{"id":"https://openalex.org/W2051277229","doi":"https://doi.org/10.1371/journal.pcbi.1002044","title":"Activated Membrane Patches Guide Chemotactic Cell Motility","display_name":"Activated Membrane Patches Guide Chemotactic Cell Motility","publication_year":2011,"publication_date":"2011-06-30","ids":{"openalex":"https://openalex.org/W2051277229","doi":"https://doi.org/10.1371/journal.pcbi.1002044","mag":"2051277229","pmid":"https://pubmed.ncbi.nlm.nih.gov/21738453"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002044","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002044","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002044&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002044&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031030154","display_name":"Inbal Hecht","orcid":null},"institutions":[{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Inbal Hecht","raw_affiliation_strings":["Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America. inbal.hecht@gmail.com","Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America","School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America. inbal.hecht@gmail.com","institution_ids":["https://openalex.org/I4210145836"]},{"raw_affiliation_string":"Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I36258959"]},{"raw_affiliation_string":"School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066016400","display_name":"Monica Skoge","orcid":"https://orcid.org/0000-0002-7346-7520"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica L. Skoge","raw_affiliation_strings":["Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026878426","display_name":"Pascale G. Charest","orcid":"https://orcid.org/0000-0002-2395-5294"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pascale G. Charest","raw_affiliation_strings":["Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113524343","display_name":"Eshel Ben\u2010Jacob","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eshel Ben-Jacob","raw_affiliation_strings":["School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019725371","display_name":"Richard Firtel","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Firtel","raw_affiliation_strings":["Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014612742","display_name":"William F. Loomis","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William F. Loomis","raw_affiliation_strings":["Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036939761","display_name":"Herbert Levine","orcid":"https://orcid.org/0000-0002-8819-9055"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert Levine","raw_affiliation_strings":["Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America","Department of Physics, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Physics, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053825565","display_name":"Wouter\u2010Jan Rappel","orcid":"https://orcid.org/0000-0003-3833-7197"},"institutions":[{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wouter-Jan Rappel","raw_affiliation_strings":["Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America","Department of Physics, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Physics, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5031030154","https://openalex.org/A5053825565"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I36258959","https://openalex.org/I4210145836"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.106,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.9413517,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"7","issue":"6","first_page":"e1002044","last_page":"e1002044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12832","display_name":"Biocrusts and Microbial Ecology","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudopodia","display_name":"Pseudopodia","score":0.8727395534515381},{"id":"https://openalex.org/keywords/dictyostelium-discoideum","display_name":"Dictyostelium discoideum","score":0.8131914734840393},{"id":"https://openalex.org/keywords/dictyostelium","display_name":"Dictyostelium","score":0.741230309009552},{"id":"https://openalex.org/keywords/motility","display_name":"Motility","score":0.6566092371940613},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"Chemotaxis","score":0.616491973400116},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6139047145843506},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.540812075138092},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5270403027534485},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5227004289627075},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4956756830215454},{"id":"https://openalex.org/keywords/cell-membrane","display_name":"Cell membrane","score":0.4904439151287079},{"id":"https://openalex.org/keywords/crawling","display_name":"Crawling","score":0.4889132082462311},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.4551619589328766},{"id":"https://openalex.org/keywords/cell-migration","display_name":"Cell migration","score":0.412916898727417},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3931795358657837},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32206255197525024},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.20496606826782227},{"id":"https://openalex.org/keywords/actin","display_name":"Actin","score":0.18241643905639648},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.14922001957893372},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10724163055419922},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.08380460739135742}],"concepts":[{"id":"https://openalex.org/C199528912","wikidata":"https://www.wikidata.org/wiki/Q165291","display_name":"Pseudopodia","level":3,"score":0.8727395534515381},{"id":"https://openalex.org/C2775969001","wikidata":"https://www.wikidata.org/wiki/Q134351","display_name":"Dictyostelium discoideum","level":3,"score":0.8131914734840393},{"id":"https://openalex.org/C2775889303","wikidata":"https://www.wikidata.org/wiki/Q17146891","display_name":"Dictyostelium","level":3,"score":0.741230309009552},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.6566092371940613},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.616491973400116},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6139047145843506},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.540812075138092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5270403027534485},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5227004289627075},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4956756830215454},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.4904439151287079},{"id":"https://openalex.org/C100368936","wikidata":"https://www.wikidata.org/wiki/Q1411725","display_name":"Crawling","level":2,"score":0.4889132082462311},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.4551619589328766},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.412916898727417},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3931795358657837},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32206255197525024},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.20496606826782227},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.18241643905639648},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14922001