{"id":"https://openalex.org/W2004437908","doi":"https://doi.org/10.1371/journal.pcbi.1001092","title":"Protein Complexes are Central in the Yeast Genetic Landscape","display_name":"Protein Complexes are Central in the Yeast Genetic Landscape","publication_year":2011,"publication_date":"2011-02-24","ids":{"openalex":"https://openalex.org/W2004437908","doi":"https://doi.org/10.1371/journal.pcbi.1001092","mag":"2004437908","pmid":"https://pubmed.ncbi.nlm.nih.gov/21390331"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1001092","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001092","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001092&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001092&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014964963","display_name":"Magali Michaut","orcid":"https://orcid.org/0000-0003-2002-2277"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Magali Michaut","raw_affiliation_strings":["The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062354734","display_name":"Anastasia Baryshnikova","orcid":"https://orcid.org/0000-0002-0123-2052"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Anastasia Baryshnikova","raw_affiliation_strings":["Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada","Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103429898","display_name":"Michael Costanzo","orcid":null},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Costanzo","raw_affiliation_strings":["Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada","Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022226374","display_name":"Chad L. Myers","orcid":"https://orcid.org/0000-0002-1026-5972"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad L. Myers","raw_affiliation_strings":["Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033568530","display_name":"Brenda Andrews","orcid":"https://orcid.org/0000-0001-6427-6493"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brenda J. Andrews","raw_affiliation_strings":["Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada","Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023165801","display_name":"Charles Boone","orcid":"https://orcid.org/0000-0002-3542-6760"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Charles Boone","raw_affiliation_strings":["Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada","Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010789029","display_name":"Gary D. Bader","orcid":"https://orcid.org/0000-0003-0185-8861"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Gary D. Bader","raw_affiliation_strings":["Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada","Department of Computer Science, University of Toronto, Toronto, Ontario, Canada","Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Computer Science, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5010789029"],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.3875,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.9303088,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"7","issue":"2","first_page":"e1001092","last_page":"e1001092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10750","display_name":"Fermentation and Sensory Analysis","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monochromatic-color","display_name":"Monochromatic color","score":0.691676139831543},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6366081833839417},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5606783628463745},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5495803952217102},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4929509162902832},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4874579906463623},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.45802056789398193},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.45767518877983093},{"id":"https://openalex.org/keywords/gene-interaction","display_name":"Gene interaction","score":0.41114920377731323}],"concepts":[{"id":"https://openalex.org/C40833965","wikidata":"https://www.wikidata.org/wiki/Q6901438","display_name":"Monochromatic color","level":2,"score":0.691676139831543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6366081833839417},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5606783628463745},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5495803952217102},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4929509162902832},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4874579906463623},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.45802056789398193},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.45767518877983093},{"id":"https://openalex.org/C2991772755","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Gene interaction","level":3,"score":0.41114920377731323},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1001092","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001092","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001092&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21390331","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21390331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:c03a4c3e73e94398b8e248ccd072ace0","is_oa":true,"landing_page_url":"https://doaj.org/article/c03a4c3e73e94398b8e248ccd072ace0","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 2, p e1001092 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/138661","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Protein_Complexes_are_Central_in_the_Yeast_Genetic_Landscape/138661","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3044758","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3044758","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1001092","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001092","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001092&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.6800000071525574}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2004437908.pdf","grobid_xml":"https://content.openalex.org/works/W2004437908.