{"id":"https://openalex.org/W2030737079","doi":"https://doi.org/10.1371/journal.pcbi.1002032","title":"How Molecular Motors Are Arranged on a Cargo Is Important for Vesicular Transport","display_name":"How Molecular Motors Are Arranged on a Cargo Is Important for Vesicular Transport","publication_year":2011,"publication_date":"2011-05-05","ids":{"openalex":"https://openalex.org/W2030737079","doi":"https://doi.org/10.1371/journal.pcbi.1002032","mag":"2030737079","pmid":"https://pubmed.ncbi.nlm.nih.gov/21573204"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002032","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002032","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002032&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002032&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000389129","display_name":"Robert P. Erickson","orcid":"https://orcid.org/0000-0001-9683-5149"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Erickson","raw_affiliation_strings":["Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044909398","display_name":"Zhiyuan Jia","orcid":"https://orcid.org/0000-0002-9072-8278"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyuan Jia","raw_affiliation_strings":["Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056985811","display_name":"Steven P. Gross","orcid":"https://orcid.org/0000-0001-5992-1793"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven P. Gross","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America","Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065634088","display_name":"Clare C. Yu","orcid":"https://orcid.org/0000-0002-6565-2988"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clare C. Yu","raw_affiliation_strings":["Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065634088"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.011,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.90862968,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"7","issue":"5","first_page":"e1002032","last_page":"e1002032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11152","display_name":"Stochastic processes and statistical mechanics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2610","display_name":"Mathematical Physics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11486","display_name":"Micro and Nano Robotics","score":0.9492999911308289,"subfield":{"id":"https://openalex.org/subfields/3104","display_name":"Condensed Matter Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynein","display_name":"Dynein","score":0.8441001176834106},{"id":"https://openalex.org/keywords/molecular-motor","display_name":"Molecular motor","score":0.8138319253921509},{"id":"https://openalex.org/keywords/microtubule","display_name":"Microtubule","score":0.7926676273345947},{"id":"https://openalex.org/keywords/motor-protein","display_name":"Motor protein","score":0.6625474691390991},{"id":"https://openalex.org/keywords/kinesin","display_name":"Kinesin","score":0.6624636650085449},{"id":"https://openalex.org/keywords/myosin","display_name":"Myosin","score":0.5487310886383057},{"id":"https://openalex.org/keywords/intracellular-transport","display_name":"Intracellular transport","score":0.5032235980033875},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.46844226121902466},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.46626028418540955},{"id":"https://openalex.org/keywords/vesicular-transport-protein","display_name":"Vesicular transport protein","score":0.4210489094257355},{"id":"https://openalex.org/keywords/axoplasmic-transport","display_name":"Axoplasmic transport","score":0.4161706566810608},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3741426467895508},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3504441976547241},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.23380118608474731},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.1047353744506836},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10004481673240662},{"id":"https://openalex.org/keywords/vesicle","display_name":"Vesicle","score":0.07539534568786621}],"concepts":[{"id":"https://openalex.org/C106987784","wikidata":"https://www.wikidata.org/wiki/Q410134","display_name":"Dynein","level":3,"score":0.8441001176834106},{"id":"https://openalex.org/C160408235","wikidata":"https://www.wikidata.org/wiki/Q423905","display_name":"Molecular motor","level":2,"score":0.8138319253921509},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.7926676273345947},{"id":"https://openalex.org/C93126451","wikidata":"https://www.wikidata.org/wiki/Q2383767","display_name":"Motor protein","level":3,"score":0.6625474691390991},{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.6624636650085449},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.5487310886383057},{"id":"https://openalex.org/C2780212709","wikidata":"https://www.wikidata.org/wiki/Q14890439","display_name":"Intracellular transport","level":3,"score":0.5032235980033875},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46844226121902466},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.46626028418540955},{"id":"https://openalex.org/C167019083","wikidata":"https://www.wikidata.org/wiki/Q4082043","display_name":"Vesicular transport protein","level":4,"score":0.4210489094257355},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.4161706566810608},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3741426467895508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3504441976547241},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.23380118608474731},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1047353744506836},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10004481673240662},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.07539534568786621}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022161","descriptor_name":"Transport Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022161","descriptor_name":"Transport Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022161","descriptor_name":"Transport Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022161","descriptor_name":"Transport Vesicles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022161","descriptor_name":"Transport Vesicles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022161","descriptor_name":"Transport Vesicles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002032","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002032","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002032&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21573204","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21573204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.291.2426","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.291.2426","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/cd/f0/PLoS_Comput_Biol_2011_May_5_7(5)_e1002032.