{"id":"https://openalex.org/W1972872960","doi":"https://doi.org/10.1371/journal.pcbi.1001093","title":"Natural Selection on Functional Modules, a Genome-Wide Analysis","display_name":"Natural Selection on Functional Modules, a Genome-Wide Analysis","publication_year":2011,"publication_date":"2011-03-03","ids":{"openalex":"https://openalex.org/W1972872960","doi":"https://doi.org/10.1371/journal.pcbi.1001093","mag":"1972872960","pmid":"https://pubmed.ncbi.nlm.nih.gov/21390268"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1001093","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001093","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001093&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001093&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084274556","display_name":"Fran\u00e7ois Serra","orcid":"https://orcid.org/0000-0003-3895-4742"},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Serra","raw_affiliation_strings":["Evolutionary Genomics Lab, Bioinformatics & Genomics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Evolutionary Genomics Lab, Bioinformatics & Genomics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030130295","display_name":"Leonardo Arbiza","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Leonardo Arbiza","raw_affiliation_strings":["Evolutionary Genomics Lab, Bioinformatics & Genomics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Evolutionary Genomics Lab, Bioinformatics & Genomics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074140420","display_name":"Joaqu\u0131\u0301n Dopazo","orcid":"https://orcid.org/0000-0003-3318-120X"},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]},{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Joaqu\u00edn Dopazo","raw_affiliation_strings":["CIBER de Enfermedades Raras (CIBERER), Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain","Functional Genomics Lab, Bioinformatics & Genomics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain","Functional Genomics Node (INB), Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"CIBER de Enfermedades Raras (CIBERER), Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109","https://openalex.org/I4210111366"]},{"raw_affiliation_string":"Functional Genomics Lab, Bioinformatics & Genomics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]},{"raw_affiliation_string":"Functional Genomics Node (INB), Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087451958","display_name":"Hern\u00e1n Dopazo","orcid":"https://orcid.org/0000-0001-6125-2357"},"institutions":[{"id":"https://openalex.org/I4210165109","display_name":"Centro de Investigacion Principe Felipe","ror":"https://ror.org/05xr2yq54","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210165109"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Hern\u00e1n Dopazo","raw_affiliation_strings":["Evolutionary Genomics Lab, Bioinformatics & Genomics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Evolutionary Genomics Lab, Bioinformatics & Genomics Department, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Valencia, Spain","institution_ids":["https://openalex.org/I4210165109"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074140420","https://openalex.org/A5087451958"],"corresponding_institution_ids":["https://openalex.org/I4210111366","https://openalex.org/I4210165109"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0013,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.77520016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"3","first_page":"e1001093","last_page":"e1001093"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-selection","display_name":"Natural selection","score":0.7769371271133423},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7461118698120117},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.6609163284301758},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6554837226867676},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.6247246861457825},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.592726469039917},{"id":"https://openalex.org/keywords/pooling","display_name":"Pooling","score":0.5179066061973572},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4289880394935608},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41672664880752563},{"id":"https://openalex.org/keywords/lineage","display_name":"Lineage (genetic)","score":0.41439586877822876},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.37137794494628906},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1071845293045044},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.10489502549171448},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.08114051818847656}],"concepts":[{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.7769371271133423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7461118698120117},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.6609163284301758},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6554837226867676},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.6247246861457825},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.592726469039917},{"id":"https://openalex.org/C70437156","wikidata":"https://www.wikidata.org/wiki/Q7228652","display_name":"Pooling","level":2,"score":0.5179066061973572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4289880394935608},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41672664880752563},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.41439586877822876},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37137794494628906},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1071845293045044},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.10489502549171448},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08114051818847656},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049750","descriptor_name":"Genome, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049750","descriptor_name":"Genome, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049750","descriptor_name":"Genome, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1001093","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001093","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001093&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21390268","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21390268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:bec045cea77246fba45cd5da1d36bbc2","is_oa":true,"landing_page_url":"https://doaj.org/article/bec045cea77246fba45cd5da1d36bbc2","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 