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1964612763","https://openalex.org/W1967220526","https://openalex.org/W1970250905","https://openalex.org/W1975931018","https://openalex.org/W1988035834","https://openalex.org/W1996159515","https://openalex.org/W2013520054","https://openalex.org/W2037225069","https://openalex.org/W2042688172","https://openalex.org/W2052815101","https://openalex.org/W2070829661","https://openalex.org/W2073881372","https://openalex.org/W2080408951","https://openalex.org/W2090951989","https://openalex.org/W2095722471","https://openalex.org/W2098013039","https://openalex.org/W2102247469","https://openalex.org/W2103017472","https://openalex.org/W2104711391","https://openalex.org/W2105638592","https://openalex.org/W2107067224","https://openalex.org/W2108480332","https://openalex.org/W2111237533","https://openalex.org/W2120423098","https://openalex.org/W2125642929","https://openalex.org/W2127073167","https://openalex.org/W2130139983","https://openalex.org/W2130907642","https://openalex.org/W2133102806","https://openalex.org/W2137917513","https://openalex.org/W2139027526","https://openalex.org/W2142437744","https://openalex.org/W2142604092","https://openalex.org/W2147069866","https://openalex.org/W2147554928","https://openalex.org/W2150749732","https://openalex.org/W2152360905","https://openalex.org/W2154600255","https://openalex.org/W2159460045","https://openalex.org/W2159675211","https://openalex.org/W2163965551","https://openalex.org/W2170583315","https://openalex.org/W3214669750","https://openalex.org/W4240974886"],"related_works":["https://openalex.org/W2509614667","https://openalex.org/W2963293152","https://openalex.org/W4302199713","https://openalex.org/W4282026465","https://openalex.org/W2626027010","https://openalex.org/W2963562790","https://openalex.org/W2909469610","https://openalex.org/W2755006503","https://openalex.org/W1629841509","https://openalex.org/W1547276641"],"abstract_inverted_index":{"If":[0],"perturbing":[1],"two":[2],"genes":[3,32,59],"together":[4],"has":[5,49],"a":[6,46,167,179,231],"stronger":[7],"or":[8,64,80,82],"weaker":[9],"effect":[10],"than":[11,151],"expected,":[12],"they":[13,24],"are":[14,21,156,164,201,266],"said":[15],"to":[16,74,97,268],"genetically":[17],"interact.":[18],"Genetic":[19],"interactions":[20,44,274],"important":[22,217],"because":[23],"help":[25],"map":[26,235],"gene":[27,128,251],"function,":[28],"and":[29,41,149,197,207,211,226,233,238,254,258],"functionally":[30],"related":[31],"have":[33],"similar":[34],"genetic":[35,43,116,273],"interaction":[36,117],"patterns.":[37,173,221],"Mapping":[38],"quantitative":[39,115],"(positive":[40],"negative)":[42],"on":[45],"global":[47],"scale":[48],"recently":[50],"become":[51,277],"possible.":[52],"This":[53,174],"data":[54,118],"clearly":[55],"shows":[56,193],"groups":[57,71],"of":[58,108,140,153,171,187,236],"connected":[60],"by":[61,145],"predominantly":[62],"positive":[63,196],"negative":[65,198],"interactions,":[66],"termed":[67],"monochromatic":[68,106,185,199,223],"groups.":[69],"These":[70],"often":[72],"correspond":[73],"functional":[75,99],"modules,":[76],"like":[77],"biological":[78,110,141,188,205,240],"processes":[79,111,206],"complexes,":[81],"connections":[83,155,210,227],"between":[84],"modules.":[85,100],"However":[86],"it":[87],"is":[88],"not":[89],"yet":[90],"known":[91,98,109,204],"how":[92],"these":[93,172,220],"patterns":[94,200],"globally":[95],"relate":[96],"Here":[101],"we":[102,159,228,264],"systematically":[103],"study":[104],"the":[105,113,131,184,243,261],"nature":[107],"using":[112],"largest":[114],"set":[119],"available,":[120],"which":[121,272],"includes":[122],"fitness":[123],"measurements":[124],"for":[125,166,250,271],"\u223c5.4":[126],"million":[127],"pairs":[129],"in":[130,182,203,208,219,242],"yeast":[132,244],"Saccharomyces":[133],"cerevisiae.":[134],"We":[135],"find":[136,229],"that":[137,161,176,194,212,246],"only":[138],"10%":[139],"processes,":[142,224],"as":[143],"defined":[144],"Gene":[146],"Ontology":[147],"annotations,":[148],"less":[150],"1%":[152],"inter-process":[154],"monochromatic.":[157],"Further,":[158],"show":[160],"protein":[162,213],"complexes":[163,177,214,225],"responsible":[165],"surprisingly":[168],"large":[169],"fraction":[170],"suggests":[175],"play":[178,215],"central":[180],"role":[181,218],"shaping":[183],"landscape":[186],"processes.":[189],"Altogether":[190],"this":[191],"work":[192],"both":[195],"found":[202],"their":[209],"an":[216],"The":[222],"chart":[230],"hierarchical":[232],"modular":[234],"sensitive":[237],"redundant":[239],"systems":[241],"cell":[245],"will":[247,275],"be":[248],"useful":[249],"function":[252],"prediction":[253],"comparison":[255],"across":[256],"phenotypes":[257],"organisms.":[259],"Furthermore":[260],"analysis":[262],"methods":[263],"develop":[265],"applicable":[267],"other":[269],"species":[270],"progressively":[276],"more":[278],"available.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}