957893372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10724163055419922},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08380460739135742},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004023","descriptor_name":"Dictyostelium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004023","descriptor_name":"Dictyostelium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004023","descriptor_name":"Dictyostelium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004023","descriptor_name":"Dictyostelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004023","descriptor_name":"Dictyostelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004023","descriptor_name":"Dictyostelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011554","descriptor_name":"Pseudopodia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002044","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002044","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002044&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21738453","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21738453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.718.2660","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.718.2660","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://physics.ucsd.edu/%7Erappel/Publications/ras_patches.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:afb2ea48273a404fadbf0be2a0267721","is_oa":true,"landing_page_url":"https://doaj.org/article/afb2ea48273a404fadbf0be2a0267721","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 6, p e1002044 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/135502","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Activated_Membrane_Patches_Guide_Chemotactic_Cell_Motility/135502","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3127810","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3127810","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002044","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002044","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002044&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.4699999988079071}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322596","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2051277229.pdf","grobid_xml":"https://content.openalex.org/works/W2051277229.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W205821215","https://openalex.org/W400660352","https://openalex.org/W1967668980","https://openalex.org/W1969777343","https://openalex.org/W1970893792","https://openalex.org/W1972114861","https://openalex.org/W1976801694","https://openalex.org/W1978678623","https://openalex.org/W1978764703","https://openalex.org/W1985396160","https://openalex.org/W1990053445","https://openalex.org/W2004084950","https://openalex.org/W2007847670","https://openalex.org/W2008143849","https://openalex.org/W2009128069","https://openalex.org/W2019410556","https://openalex.org/W2024813407","https://openalex.org/W2026972975","https://openalex.org/W2028878400","https://openalex.org/W2031497507","https://openalex.org/W2041797933","https://openalex.org/W2047886675","https://openalex.org/W2051413099","https://openalex.org/W2052373118","https://openalex.org/W2055882856","https://openalex.org/W2061472058","https://openalex.org/W2063220206","https://openalex.org/W2063993190","https://openalex.org/W2064441783","https://openalex.org/W2065323391","https://openalex.org/W2068243144","https://openalex.org/W2068978083","https://openalex.org/W2072785032","https://openalex.org/W2073326896","https://openalex.org/W2078423846","https://openalex.org/W2081098704","https://openalex.org/W2082690651","https://openalex.org/W2094806352","https://openalex.org/W2106479217","https://openalex.org/W2114053889","https://openalex.org/W2119276853","https://openalex.org/W2124642745","https://openalex.org/W2125164122","https://openalex.org/W2125852686","https://openalex.org/W2126496496","https://openalex.org/W2139288598","https://openalex.org/W2143684023","https://openalex.org/W2146354638","https://openalex.org/W2146749791","https://openalex.org/W2147610677","https://openalex.org/W2149216170","https://openalex.org/W2154255383","https://openalex.org/W2156431271","https://openalex.org/W2164495477","https://openalex.org/W4246353266","https://openalex.org/W6828099078"],"related_works":["https://openalex.org/W2015540209","https://openalex.org/W2034720620","https://openalex.org/W3015698348","https://openalex.org/W2519058576","https://openalex.org/W3209588668","https://openalex.org/W2015897732","https://openalex.org/W2074272806","https://openalex.org/W247369369","https://openalex.org/W2399065385","https://openalex.org/W2394887779"],"abstract_inverted_index":{"Many":[0],"eukaryotic":[1],"cells":[2,34,76],"are":[3,19,35,43,60,168,205],"able":[4,194],"to":[5,26,62,195],"crawl":[6],"on":[7,14,109],"surfaces":[8],"and":[9,105,140,182,200],"guide":[10],"their":[11],"motility":[12],"based":[13],"environmental":[15],"cues.":[16],"These":[17],"cues":[18],"interpreted":[20],"by":[21,38],"signaling":[22,53,230],"systems":[23],"which":[24,42,174],"couple":[25],"cell":[27,63,85,118,165],"mechanics;":[28],"indeed":[29],"membrane":[30,40,106,161],"protrusions":[31,162],"in":[32,72,170],"crawling":[33],"often":[36],"accompanied":[37],"activated":[39,103,155],"patches,":[41],"localized":[44,141],"areas":[45,142],"of":[46,49,70,83,90,97,102,122,143,146,148,160,185,220,228],"increased":[47],"concentration":[48,145],"one":[50,147],"or":[51],"more":[52],"components.":[54],"To":[55],"determine":[56,157],"how":[57],"these":[58,110],"patches":[59,101,156],"related":[61],"motion,":[64],"we":[65,112,213],"examine":[66],"the":[67,80,84,91,149,152,158,171,179,183,216,226,229],"spatial":[68,98],"localization":[69],"RasGTP":[71],"chemotaxing":[73],"Dictyostelium":[74],"discoideum":[75],"under":[77],"conditions":[78],"where":[79],"vertical":[81],"extent":[82],"was":[86],"restricted.":[87],"Quantitative":[88],"analyses":[89],"data":[92],"reveal":[93],"a":[94,114,130],"high":[95],"degree":[96],"correlation":[99],"between":[100],"Ras":[104],"protrusions.":[107],"Based":[108],"findings,":[111],"formulate":[113],"model":[115,136,192],"for":[116],"amoeboid":[117],"motion":[119,199],"that":[120,137,167,190,201,215],"consists":[121],"two":[123],"coupled":[124],"modules.":[125],"The":[126,154],"first":[127],"module":[128],"utilizes":[129],"recently":[131],"developed":[132],"two-component":[133],"reaction":[134],"diffusion":[135],"generates":[138],"transient":[139],"elevated":[144],"components":[150],"along":[151],"membrane.":[153],"location":[159],"(and":[163],"overall":[164],"motion)":[166],"computed":[169],"second":[172],"module,":[173],"also":[175],"takes":[176],"into":[177],"account":[178],"cortical":[180],"tension":[181],"availability":[184],"protrusion":[186],"resources.":[187],"We":[188],"show":[189,214],"our":[191,202],"is":[193],"produce":[196],"realistic":[197],"amoeboid-like":[198],"numerical":[203],"results":[204],"consistent":[206],"with":[207],"experimentally":[208],"observed":[209,218],"pseudopod":[210],"dynamics.":[211],"Specifically,":[212],"commonly":[217],"splitting":[219],"pseudopods":[221],"can":[222],"result":[223],"directly":[224],"from":[225],"dynamics":[227],"patches.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
