{"id":"https://openalex.org/W2054073386","doi":"https://doi.org/10.1371/journal.pcbi.1002046","title":"Distributions of Transposable Elements Reveal Hazardous Zones in Mammalian Introns","display_name":"Distributions of Transposable Elements Reveal Hazardous Zones in Mammalian Introns","publication_year":2011,"publication_date":"2011-05-05","ids":{"openalex":"https://openalex.org/W2054073386","doi":"https://doi.org/10.1371/journal.pcbi.1002046","mag":"2054073386","pmid":"https://pubmed.ncbi.nlm.nih.gov/21573203"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002046","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002046","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002046&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002046&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104032520","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0002-5187-204X"},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada","Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada"],"affiliations":[{"raw_affiliation_string":"Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070262288","display_name":"Mark T. Romanish","orcid":null},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark T. Romanish","raw_affiliation_strings":["Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada","Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005840834","display_name":"Dixie L. Mager","orcid":"https://orcid.org/0000-0002-5955-2550"},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Dixie L. Mager","raw_affiliation_strings":["Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada","Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I1289530486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005840834"],"corresponding_institution_ids":["https://openalex.org/I1289530486","https://openalex.org/I141945490"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":10.2611,"has_fulltext":true,"cited_by_count":99,"citation_normalized_percentile":{"value":0.98086159,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"7","issue":"5","first_page":"e1002046","last_page":"e1002046"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intron","display_name":"Intron","score":0.8643403053283691},{"id":"https://openalex.org/keywords/transposable-element","display_name":"Transposable element","score":0.7910516262054443},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7584284543991089},{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.7442350387573242},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6640934944152832},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6566188931465149},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.5845169425010681},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.5263763070106506},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5171710848808289},{"id":"https://openalex.org/keywords/splice","display_name":"splice","score":0.49346816539764404},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.4514913558959961},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.15973591804504395}],"concepts":[{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.8643403053283691},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.7910516262054443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7584284543991089},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7442350387573242},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6640934944152832},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6566188931465149},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.5845169425010681},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5263763070106506},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5171710848808289},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.49346816539764404},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4514913558959961},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.15973591804504395},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074287","descriptor_name":"TRPC6 Cation Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074287","descriptor_name":"TRPC6 Cation Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074287","descriptor_name":"TRPC6 Cation Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020079","descriptor_name":"Terminal Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020079","descriptor_name":"Terminal Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020079","descriptor_name":"Terminal Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050052","descriptor_name":"TRPC Cation Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050052","descriptor_name":"TRPC Cation Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050052","descriptor_name":"TRPC Cation Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002046","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002046","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002046&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21573203","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21573203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1028.1948","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1028.1948","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC3088655%26blobtype%3Dpdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:4dbee1e84501471d9d3066576c52b02c","is_oa":true,"landing_page_url":"https://doaj.org/article/4dbee1e84501471d9d3066576c52b02c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 5, p e1002046 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/136966","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Distributions_of_Transposable_Elements_Reveal_Hazardous_Zones_in_Mammalian_Introns/136966","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3088655","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088655","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002046","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002046","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002046&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/14","display_name":"Life below water"}],"awards":[{"id":"https://openalex.org/G6282788884","display_name":null,"funder_award_id":"Canadian Institutes of Health","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2054073386.pdf","grobid_xml":"https://content.openalex.org/works/W2054073386.