{"id":"https://openalex.org/W1991930264","doi":"https://doi.org/10.1371/journal.pcbi.1002015","title":"Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies","display_name":"Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies","publication_year":2011,"publication_date":"2011-03-17","ids":{"openalex":"https://openalex.org/W1991930264","doi":"https://doi.org/10.1371/journal.pcbi.1002015","mag":"1991930264","pmid":"https://pubmed.ncbi.nlm.nih.gov/21483468"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002015","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002015","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002015&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002015&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068126807","display_name":"Vincent T. Metzger","orcid":"https://orcid.org/0000-0002-8041-0370"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent T. Metzger","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052657259","display_name":"James O. Lloyd\u2010Smith","orcid":"https://orcid.org/0000-0001-7941-502X"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I874236823","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I874236823"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James O. Lloyd-Smith","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America","Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I874236823","https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043702774","display_name":"Leor S. Weinberger","orcid":"https://orcid.org/0000-0002-9987-6357"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leor S. Weinberger","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America","Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043702774","https://openalex.org/A5052657259"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I161318765","https://openalex.org/I36258959","https://openalex.org/I874236823"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.5914,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.80717579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"7","issue":"3","first_page":"e1002015","last_page":"e1002015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9476000070571899,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5972805619239807},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.5416529774665833},{"id":"https://openalex.org/keywords/pathogen","display_name":"Pathogen","score":0.5370925664901733},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5190628170967102},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.5107417106628418},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.506131112575531},{"id":"https://openalex.org/keywords/vaccination","display_name":"Vaccination","score":0.49700430035591125},{"id":"https://openalex.org/keywords/hiv-vaccine","display_name":"HIV vaccine","score":0.4923921823501587},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.47538578510284424},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.4442911446094513},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"Vaccine efficacy","score":0.4275376796722412},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.420675128698349},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37250053882598877},{"id":"https://openalex.org/keywords/vaccine-trial","display_name":"Vaccine trial","score":0.2687114477157593},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.25538790225982666},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.14029434323310852},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.11941695213317871},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11762091517448425}],"concepts":[{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5972805619239807},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.5416529774665833},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5370925664901733},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5190628170967102},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5107417106628418},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.506131112575531},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.49700430035591125},{"id":"https://openalex.org/C2780195530","wikidata":"https://www.wikidata.org/wiki/Q1479804","display_name":"HIV vaccine","level":4,"score":0.4923921823501587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47538578510284424},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4442911446094513},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.4275376796722412},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.420675128698349},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37250053882598877},{"id":"https://openalex.org/C2778190748","wikidata":"https://www.wikidata.org/wiki/Q7907956","display_name":"Vaccine trial","level":3,"score":0.2687114477157593},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.25538790225982666},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.14029434323310852},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11941695213317871},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11762091517448425}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000349","descriptor_name":"Africa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000349","descriptor_name":"Africa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000349","descriptor_name":"Africa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003140","descriptor_name":"Communicable Disease Control","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003140","descriptor_name":"Communicable Disease Control","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003140","descriptor_name":"Communicable Disease Control","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1002015","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002015","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002015&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21483468","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21483468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:35ddb37f5e694ea5b3da9d0117802d25","is_oa":true,"landing_page_url":"https://doaj.org/article/35ddb37f5e694ea5b3da9d0117802d25","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 3, p e1002015 (2011)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9js4s3ms","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9js4s3ms","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 7, iss 