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:0888df6886744fdfbc2575e6d2b096c6","is_oa":true,"landing_page_url":"https://doaj.org/article/0888df6886744fdfbc2575e6d2b096c6","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 5, p e1002032 (2011)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt8nx299db","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8nx299db","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, vol 7, iss 5","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/136964","is_oa":true,"landing_page_url":"https://figshare.com/articles/How_Molecular_Motors_Are_Arranged_on_a_Cargo_Is_Important_for_Vesicular_Transport/136964","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3088656","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088656","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002032","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002032","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002032&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310042","display_name":"Aspen Center for Physics","ror":"https://ror.org/05gqcbq50"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2030737079.pdf","grobid_xml":"https://content.openalex.org/works/W2030737079.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1545569420","https://openalex.org/W1965356195","https://openalex.org/W1969680512","https://openalex.org/W1972398314","https://openalex.org/W1975985582","https://openalex.org/W1989729787","https://openalex.org/W2022214576","https://openalex.org/W2024662090","https://openalex.org/W2033859483","https://openalex.org/W2047090408","https://openalex.org/W2055895995","https://openalex.org/W2074343061","https://openalex.org/W2092405548","https://openalex.org/W2098889694","https://openalex.org/W2100561868","https://openalex.org/W2103890279","https://openalex.org/W2110641277","https://openalex.org/W2114220612","https://openalex.org/W2128950665","https://openalex.org/W2130379504","https://openalex.org/W2130964922","https://openalex.org/W2165742869","https://openalex.org/W4230981482"],"related_works":["https://openalex.org/W3093807067","https://openalex.org/W4297855412","https://openalex.org/W4319931874","https://openalex.org/W4289868947","https://openalex.org/W2584157162","https://openalex.org/W4246998798","https://openalex.org/W2914041924","https://openalex.org/W4238657625","https://openalex.org/W2583492548","https://openalex.org/W2531304830"],"abstract_inverted_index":{"The":[0],"spatial":[1],"organization":[2,64],"of":[3,10,52,84,121,132,153,173,175,184,241,256,274],"the":[4,19,60,66,111,115,130,133,138,144,146,158,168,182,239,254,257,263,275],"cell":[5],"depends":[6],"upon":[7],"intracellular":[8],"trafficking":[9],"cargos":[11,41,156],"hauled":[12],"along":[13],"microtubules":[14,196],"and":[15,25,98,119,150,278],"actin":[16],"filaments":[17],"by":[18,46,202],"molecular":[20],"motor":[21,54,63,139],"proteins":[22],"kinesin,":[23,267],"dynein,":[24],"myosin.":[26],"Although":[27],"much":[28],"is":[29,37,219],"known":[30],"about":[31],"how":[32,59],"single":[33],"motors":[34,85,159,212,244,286],"function,":[35],"there":[36,193],"significant":[38],"evidence":[39],"that":[40,94,103,176,197,208,235],"in":[42],"vivo":[43],"are":[44],"carried":[45],"multiple":[47,53],"motors.":[48],"While":[49,259],"some":[50],"aspects":[51],"function":[55],"have":[56,77],"received":[57],"attention,":[58],"cargo":[61,134],"itself--and":[62],"on":[65,110],"cargo--affects":[67],"transport":[68],"has":[69],"not":[70],"been":[71],"considered.":[72],"To":[73],"address":[74],"this,":[75],"we":[76],"developed":[78],"a":[79,87,108,165,188],"three-dimensional":[80],"Monte":[81],"Carlo":[82],"simulation":[83,261],"transporting":[86],"spherical":[88],"cargo,":[89],"subject":[90],"to":[91,140,143,162,164,187,220,227,236,284],"thermal":[92],"fluctuations":[93,105],"produce":[95],"both":[96],"rotational":[97,151],"translational":[99,149,203],"diffusion.":[100,204],"We":[101],"found":[102,207],"these":[104,268],"could":[106,135,199],"exert":[107],"load":[109],"motor(s),":[112],"significantly":[113],"decreasing":[114],"mean":[116],"travel":[117],"distance":[118],"velocity":[120],"large":[122,126],"cargos,":[123,181,277],"especially":[124],"at":[125],"viscosities.":[127],"In":[128],"addition,":[129],"presence":[131],"dramatically":[136],"help":[137],"bind":[141,163],"productively":[142],"microtubule:":[145],"relatively":[147],"slow":[148],"diffusion":[152],"moderately":[154],"sized":[155,229],"gave":[157],"ample":[160],"opportunity":[161],"microtubule":[166,189],"before":[167],"motor/cargo":[169],"ensemble":[170],"diffuses":[171],"out":[172],"range":[174],"microtubule.":[177],"For":[178],"rapidly":[179],"diffusing":[180],"probability":[183],"their":[185,222],"binding":[186],"was":[190],"high":[191],"if":[192],"were":[194],"nearby":[195],"they":[198,281],"easily":[200],"reach":[201],"Our":[205],"simulations":[206],"one":[209],"reason":[210],"why":[211],"may":[213],"be":[214,246],"approximately":[215],"100":[216],"nm":[217],"long":[218],"improve":[221],"'on'":[223],"rates":[224],"when":[225],"attached":[226],"comparably":[228],"cargos.":[230],"Finally,":[231],"our":[232,260],"results":[233],"suggested":[234],"efficiently":[237],"regulate":[238],"number":[240],"active":[242],"motors,":[243,276],"should":[245,282],"clustered":[247],"together":[248],"rather":[249],"than":[250],"spread":[251],"randomly":[252],"over":[253],"surface":[255],"cargo.":[258],"uses":[262],"specific":[264],"parameters":[265],"for":[266],"effects":[269],"result":[270],"from":[271],"generic":[272],"properties":[273],"filaments,":[279],"so":[280],"apply":[283],"other":[285],"as":[287],"well.":[288]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}