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W163190881","https://openalex.org/W1582323020","https://openalex.org/W1733555588","https://openalex.org/W1976579208","https://openalex.org/W1978536034","https://openalex.org/W1978721989","https://openalex.org/W1984372197","https://openalex.org/W1984502430","https://openalex.org/W1987284359","https://openalex.org/W1987875612","https://openalex.org/W1990624082","https://openalex.org/W1995845059","https://openalex.org/W1996177514","https://openalex.org/W1996942642","https://openalex.org/W1999676455","https://openalex.org/W2011016615","https://openalex.org/W2011549524","https://openalex.org/W2011832001","https://openalex.org/W2019469673","https://openalex.org/W2029087704","https://openalex.org/W2029315142","https://openalex.org/W2030426729","https://openalex.org/W2035120673","https://openalex.org/W2038624062","https://openalex.org/W2042086471","https://openalex.org/W2051525197","https://openalex.org/W2051541780","https://openalex.org/W2054430532","https://openalex.org/W2055143633","https://openalex.org/W2056967728","https://openalex.org/W2063669037","https://openalex.org/W2072204610","https://openalex.org/W2074813718","https://openalex.org/W2075168304","https://openalex.org/W2080796860","https://openalex.org/W2091279754","https://openalex.org/W2096823774","https://openalex.org/W2100725064","https://openalex.org/W2106021702","https://openalex.org/W2108933538","https://openalex.org/W2108994383","https://openalex.org/W2120762351","https://openalex.org/W2123267739","https://openalex.org/W2134075431","https://openalex.org/W2137896927","https://openalex.org/W2146892790","https://openalex.org/W2147594812","https://openalex.org/W2151464048","https://openalex.org/W2152447080","https://openalex.org/W2153586836","https://openalex.org/W2157599849","https://openalex.org/W2157891416","https://openalex.org/W2158322957","https://openalex.org/W2166968081","https://openalex.org/W2168909179","https://openalex.org/W2465591554","https://openalex.org/W4247292500","https://openalex.org/W6719385719"],"related_works":["https://openalex.org/W3090446747","https://openalex.org/W2083872838","https://openalex.org/W2056412942","https://openalex.org/W2087463521","https://openalex.org/W2045666137","https://openalex.org/W2093797995","https://openalex.org/W4211196276","https://openalex.org/W2171581216","https://openalex.org/W4240704896","https://openalex.org/W2162713462"],"abstract_inverted_index":{"Comprising":[0],"nearly":[1],"half":[2],"of":[3,21,112,180,198,232,243,276],"the":[4,18,28,37,54,110,163,178,251,263],"human":[5,76,203],"and":[6,30,44,77,79,133,167,215,239,253,273],"mouse":[7,78,234],"genomes,":[8],"transposable":[9],"elements":[10,208,236],"(TEs)":[11],"are":[12,25,63,102,129],"found":[13,80,176],"within":[14,126,190,202],"most":[15,278],"genes.":[16,255,285],"Although":[17],"vast":[19],"majority":[20],"TEs":[22,99,125,139,181,277],"in":[23,27,46,74,123,140,237,250],"introns":[24,238],"fixed":[26],"species":[29],"presumably":[31],"exert":[32,281],"no":[33],"significant":[34],"effects":[35,283],"on":[36,131,224,284],"enclosing":[38],"gene,":[39],"some":[40],"markedly":[41],"perturb":[42],"transcription":[43,62],"result":[45],"disease":[47],"or":[48],"a":[49,88,149,210,230],"mutated":[50],"phenotype.":[51],"Factors":[52],"determining":[53],"likelihood":[55],"that":[56,83,98,177,267],"an":[57,196],"intronic":[58,71,159,219,270],"TE":[59,72,90,118,160,271],"will":[60],"affect":[61],"not":[64],"clear.":[65],"In":[66,194],"this":[67],"study,":[68],"we":[69,96,175,227],"examined":[70,229],"distributions":[73,272],"both":[75],"several":[81],"factors":[82],"likely":[84,279],"contribute":[85],"to":[86,106,121,146,152,183,280],"whether":[87],"particular":[89],"can":[91],"influence":[92],"gene":[93],"transcription.":[94],"Specifically,":[95],"observed":[97],"near":[100,154,221],"exons":[101,147],"greatly":[103],"underrepresented":[104],"compared":[105],"random":[107],"distributions,":[108],"but":[109],"size":[111],"these":[113,127,225,258],"\"underrepresentation":[114],"zones\"":[115],"differs":[116],"between":[117],"classes.":[119],"Compared":[120],"elsewhere":[122],"introns,":[124],"zones":[128],"shorter":[130],"average":[132],"show":[134,148,162],"stronger":[135],"orientation":[136],"biases.":[137],"Moreover,":[138],"extremely":[141],"close":[142],"proximity":[143],"(<20":[144],"bp)":[145],"strong":[150],"bias":[151],"be":[153],"splice-donor":[155],"sites.":[156],"Interestingly,":[157],"disease-causing":[158],"insertions":[161,249],"opposite":[164],"distributional":[165],"trends,":[166],"by":[168,246],"examining":[169],"expressed":[170],"sequence":[171],"tag":[172],"(EST)":[173],"databases,":[174],"proportion":[179],"contributing":[182],"chimeric":[184],"TE-gene":[185],"transcripts":[186],"is":[187],"significantly":[188,211],"higher":[189],"their":[191],"underrepresentation":[192],"zones.":[193],"addition,":[195],"analysis":[197],"predicted":[199],"splice":[200],"sites":[201],"long":[204],"terminal":[205],"repeat":[206],"(LTR)":[207],"showed":[209,240],"lower":[212],"total":[213],"number":[214],"weaker":[216],"strength":[217],"for":[218],"LTRs":[220],"exons.":[222],"Based":[223],"factors,":[226],"selectively":[228],"list":[231],"polymorphic":[233],"LTR":[235,247],"clear":[241],"evidence":[242],"transcriptional":[244,282],"disruption":[245],"element":[248],"Trpc6":[252],"Kcnh6":[254],"Taken":[256],"together,":[257],"studies":[259],"lend":[260],"insight":[261],"into":[262],"potential":[264],"selective":[265],"forces":[266],"have":[268],"shaped":[269],"enable":[274],"identification":[275]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}