3","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2084126","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3060167","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/138155","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Autonomous_Targeting_of_Infectious_Superspreaders_Using_Engineered_Transmissible_Therapies/138155","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002015","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002015","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002015&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6800000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1128133788","display_name":null,"funder_award_id":"Gates","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G1290574323","display_name":null,"funder_award_id":"Award","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G2359873403","display_name":"Collaborative Research:  Evolutionary dynamics of invasion and escape in hierarchical systems","funder_award_id":"0928690","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3933114365","display_name":null,"funder_award_id":"RAPID","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5741122423","display_name":null,"funder_award_id":"EF-0928690","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306110","display_name":"U.S. Department of Homeland Security","ror":"https://ror.org/00jyr0d86"},{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1991930264.pdf","grobid_xml":"https://content.openalex.org/works/W1991930264.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W30625346","https://openalex.org/W1531725059","https://openalex.org/W1575154287","https://openalex.org/W1606697907","https://openalex.org/W1663829637","https://openalex.org/W1981259148","https://openalex.org/W1981421312","https://openalex.org/W1981630986","https://openalex.org/W1982306896","https://openalex.org/W1988949750","https://openalex.org/W1989318293","https://openalex.org/W1993846907","https://openalex.org/W1994482513","https://openalex.org/W1998704599","https://openalex.org/W2001111303","https://openalex.org/W2002574877","https://openalex.org/W2012139740","https://openalex.org/W2020437257","https://openalex.org/W2022098233","https://openalex.org/W2031837694","https://openalex.org/W2032735736","https://openalex.org/W2038883764","https://openalex.org/W2040139732","https://openalex.org/W2060261240","https://openalex.org/W2066271426","https://openalex.org/W2069251911","https://openalex.org/W2070649137","https://openalex.org/W2085344865","https://openalex.org/W2087946368","https://openalex.org/W2090080821","https://openalex.org/W2093519165","https://openalex.org/W2097471623","https://openalex.org/W2098729341","https://openalex.org/W2111550532","https://openalex.org/W2118726788","https://openalex.org/W2124995497","https://openalex.org/W2127832030","https://openalex.org/W2133773667","https://openalex.org/W2136165756","https://openalex.org/W2139894829","https://openalex.org/W2146082879","https://openalex.org/W2152048324","https://openalex.org/W2153641115","https://openalex.org/W2155544038","https://openalex.org/W2156623624","https://openalex.org/W2169691456","https://openalex.org/W2171228793","https://openalex.org/W2998115530","https://openalex.org/W3113819781","https://openalex.org/W3140017782","https://openalex.org/W4388299012","https://openalex.org/W6634584992","https://openalex.org/W7020753545"],"related_works":["https://openalex.org/W2040680680","https://openalex.org/W2278541745","https://openalex.org/W2520822804","https://openalex.org/W2095170513","https://openalex.org/W2072042984","https://openalex.org/W4205263524","https://openalex.org/W2161157573","https://openalex.org/W1971729485","https://openalex.org/W2178831599","https://openalex.org/W183890156"],"abstract_inverted_index":{"Infectious":[0],"disease":[1,26,131,237,246],"treatments,":[2],"both":[3],"pharmaceutical":[4],"and":[5,38,41,77,128,159,210,230],"vaccine,":[6],"face":[7],"three":[8],"universal":[9],"challenges:":[10],"the":[11,22,31,42,72,75,91,114,119,191,196,219],"difficulty":[12],"of":[13,25,44,74,100,121,190],"targeting":[14],"treatments":[15],"to":[16,68,81,95,117,200,225],"high-risk":[17],"'superspreader'":[18],"populations":[19],"who":[20],"drive":[21],"great":[23],"majority":[24],"spread,":[27],"behavioral":[28,208],"barriers":[29],"in":[30,71],"host":[32],"population":[33],"(such":[34],"as":[35,195],"poor":[36],"compliance":[37],"risk":[39,193],"disinhibition),":[40],"evolution":[43],"pathogen":[45,76,241],"resistance.":[46,213],"Here,":[47],"we":[48,107],"describe":[49],"a":[50,109,137,144,233],"proposed":[51],"intervention":[52],"that":[53,65,84,136],"would":[54,231],"overcome":[55],"these":[56],"challenges":[57],"by":[58,154,178],"capitalizing":[59],"upon":[60],"Therapeutic":[61],"Interfering":[62],"Particles":[63],"(TIPs)":[64],"are":[66],"engineered":[67,139],"replicate":[69],"conditionally":[70],"presence":[73],"spread":[78],"between":[79],"individuals--analogous":[80],"'transmissible":[82],"immunization'":[83],"occurs":[85],"with":[86,140],"live-attenuated":[87],"vaccines":[88],"(but":[89],"without":[90],"potential":[92],"for":[93,217,236],"reversion":[94],"virulence).":[96],"Building":[97],"on":[98,123,143],"analyses":[99],"HIV":[101,146],"field":[102],"data":[103],"from":[104,187,240],"sub-Saharan":[105],"Africa,":[106],"construct":[108],"multi-scale":[110],"model,":[111],"beginning":[112],"at":[113],"single-cell":[115],"level,":[116],"predict":[118],"effect":[120],"TIPs":[122],"individual":[124],"patient":[125],"viral":[126,212,227],"loads":[127],"ultimately":[129],"population-level":[130],"prevalence.":[132],"Our":[133],"results":[134],"show":[135],"TIP,":[138],"properties":[141],"based":[142],"recent":[145],"gene-therapy":[147],"trial,":[148],"could":[149,160,173,222],"stably":[150],"lower":[151,175],"HIV/AIDS":[152,176],"prevalence":[153,177],"\u223c30-fold":[155],"within":[156],"50":[157,181],"years":[158],"complement":[161],"current":[162],"therapies.":[163],"In":[164],"contrast,":[165],"optimistic":[166],"antiretroviral":[167],"therapy":[168],"or":[169],"vaccination":[170],"campaigns":[171],"alone":[172],"only":[174],"<2-fold":[179],"over":[180],"years.":[182],"The":[183],"TIP's":[184],"efficacy":[185,206],"arises":[186],"its":[188],"exploitation":[189],"same":[192],"factors":[194],"pathogen,":[197],"allowing":[198],"it":[199],"autonomously":[201],"penetrate":[202],"superspreader":[203],"populations,":[204],"maintain":[205],"despite":[207],"disinhibition,":[209],"limit":[211],"While":[214],"demonstrated":[215],"here":[216],"HIV,":[218],"TIP":[220],"concept":[221],"apply":[223],"broadly":[224],"many":[226],"infectious":[228],"diseases":[229],"represent":[232],"new":[234],"paradigm":[235],"control,":[238],"away":[239],"eradication":[242],"but":[243],"toward":[244],"robust":[245],"suppression.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-03-16T09:10:04.655348","created_date":"2025-10-10T00:00:00"}