3, p e1001093 (2011)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2064599","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3048381","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/138484","is_oa":true,"landing_page_url":"https://figshare.com/articles/Natural_Selection_on_Functional_Modules_a_Genome_Wide_Analysis/138484","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1001093","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001093","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001093&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1224945033","display_name":null,"funder_award_id":"FEDER","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G1952936224","display_name":null,"funder_award_id":"RD06/0020","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G3695962793","display_name":null,"funder_award_id":"BIO2008-04212","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G4715792684","display_name":null,"funder_award_id":"CIBER","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G5544519660","display_name":null,"funder_award_id":"FEDER","funder_id":"https://openalex.org/F4320321864","funder_display_name":"Generalitat Valenciana"},{"id":"https://openalex.org/G6042583956","display_name":null,"funder_award_id":"ISCIII","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G7779868532","display_name":null,"funder_award_id":"FEDER","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320321864","display_name":"Generalitat Valenciana","ror":"https://ror.org/0097mvx21"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1972872960.pdf","grobid_xml":"https://content.openalex.org/works/W1972872960.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1511771787","https://openalex.org/W1547248981","https://openalex.org/W1969761972","https://openalex.org/W1976626942","https://openalex.org/W1984225101","https://openalex.org/W1985035274","https://openalex.org/W1987378985","https://openalex.org/W2002854942","https://openalex.org/W2005245900","https://openalex.org/W2008609077","https://openalex.org/W2009868245","https://openalex.org/W2027938985","https://openalex.org/W2049527386","https://openalex.org/W2069824853","https://openalex.org/W2080618944","https://openalex.org/W2097977090","https://openalex.org/W2098704509","https://openalex.org/W2099762535","https://openalex.org/W2102176540","https://openalex.org/W2103017472","https://openalex.org/W2106339860","https://openalex.org/W2110335151","https://openalex.org/W2115011276","https://openalex.org/W2115888213","https://openalex.org/W2117790117","https://openalex.org/W2122863959","https://openalex.org/W2132926880","https://openalex.org/W2133465414","https://openalex.org/W2134542215","https://openalex.org/W2142237411","https://openalex.org/W2145025818","https://openalex.org/W2154770881","https://openalex.org/W2164154943","https://openalex.org/W2166838894","https://openalex.org/W2324145849","https://openalex.org/W4210430020","https://openalex.org/W4229880569","https://openalex.org/W4246704063","https://openalex.org/W4301156742","https://openalex.org/W6630672041","https://openalex.org/W7058562822"],"related_works":["https://openalex.org/W2953234277","https://openalex.org/W2626256601","https://openalex.org/W2900413183","https://openalex.org/W4390975304","https://openalex.org/W147410782","https://openalex.org/W1521359361","https://openalex.org/W1942139584","https://openalex.org/W4213088723","https://openalex.org/W1967418371","https://openalex.org/W4238809353"],"abstract_inverted_index":{"Classically,":[0],"the":[1,13,30,73,94,156,219,224],"functional":[2,111,128,142,158,178],"consequences":[3],"of":[4,16,25,34,36,77,107,127,141,152,155,223,226],"natural":[5,108],"selection":[6,109,216],"over":[7],"genomes":[8,137,194],"have":[9,164],"been":[10,52,165],"analyzed":[11],"as":[12,168],"compound":[14],"effects":[15],"individual":[17,37,65],"genes.":[18],"The":[19],"current":[20],"paradigm":[21],"for":[22,75,86,105,192],"large-scale":[23],"analysis":[24],"adaptation":[26,206],"is":[27,114],"based":[28],"on":[29,110],"observed":[31],"significant":[32,145],"deviations":[33],"rates":[35,151,163],"genes":[38,63],"from":[39],"neutral":[40],"evolutionary":[41,120,162],"expectation.":[42],"This":[43],"approach,":[44],"which":[45,185],"assumed":[46],"independence":[47],"among":[48],"genes,":[49,184],"has":[50,71],"not":[51,83,211],"able":[53,115],"to":[54,103,116,147,195,218],"identify":[55],"biological":[56,169],"functions":[57,170],"significantly":[58],"enriched":[59],"in":[60,64,123,132],"positively":[61,182],"selected":[62,183,191],"species.":[66,90,227],"Alternatively,":[67],"pooling":[68],"related":[69],"species":[70],"enhanced":[72],"search":[74],"signatures":[76,81],"selection.":[78,173],"However,":[79],"grouping":[80],"does":[82],"allow":[84],"testing":[85],"adaptive":[87,220],"differences":[88],"between":[89],"Here":[91],"we":[92],"introduce":[93],"Gene-Set":[95],"Selection":[96],"Analysis":[97],"(GSSA),":[98],"a":[99,124],"new":[100],"genome-wide":[101],"approach":[102],"test":[104],"evidences":[106],"modules.":[112,129],"GSSA":[113,138,175],"detect":[117],"lineage":[118],"specific":[119],"rate":[121],"changes":[122],"notable":[125],"number":[126],"For":[130],"example,":[131],"nine":[133],"mammal":[134],"and":[135,149],"Drosophilae":[136],"identifies":[139,176],"hundreds":[140],"modules":[143,159,179],"with":[144,160,180,201],"associations":[146],"high":[148,161],"low":[150],"evolution.":[153],"Many":[154],"detected":[157],"previously":[166],"identified":[167],"under":[171,214],"positive":[172,208,215],"Notably,":[174],"conserved":[177],"many":[181],"questions":[186],"whether":[187],"they":[188],"are":[189],"exclusively":[190],"fitting":[193],"environmental":[196],"changes.":[197],"Our":[198],"results":[199],"agree":[200],"previous":[202],"studies":[203],"suggesting":[204],"that":[205],"requires":[207],"selection,":[209],"but":[210],"every":[212],"mutation":[213],"contributes":[217],"dynamical":[221],"process":[222],"evolution":[225]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}