{"id":"https://openalex.org/W2017851065","doi":"https://doi.org/10.1371/journal.pcbi.1001073","title":"Pharmacodynamic Modeling of Anti-Cancer Activity of Tetraiodothyroacetic Acid in a Perfused Cell Culture System","display_name":"Pharmacodynamic Modeling of Anti-Cancer Activity of Tetraiodothyroacetic Acid in a Perfused Cell Culture System","publication_year":2011,"publication_date":"2011-02-03","ids":{"openalex":"https://openalex.org/W2017851065","doi":"https://doi.org/10.1371/journal.pcbi.1001073","mag":"2017851065","pmid":"https://pubmed.ncbi.nlm.nih.gov/21304935"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1001073","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001073","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001073&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001073&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067497938","display_name":"Hung\u2010Yun Lin","orcid":"https://orcid.org/0000-0003-2824-6419"},"institutions":[{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hung-Yun Lin","raw_affiliation_strings":["Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210116763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030691636","display_name":"Cornelia B. Landersdorfer","orcid":"https://orcid.org/0000-0003-0928-4743"},"institutions":[{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cornelia B. Landersdorfer","raw_affiliation_strings":["Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210116763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102993262","display_name":"David London","orcid":"https://orcid.org/0000-0003-4561-3778"},"institutions":[{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David London","raw_affiliation_strings":["Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210116763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045283142","display_name":"Ran Meng","orcid":"https://orcid.org/0000-0002-5267-5662"},"institutions":[{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ran Meng","raw_affiliation_strings":["Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210116763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047629165","display_name":"Chang\u2010Uk Lim","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang-Uk Lim","raw_affiliation_strings":["Flow Cytometry Core Facility, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Flow Cytometry Core Facility, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210116763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110025634","display_name":"Cassie Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassie Lin","raw_affiliation_strings":["Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210116763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046536980","display_name":"Sharon Lin","orcid":"https://orcid.org/0000-0001-7566-482X"},"institutions":[{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Lin","raw_affiliation_strings":["Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210116763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040532034","display_name":"Heng\u2010Yuan Tang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heng-Yuan Tang","raw_affiliation_strings":["Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210116763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103582691","display_name":"David Brown","orcid":null},"institutions":[{"id":"https://openalex.org/I4210118651","display_name":"Institute for Clinical Pharmacodynamics (United States)","ror":"https://ror.org/02gck7e73","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Brown","raw_affiliation_strings":["Emerging Infections and Pharmacodynamics Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Emerging Infections and Pharmacodynamics Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210118651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085070050","display_name":"Brian Van Scoy","orcid":null},"institutions":[{"id":"https://openalex.org/I4210118651","display_name":"Institute for Clinical Pharmacodynamics (United States)","ror":"https://ror.org/02gck7e73","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Van Scoy","raw_affiliation_strings":["Emerging Infections and Pharmacodynamics Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Emerging Infections and Pharmacodynamics Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210118651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006954842","display_name":"Robert Kulawy","orcid":null},"institutions":[{"id":"https://openalex.org/I4210118651","display_name":"Institute for Clinical Pharmacodynamics (United States)","ror":"https://ror.org/02gck7e73","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Kulawy","raw_affiliation_strings":["Emerging Infections and Pharmacodynamics Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Emerging Infections and Pharmacodynamics Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210118651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012909246","display_name":"Lurdes Queimado","orcid":"https://orcid.org/0000-0002-1106-4873"},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lurdes Queimado","raw_affiliation_strings":["Department of Otorhinolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036512885","display_name":"George L. Drusano","orcid":"https://orcid.org/0000-0001-9162-7332"},"institutions":[{"id":"https://openalex.org/I4210118651","display_name":"Institute for Clinical Pharmacodynamics (United States)","ror":"https://ror.org/02gck7e73","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George