spain","Functional Genomics Node (INB) at CIPF, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"CIBER de Enfermedades Raras (CIBERER), Valencia, Spain","institution_ids":["https://openalex.org/I4210161579","https://openalex.org/I4210111366"]},{"raw_affiliation_string":"Department of Bioinformatics and Genomics, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe (CIPF), Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]},{"raw_affiliation_string":"Functional Genomics Node (INB) at CIPF, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031589452","display_name":"Joost Schymkowitz","orcid":"https://orcid.org/0000-0003-2020-0168"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Joost Schymkowitz","raw_affiliation_strings":["VIB Switch Laboratory, VIB, Brussels, Belgium","Vrije Universiteit Brussel, Brussels, Belgium"],"affiliations":[{"raw_affiliation_string":"VIB Switch Laboratory, VIB, Brussels, Belgium","institution_ids":["https://openalex.org/I4210153928"]},{"raw_affiliation_string":"Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008256216","display_name":"Fr\u00e9d\u00e9ric Rousseau","orcid":"https://orcid.org/0000-0002-9189-7399"},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]},{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Frederic Rousseau","raw_affiliation_strings":["VIB Switch Laboratory, VIB, Brussels, Belgium","Vrije Universiteit Brussel, Brussels, Belgium"],"affiliations":[{"raw_affiliation_string":"VIB Switch Laboratory, VIB, Brussels, Belgium","institution_ids":["https://openalex.org/I4210153928"]},{"raw_affiliation_string":"Vrije Universiteit Brussel, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5008256216","https://openalex.org/A5031589452"],"corresponding_institution_ids":["https://openalex.org/I13469542","https://openalex.org/I4210153928"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.5347,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.89360877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"7","issue":"6","first_page":"e1002090","last_page":"e1002090"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9714999794960022,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9664999842643738,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"Protein aggregation","score":0.8155250549316406},{"id":"https://openalex.org/keywords/chaperone","display_name":"Chaperone (clinical)","score":0.5876281261444092},{"id":"https://openalex.org/keywords/protein-turnover","display_name":"Protein turnover","score":0.5834300518035889},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.47233667969703674},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.4505395293235779},{"id":"https://openalex.org/keywords/homogeneous","display_name":"Homogeneous","score":0.42430973052978516},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.40179187059402466},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.36566591262817383},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3590603470802307},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.358291894197464},{"id":"https://openalex.org/keywords/protein-biosynthesis","display_name":"Protein biosynthesis","score":0.2558470368385315}],"concepts":[{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.8155250549316406},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.5876281261444092},{"id":"https://openalex.org/C195580219","wikidata":"https://www.wikidata.org/wiki/Q7251511","display_name":"Protein turnover","level":3,"score":0.5834300518035889},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47233667969703674},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4505395293235779},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.42430973052978516},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40179187059402466},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36566591262817383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3590603470802307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.358291894197464},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.2558470368385315},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1002090","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002090","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002090&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21731483","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21731483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:7f914652200e4405911b24ffec16df79","is_oa":true,"landing_page_url":"https://doaj.org/article/7f914652200e4405911b24ffec16df79","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 6, p e1002090 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/135808","is_oa":true,"landing_page_url":"https://figshare.com/articles/An_Evolutionary_Trade_Off_between_Protein_Turnover_Rate_and_Protein_Aggregation_Favors_a_Higher_Aggregation_Propensity_in_Fast_Degrading_Proteins/135808","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3121684","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3121684","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002090","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002090","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002090&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1952936224","display_name":null,"funder_award_id":"RD06/0020","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G3695962793","display_name":null,"funder_award_id":"BIO2008-04212","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320321864","display_name":"Generalitat Valenciana","ror":"https://ror.org/0097mvx21"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1966406470.pdf","grobid_xml":"https://content.openalex.org/works/W1966406470.