L. Drusano","raw_affiliation_strings":["Emerging Infections and Pharmacodynamics Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Emerging Infections and Pharmacodynamics Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210118651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011691262","display_name":"Arnold Louie","orcid":"https://orcid.org/0000-0001-6227-7580"},"institutions":[{"id":"https://openalex.org/I4210118651","display_name":"Institute for Clinical Pharmacodynamics (United States)","ror":"https://ror.org/02gck7e73","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold Louie","raw_affiliation_strings":["Emerging Infections and Pharmacodynamics Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Emerging Infections and Pharmacodynamics Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210118651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019179538","display_name":"Faith B. Davis","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faith B. Davis","raw_affiliation_strings":["Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210116763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032045966","display_name":"Shaker A. Mousa","orcid":"https://orcid.org/0000-0002-9294-015X"},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaker A. Mousa","raw_affiliation_strings":["Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, New York, United States of America","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064680897","display_name":"Paul J. Davis","orcid":"https://orcid.org/0000-0002-6794-4917"},"institutions":[{"id":"https://openalex.org/I77920804","display_name":"Albany Medical Center Hospital","ror":"https://ror.org/0307crw42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I77920804"]},{"id":"https://openalex.org/I4210116763","display_name":"Albany Research Institute","ror":"https://ror.org/01hv1yg09","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116763"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Davis","raw_affiliation_strings":["Albany Medical College, Albany, New York, United States of America","Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Albany Medical College, Albany, New York, United States of America","institution_ids":["https://openalex.org/I77920804"]},{"raw_affiliation_string":"Signal Transduction Laboratory, Ordway Research Institute, Albany, New York, United States of America","institution_ids":["https://openalex.org/I4210116763"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5030691636"],"corresponding_institution_ids":["https://openalex.org/I4210116763"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.0807,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.93625777,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"7","issue":"2","first_page":"e1001073","last_page":"e1001073"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.5785121321678162},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.5208911895751953},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.48759761452674866},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.43960073590278625},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.4236324429512024},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.4168641269207001},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.3682568073272705},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3460080921649933},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3375598192214966},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3314897119998932},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3110795021057129},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.21991759538650513},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18697983026504517},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16484546661376953},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.06925362348556519}],"concepts":[{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5785121321678162},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5208911895751953},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48759761452674866},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43960073590278625},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4236324429512024},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4168641269207001},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3682568073272705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3460080921649933},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3375598192214966},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3314897119998932},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3110795021057129},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21991759538650513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18697983026504517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16484546661376953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06925362348556519},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1001073","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001073","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001073&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21304935","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21304935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1001073","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1001073","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:5eedb33720284bba9ec8a469709b8972","is_oa":true,"landing_page_url":"https://doaj.org/article/5eedb33720284bba9ec8a469709b8972","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 2, p e1001073 (2011)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3033367","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3033367","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1001073","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001073","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001073&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2017851065.pdf","grobid_xml":"https://content.openalex.org/works/W2017851065.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W165254100","https://openalex.org/W1981254316","https://openalex.org/W1987475341","https://openalex.org/W1996476040","https://openalex.org/W1999404859","https://openalex.org/W1999970915","https://openalex.org/W2007596750","https://openalex.org/W2020433921","https://openalex.org/W2035031389","https://openalex.org/W2040739348","https://openalex.org/W2043192769","https://openalex.org/W2047105340","https://openalex.org/W2049159592","https://openalex.org/W2053848912","https://openalex.org/W2056249941","https://openalex.org/W2057713336","https://openalex.org/W2063525790","https://openalex.org/W2065616344","https://openalex.org/W2073791430","https://openalex.org/W2074532062","https://openalex.org/W2075592803","https://openalex.org/W2077945404","https://openalex.org/W2079363836","https://openalex.org/W2082234110","https://openalex.org/W2090493150","https://openalex.org/W2095201384","https://openalex.org/W2099216474","https://openalex.org/W2123110143","https://openalex.org/W2127640925","https://openalex.org/W2131621463","https://openalex.org/W2134989772","https://openalex.org/W2136706836","https://openalex.org/W2155813667","https://openalex.org/W2157497229","https://openalex.org/W2162589718","https://openalex.org/W2334765105","https://openalex.org/W4301066098"],"related_works":["https://openalex.org/W3148810057","https://openalex.org/W2755853517","https://openalex.org/W2380755462","https://openalex.org/W3152233030","https://openalex.org/W2471519923","https://openalex.org/W3150682115","https://openalex.org/W2384087372","https://openalex.org/W1985998670","https://openalex.org/W2072481810","https://openalex.org/W2347992620"],"abstract_inverted_index":{"Unmodified":[0,108],"or":[1,71,86,301],"as":[2,229],"a":[3,49,72,153,195,199,241],"poly[lactide-co-glycolide]":[4],"nanoparticle,":[5],"tetraiodothyroacetic":[6],"acid":[7],"(tetrac)":[8],"acts":[9],"at":[10],"the":[11,31,37,93,111,139,159,167,174,180,251,278,295],"integrin":[12],"\u03b1v\u03b23":[13],"receptor":[14],"on":[15,58,135,161,169,182],"human":[16,147],"cancer":[17,114,149,269],"cells":[18,115,212],"to":[19,63,76,158],"inhibit":[20],"tumor":[21],"cell":[22,52,124,140,207,270],"proliferation":[23,112],"and":[24,40,61,82,92,116,198,215,233,255,258,261,263,285,287,293],"xenograft":[25],"growth.":[26],"To":[27],"study":[28],"in":[29,36,41,101,122,266],"vitro":[30,267],"pharmacodynamics":[32,296],"of":[33,39,66,113,133,138,164,171,210,225,253,283,297],"tetrac":[34,109,134,186,214,239,254,257,284],"formulations":[35],"absence":[38],"conjunction":[42],"with":[43,119,223,273],"other":[44,298],"chemotherapeutic":[45,299],"agents,":[46],"we":[47],"developed":[48,127],"perfusion":[50,268],"bellows":[51],"culture":[53],"system.":[54],"Cells":[55,79],"were":[56,80,103,248],"grown":[57],"polymer":[59],"flakes":[60],"exposed":[62],"various":[64],"concentrations":[65],"tetrac,":[67],"nano-tetrac,":[68,236],"resveratrol,":[69,256],"cetuximab,":[70],"combination":[73],"for":[74,105,179,235,250,291],"up":[75],"18":[77],"days.":[78,88],"harvested":[81,211],"counted":[83],"every":[84],"one":[85],"two":[87,131],"Both":[89],"NONMEM":[90],"VI":[91],"exact":[94],"Monte":[95],"Carlo":[96],"parametric":[97],"expectation":[98],"maximization":[99],"algorithm":[100],"S-ADAPT":[102],"utilized":[104],"mathematical":[106,274],"modeling.":[107],"inhibited":[110],"did":[117],"so":[118],"differing":[120],"potency":[121,197],"different":[123,136,242],"lines.":[125],"The":[126],"mechanism-based":[128],"model":[129],"included":[130],"effects":[132,247,280],"parts":[137],"cycle":[141],"which":[142,188],"could":[143],"be":[144,289],"distinguished.":[145],"For":[146],"breast":[148],"cells,":[150,193],"modeling":[151,275],"suggested":[152],"higher":[154,196],"sensitivity":[155],"(lower":[156],"IC50)":[157],"effect":[160,168,181,202],"success":[162],"rate":[163,170],"replication":[165],"than":[166,203],"growth,":[172],"whereas":[173],"capacity":[175],"(Imax)":[176],"was":[177,221],"larger":[178,200],"growth":[183],"rate.":[184],"Nanoparticulate":[185],"(nano-tetrac),":[187],"does":[189],"not":[190],"enter":[191],"into":[192],"had":[194],"anti-proliferative":[201,246,279],"unmodified":[204,238],"tetrac.":[205],"Fluorescence-activated":[206],"sorting":[208],"analysis":[209],"revealed":[213],"nano-tetrac":[216,262,286],"induced":[217],"concentration-dependent":[218],"apoptosis":[219],"that":[220],"correlated":[222],"expression":[224],"pro-apoptotic":[226],"proteins,":[227],"such":[228],"p53,":[230],"p21,":[231],"PIG3":[232],"BAD":[234],"while":[237],"showed":[240],"profile.":[243],"Approximately":[244],"additive":[245],"found":[249],"combinations":[252],"cetuximab":[259],"(Erbitux),":[260],"cetuximab.":[264],"Our":[265],"system":[271],"together":[272],"successfully":[276],"described":[277],"over":[281],"time":[282],"may":[288],"useful":[290],"dose-finding":[292],"studying":[294],"agents":[300],"their":[302],"combinations.":[303]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}