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1782287000","https://openalex.org/W1967025628","https://openalex.org/W1968280815","https://openalex.org/W1968569587","https://openalex.org/W1976078149","https://openalex.org/W1976626942","https://openalex.org/W1991210194","https://openalex.org/W1999959431","https://openalex.org/W2004175178","https://openalex.org/W2009753565","https://openalex.org/W2012108346","https://openalex.org/W2013318867","https://openalex.org/W2014297210","https://openalex.org/W2015660958","https://openalex.org/W2018755224","https://openalex.org/W2019861313","https://openalex.org/W2023490488","https://openalex.org/W2024543003","https://openalex.org/W2027839322","https://openalex.org/W2034693087","https://openalex.org/W2040388827","https://openalex.org/W2043876754","https://openalex.org/W2048165254","https://openalex.org/W2052717453","https://openalex.org/W2052899770","https://openalex.org/W2061600637","https://openalex.org/W2069595298","https://openalex.org/W2076159058","https://openalex.org/W2078067526","https://openalex.org/W2078589754","https://openalex.org/W2080908359","https://openalex.org/W2086272648","https://openalex.org/W2087357689","https://openalex.org/W2091451344","https://openalex.org/W2093861673","https://openalex.org/W2096525273","https://openalex.org/W2097503860","https://openalex.org/W2098949725","https://openalex.org/W2100630099","https://openalex.org/W2101520669","https://openalex.org/W2101549409","https://openalex.org/W2101696428","https://openalex.org/W2105908180","https://openalex.org/W2106243980","https://openalex.org/W2107904341","https://openalex.org/W2116633256","https://openalex.org/W2119711780","https://openalex.org/W2121543180","https://openalex.org/W2129507901","https://openalex.org/W2130479394","https://openalex.org/W2133425057","https://openalex.org/W2133984969","https://openalex.org/W2139418286","https://openalex.org/W2141690555","https://openalex.org/W2149280464","https://openalex.org/W2152217159","https://openalex.org/W2154362705","https://openalex.org/W2156576736","https://openalex.org/W2162390984","https://openalex.org/W2164687214","https://openalex.org/W2189429565","https://openalex.org/W2905835080","https://openalex.org/W2917375902","https://openalex.org/W4239678514"],"related_works":["https://openalex.org/W2366986171","https://openalex.org/W4239727325","https://openalex.org/W1952548524","https://openalex.org/W2018641097","https://openalex.org/W1603717990","https://openalex.org/W2566200359","https://openalex.org/W4387709260","https://openalex.org/W2072744250","https://openalex.org/W2058658547","https://openalex.org/W2167924958"],"abstract_inverted_index":{"We":[0,59,90],"previously":[1],"showed":[2],"the":[3,12,22,29,107,133],"existence":[4],"of":[5,14,24,54,110,135],"selective":[6,62],"pressure":[7,63],"against":[8,67],"protein":[9,32,35,65],"aggregation":[10,36,68,81,134],"by":[11,37],"enrichment":[13],"aggregation-opposing":[15],"'gatekeeper'":[16],"residues":[17],"at":[18],"strategic":[19],"places":[20],"along":[21],"sequence":[23],"proteins.":[25,58,89,137],"Here":[26],"we":[27],"analyzed":[28],"relationship":[30],"between":[31],"lifetime":[33],"and":[34,47,83],"combining":[38],"experimentally":[39],"determined":[40],"turnover":[41],"rates,":[42],"expression":[43],"data,":[44],"structural":[45],"data":[46,50],"chaperone":[48,85],"interaction":[49],"on":[51,64,76],"a":[52,79],"set":[53],"more":[55,97],"than":[56,87],"500":[57],"find":[60,92],"that":[61,73,93,106,120,122],"sequences":[66],"is":[69,113],"not":[70],"homogeneous":[71],"but":[72,118],"short-living":[74,94,136],"proteins":[75,95,112],"average":[77],"have":[78],"higher":[80],"propensity":[82],"fewer":[84],"interactions":[86],"long-living":[88],"also":[91,119],"are":[96],"often":[98],"associated":[99],"to":[100,115],"deposition":[101],"diseases.":[102],"These":[103],"findings":[104],"suggest":[105],"efficient":[108],"degradation":[109],"high-turnover":[111],"sufficient":[114],"preclude":[116],"aggregation,":[117],"factors":[121],"inhibit":[123],"proteasomal":[124],"activity,":[125],"such":[126],"as":[127],"physiological":[128],"ageing,":[129],"will":[130],"primarily":[131],"affect":[132]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-23T09:07:50.710637","created_date":"2025-10-10T00:00:00"}
